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22 p, 644.2 KB Germline polymorphisms in genes involved in the Hippo pathway as recurrence biomarkers in stage II/III colon cancer / Sebio, Ana (Institut d'Investigació Biomèdica Sant Pau) ; Matsusaka, Satoshi (Keck School of Medicine, University of Southern California) ; Zhang, Wu (Keck School of Medicine, University of Southern California) ; Yang, Dongyun (Keck School of Medicine, University of Southern California) ; Ning, Yan (Keck School of Medicine, University of Southern California) ; Stremitzer, Stefan (Keck School of Medicine, University of Southern California) ; Stintzing, Sebastian (Department of Hematology and Oncology, Klinikum der Universitat, University of Munich, Munich, Germany) ; Sunakawa, Yu (Keck School of Medicine, University of Southern California) ; Yamauchi, Shinichi (Keck School of Medicine, University of Southern California) ; Fujimoto, Yoshiya (Cancer Institute Hospital. Department of Gastroenterological Surgery (Tokyo)) ; Ueno, Masashi (Cancer Institute Hospital. Department of Gastroenterological Surgery (Tokyo)) ; Lenz, Heinz-Josef (Keck School of Medicine, University of Southern California) ; Universitat Autònoma de Barcelona
The Hippo pathway regulates tissue growth and cell fate. In colon cancer, Hippo pathway deregulation promotes cellular quiescence and resistance to 5-Fluorouracil. In this study 14 polymorphisms in 8 genes involved in the Hippo pathway (MST1, MST2, LATS1, LATS2, YAP, TAZ, FAT4 and RASSF1A) were evaluated as recurrence predictors in 194 patients with stages II/III colon cancer treated with 5-Fu-based adjuvant chemotherapy. [...]
2015 - 10.1038/tpj.2015.64
The pharmacogenomics journal, Vol. 16 (september 2015) , p. 312-319  

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