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35 p, 2.1 MB Modeling Fanconi anemia pathogenesis and therapeutics using integration-free patient iPSCs / Liu, Guang-Hui (Laboratory of Gene Expression, Salk Institute for Biological Studies) ; Suzuki (Laboratory of Gene Expression, Salk Institute for Biological Studies) ; Li, Mo (Laboratory of Gene Expression, Salk Institute for Biological Studies) ; Qu, Jing (Laboratory of Gene Expression, Salk Institute for Biological Studies) ; Montserrat, Núria (Centre de Medicina Regenerativa de Barcelona) ; Tarantino, Carolina (Centre de Medicina Regenerativa de Barcelona) ; Gu, Ying (Laboratory of Gene Expression, Salk Institute for Biological Studies) ; Yi, Fei (Laboratory of Gene Expression, Salk Institute for Biological Studies) ; Xu, Xiuling (Zhongguo ke xue yuan. National Laboratory of Biomacromolecules) ; Zhang, Weiqi (Zhongguo ke xue yuan. National Laboratory of Biomacromolecules) ; Ruiz, Sergio (Laboratory of Gene Expression, Salk Institute for Biological Studies) ; Plongthongkum, Nongluk (University of California. Department of Bioengineering) ; Zhang, Kun (University of California. Department of Bioengineering) ; Masuda, Shigeo (Laboratory of Gene Expression, Salk Institute for Biological Studies) ; Nivet, Emmanuel (Laboratory of Gene Expression, Salk Institute for Biological Studies) ; Tsunokawa, Yuji (Laboratory of Gene Expression, Salk Institute for Biological Studies) ; Soligalla, Rupa Devi (Laboratory of Gene Expression, Salk Institute for Biological Studies) ; Goebl, April (Laboratory of Gene Expression, Salk Institute for Biological Studies) ; Aizawa, Emi (Laboratory of Gene Expression, Salk Institute for Biological Studies) ; Kim, Na Young (Laboratory of Gene Expression, Salk Institute for Biological Studies) ; Kim, Jessica (Laboratory of Gene Expression, Salk Institute for Biological Studies) ; Dubova, Ilir (Laboratory of Gene Expression, Salk Institute for Biological Studies) ; Li, Ying (Zhongguo ke xue yuan. National Laboratory of Biomacromolecules) ; Ren, Ruotong (Zhongguo ke xue yuan. National Laboratory of Biomacromolecules) ; Benner, Chris (Integrative Genomics and Bioinformatics Core. Salk Institute for Biological Studies) ; Sol, Antonio del (Luxembourg Centre for Systems Biomedicine) ; Bueren, Juan (Fundación Jiménez Díaz. Instituto de Investigación Sanitaria) ; Trujillo Quintero, Juan Pablo (Universitat Autonoma de Barcelona. Departament de Genètica i de Microbiologia) ; Surrallés i Calonge, Jordi (Universitat Autonoma de Barcelona. Departament de Genètica i de Microbiologia) ; Cappelli, Enrico (Istituto "Giannina Gaslini" di Genova) ; Dufour, Carlo (Istituto "Giannina Gaslini" di Genova) ; Rodriguez Esteban, Concepción (Laboratory of Gene Expression, Salk Institute for Biological Studies) ; Izpisua Belmonte, Juan Carlos (Laboratory of Gene Expression, Salk Institute for Biological Studies)
Fanconi anaemia (FA) is a recessive disorder characterized by genomic instability, congenital abnormalities, cancer predisposition and bone marrow (BM) failure. However, the pathogenesis of FA is not fully understood partly due to the limitations of current disease models. [...]
Altres ajuts: Strategic Priority Research Program of the Chinese Academy of Sciences (XDA01020312), National Basic Research Program of China (973 Program,2014CB964600;2014CB910500), NSFC (81271266, 31222039, 81330008, 31201111, 81371342, 81300261, 81300677), Key Research Program of the Chinese Academy of Sciences (KJZD-EW-TZ-L05), Beijing Natural Science Foundation (7141005; 5142016), the Thousand Young Talents program of China, National Laboratory of Biomacromolecules (012kf02, 2013kf05;2013kf11;2014kf02), and State Key Laboratory of Drug Research (SIMM1302KF-17). [...]

2014 - 10.1038/ncomms5330
Nature Communications, Vol. 5, article 4330 (July 2014)  

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