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19 p, 4.3 MB Deficits in neuronal architecture but not over-inhibition are main determinants of reduced neuronal network activity in a mouse model of overexpression of Dyrk1A / Manubens-Gil, Linus (Southeast University (SEU)) ; Pons-Espinal, Meritxell (Universitat de Barcelona. Institut de Biomedicina) ; Gener, Thomas (Institut Català de Nanociència i Nanotecnologia) ; Ballesteros-Yañez, Inmaculada (Universidad de Castilla-La Mancha) ; Martínez de Lagrán, María (Center for Genomic Regulation) ; Dierssen, Mara (Biomedical Research Networking Center for Rare Diseases (CIBERER))
In this study, we investigated the impact of Dual specificity tyrosine-phosphorylation-regulated kinase 1A (Dyrk1A) overexpression, a gene associated with Down syndrome, on hippocampal neuronal deficits in mice. [...]
2024 - 10.1093/cercor/bhad431
Cerebral cortex (New York, N.Y.), Vol. 34, Issue 1, (January 2024) , art. bhad431  

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