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UAB Digital Repository of Documents 12 records found  1 - 10next  jump to record: Search took 0.00 seconds. 
1.
11 p, 903.6 KB Complete mitochondrial DNA profile in stroke : A geographical matched case-control study in Spanish population / Onieva, Ana (Universitat Autònoma de Barcelona. Departament de Biologia Animal, de Biologia Vegetal i d'Ecologia) ; Martin, Joan (Universitat Autònoma de Barcelona. Departament de Genètica i de Microbiologia) ; Cuesta-Aguirre, Daniel R (Universitat Autònoma de Barcelona. Departament de Biologia Animal, de Biologia Vegetal i d'Ecologia) ; Planells, Violeta (Universitat Autònoma de Barcelona. Departament de Biologia Animal, de Biologia Vegetal i d'Ecologia) ; Coronado-Zamora, Marta (Universitat Autònoma de Barcelona. Institut de Biotecnologia i de Biomedicina "Vicent Villar Palasí") ; Beyer, Katrin (Institut Germans Trias i Pujol) ; Vega, Tomás (Dirección General de Salud Pública de la Junta de Castilla y León) ; Lozano, José Eugenio (Dirección General de Salud Pública de la Junta de Castilla y León) ; Santos, Cristina (Universitat Autònoma de Barcelona. Departament de Biologia Animal, de Biologia Vegetal i d'Ecologia) ; Aluja París, Maria Pilar (Universitat Autònoma de Barcelona. Departament de Biologia Animal, de Biologia Vegetal i d'Ecologia)
Introduction: Stroke, the second leading cause of death worldwide, is a complex disease influenced by many risk factors among which we can find reactive oxygen species (ROS). Since mitochondria are the main producers of cellular ROS, nowadays studies are trying to elucidate the role of these organelles and its DNA (mtDNA) variation in stroke risk. [...]
2023 - 10.1016/j.mito.2023.10.001
Mitochondrion, Vol. 73 (November 2023) , p. 51-61  
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2.
20 p, 2.2 MB Obtaining miRNA from Saliva-Comparison of Sampling and Purification Methods / Urbizu, Aintzane (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ; Arnaldo, Laura (Universitat Autònoma de Barcelona. Departament de Bioquímica i de Biologia Molecular) ; Beyer, Katrin (Universitat Autònoma de Barcelona. Departament de Bioquímica i de Biologia Molecular)
The use of saliva as a biomarker source has advantages over other biofluids and imaging techniques, and miRNAs are ideal biomarker candidates. They are involved in numerous cellular processes, and their altered expression suggests that miRNAs play a crucial regulatory role in disease development. [...]
2023 - 10.3390/ijms24032386
International journal of molecular sciences, Vol. 24 (january 2023)  
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3.
10 p, 3.4 MB Alternative platelet activation pathways and their role in neurodegenerative diseases / Ferrer Raventós, Paula (Institut d'Investigació Biomèdica Sant Pau) ; Beyer, Katrin (Institut Germans Trias i Pujol) ; Universitat Autònoma de Barcelona
Purpose of the review: The study of platelets in the context of neurodegenerative diseases is intensifying, and increasing evidence suggests that platelets may play an important role in the pathogenesis of neurodegenerative disorders. [...]
2021 - 10.1016/j.nbd.2021.105512
Neurobiology of Disease, Vol. 159 (november 2021) , p. 105512  
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4.
0 p, 8.2 MB El papel del sistema autofágico lisosomal en las enfermedades con cuerpos de Lewy / Pérez Roca, Laia ; Beyer, Katrin, dir. ; Ariza Fernández, A, dir.
En aquesta tesi hem estudiat el paper de sistema autofágic-lisosomal durant el desenvolupament de les malalties amb cossos de Lewy, especialment la demència amb cossos de Lewy (DCL). Tot i que aquesta demència representa, després de la malaltia d'Alzheimer (MA), la segona causa més important de la demència, el seu diagnòstic clínic és molt complex i fins al 80% de tots els casos segueixen sent diagnosticats erròniament. [...]
En esta tesis hemos estudiado el papel del sistema autofágico-lisosomal durante el desarrollo de las enfermedades con cuerpos de Lewy, especialmente la demencia con cuerpos de Lewy (DCL). Aunque esta demencia representa, después de la enfermedad de Alzheimer (EA), la segunda causa más importante de la demencia, su diagnóstico clínico es muy complejo y hasta el 80% de todos los casos siguen siendo diagnosticados erróneamente. [...]
In this thesis we have studied the role of the autophagy-lysosomal system during the development of Lewy body diseases, especially of dementia with Lewy bodies (DLB). Although this dementia represents the second most important cause of dementia after Alzheimer's disease (AD), its clinical diagnosis is very complex and up to 80% of all cases continue to be misdiagnosed. [...]
2021  
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5.
12 p, 592.9 KB Glucocerebrosidase mRNA is Diminished in Brain of Lewy Body Diseases and Changes with Disease Progression in Blood / Pérez-Roca, Laia (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ; Adame Castillo, Cristina (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ; Campdelacreu, Jaume (Hospital Universitari de Bellvitge) ; Ispierto, Lourdes (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ; Vilas, Dolores (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ; Rene, Ramon (Hospital Universitari de Bellvitge) ; Álvarez, Ramiro (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ; Gascon-Bayarri, Jordi (Hospital Universitari de Bellvitge) ; Serrano-Munoz, Maria A. (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ; Ariza Fernández, A.. (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ; Beyer, Katrin (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ; Universitat Autònoma de Barcelona
Parkinson disease (PD) and dementia with Lewy bodies (DLB) are Lewy body diseases characterized by abnormal alpha-synuclein deposits and overlapping pathological features in the brain. Several studies have shown that glucocerebrosidase (GBA) deficiency is involved in the development of LB diseases. [...]
2018 - 10.14336/AD.2017.0505
Aging and Disease, Vol. 9 (april 2018) , p. 208-219  
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6.
15 p, 2.7 MB Expression Levels of an Alpha-Synuclein Transcript in Blood May Distinguish between Early Dementia with Lewy Bodies and Parkinson's Disease / Marsal-García, Laura (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ; Campdelacreu, Jaume (Hospital Universitari de Bellvitge) ; Vilas, Dolores (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ; Ispierto, Lourdes (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ; Gascon-Bayarri, Jordi (Hospital Universitari de Bellvitge) ; Reñé, Ramón (Hospital Universitari de Bellvitge) ; Álvarez, Ramiro (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ; Beyer, Katrin (Institut Germans Trias i Pujol) ; Urbizu, Aintzane (Institut Germans Trias i Pujol) ; Arnaldo, Laura (Institut Germans Trias i Pujol) ; Universitat Autònoma de Barcelona
Lewy body diseases (LBD) including dementia with Lewy bodies (DLB) and Parkinson disease (PD) are characterized by alpha-synuclein pathology. DLB is difficult to diagnose and peripheral biomarkers are urgently needed. [...]
2021 - 10.3390/ijms22020725
International journal of molecular sciences, Vol. 22 Núm. 2 (2021) , p. 725  
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7.
17 p, 1.4 MB Exploratory study on microRNA profiles from plasma-derived extracellular vesicles in Alzheimer's disease and dementia with Lewy bodies / Gámez-Valero, Ana (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ; Campdelacreu, Jaume (Hospital Universitari de Bellvitge) ; Vilas, Dolores (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ; Ispierto, Lourdes (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ; Reñé, Ramón (Hospital Universitari de Bellvitge) ; Álvarez, Ramiro (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ; Armengol Barnils, Maria del Pilar (Institut Germans Trias i Pujol) ; Borràs i Serres, Francesc Enric (Universitat Autònoma de Barcelona. Departament de Biologia Cel·lular, de Fisiologia i d'Immunologia) ; Beyer, Katrin (Institut Germans Trias i Pujol)
Because of the increasing life expectancy in our society, aging-related neurodegenerative disorders are one of the main issues in global health. Most of these diseases are characterized by the deposition of misfolded proteins and a progressive cognitive decline. [...]
2019 - 10.1186/s40035-019-0169-5
Translational Neurodegeneration, Vol. 8 (october 2019)  
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8.
13 p, 3.2 MB Comprehensive proteomic profiling of plasma-derived Extracellular Vesicles from dementia with Lewy Bodies patients / Gámez-Valero, Ana (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ; Campdelacreu, Jaume (Hospital Universitari de Bellvitge) ; Reñé, Ramón (Hospital Universitari de Bellvitge) ; Beyer, Katrin (Institut Germans Trias i Pujol) ; Borràs i Serres, Francesc Enric (Universitat Autònoma de Barcelona. Departament de Biologia Cel·lular, de Fisiologia i d'Immunologia)
Proteins and nucleic acids contained in extracellular vesicles (EVs) are considered a feasible source of putative biomarkers for physiological and pathological conditions. Within the nervous system, not only neurons but also other brain cells are able to produce EVs, which have been involved in their physiological processes and also in the development and course of several neurodegenerative diseases. [...]
2019 - 10.1038/s41598-019-49668-y
Scientific reports, Vol. 9 (September 2019) , art. 13282  
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9.
9 p, 1.4 MB Size-Exclusion Chromatography-based isolation minimally alters Extracellular Vesicles' characteristics compared to precipitating agents / Gámez-Valero, Ana (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ; Monguió Tortajada, Marta (Institut Germans Trias i Pujol) ; Carreras-Planella, Laura (Institut Germans Trias i Pujol) ; Franquesa, Marcel·la (Institut Germans Trias i Pujol) ; Beyer, Katrin (Institut Germans Trias i Pujol) ; Borràs i Serres, Francesc Enric (Institut Germans Trias i Pujol)
Extracellular vesicles (EVs) have become an attractive field among the scientific community. Yet, a major challenge is to define a consensus method for EVs isolation. Ultracentrifugation has been the most widely used methodology but rapid methods, including Size Exclusion Chromatography (SEC) and/or precipitating agents such as Polyethylene glycol (PEG) or PRotein Organic Solvent PRecipitation (PROSPR) have emerged. [...]
2016 - 10.1038/srep33641
Scientific reports, Vol. 6 (September 2016)  
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10.
22 p, 99.8 KB Molecular Pathology of Lewy Body Diseases / Beyer, Katrin (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ; Domingo-Sàbat, Montse (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ; Ariza Fernández, A.. (Aurelio) (Universitat Autònoma de Barcelona. Departament de Ciències Morfològiques)
Lewy body diseases are characterized by the presence of Lewy bodies, alphasynuclein(AS)-positive inclusions in the brain. Since their main component is conformationally modified AS, aggregation of the latter is thought to be a key pathogenic event in these diseases. [...]
2009 - 10.3390/ijms10030724
International journal of molecular sciences, Vol. 10 (2009) , p. 724-745  
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