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8 p, 1.2 MB |
Quantifying the contribution of established risk factors to cardiovascular mortality differences between Russia and Norway
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Trias-Llimós, Sergi ;
Pennells, Lisa ;
Tverdal, Aage ;
Kudryavtsev, Alexander V. ;
Malyutina, Sofia ;
Hopstock, Laila A. ;
Iakunchykova, Olena ;
Nikitin, Yuri ;
Magnus, Per ;
Kaptoge, Stephen ;
Di Angelantonio, Emanuele ;
Leon, David A.
Surprisingly few attempts have been made to quantify the simultaneous contribution of wellestablished risk factors to CVD mortality diferences between countries. We aimed to develop and critically appraise an approach to doing so, applying it to the substantial CVD mortality gap between Russia and Norway using survey data in three cities and mortality risks from the Emerging Risk Factor Collaboration. [...]
2020 -  10.1038/s41598-020-77877-3.
Scientific reports (Nature Publishing Group), Vol. 10 Núm. 20796 (2020)
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9 p, 2.0 MB |
Hsa-miR-210-3p expression in breast cancer and its putative association with worse outcome in patients treated with Docetaxel
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Pasculli, B. (Fondazione IRCCS Casa Sollievo della Sofferenza Laboratorio di Oncologia) ;
Barbano, R. (Fondazione IRCCS Casa Sollievo della Sofferenza Laboratorio di Oncologia) ;
Rendina, M. (Fondazione IRCCS Casa Sollievo della Sofferenza Laboratorio di Oncologia) ;
Fontana, A. (Fondazione IRCCS Casa Sollievo della Sofferenza. UO di Biostatistica) ;
Copetti, M. (Fondazione IRCCS Casa Sollievo della Sofferenza. UO di Biostatistica) ;
Mazza, T. (Fondazione IRCCS Casa Sollievo della Sofferenza. Bioinformatics Unit) ;
Valori, V.M. (Fondazione IRCCS Casa Sollievo della Sofferenza. UO di Oncologia) ;
Morritti, M. (Fondazione IRCCS Casa Sollievo della Sofferenza. UO di Oncologia) ;
Maiello, E. (Fondazione IRCCS Casa Sollievo della Sofferenza. UO di Oncologia) ;
Graziano, P. (Fondazione IRCCS Casa Sollievo della Sofferenza. UO di Anatomia Patologica) ;
Murgo, R. (Fondazione IRCCS Casa Sollievo della Sofferenza. UO di Chirurgia Senologica) ;
Fazio, V.M. (Fondazione IRCCS Casa Sollievo della Sofferenza Laboratorio di Oncologia) ;
Esteller, M. (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ;
Parrella, P. (Fondazione IRCCS Casa Sollievo della Sofferenza Laboratorio di Oncologia) ;
Universitat Autònoma de Barcelona
MicroRNA-210-3p is the most prominent hypoxia regulated microRNA, and it has been found significantly overexpressed in different human cancers. We performed the expression analysis of miR-210-3p in a retrospective cohort of breast cancer patients with a median follow-up of 76 months (n = 283). [...]
2019 - 10.1038/s41598-019-51581-3
Scientific reports (Nature Publishing Group), Vol. 9 Núm. 1 (january 2019) , p. 14913
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17 p, 2.7 MB |
Identification of strong candidate genes for backfat and intramuscular fatty acid composition in three crosses based on the Iberian pig
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Crespo-Piazuelo, Daniel (Centre de Recerca en Agrigenòmica) ;
Criado Mesas, Lourdes (Centre de Recerca en Agrigenòmica) ;
Revilla Sánchez, Manuel (Centre de Recerca en Agrigenòmica) ;
Castelló, Anna (Centre de Recerca en Agrigenòmica) ;
Noguera, José L. (Institut de Recerca i Tecnologia Agroalimentàries. Genètica i Millora Animal) ;
Fernández, Ana I. (Instituto Nacional de Investigación y Tecnología Agraria y Alimentaria. Departamento de Mejora Genética Animal) ;
Ballester Devis, Maria (Institut de Recerca i Tecnologia Agroalimentàries. Departament de Genètica i Millora Animal) ;
Folch, Josep M. (Centre de Recerca en Agrigenòmica) ;
Universitat Autònoma de Barcelona.
Departament de Ciència Animal i dels Aliments
Meat quality has an important genetic component and can be modified by the fatty acid (FA) composition and the amount of fat contained in adipose tissue and muscle. The present study aimed to find genomic regions associated with the FA composition in backfat and muscle (longissimus dorsi) in 439 pigs with three different genetic backgrounds but having the Iberian breed in common. [...]
2020 - 10.1038/s41598-020-70894-2
Scientific reports (Nature Publishing Group), Vol. 10 (August 2020) , art. 13962
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11 p, 2.4 MB |
Amino acid substitutions at sugar-recognizing codons confer ABO blood group system-related α1,3 Gal(NAc) transferases with differential enzymatic activity
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Cid, Emili (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ;
Yamamoto, Miyako (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ;
Yamamoto, Fumiichiro (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ;
Universitat Autònoma de Barcelona
Functional paralogous ABO, GBGT1, A3GALT2, and GGTA1 genes encode blood group A and B transferases (AT and BT), Forssman glycolipid synthase (FS), isoglobotriaosylceramide synthase (iGb3S), and α1,3-galactosyltransferase (GT), respectively. [...]
2019 - 10.1038/s41598-018-37515-5
Scientific reports (Nature Publishing Group), Vol. 9 Núm. 1 (january 2019) , p. 846
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8 p, 1.4 MB |
Antitumoral effect of maintained neutrophilia induced by rhG-CSF in a murine model of pancreatic cancer
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Brú, A. (Faculty of Mathematics. Universidad Complutense de Madrid) ;
Bosch, R. (Institut d'Investigació Biomèdica Sant Pau) ;
Céspedes, María Virtudes (Institut d'Investigació Biomèdica Sant Pau) ;
Carmona, Silvia (Institut d'Investigació Biomèdica Sant Pau) ;
Pascual, E. (Institut d'Investigació Biomèdica Sant Pau) ;
Brú, I. (Centro de Salud La Estación) ;
Souto, J.C. (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ;
Universitat Autònoma de Barcelona
Although the protumoral functions of polymorphonuclear neutrophils are well known, some now-forgotten studies report antitumoral roles for these cells. The present work examines the antitumoral effect of maintained neutrophilia induced via the injection of recombinant human granulocyte colony stimulating factor (rhG-CSF, 100 μg/kg/day) in a Panc-1 subcutaneous xenograft murine model of pancreatic cancer. [...]
2019 - 10.1038/s41598-019-39805-y
Scientific reports (Nature Publishing Group), Vol. 9 Núm. 1 (january 2019) , p. 2879
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14 p, 4.1 MB |
Inhibition of inflammatory signaling in Pax5 mutant cells mitigates B-cell leukemogenesis
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Isidro-Hernández, M. (Institute for Biomedical Research of Salamanca (IBSAL)) ;
Mayado, A. (Servicio de Citometría. Departamento de Medicina. Biomedical Research Networking Centre on Cancer CIBER- CIBERONC (CB16/12/00400). Institute of Health Carlos III. and Instituto de Biología Molecular y Celular del Cáncer. CSIC/Universidad de Salamanca) ;
Casado-García, A. (Institute for Biomedical Research of Salamanca (IBSAL)) ;
Martínez-Cano, J. (Immune system development and function Unit. Centro de Biología Molecular Severo Ochoa (Consejo Superior de Investigaciones Científicas -Universidad Autónoma de Madrid)) ;
Palmi, C. (Centro Ricerca Tettamanti. Dept of Medicine. University of Milan Bicocca) ;
Fazio, G. (Centro Ricerca Tettamanti. Dept of Medicine. University of Milan Bicocca) ;
Orfao, A. (Servicio de Citometría. Departamento de Medicina. Biomedical Research Networking Centre on Cancer CIBER- CIBERONC (CB16/12/00400). Institute of Health Carlos III. and Instituto de Biología Molecular y Celular del Cáncer. CSIC/Universidad de Salamanca) ;
Ribera Salas, Jordi (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ;
Ribera, Jose-Maria (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ;
Zamora, Lurdes (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ;
Raboso-Gallego, J. (Institute for Biomedical Research of Salamanca (IBSAL)) ;
Blanco, O. (Departamento de Anatomía Patológica. Universidad de Salamanca) ;
Alonso-López, D. (Bioinformatics Unit. Cancer Research Center (CSIC-USAL)) ;
De Las Rivas, J. (Bioinformatics and Functional Genomics Research Group. Cancer Research Center (CSIC-USAL)) ;
Jiménez, R. (Departamento de Fisiología y Farmacología. Universidad de Salamanca) ;
García Criado, F.J. (Departamento de Cirugía. Universidad de Salamanca) ;
García Cenador, M.B. (Departamento de Cirugía. Universidad de Salamanca) ;
Ramírez-Orellana, M. (Department of Pediatric Hematology and Oncology. Hospital Infantil Universitario Niño Jesús. Universidad Autónoma de Madrid) ;
Cazzaniga, G. (Centro Ricerca Tettamanti. Dept of Medicine. University of Milan Bicocca) ;
Cobaleda, C. (Immune system development and function Unit. Centro de Biología Molecular Severo Ochoa (Consejo Superior de Investigaciones Científicas -Universidad Autónoma de Madrid)) ;
Vicente-Dueñas, C. (Institute for Biomedical Research of Salamanca (IBSAL)) ;
Sánchez-García, I. (Institute for Biomedical Research of Salamanca (IBSAL)) ;
Universitat Autònoma de Barcelona
PAX5 is one of the most frequently mutated genes in B-cell acute lymphoblastic leukemia (B-ALL), and children with inherited preleukemic PAX5 mutations are at a higher risk of developing the disease. [...]
2020 - 10.1038/s41598-020-76206-y
Scientific reports (Nature Publishing Group), Vol. 10 Núm. 1 (january 2020) , p. 19189
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11 p, 4.3 MB |
Antigen-specific immunotherapy combined with a regenerative drug in the treatment of experimental type 1 diabetes
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Villalba Felipe, Adrián (Institut Germans Trias i Pujol) ;
Rodríguez-Fernández, Silvia (Institut Germans Trias i Pujol) ;
Perna-Barrull, David (Institut Germans Trias i Pujol) ;
Ampudia, Rosa Maria (Institut Germans Trias i Pujol) ;
Gomez-Muñoz, Laia (Institut Germans Trias i Pujol) ;
Pujol-Autonell, Irma (Institut Germans Trias i Pujol) ;
Aguilera, Eva (Institut Germans Trias i Pujol) ;
Risueño, Ruth M. (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ;
Cano-Sarabia, Mary (Institut Català de Nanociència i Nanotecnologia) ;
Maspoch Comamala, Daniel (Institut Català de Nanociència i Nanotecnologia) ;
Vázquez, Federico (Institut Germans Trias i Pujol) ;
Vives-Pi, Marta (Institut Germans Trias i Pujol)
Type 1 diabetes is an autoimmune disease caused by the destruction of the insulin-producing β-cells. To revert type 1 diabetes, the suppression of the autoimmune attack should be combined with a β-cell replacement strategy. [...]
2020 - 10.1038/s41598-020-76041-1
Scientific reports (Nature Publishing Group), Vol. 10 (2020) , art. 18927
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