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19 p, 1.2 MB Identification of Immunogenic Cytotoxic T Lymphocyte Epitopes Containing Drug Resistance Mutations in Antiretroviral Treatment-Naïve HIV-Infected Individuals / Blanco Heredia, Juan (Instituto Nacional de Enfermedades Respiratorias (México)) ; Lecanda, Aarón (Instituto Nacional de Enfermedades Respiratorias (México)) ; Valenzuela Ponce, Humberto (Instituto Nacional de Enfermedades Respiratorias (México)) ; Brander Silva, Christian (Institut Germans Trias i Pujol. Institut de Recerca de la Sida IrsiCaixa) ; Ávila Ríos, Santiago (Instituto Nacional de Enfermedades Respiratorias (México)) ; Reyes Terán, Gustavo (Instituto Nacional de Enfermedades Respiratorias (México))
Background: therapeutic HIV vaccines may prove helpful to intensify antiretroviral treatment (ART) efficacy and may be an integral part of future cure strategies. Methods: we examined IFN-gamma ELISpot responses to a panel of 218 HIV clade B consensus-based HIV protease-reverse transcriptase peptides, designed to mimic previously described and predicted cytotoxic T lymphocyte epitopes overlapping drug resistance (DR) positions, that either included the consensus sequence or the DR variant sequence, in 49 ART-naïve HIV-infected individuals. [...]
2016 - 10.1371/journal.pone.0147571
PloS one, Vol. 11 Núm. 1 (January 2016)  

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