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1.
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10 p, 1.5 MB |
Assessment of two complementary influenza surveillance systems : Sentinel primary care influenza-like illness versus severe hospitalized laboratory-confirmed influenza using the moving epidemic method
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Torner, Nuria (Universitat de Barcelona) ;
Basile, Luca (Generalitat de Catalunya) ;
Martínez, Ana (Instituto de Salud Carlos III) ;
Rius i Gibert, Maria Cristina (Agència de Salut Pública de Barcelona) ;
Godoy, Pere (Agència de Salut Pública de Catalunya) ;
Jané, Mireia (Instituto de Salud Carlos III) ;
Domínguez, Ángela (Universitat de Barcelona) ;
Aizpurua, J. ;
Alonso, J. ;
Azemar, J. ;
Aizpurua, P. ;
Ardaya, P.M. ;
Basas, M.D. ;
Batalla, J. ;
Biendicho, P. ;
Bonet, M. ;
Callado, M. ;
Campos, S. ;
Casanovas, J. M. ;
Ciurana, E. ;
Clapes, M. ;
Cots, J.M. ;
De La Rica, D. ;
Domingo, I. ;
Elizalde, G. ;
Escapa, P. ;
Fajardo, S. ;
Fau, E. ;
Fernandez, O. ;
Fernandez, M. ;
Ferrer, C. ;
Forcada, A. ;
Fos, E. ;
Gadea, G. ;
Garcia, J. ;
Garcia, R. ;
Gatius, C. ;
Gelado, M.J. ;
Grau, M. ;
Grivé, M. ;
Guzman, M.C. ;
Hernández, R. ;
Jimenez, G. ;
Juscafresa, A. ;
Llussa, A.M. ;
López, C. ;
Kristensen, L. ;
MacIà, E. ;
Mainou, A. ;
Marco, E. ;
Martínez, M. ;
Martínez, J.G. ;
Marulanda, K.V. ;
Masa, R. ;
Moncosí, X. ;
Naranjo, M.A. ;
Navarro, D. ;
Ortolà, E. ;
París, F. ;
Pérez, M.M. ;
Pozo, C. ;
Pujol, R. ;
Ribatallada, A. ;
Ruiz, G. ;
Sabaté, S. ;
Sanchez, R. ;
Sarrà, N. ;
Tarragó, E. ;
Teixidó, A.M. ;
Torres, A. ;
Valén, E. ;
Van Esso, D. ;
Van Tarjcwick, C. ;
Vink Schoenholzer, R. ;
Zabala, E. ;
Marcos, María Ángeles ;
Mosquera, Maria del Mar ;
De Molina, P. ;
Rubio, E. ;
Isanta, Ricard ;
Antón, Andrés ;
Pumarola Suñé, Tomàs ;
Vilella, Anna ;
Gorrindo, Pilar ;
Espejo, Elena ;
Andrés Santamaría, Marta ;
Barcenilla, Fernando ;
Navarro Rubio, Gema ;
Barrabeig, Irene (Agència de Salut Pública de Catalunya) ;
Pou, J. ;
Alvarez, P. ;
Plasencia, Elsa ;
Rebull Fatsini, Josep ;
Sala-Farré, Maria Rosa ;
Riera Garcia, Montserrat ;
Camps, Neus ;
Follia, Núria ;
Oller, A. ;
Bach Foradada, Pilar ;
Hernández, R. ;
Perez, Rafael ;
Torra Bastardas, Roser ;
Carol, Mónica ;
Minguell, Sofía ;
Marce, R. ;
Garcia-Pardo, Graciano ;
Olona, Montserrat ;
Alvarez, A. ;
Ramon, J.M. ;
Mòdol, Josep Maria (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Mena Pinilla, Guillermo ;
Campins Martí, Magda ;
Massuet, C. ;
Tora, G. ;
Ferràs, Joaquim (Agència de Salut Pública de Catalunya) ;
Ferrús, Glòria (Agència de Salut Pública de Catalunya) ;
Universitat Autònoma de Barcelona
Monitoring seasonal influenza epidemics is the corner stone to epidemiological surveillance of acute respiratory virus infections worldwide. This work aims to compare two sentinel surveillance systems within the Daily Acute Respiratory Infection Information System of Catalonia (PIDIRAC), the primary care ILI and Influenza confirmed samples from primary care (PIDIRAC-ILI and PIDIRAC-FLU) and the severe hospitalized laboratory confirmed influenza system (SHLCI), in regard to how they behave in the forecasting of epidemic onset and severity allowing for healthcare preparedness. [...]
2019 -  10.1186/s12889-019-7414-9
BMC public health, Vol. 19 Núm. 1 (13 2019) , p. 1089
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2.
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10 p, 4.0 MB |
Synthesis of γ-Hydroxy-α-amino Acid Derivatives by Enzymatic Tandem Aldol Addition-Transamination Reactions
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Moreno, Carlos J. (Institut de Química Avançada de Catalunya) ;
Hernández, Karel (Institut de Química Avançada de Catalunya) ;
Charnok, Simon J. (Prozomix Limited West End Industrial Estate) ;
Gittings, Samantha (Prozomix Limited West End Industrial Estate) ;
Bolte, Michael (Goethe-Universität) ;
Joglar, Jesús (Institut de Química Avançada de Catalunya) ;
Bujons, Jordi (Institut de Química Avançada de Catalunya) ;
Parella Coll, Teodor (Universitat Autònoma de Barcelona. Servei de Ressonància Magnètica Nuclear) ;
Clapés, Pere (Institut de Química Avançada de Catalunya)
Three enzymatic routes toward γ-hydroxy-α-amino acids by tandem aldol addition-transamination one-pot two-step reactions are reported. The approaches feature an enantioselective aldol addition of pyruvate to various nonaromatic aldehydes catalyzed by trans - o -hydroxybenzylidene pyruvate hydratase-aldolase (HBPA) from Pseudomonas putida. [...]
2021 - 10.1021/acscatal.1c00210
ACS catalysis, Vol. 11, Issue 8 (April 2021) , p. 4660-4669
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3.
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6 p, 2.1 MB |
Biocatalytic Aldol Addition of Simple Aliphatic Nucleophiles to Hydroxyaldehydes
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Roldán, Raquel (Institut de Química Avançada de Catalunya) ;
Hernández, Karel (Institut de Química Avançada de Catalunya) ;
Joglar, Jesús (Institut de Química Avançada de Catalunya) ;
Bujons, Jordi (Institut de Química Avançada de Catalunya) ;
Parella Coll, Teodor (Universitat Autònoma de Barcelona. Servei de Ressonància Magnètica Nuclear) ;
Sánchez-Moreno, Israel (University Clermont Auvergne, CNRS, SIGMA Clermont) ;
Hélaine, Virgil (University Clermont Auvergne, CNRS, SIGMA Clermont) ;
Lemaire, Marielle (University Clermont Auvergne, CNRS, SIGMA Clermont) ;
Guérard-Hélaine, Christine (University Clermont Auvergne, CNRS, SIGMA Clermont) ;
Fessner, Wolf-Dieter (Technische Universität Darmstadt) ;
Clapés, Pere (Institut de Química Avançada de Catalunya)
Asymmetric aldol addition of simple aldehydes and ketones to electrophiles is a cornerstone reaction for the synthesis of unusual sugars and chiral building blocks. We investigated -fructose-6-phosphate aldolase from E. [...]
2018 - 10.1021/acscatal.8b02486
ACS catalysis, Vol. 8 (08 2018) , p. 8804-8809
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4.
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15 p, 3.1 MB |
Aldolase-Catalyzed Asymmetric Synthesis of N-Heterocycles by Addition of Simple Aliphatic Nucleophiles to Aminoaldehydes
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Roldán, Raquel (Institut de Química Avançada de Catalunya) ;
Hernández, Karel (Institut de Química Avançada de Catalunya) ;
Joglar, Jesús (Institut de Química Avançada de Catalunya) ;
Bujons, Jordi (Institut de Química Avançada de Catalunya) ;
Parella Coll, Teodor (Universitat Autònoma de Barcelona. Servei de Ressonància Magnètica Nuclear) ;
Fessner, Wolf-Dieter (Technische Universität Darmstadt) ;
Clapés, Pere (Institut de Química Avançada de Catalunya)
Nitrogen heterocycles are structural motifs found in many bioactive natural products and of utmost importance in pharmaceutical drug development. In this work, a stereoselective synthesis of functionalized N-heterocycles was accomplished in two steps, comprising the biocatalytic aldol addition of ethanal and simple aliphatic ketones such as propanone, butanone, 3-pentanone, cyclobutanone, and cyclopentanone to N -Cbz-protected aminoaldehydes using engineered variants of -fructose-6-phosphate aldolase from Escherichia coli (FSA) or 2-deoxy--ribose-5-phosphate aldolase from Thermotoga maritima (DERA) as catalysts. [...]
2019 - 10.1002/adsc.201801530
Advanced synthesis & catalysis, Vol. 361, Issue 11 (January 2019) , p. 2673-2687
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5.
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249 p, 4.2 MB |
Studies on antimicrobial activity of arginine-based surfactants and chemoenyzmatic synthesis of novel amphiphiles based on L-Arginine and d-Fagomine
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Castillo Expósito, José Antonio ;
Clapes, Pere, dir. ;
Manresa, Àngels, dir.
Los conjugados de lípidos y aminoácidos presentan excelentes propiedades tensioactivas, alta biodegradabilidad y baja toxicidad. De entre ellos, los derivados de arginina poseen un amplio espectro de actividad antimicrobiana. [...]
Amino acid lipid conjugates possess excellent surface properties, high biodegradability and low toxicity. Among them, arginine-based surfactants show a broad antimicrobial activity. The mode of action of arginine-based surfactants was investigated. [...]
Bellaterra : Universitat Autònoma de Barcelona, 2007
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