UAB Digital Repository of Documents 11 records found  1 - 10next  jump to record: Search took 0.01 seconds. 
1.
36 p, 1.9 MB Time course study of long-term biocompatibility and foreign body reaction to intraneural polyimide-based implants / de la Oliva, Natàlia (Universitat Autònoma de Barcelona. Institut de Neurociències) ; Navarro, X. (Xavier) (Universitat Autònoma de Barcelona. Institut de Neurociències) ; Del Valle, Jaume (Institut Català de Nanociència i Nanotecnologia)
The foreign body reaction (FBR) against an implanted device is characterized by the formation of a fibrotic tissue around the implant. In the case of interfaces for peripheral nerves, used to stimulate specific group of axons and to record different nerve signals, the FBR induces a matrix deposition around the implant creating a physical separation between nerve fibers and the interface that may reduce its functionality over time. [...]
2018 - 10.1002/jbm.a.36274
Journal of biomedical materials research : Part A, Vol. 106, Issue 3 (March 2018) , p. 746-757  
2.
26 p, 1.4 MB Dexamethasone Reduces the Foreign Body Reaction to Intraneural Electrode Implants in the Peripheral Nerve of the Rat / de la Oliva, Natàlia (Universitat Autònoma de Barcelona. Institut de Neurociències) ; Navarro, X. (Xavier) (Universitat Autònoma de Barcelona. Institut de Neurociències) ; Del Valle, Jaume (Institut Català de Nanociència i Nanotecnologia)
Intraneural electrodes must be in intimate contact with nerve fibers to have a proper function, but this interface is compromised due to the foreign body reaction (FBR). The FBR is characterized by a first inflammatory phase followed by a second anti-inflammatory and fibrotic phase, which results in the formation of a tissue capsule around the implant, causing physical separation between the active sites of the electrode and the nerve fibers. [...]
2018 - 10.1002/ar.23920
Anatomical record, Vol. 301, Issue 10 (October 2018) , p. 1722-1733  
3.
26 p, 1.2 MB Segregation of motor and sensory axons regenerating through bicompartmental tubes by combining extracellular matrix components with neurotrophic factors / Del Valle, Jaume (Institut Català de Nanociència i Nanotecnologia) ; Santos, Daniel (Universitat Autònoma de Barcelona. Institut de Neurociències) ; Delgado Martínez, Ignacio (Universitat Autònoma de Barcelona. Institut de Neurociències) ; de la Oliva, Natàlia (Universitat Autònoma de Barcelona. Institut de Neurociències) ; Giudetti, Guido (Scuola Superiore Sant׳Anna (Pontedera, Itàlia). BioRobotics Institute) ; Micera, Silvestro (Scuola Superiore Sant׳Anna (Pontedera, Itàlia). BioRobotics Institute) ; Navarro, X. (Xavier) (Universitat Autònoma de Barcelona. Institut de Neurociències)
Segregation of regenerating motor and sensory axons may be a good strategy to improve selective functionality of regenerative interfaces to provide closed-loop commands. Provided that extracellular matrix components and neurotrophic factors exert guidance effects on different neuronal populations, we assessed in vivo the potential of separating sensory and motor axons regenerating in a bicompartmental Y-type tube, with each branch prefilled with an adequate combination of extracellular matrix and neurotrophic factors. [...]
2018 - 10.1002/term.2629
Journal of tissue engineering and regenerative medicine, Vol. 12, Issue 4 (April 2018) , p. e1991-e2000  
4.
12 p, 2.6 MB On the use of Parylene C polymer as substrate for peripheral nerve electrodes / de la Oliva, Natàlia (Universitat Autònoma de Barcelona. Institut de Neurociències) ; Mueller, Matthias (Albert-Ludwig-University Freiburg. Department of Microsystems Engineering-IMTEK) ; Stieglitz, Thomas (Albert-Ludwig-University Freiburg. Department of Microsystems Engineering-IMTEK) ; Navarro, X. (Xavier) (Universitat Autònoma de Barcelona. Institut de Neurociències) ; Del Valle, Jaume (Institut Català de Nanociència i Nanotecnologia)
Parylene C is a highly flexible polymer used in several biomedical implants. Since previous studies have reported valuable biocompatible and manufacturing characteristics for brain and intraneural implants, we tested its suitability as a substrate for peripheral nerve electrodes. [...]
2018 - 10.1038/s41598-018-24502-z
Scientific reports, Vol. 8 (April 2018) , art. 5965  
5.
9 p, 973.4 KB Long-term functionality of transversal intraneural electrodes is improved by dexamethasone treatment / de la Oliva, Natàlia (Universitat Autònoma de Barcelona. Institut de Neurociències) ; Del Valle, Jaume (Universitat Autònoma de Barcelona. Institut de Neurociències) ; Delgado Martínez, Ignacio (Universitat Autònoma de Barcelona. Institut de Neurociències) ; Mueller, Matthias (Albert Ludwig University Freiburg. Laboratory for Biomedical Microtechnology) ; Stieglitz, Thomas (Albert Ludwig University Freiburg. Laboratory for Biomedical Microtechnology) ; Navarro, X. (Xavier) (Universitat Autònoma de Barcelona. Institut de Neurociències) ; Universitat Autònoma de Barcelona. Institut Català de Nanociència i Nanotecnologia
Neuroprostheses aimed to restore lost functions after a limb amputation are based on the interaction with the nervous system by means of neural interfaces. Among the different designs, intraneural electrodes implanted in peripheral nerves represent a good strategy to stimulate nerve fibers to send sensory feedback and to record nerve signals to control the prosthetic limb. [...]
2019 - 10.1109/TNSRE.2019.2897256
IEEE Transactions on Neural Systems and Rehabilitation Engineering, 2019  
6.
11 p, 1.2 MB Lack of synergistic effect of resveratrol and sigma-1 receptor agonist (PRE-084) in SOD1 G93A ALS mice : overlapping effects or limited therapeutic opportunity? / Mancuso, Renzo (Universitat Autònoma de Barcelona. Institut de Neurociències) ; Del Valle, Jaume (Universitat Autònoma de Barcelona. Institut de Neurociències) ; Morell, Marta (Universitat Autònoma de Barcelona. Institut de Neurociències) ; Pallàs i Llibería, Mercè (Universitat de Barcelona. Institut de Biomedicina) ; Osta, Rosario (Universidad de Zaragoza) ; Navarro, X. (Xavier) (Universitat Autònoma de Barcelona. Institut de Neurociències) ; Universitat Autònoma de Barcelona. Departament de Biologia Cel·lular, de Fisiologia i d'Immunologia
Amyotrophic lateral sclerosis (ALS) is an adult onset neurodegenerative disease characterized by the loss of motoneurons (MNs) in the spinal cord, brainstem and motor cortex, causing progressive paralysis and death. [...]
2014 - 10.1186/1750-1172-9-78
Orphanet Journal of Rare Diseases, Vol. 9 (May 2014) , art. 78  
7.
16 p, 7.1 MB Preferential enhancement of sensory and motor axon regeneration by combining extracellular matrix components with neurotrophic factors / Santos, Daniel (Universitat Autònoma de Barcelona. Institut de Neurociències) ; González Pérez, Francisco J. (Universitat Autònoma de Barcelona. Institut de Neurociències) ; Giudetti, Guido (Scuola Superiore Sant׳Anna (Pontedera, Itàlia). BioRobotics Institute) ; Micera, Silvestro (Scuola Superiore Sant׳Anna (Pontedera, Itàlia). BioRobotics Institute) ; Udina i Bonet, Esther (Universitat Autònoma de Barcelona. Institut de Neurociències) ; Del Valle, Jaume (Universitat Autònoma de Barcelona. Institut de Neurociències) ; Navarro, X. (Xavier) (Universitat Autònoma de Barcelona. Departament de Biologia Cel·lular, de Fisiologia i d'Immunologia)
After peripheral nerve injury, motor and sensory axons are able to regenerate but inaccuracy of target reinnervation leads to poor functional recovery. Extracellular matrix (ECM) components and neurotrophic factors (NTFs) exert their effect on different neuronal populations creating a suitable environment to promote axonal growth. [...]
2017 - 10.3390/ijms18010065
International journal of molecular sciences, Vol. 18 Núm. 1 (January 2017)  
8.
14 p, 5.6 MB Dose-dependent differential effect of neurotrophic factors on in vitro and in iivo regeneration of motor and sensory neurons / Santos, Daniel (Universitat Autònoma de Barcelona. Institut de Neurociències) ; González Pérez, Francisco J. (Universitat Autònoma de Barcelona. Institut de Neurociències) ; Navarro, X. (Xavier) (Universitat Autònoma de Barcelona. Departament de Biologia Cel·lular, de Fisiologia i d'Immunologia) ; Del Valle, Jaume (Universitat Autònoma de Barcelona. Institut de Neurociències)
Although peripheral axons can regenerate after nerve transection and repair, functional recovery is usually poor due to inaccurate reinnervation. Neurotrophic factors promote directional guidance to regenerating axons and their selective application may help to improve functional recovery. [...]
2016
Neural Plasticity, Vol. 2016 (September 2016) , Article ID 4969523  
9.
14 p, 335.5 KB Long-term exercise modulates hippocampal gene expression in sencescent females mice / Álvarez Torres, María Jesús (Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS)) ; Castro-Freire, Marco (Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS)) ; Cosín-Tomás, Marta (Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS)) ; Sanchez Roige, Sandra (Universitat Autònoma de Barcelona. Institut de Neurociències) ; Ferrer Lalanza, Jaume (Universitat Autònoma de Barcelona. Institut de Neurociències) ; Del Valle, Jaume (Universitat de Barcelona. Institut de Biomedicina) ; Párrizas, Marcelina (Centro de Investigación Biomédica en Red de Diabetes y Enfermedades Metabólicas Asociadas (CIBERDEM)) ; Camins Espuny, Antoni (Universitat de Barcelona. Institut de Biomedicina) ; Pallàs i Llibería, Mercè, 1964- (Universitat de Barcelona. Institut de Biomedicina) ; Escorihuela, Rosa Maria (Universitat Autònoma de Barcelona. Institut de Neurociències) ; Kaliman, Perla (Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS))
The senescence-accelerated SAMP8 mouse is considered a useful non-transgenic model for studying aspects of progressive cognitive decline and Alzheimer's disease (AD). Using SAMR1 mice as controls, here we explored the effects of 6 months of voluntary wheel running in 10-month-old female SAMP8 mice. [...]
2013 - 10.3233/JAD-121264
Journal of Alzheimer's disease, Vol. 33, Num. 4 (2013) , p. 1177-1190  
10.
17 p, 38.6 MB Wnt signaling alteration in the spinal cord of Amyotrophic Lateral Sclerosis transgenic mice : special focus on Frizzled-5 cellular expression pattern / González-Fernández, Carlos (Hospital Nacional de Parapléjicos (Toledo)) ; Mancuso, Renzo (Universitat Autònoma de Barcelona. Institut de Neurociències) ; Del Valle, Jaume (Universitat Autònoma de Barcelona. Institut de Neurociències) ; Navarro, X. (Xavier) (Universitat Autònoma de Barcelona. Departament de Biologia Cel·lular, de Fisiologia i d'Immunologia) ; Rodríguez, Francisco Javier (Hospital Nacional de Parapléjicos (Toledo))
Background: Amyotrophic lateral sclerosis is a chronic neurodegenerative disease characterized by progressive paralysis due to degeneration of motor neurons by unknown causes. Recent evidence shows that Wnt signaling is involved in neurodegenerative processes, including Amyotrophic Lateral Sclerosis. [...]
2016 - 10.1371/journal.pone.0155867
PloS one, Vol. 11, No 5 (May 2016) , p. e0155867  

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