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Histone variant MacroH2A1 is downregulated in prostate cancer and influences malignant cell phenotype
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Vieira-Silva, T.S. (Cancer Biology and Epigenetics Group. Research Center (CI-IPOP). Portuguese Oncology Institute of Porto (IPO Porto). Research Center-LAB 3) ;
Monteiro-Reis, S. (Cancer Biology and Epigenetics Group. Research Center (CI-IPOP). Portuguese Oncology Institute of Porto (IPO Porto). Research Center-LAB 3) ;
Barros-Silva, D. (Cancer Biology and Epigenetics Group. Research Center (CI-IPOP). Portuguese Oncology Institute of Porto (IPO Porto). Research Center-LAB 3) ;
Ramalho-Carvalho, J. (Cancer Biology and Epigenetics Group. Research Center (CI-IPOP). Portuguese Oncology Institute of Porto (IPO Porto). Research Center-LAB 3) ;
Graça, I. (Cancer Biology and Epigenetics Group. Research Center (CI-IPOP). Portuguese Oncology Institute of Porto (IPO Porto). Research Center-LAB 3) ;
Carneiro, I. (Department of Pathology. Portuguese Oncology Institute of Porto (IPO Porto)) ;
Martins, A.T. (Department of Pathology. Portuguese Oncology Institute of Porto (IPO Porto)) ;
Oliveira, J. (Department of Urology. Portuguese Oncology Institute of Porto (IPO Porto)) ;
Antunes, L. (Department of Epidemiology. Portuguese Oncology Institute of Porto (IPO Porto)) ;
Hurtado-Bagès, Sarah (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ;
Buschbeck, Marcus (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ;
Henrique, R. (Department of Pathology and Molecular Immunology. Institute of Biomedical Sciences Abel Salazar (ICBAS). University of Porto) ;
Jerónimo, C. (Department of Pathology and Molecular Immunology. Institute of Biomedical Sciences Abel Salazar (ICBAS). University of Porto) ;
Universitat Autònoma de Barcelona
Background: Prostate cancer (PCa), a major cause of cancer-related morbidity and mortality worldwide and mostly asymptomatic at earliest stages, is characterized by disruption of genetic and epigenetic balance. [...]
2019 -  10.1186/s12935-019-0835-9
Cancer Cell International, Vol. 19 Núm. 1 (29 2019) , p. 112
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13 p, 3.4 MB |
NG2 antigen is a therapeutic target for MLL-rearranged B-cell acute lymphoblastic leukemia
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López-Millán, Belén (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ;
Sanchéz-Martínez, Diego (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ;
Roca Ho, Heleia (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ;
Gutiérrez-Agüera, Francisco (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ;
Molina, Oscar (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ;
Díaz de la Guardia, Rafael (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ;
Torres, Raul (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ;
Fuster, J.L. (Pediatric Hematology and Oncology Section. Hospital Clínico Virgen de la Arrixaca) ;
Ballerini, P. (Pediatric Hematology. Armand Trousseau Hospital) ;
Suessbier, U. (Hematology Department. University Hospital-University of Zurich) ;
Nombela-Arrieta, C. (Hematology Department. University Hospital-University of Zurich) ;
Bueno, Clara (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ;
Menéndez, Pablo (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ;
Universitat Autònoma de Barcelona
B cell acute lymphoblastic leukemia (B-ALL) is the most common childhood cancer, with cure rates of ∼80%. MLL-rearranged (MLLr) B-ALL (MLLr-B-ALL) has, however, an unfavorable prognosis with common therapy refractoriness and early relapse, and therefore new therapeutic targets are needed for relapsed/refractory MLLr-B-ALL. [...]
2019 - 10.1038/s41375-018-0353-0
Leukemia, Vol. 33 Núm. 7 (january 2019) , p. 1557-1569
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6 p, 378.5 KB |
Quantitative PCR Is Faster, More Objective, and More Reliable Than Immunohistochemistry for the Diagnosis of Cytomegalovirus Gastrointestinal Disease in Allogeneic Stem Cell Transplantation
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Suárez-Lledó, M. (Hematopoietic Stem Cell Transplantation Unit. Hematology Department. Hospital Clínic Barcelona) ;
Marcos, M.Á. (University of Barcelona. Institute for Global Health (ISGlobal)) ;
Cuatrecasas, M. (Pathology Department. Hospital Clínic Barcelona) ;
Bombi, J.A. (Pathology Department. Hospital Clínic Barcelona) ;
Fernández-Avilés, Francesc (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ;
Magnano, L. (Hematopoietic Stem Cell Transplantation Unit. Hematology Department. Hospital Clínic Barcelona) ;
Martínez-Cibrián, N. (Hematopoietic Stem Cell Transplantation Unit. Hematology Department. Hospital Clínic Barcelona) ;
Llobet, N. (Hematopoietic Stem Cell Transplantation Unit. Hematology Department. Hospital Clínic Barcelona) ;
Rosiñol Dachs, Laura (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ;
Gutiérrez-García, G. (Institut d'Investigació Biomèdica August Pi I Sunyer (IDIBAPS). University of Barcelona) ;
Jorge, S. (Hematopoietic Stem Cell Transplantation Unit. Hematology Department. Hospital Clínic Barcelona) ;
Martínez, Carmen (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ;
Rovira Tarrats, Montserrat (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ;
Urbano Ispizua, Álvaro (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ;
Universitat Autònoma de Barcelona
Diagnosis of gastrointestinal (GI) cytomegalovirus (CMV) disease relies on the presence of GI symptoms and detection of CMV, mainly by immunohistochemistry (IHC), in GI biopsy specimens. Thus, in a symptomatic patient, a positive CMV-IHC result is accepted as a diagnosis of CMV disease. [...]
2019 - 10.1016/j.bbmt.2019.07.016
Biology of Blood and Marrow Transplantation, Vol. 25 Núm. 11 (november 2019) , p. 2281-2286
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12 p, 1.8 MB |
Efficacy and safety of weekly carfilzomib (70 mg/m2), dexamethasone, and daratumumab (KdD70) is comparable to twice-weekly KdD56 while being a more convenient dosing option : a cross-study comparison of the CANDOR and EQUULEUS studies
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Leleu, X. (Service d'Hématologie et Thérapie cellulaire. CHU and Inserm) ;
Beksac, M. (Department of Hematology. Ankara University) ;
Chou, T. (Department of Internal Medicine. Niigata Cancer Center Hospital) ;
Dimopoulos, M. (Hematology and Medical Oncology. Department of Clinical Therapeutics. National and Kapodistrian University of Athens School of Medicine) ;
Yoon, S.S. (Department of Internal Medicine. Seoul National University) ;
Prince, H.M. (Epworth Healthcare and Sir Peter MacCallum Department of Oncology. University of Melbourne) ;
Pour, L. (Department of Internal Medicine. Hematology and Oncology. University Hospital Brno) ;
Shelekhova, T. (Clinic of Professional Pathology) ;
Chari, A. (Tisch Cancer Institute. Icahn School of Medicine at Mount Sinai) ;
Khurana, M. (Clinical Development. Oncology. Amgen Inc) ;
Zhang, J. (Global Biostatistical Science. Amgen Inc) ;
Obreja, M. (Global Biostatistical Science. Amgen Inc) ;
Qi, M. (Hematology and Oncology. Janssen Research and Development. LLC) ;
Oriol, Albert (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ;
Siegel, D. (John Theurer Cancer Center. Hackensack University Medical Center) ;
Universitat Autònoma de Barcelona
The regimen of carfilzomib, daratumumab, and dexamethasone (KdD) shows activity in patients with relapsed/refractory multiple myeloma. KdD at the twice-weekly 56 mg/m carfilzomib dose (KdD56) was used in the randomized phase 3 CANDOR study (NCT03158688), whereas KdD at the once-weekly 70 mg/m carfilzomib dose (KdD70) was used in the phase 1 b EQUULEUS study (NCT01998971). [...]
2020 - 10.1080/10428194.2020.1832672
Leukemia and Lymphoma, 2020
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22 p, 564.3 KB |
Qui decideix sobre la música a l'escola? : investigant l'equilibri entre perfils professionals i projectes escolars
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Sambola, Anna Ma ;
Casals Ibañez, Albert (Universitat Autònoma de Barcelona. Departament de Didàctica de l'Expressió Musical, Plàstica i Corporal)
El present article té per objectiu reflexionar sobre la importància de la figura del professorat de mú-sica a l'hora de configurar la seva assignatura respecte al que s'indica en el projecte educatiu de centre dins de l'etapa d'educació primària. [...]
El presente artículo tiene como objetivo reflexionar sobre la importancia de la figura del maestro de música en cuanto a laconfiguración de su asignatura respecto a lo que se indica en el proyecto educa-tivo de centro en la etapa de educación primaria. [...]
Le présent article a pour objectif d'engager une réflexion sur l'importance de la figure des profes-seurs de musique pour la configuration de cette matière par rapport aux indications figurant dans le projet éducatif d'enseignement primaire de l'établissement. [...]
This article reflects on the figure of the music teacher in the design of the school subject music education and as part of primary education mission statements and plans. In this qualitative case study of Joan Juncadella school in Barcelona, the data was collected through a literature review and interviews and observations of music classes and classes in other subjects, during the course of one school year. [...]
2020
Temps d'educació, Núm. 58 (2020) , p. 137-158
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6 p, 605.0 KB |
Histamine receptor 1 is expressed in leukaemic cells and affects differentiation sensitivity
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Cornet-Masana, Josep Maria (Faculty of Medicine. University of Barcelona) ;
Banús, Antonia (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ;
Cuesta-Casanovas, Laia (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ;
Carbó, José M. (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ;
Guijarro, F. (Department of Hematology. Hospital Clínic) ;
Torrente, M.Á. (Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS)) ;
Esteve Reyner, Jordi (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ;
M. Risueño, Ruth (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ;
Universitat Autònoma de Barcelona
Despite the success of immunotherapy in several haematological neoplasms, the effectiveness in acute myeloid leukaemia (AML) is still controversial, partially due to the lack of knowledge regarding immune-related processes in this disease and similar neoplasias. [...]
2020 - 10.1111/jcmm.15930
Journal of Cellular and Molecular Medicine, Vol. 24 Núm. 22 (november 2020) , p. 13536-13541
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12 p, 1.4 MB |
KatE from the bacterial plant pathogen Ralstonia solanacearum is a monofunctional catalase controlled by HrpG that plays a major role in bacterial survival to hydrogen peroxide
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Tondo, Maria Laura (Universidad Nacional de Rosario. Área Biología Molecular (Argentina)) ;
de Pedro-Jové, Roger (Centre de Recerca en Agrigenòmica) ;
Vandecaveye, Agustina (Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Biología Molecular y Celular de Rosario (Argentina)) ;
Piskulic, Laura (Universidad Nacional de Rosario. Área Estadística y Procesamiento de Datos (Argentina)) ;
Orellano, Elena G. (Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Biología Molecular y Celular de Rosario (Argentina)) ;
Valls, Marc (Centre de Recerca en Agrigenòmica)
Ralstonia solanacearum is the causative agent of bacterial wilt disease on a wide range of plant species. Besides the numerous bacterial activities required for host invasion, those involved in the adaptation to the plant environment are key for the success of infection. [...]
2020 - 10.3389/fpls.2020.01156
Frontiers in plant science, Vol. 11 (July 2020) , art. 1156
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11 p, 1.2 MB |
Up-regulation of HDACs, a harbinger of uraemic endothelial dysfunction, is prevented by defibrotide
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Palomo, Marta (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ;
Vera, Manuel (Nephrology Department. Hospital Clinic. Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS). Universitat de Barcelona (UB)) ;
Martin, S. (Hematopathology. Centre Diagnòstic Biomèdic (CDB). Hospital Clinic. Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS). Universitat de Barcelona (UB)) ;
Torramadé-Moix, S. (Hematopathology. Centre Diagnòstic Biomèdic (CDB). Hospital Clinic. Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS). Universitat de Barcelona (UB)) ;
Martinez-Sanchez, Julia (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ;
Belen Moreno, A. (Hematopathology. Centre Diagnòstic Biomèdic (CDB). Hospital Clinic. Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS). Universitat de Barcelona (UB)) ;
Carreras, Enric (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ;
Escolar, G. (Hematopathology. Centre Diagnòstic Biomèdic (CDB). Hospital Clinic. Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS). Universitat de Barcelona (UB)) ;
Cases, A. (Nephrology Department. Hospital Clinic. Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS). Universitat de Barcelona (UB)) ;
Díaz-Ricart, M. (Barcelona Endothelium Team (BET)) ;
Universitat Autònoma de Barcelona
Endothelial dysfunction is an earlier contributor to the development of atherosclerosis in chronic kidney disease (CKD), in which the role of epigenetic triggers cannot be ruled out. Endothelial protective strategies, such as defibrotide (DF), may be useful in this scenario. [...]
2020 - 10.1111/jcmm.14865
Journal of Cellular and Molecular Medicine, Vol. 24 Núm. 2 (january 2020) , p. 1713-1723
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