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12 p, 468.2 KB |
In Vitro Antifungal Activity of Ibrexafungerp (SCY-078) Against Contemporary Blood Isolates From Medically Relevant Species of Candida : A European Study
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Quindós, Guillermo (Universidad del País Vasco/Euskal Herriko Unibertsitatea (UPV/EHU)) ;
Miranda-Cadena, Katherine (Universidad del País Vasco/Euskal Herriko Unibertsitatea (UPV/EHU)) ;
San-Millán, Rosario (Universidad del País Vasco/Euskal Herriko Unibertsitatea (UPV/EHU)) ;
Borroto-Esoda, Katyna ;
Cantón, Emilia (Hospital Universitari i Politècnic La Fe (València)) ;
Linares-Sicilia, María José (Universidad de Córdoba) ;
Hamprecht, Axel (University of Oldenburg) ;
Montesinos, Isabel (Hospital Universitario Basurto BioCruces Bizkaia) ;
Tortorano, Anna Maria (Università degli Studi di Milano) ;
Prigitano, Anna (Università degli Studi di Milano) ;
Vidal-García, Matxalen (Hospital Universitario Basurto BioCruces Bizkaia) ;
Marcos-Arias, Cristina (Universidad del País Vasco/Euskal Herriko Unibertsitatea (UPV/EHU)) ;
Guridi, Andrea (Universidad del País Vasco/Euskal Herriko Unibertsitatea (UPV/EHU)) ;
Sanchez-Reus, Ferran (Institut d'Investigació Biomèdica Sant Pau) ;
Machuca-Bárcena, Jesús (Universidad de Cádiz) ;
Rodríguez-Iglesias, Manuel Antonio (Universidad de Cádiz) ;
Martín-Mazuelos, Estrella (Hospital Universitario Virgen de Valme (Sevilla, Andalusia)) ;
Castro-Méndez, Carmen (Hospital Universitario Virgen de Valme (Sevilla, Andalusia)) ;
López-Soria, Leyre (Hospital Universitario de Cruces and BioCruces Bizkaia) ;
Ruiz-Gaitán, Alba (Instituto de Investigación Sanitaria. Hospital Universitario y Politécnico La Fe) ;
Fernandez-Rivero, Marcelo (Hospital Universitari i Politècnic La Fe (València)) ;
Lorenzo, Damaris (Universitat Rovira i Virgili) ;
Capilla, Javier (Universitat Rovira i Virgili) ;
Rezusta, Antonio ;
Pemán, Javier (Hospital Universitari i Politècnic La Fe (València)) ;
Guarro, Josep (Universitat Rovira i Virgili) ;
Pereira, Joana (University of Minho) ;
Pais, Célia (University of Minho) ;
Romeo, Orazio (University of Messina) ;
Ezpeleta, Guillermo (Universidad del País Vasco/Euskal Herriko Unibertsitatea (UPV/EHU)) ;
Jauregizar, Nerea (Universidad del País Vasco) ;
Angulo, David ;
Eraso, Elena (Universidad del País Vasco/Euskal Herriko Unibertsitatea (UPV/EHU)) ;
Universitat Autònoma de Barcelona
Ibrexafungerp (SCY-078) is the newest oral and intravenous antifungal drug with broad activity, currently undergoing clinical trials for invasive candidiasis. The aim of this study was to assess the in vitro activity of ibrexafungerp and comparators against a collection of 434 European blood isolates of Candida. [...]
2022 -  10.3389/fcimb.2022.906563
Frontiers in cellular and infection microbiology, Vol. 12 (16 2022) , p. 906563
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0 p, 943.5 KB |
The contribution of historical processes to contemporary extinction risk in placental mammals
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Wilder, Aryn P. (San Diego Zoo Wildlife Alliance. Conservation Genetics) ;
Supple, Megan A. (University of California. Department of Ecology and Evolutionary Biology) ;
Subramanian, Ayshwarya (Broad Institute of MIT and Harvard) ;
Mudide, Anish (Phillips Exeter Academy) ;
Swofford, Ross (Broad Institute of MIT and Harvard) ;
Serres-Armero, Aitor (Institut de Biologia Evolutiva (UPF-CSIC) (Barcelona)) ;
Steiner, Cynthia (San Diego Zoo Wildlife Alliance. Conservation Genetics) ;
Koepfli, Klaus-Peter (Smithsonian Conservation Biology Institute) ;
Genereux, Diane P. (Broad Institute of MIT and Harvard) ;
Karlsson, Elinor K. (University of Massachusetts Medical School) ;
Lindblad-Toh, Kerstin (Uppsala University. Department of Medical Biochemistry & Microbiology) ;
Marques-Bonet, Tomas 1975- (Institut Català de Paleontologia Miquel Crusafont) ;
Muñoz-Fuentes, Violeta (European Molecular Biology Laboratory-European Bioinformatics Institute. Wellcome Genome Campus) ;
Foley, Kathleen (Lehigh University. Department of Biological Sciences) ;
Meyer, Wynn K. (Lehigh University, Department of Biological Sciences) ;
Ryder, Oliver A. (University of California. Department of Evolution, Behavior and Ecology) ;
Shapiro, Beth (University of California. Howard Hughes Medical Institute)
Species persistence can be influenced by the amount, type, and distribution of diversity across the genome, suggesting a potential relationship between historical demography and resilience. Here, we surveyed genetic variation across single genomes of 240 mammals comprising the Zoonomia alignment to evaluate how historical effective population size (N ) impacts heterozygosity and deleterious genetic load and how these factors may contribute to extinction risk. [...]
2023 - 10.1126/science.abn5856
Science, Vol. 380, Num. 6643 (April 2023) , art. eabn5856
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10 p, 1.6 MB |
Incremental prognostic value of lung ultrasound on contemporary heart failure risk scores
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Maestro, Alba (Institut d'Investigació Biomèdica Sant Pau) ;
Rivas-Lasarte, Mercedes (Centro de Investigación Biomédica en Red en Enfermedades Cardiovasculares) ;
Fernández-Martínez, Juan (Hospital de la Santa Creu i Sant Pau (Barcelona, Catalunya)) ;
López-López, Laura (Hospital de la Santa Creu i Sant Pau (Barcelona, Catalunya)) ;
Solé-González, Eduard (Hospital Clínic i Provincial de Barcelona. Servei de Cardiologia) ;
Brossa Loidi, Vicens (Hospital de la Santa Creu i Sant Pau (Barcelona, Catalunya)) ;
Mirabet Pérez, Sonia (Institut d'Investigació Biomèdica Sant Pau) ;
Roig, Eulàlia (Hospital de la Santa Creu i Sant Pau (Barcelona, Catalunya)) ;
Cinca, Juan (Hospital de la Santa Creu i Sant Pau (Barcelona, Catalunya)) ;
Alvarez-Garcia, Jesus (Centro de Investigación Biomédica en Red en Enfermedades Cardiovasculares) ;
Sionis, Alessandro (Institut d'Investigació Biomèdica Sant Pau)
Introduction: Over the last decades, several scores have been developed to aid clinicians in assessing prognosis in patients with heart failure (HF) based on clinical data, medications and, ultimately, biomarkers. [...]
2022 - 10.3389/fphys.2022.1006589
Frontiers in physiology, Vol. 13 (14 2022) , p. 1006589
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9 p, 375.8 KB |
Retos contemporáneos para la psicología comunitaria : Reflexiones sobre la noción de comunidad
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Rodríguez, Alicia Raquel (Universidad de la República (Uruguai)) ;
Montenegro Martínez, Marisela (Universitat Autònoma de Barcelona)
La Psicología Comunitaria en América Latina, haciendo uso del concepto de comunidad, ha generado procesos participativos para la transformación de las condiciones de vida de las poblaciones con las que trabaja. [...]
Community Psychology in Latin America, by using the concept of community, has generated participatory processes, in alliance with populations that seek the transformation of their living conditions. However, at present, the preponderance of values such as individualism and competition and increasing feelings of helplessness and distrust have resulted in progressive processes of disaffiliation and discrimination in community settings. [...]
2016 - 10.30849/rip/ijp.v50i1.40
Revista interamericana de psicología, Vol. 50 Núm. 1 (2016) , p. 14-22
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14 p, 1.1 MB |
Imaging Response to Contemporary Immuno-oncology Combination Therapies in Patients With Metastatic Renal Cell Carcinoma
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Navani, Vishal (University of Calgary) ;
Ernst, Matthew (University of Calgary) ;
Wells, J. Connor (BC Cancer Agency) ;
Yuasa, Takeshi (Japanese Foundation for Cancer Research) ;
Takemura, Kosuke (Japanese Foundation for Cancer Research) ;
Donskov, Frede (Aarhus University Hospital (Aarhus, Dinamarca)) ;
Basappa, Naveen S. (University of Alberta) ;
Schmidt, Andrew (Dana-Farber Cancer Institute (Boston, Estats Units d'Amèrica)) ;
Pal, Sumanta K. (City of Hope Comprehensive Cancer Center) ;
Meza, Luis (City of Hope Comprehensive Cancer Center) ;
Wood, Lori A. (Queen Elizabeth II Health Sciences Centre) ;
Ernst, D. Scott (London Regional Cancer Centre) ;
Szabados, Bernadett (Queen Mary University of London) ;
Powles, Thomas (Queen Mary University of London) ;
McKay, Rana R. (University of California) ;
Weickhardt, Andrew (Olivia Newton-John Cancer and Wellness Centre) ;
Suárez, Cristina (Hospital Universitari Vall d'Hebron) ;
Kapoor, Anil (McMaster University (Canadà)) ;
Lee, Jae Lyun (University of Ulsan College of Medicine) ;
Choueiri, Toni K. (Dana-Farber Cancer Institute (Boston, Estats Units d'Amèrica)) ;
Heng, Daniel Y. C. (University of Calgary) ;
Universitat Autònoma de Barcelona
Do contemporary first-line therapy options for metastatic renal cell carcinoma (mRCC) have different likelihoods of objective imaging response (complete or partial response), and is objective imaging response associated with overall survival? In this cohort study involving 899 patients with mRCC, treatment with immune checkpoint blockade plus vascular endothelial growth factor receptor inhibitor combination therapies was more likely to be associated with objective imaging response than doublet immune checkpoint blockade therapy after adjustment for baseline demographic and clinical characteristics, including International Metastatic Renal Cell Carcinoma Database Consortium risk criteria. [...]
2022 - 10.1001/jamanetworkopen.2022.16379
JAMA network open, Vol. 5 (june 2022)
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