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Preclinical and randomized phase I studies of plitidepsin in adults hospitalized with COVID-19
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Varona, Jose F. (Universidad San Pablo-CEU. Facultad de Medicina, Madrid) ;
Landete, Pedro (Universidad Autónoma de Madrid) ;
Lopez-Martin, Jose A. (Virology and Inflammation Unit, PharmaMar, SA, Madrid) ;
Estrada, Vicente (Universidad Complutense de Madrid) ;
Paredes, Roger (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Guisado-Vasco, Pablo (Universidad Europea de Madrid) ;
Fernandez de Orueta, Lucia (Hospital Universitario de Getafe (Madrid)) ;
Torralba, Miguel (Hospital Universitario de Guadalajara) ;
Fortún, Jesús (Hospital Universitario Ramón y Cajal (Madrid)) ;
Vates, Roberto (Hospital Universitario de Getafe (Madrid)) ;
Barberán, José (Facultad de Medicina, Universidad San Pablo-CEU, Madrid) ;
Clotet Sala, Bonaventura (Universitat Autònoma de Barcelona. Departament de Medicina) ;
Ancochea, Julio (Centro de Investigación Biomédica en Red de Enfermedades Respiratorias) ;
Carnevali, Daniel (Universidad Europea de Madrid) ;
Cabello, Noemi (Hospital Clínico San Carlos (Madrid)) ;
Porras, Lourdes (Hospital General Universitario de Ciudad Real) ;
Gijon, Paloma (Hospital General Universitario Gregorio Marañón. Instituto de Investigación Sanitaria Gregorio Marañón (IiSGM)) ;
Monereo, Alfonso (Hospital Universitario de Getafe (Madrid)) ;
Abad, Daniel (Hospital Universitario de Getafe (Madrid)) ;
Zuñiga, Sonia (Department of Molecular and Cell Biology, Centro Nacional de Biotecnología (CNB-CSIC), Madrid) ;
Sola, Isabel (Department of Molecular and Cell Biology, Centro Nacional de Biotecnología (CNB-CSIC), Madrid) ;
Rodon, Jordi (Institut de Recerca i Tecnologia Agroalimentàries. Centre de Recerca en Sanitat Animal) ;
Vergara-Alert, Júlia (Institut de Recerca i Tecnologia Agroalimentàries. Centre de Recerca en Sanitat Animal) ;
Izquierdo Useros, Nuria (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Fudio, Salvador (Clinical Pharmacology Unit, PharmaMar, Madrid) ;
Pontes, Maria Jose (Medical Affairs, PharmaMar, Madrid) ;
de Rivas, Beatriz (Medical Affairs, PharmaMar, Madrid) ;
Giron de Velasco, Patricia (Virology and Inflammation Unit, PharmaMar, Madrid) ;
Nieto, Antonio (Bio Statistics Unit, PharmaMar, Madrid) ;
Gomez, Javier (Bio Statistics Unit, PharmaMar, Madrid) ;
Avilés, Pablo (Preclinical Unit, Pharmamar, Madrid) ;
Lubomirov, Rubin (Clinical Pharmacology Unit, PharmaMar, Madrid) ;
Belgrano, Alvaro (Bio Statistics Unit, PharmaMar, Madrid) ;
Sopesen, Belen (Biocross, SL, Valladolid) ;
White, Kris M. (Global Health Emerging Pathogens Institute, Icahn School of Medicine at Mount Sinai, New York) ;
Rosales, Romel (Global Health Emerging Pathogens Institute, Icahn School of Medicine at Mount Sinai, New York) ;
Yildiz, Soner (Global Health Emerging Pathogens Institute, Icahn School of Medicine at Mount Sinai, New York) ;
Reuschl, Ann-Kathrin (Division of Infection and Immunity, University College London) ;
Thorne, Lucy G. (Division of Infection and Immunity, University College London, London, UK) ;
Jolly, Clare (Division of Infection and Immunity, University College London) ;
Towers, Greg J. (Division of Infection and Immunity, University College London) ;
Zuliani-Alvarez, Lorena (Department of Cellular and Molecular Pharmacology, University of California, San Francisco) ;
Bouhaddou, Mehdi (Department of Cellular and Molecular Pharmacology, University of California, San Francisco) ;
Obernier, Kirsten (Department of Cellular and Molecular Pharmacology, University of California, San Francisco) ;
McGovern, Briana L. (Global Health Emerging Pathogens Institute, Icahn School of Medicine at Mount Sinai, New York) ;
Rodriguez, M. Luis (Global Health Emerging Pathogens Institute, Icahn School of Medicine at Mount Sinai, New York) ;
Enjuanes, Luis (Department of Molecular and Cell Biology, Centro Nacional de Biotecnología (CNB-CSIC), Madrid) ;
Fernandez-Sousa, Jose M. (Pharmamar, Madrid) ;
Krogan, Nevan J. (Department of Cellular and Molecular Pharmacology, University of California, San Francisco) ;
Jimeno, Jose M. (Virology and Inflammation Unit, PharmaMar, SA, Madrid) ;
Garcia-Sastre, Adolfo (Icahn School of Medicine at Mount Sinai, New York)
This proof-of-concept study shows that plitidepsin, a marine peptide that inhibits SARS-CoV-2 replication, has a favorable safety profile and may be an efficacious treatment for patients with COVID-19. [...]
2022 -  10.26508/lsa.202101200
Life Science Alliance, Vol. 5 (january 2022)
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