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14 p, 308.2 KB |
At-Home Foscarnet Administration in Patients with Cytomegalovirus Infection Post-Allogeneic Stem Cell Transplantation : A Unicentric, Safe, and Feasible Program
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Ruiz-Boy, Sonia (Hospital Clínic i Provincial de Barcelona) ;
Pedraza, Alexandra (Hospital Clínic i Provincial de Barcelona) ;
Prat, Marta (Hospital Clínic i Provincial de Barcelona) ;
Salas, María Queralt (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ;
Carcelero, Ester (Hospital Clínic i Provincial de Barcelona) ;
Riu-Viladoms, G (Hospital Clínic i Provincial de Barcelona) ;
Suárez-Lledó Grande, María (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ;
Monge-Escartín, Inés (Hospital Clínic i Provincial de Barcelona) ;
Rodríguez-Lobato, Luís Gerardo (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ;
Martínez-Roca, Alexandra (Hospital Clínic i Provincial de Barcelona) ;
Rovira Argelagués, Montserrat (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ;
Martínez, Carmen (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ;
Gallego, Cristina (Hospital Clínic i Provincial de Barcelona) ;
Urbano-Ispizua, Álvaro (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ;
Sánchez, Juan (Hospital Clínic i Provincial de Barcelona) ;
Marcos, María Ángeles (Hospital Clínic i Provincial de Barcelona) ;
Fernández-Avilés, Francesc (Hospital Clínic i Provincial de Barcelona)
Cytomegalovirus (CMV) infection is a relevant cause of morbimortality in patients receiving allogeneic stem cell transplantation (allo-HCT). Foscarnet (FCN) is an effective drug against CMV administered intravenously and usually on an inpatient basis. [...]
2023 -  10.3390/ph16121741
Pharmaceuticals, Vol. 16 Núm. 12 (december 2023) , p. 1741
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10 p, 3.0 MB |
Applicability and validation of different prognostic scores in allogeneic hematopoietic cell transplant (HCT) in the post-transplant cyclophosphamide era
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Salas, María Queralt (Hospital Clínic i Provincial de Barcelona) ;
Rodríguez Lobato, Luis Gerardo (Hospital Clínic i Provincial de Barcelona) ;
Charry, Paola (Hospital Clínic i Provincial de Barcelona) ;
Suárez-Lledó, Maria (Hospital Clínic i Provincial de Barcelona) ;
Pedraza, Alexandra (Hospital Clínic i Provincial de Barcelona) ;
Solano, María Teresa (Hospital Clínic i Provincial de Barcelona) ;
Arcarons, Jordi (Hospital Clínic i Provincial de Barcelona) ;
Cid, Joan (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ;
Lozano, Miquel (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ;
Rosiñol, Laura (Hospital Clínic i Provincial de Barcelona) ;
Esteve, Jordi (Hospital Clínic i Provincial de Barcelona) ;
Carreras, Enric (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ;
Fernandez Aviles, Francesc (Hospital Clínic i Provincial de Barcelona) ;
Martínez, Carmen (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ;
Rovira Tarrats, Montserrat (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras)
We investigated the predictive capacity of six prognostic indices [Karnofsky Performance Status (KPS), Hematopoietic Cell Transplant-Specific Comorbidity Index (HCT-CI), Disease Risk Index (DRI), European Bone Marrow Transplantation (EBMT) and Revised Pre-Transplantation Assessment of Mortality (rPAM) Scores and Endothelial Activation and Stress Index (EASIX)] in 205 adults undergoing post-transplant cyclophosphamide (PTCy)-based allo-HCT. [...]
2023 - 10.1016/j.htct.2023.07.008
Hematology, Transfusion and Cell Therapy, 2023
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12 p, 7.7 MB |
Differential protein expression in endothelial cells exposed to serum from patients with acute graft-vs-host disease, depending on steroid response
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Martinez-Sanchez, Julia (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ;
Palomo, Marta (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ;
Pedraza, Alexandra (Hospital Clínic i Provincial de Barcelona) ;
Moreno-Castaño, Ana Belén (Hospital Clínic i Provincial de Barcelona) ;
Torramade-Moix, Sergi (Hospital Clínic i Provincial de Barcelona) ;
Rovira, Montserrat (Hospital Clínic i Provincial de Barcelona) ;
Salas, María Queralt (Hospital Clínic i Provincial de Barcelona) ;
Cid, Joan (Hospital Clínic i Provincial de Barcelona) ;
Escolar, Gines (Hospital Clínic i Provincial de Barcelona) ;
Penack, Olaf (Universität zu Berlin, Germany) ;
Carreras, Enric (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ;
Diaz-Ricart, Maribel (Hospital Clínic i Provincial de Barcelona)
Graft-versus-host disease (GVHD) is a complication of allogeneic haematopoietic cell transplantation. Endothelial injury is crucial as pathophysiological substrate for GVHD. GVHD first-line treatment is high-dose corticosteroids, although some patients are steroid-refractory. [...]
2023 - 10.1111/jcmm.17712
Journal of Cellular and Molecular Medicine, Vol. 27 Núm. 9 (may 2023) , p. 1227-1238
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9 p, 599.8 KB |
Reduced 8-Gray Compared to Standard 12-Gray Total Body Irradiation for Allogeneic Transplantation in First Remission Acute Lymphoblastic Leukemia : A Study of the Acute Leukemia Working Party of the EBMT
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Spyridonidis, Alexandros (University of Patras) ;
Labopin, Myriam (Sorbonne University) ;
Savani, Bipin (Vanderbilt University Medical Center) ;
Giebel, Sebastian (Maria Sklodowska-Curie National Research Institute of Oncology) ;
Bug, Gesine (Department of Medicine II. Goethe-University) ;
Schönland, Stefan (Medical Department V. University Hospital Heidelberg) ;
Kröger, Nicolaus (Department of Stem Cell Transplantation. University Medical Center) ;
Stelljes, Matthias (Department of Hematology/Oncology. University of Muenster) ;
Schroeder, Thomas (Department of Bone Marrow Transplantation. University Hospital) ;
Mcdonald, Andrew (Netcare Pretoria East Hospital) ;
Blau, Igor-Wolfgang (Charité - Universitätsmedizin Berlin) ;
Bornhäuser, Martin (University Hospital. TU Dresden) ;
Rovira, Montse (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ;
Bethge, Wolfgang (Department of Hematology & Oncology. University Hospital Tuebingen.) ;
Neubauer, Andreas (Philipps Universitaet Marburg) ;
Ganser, Arnold (Hannover Medical School) ;
Bourhis, Jean Henri (Gustave Roussy Cancer Campus BMT. Department of Hematology) ;
Edinger, Matthias (University Regensburg. Department of Hematology and Oncology) ;
Lioure, Bruno (Hematology. Stem Cell Transplant Unit. ICANS) ;
Wulf, Gerald (University Medicine Goettingen) ;
Schäfer-Eckart, Kerstin (Klinikum Nuernberg. 5. Medizinische Klinik. BMT-Unit) ;
Arat, Mutlu (Demiroglu Bilim Univ. Istanbul Florence Nightingale Hospital) ;
Peric, Zinaida (University Hospital Centre) ;
Schmid, Christoph (Universitatsklinikum Augsburg. Section Stem Cell Transplantation. Augsburg University and Medical Faculty) ;
Bazarbachi, Ali (Bone Marrow Transplantation Program. Department of Internal Medicine. American University of Beirut-Medical Center) ;
Ciceri, Fabio (Ospedale San Raffaele) ;
Nagler, Arnon (Hematology Division. Chaim Sheba Medical Center) ;
Mohty, Mohamad (Sorbonne Université)
In this registry-based study, we compared outcomes of allogeneic hematopoietic cell transplantation (allo-HCT) in adult patients with acute lymphoblastic leukemia (ALL) transplanted in first complete remission (CR-1), following conditioning with total body irradiation (TBI) at a standard 12-Gray or at a lower 8-Gray total dose. [...]
2023 - 10.1097/HS9.0000000000000812
HemaSphere, Vol. 7 Núm. 1 (september 2023) , p. e812
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16 p, 1.1 MB |
Endothelial activation and damage as a common pathological substrate in different pathologies and cell therapy complications
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Palomo, Marta (Hospital Clínic i Provincial de Barcelona) ;
Moreno-Castaño, Ana Belén (Institut d'Investigacions Biomèdiques August Pi i Sunyer) ;
Salas, María Queralt (Institut d'Investigacions Biomèdiques August Pi i Sunyer) ;
Escribano-Serrat, Silvia (Institut d'Investigacions Biomèdiques August Pi i Sunyer) ;
Rovira, Montserrat (Institut d'Investigacions Biomèdiques August Pi i Sunyer) ;
Guillen-Olmos, Elena (Hospital Clínic i Provincial de Barcelona) ;
Fernandez, Sara (Hospital Clínic i Provincial de Barcelona) ;
Ventosa-Capell, Helena (Hospital Clínic i Provincial de Barcelona) ;
Youssef, Lina (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ;
Crispi, Fatima (Centro de Investigación Biomédica en Red de Enfermedades Raras) ;
Nomdedeu, Meritxell (Hospital Clínic i Provincial de Barcelona) ;
Martinez-Sanchez, Julia (Institut d'Investigacions Biomèdiques August Pi i Sunyer) ;
De Moner, Blanca (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ;
Diaz-Ricart, Maribel (Institut d'Investigacions Biomèdiques August Pi i Sunyer)
The endothelium is a biologically active interface with multiple functions, some of them common throughout the vascular tree, and others that depend on its anatomical location. Endothelial cells are continually exposed to cellular and humoral factors, and to all those elements (biological, chemical, or hemodynamic) that circulate in blood at a certain time. [...]
2023 - 10.3389/fmed.2023.1285898
Frontiers in Medicine, Vol. 10 (2023) , p. 1285898
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19 p, 3.8 MB |
Espais agraris, assentaments andalusins i la ciutat de Tortosa (Baix Ebre)
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Kirchner, Helena 1963- (Universitat Autònoma de Barcelona. Departament de Ciències de l'Antiguitat i de l'Edat Mitjana) ;
Virgili Colet, Antoni, 1956- (Universitat Autònoma de Barcelona. Departament de Ciències de l'Antiguitat i de l'Edat Mitjana) ;
Marfull, Josep (Universitat Autònoma de Barcelona. Departament de Ciències de l'Antiguitat i de l'Edat Mitjana) ;
Pacheco Catalán, Núria (Universitat Autònoma de Barcelona. Departament de Ciències de l'Antiguitat i de l'Edat Mitjana) ;
Pica, Manel (Universitat Autònoma de Barcelona. Departament de Ciències de l'Antiguitat i de l'Edat Mitjana) ;
Rovira Argelagués, Montserrat (Universitat Autònoma de Barcelona. Departament de Ciències de l'Antiguitat i de l'Edat Mitjana)
La distribució dels assentaments rurals andalusins al Baix Ebre, a l'entorn de Madîna Turtûša (Tortosa), així com el desenvolupament de la ciutat estan estretament vinculats a la creació d'espais de cultiu en els marges del riu. [...]
The distribution of rural islamic settlements in the Baix Ebre (the final stretch of Ebro River), nearby Madîna Turtûša (Tortosa), and the development of the city are closely connected with the construction of cultivation areas in both riversides. [...]
Barcelona: Generalitat de Catalunya. Departament de Cultura, 2016
Actes de les I Jornades d'Arqueologia de les Terres de l'Ebre 2016. (Volum II), pag 11-29
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7 p, 473.0 KB |
Association of uric acid levels before start of conditioning with mortality after allogeneic hematopoietic stem cell transplantation - a prospective, non-interventional study of the EBMT Transplant Complication Working Party
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Penack, Olaf (Charité - Universitätsmedizin Berlin) ;
Peczynski, Christophe (EBMT Statistical Unit) ;
van der Werf, Steffie (EBMT Data Office) ;
Finke, Jürgen (University of Freiburg) ;
Ganser, Arnold (Hannover Medical School) ;
Schoemans, Helene (University Hospitals Leuven (Bèlgica)) ;
Pavlu, Jiri (Imperial College London) ;
Niittyvuopio, Riitta. (HUCH Comprehensive Cancer Center) ;
Schroyens, Wilfried (University Hospital Antwerp (Bèlgica)) ;
Kaynar, Leylagül (Erciyes University Medical Faculty) ;
Blau, Igor W. (Charité - Universitätsmedizin Berlin) ;
van der Velden, Walter (Radboud University - Nijmegen Medical Centre) ;
Sierra, Jorge (Institut d'Investigació Biomèdica Sant Pau) ;
Cortelezzi, Agostino (Fondazione IRCCS - Ca'Granda) ;
Wulf, Gerald (Universitätsklinikum Göttingen) ;
Turlure, Pascal (CHRU Limoges) ;
Rovira, Montserrat (Hospital Clínic i Provincial de Barcelona) ;
Ozkurt, Zubeydenur (Gazi University) ;
Pascual-Cascon, Maria J. (Hospital Regional Universitario de Málaga) ;
Moreira, Maria C. (Instituto National do Cancer) ;
Clausen, Johannes (Ordensklinikum Linz Elisabethinen) ;
Greinix, Hildegard (LKH - University Hospital Graz) ;
Duarte, Rafael F. (Hospital Universitario Puerta de Hierro Majadahonda (Madrid)) ;
Basak, Grzegorz (Medical University of Warsaw) ;
Universitat Autònoma de Barcelona
ric acid is a danger signal contributing to inflammation. Its relevance to allogeneic stem cell transplantation (alloSCT) derives from preclinical models where the depletion of uric acid led to improved survival and reduced graft-versus-host disease (GvHD). [...]
2020 - 10.3324/haematol.2019.228668
Haematologica, Vol. 105 Núm. 7 (january 2020) , p. 1977-1983
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8 p, 3.0 MB |
Association of Serum Ferritin Levels Before Start of Conditioning With Mortality After alloSCT - A Prospective, Non-interventional Study of the EBMT Transplant Complications Working Party
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Penack, Olaf (Charité - Universitätsmedizin Berlin) ;
Peczynski, Christophe (EBMT Statistical Unit) ;
van der Werf, Steffie (EBMT Data Office) ;
Finke, Jürgen (University of Freiburg) ;
Ganser, Arnold (Hannover Medical School) ;
Schoemans, Helene (University Hospitals Leuven (Bèlgica)) ;
Pavlu, Jiri (Imperial College London) ;
Niittyvuopio, Riitta (HUCH Comprehensive Cancer Center) ;
Schroyens, W.ilfried (University Hospital Antwerp (Bèlgica)) ;
Kaynar, Leylagül (Erciyes University) ;
Blau, Igor W. (Department of Hematology. Oncology. and Tumor Immunology) ;
van der Velden, Walter J.F.M. (Radboud University) ;
Malouf Sierra, Jorge 1971- (Institut d'Investigació Biomèdica Sant Pau) ;
Cortelezzi, Agostini (University of Milan) ;
Wulf, Gerald (Universitätsklinikum Göttingen) ;
Turlure, Pascal (CHRU Limoges) ;
Rovira Argelagués, Montserrat (Hospital Clínic i Provincial de Barcelona) ;
Ozkurt, Zubeydenur (Gazi University) ;
Pascual-Cascon, Maria J. (Hospital Regional Universitario de Málaga) ;
Moreira, Maria C. (Instituto National do Cancer) ;
Clausen, Johannes (Ordensklinikum Linz Elisabethinen) ;
Greinix, Hildegard (Medical University of Graz) ;
Duarte, Rafael F. (Hospital Universitario Puerta de Hierro Majadahonda (Madrid)) ;
Basak, Grzegorz (Medical University of Warsaw) ;
Universitat Autònoma de Barcelona
Elevated serum ferritin levels occur due to iron overload or during inflammation and macrophage activation. A correlation of high serum ferritin levels with increased mortality after alloSCT has been suggested by several retrospective analyses as well as by two smaller prospective studies. [...]
2020 - 10.3389/fimmu.2020.00586
Frontiers in immunology, Vol. 11 (15 2020) , p. 586
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