UAB Digital Repository of Documents 5 records found  Search took 0.01 seconds. 
1.
8 p, 3.1 MB Lkb1 Loss Promotes Tumor Progression of BRAF V600E -Induced Lung Adenomas / González-Sánchez, Elena (Hospital Universitari Vall d'Hebron. Institut de Recerca) ; Martín-Caballero, Juan (Hospital Universitari Vall d'Hebron. Institut de Recerca) ; Flores, Juana María (Hospital Universitari Vall d'Hebron. Institut de Recerca) ; Hernandez-Losa, Javier (Hospital Universitari Vall d'Hebron) ; Cortés, Javier (Hospital Universitari Vall d'Hebron. Institut de Recerca) ; Marés, Roso (Hospital Universitari Vall d'Hebron. Institut de Recerca) ; Barbacid, Mariano (Centro Nacional de Investigaciones Oncológicas) ; Recio Conde, Juan Ángel (Hospital Universitari Vall d'Hebron. Institut de Recerca) ; Universitat Autònoma de Barcelona
Aberrant activation of MAP kinase signaling pathway and loss of tumor suppressor LKB1 have been implicated in lung cancer development and progression. Although oncogenic KRAS mutations are frequent, BRAF mutations (BRAF V600E) are found in 3% of human non-small cell lung cancers. [...]
2013 - 10.1371/journal.pone.0066933
PloS one, Vol. 8 (june 2013)  
2.
19 p, 4.7 MB Genetic manipulation of LKB1 elicits lethal metastatic prostate cancer / Hermanova, Ivana (Basque Research and Technology Alliance (BRTA)) ; Zúñiga-García, Patricia (Basque Research and Technology Alliance (BRTA)) ; Caro-Maldonado, Alfredo (Basque Research and Technology Alliance (BRTA)) ; Fernandez-Ruiz, Sonia (Centro de Investigación Biomédica en Red de Cáncer) ; Salvador, Fernando (Institut de Recerca Biomèdica) ; Martín-Martín, Natalia (Centro de Investigación Biomédica en Red de Cáncer) ; Zabala-Letona, Amaia (Centro de Investigación Biomédica en Red de Cáncer) ; Nuñez-Olle, Marc (Institut de Recerca Biomèdica) ; Torrano, Verónica (Universidad del País Vasco. Departamento de Bioquímica y Biología Molecular) ; Camacho, Laura (Universidad del País Vasco. Departamento de Bioquímica y Biología Molecular) ; Lizcano de Vega, José Miguel (Universitat Autònoma de Barcelona. Departament de Bioquímica i de Biologia Molecular) ; Talamillo, Ana (Basque Research and Technology Alliance (BRTA)) ; Carreira, Suzanne (The Institute of Cancer Research (London, Regne Unit)) ; Gurel, Bora (The Institute of Cancer Research (London, Regne Unit)) ; Cortazar, Ana Rosa (Centro de Investigación Biomédica en Red de Cáncer) ; Guiu, Marc (Institut de Recerca Biomèdica) ; López, Jose I. (Universidad del País Vasco) ; Martinez-Romero, Anabel (Institut d'Investigació Biomèdica de Bellvitge) ; Astobiza, Ianire (Centro de Investigación Biomédica en Red de Cáncer) ; Valcarcel-Jimenez, Lorea (Basque Research and Technology Alliance (BRTA)) ; Lorente, Mar (Universidad Complutense de Madrid. Departamento de Bioquímica y Biología Molecular) ; Arruabarrena-Aristorena, Amaia (Basque Research and Technology Alliance (BRTA)) ; Velasco, Guillermo (Instituto de Investigación Sanitaria del Hospital Clínico San Carlos) ; Gomez Muñoz, Antonio (Universidad del País Vasco. Departamento de Bioquímica y Biología Molecular) ; Suárez-Cabrera, Cristian (Centro de Investigaciones Energéticas, Medioambientales y Tecnológicas (Espanya)) ; Lodewijk, Iris (Centro de Investigaciones Energéticas, Medioambientales y Tecnológicas (Espanya)) ; Flores, Juana M. (Universidad Complutense de Madrid. Departamento de Medicina y Cirugía Animal) ; Sutherland, James D. (Basque Research and Technology Alliance (BRTA)) ; Barrio, Rosa (Basque Research and Technology Alliance (BRTA)) ; de Bono, Johann S. (The Royal Marsden National Health Service Foundation Trust (London, Regne Unit)) ; Paramio, Jesús M. (Centro de Investigaciones Energéticas, Medioambientales y Tecnológicas (Espanya)) ; Trka, Jan (Charles University (Praga, República Txeca). Department of Paediatric Haematology/Oncology) ; Graupera, Mariona (Institut d'Investigació Biomèdica de Bellvitge) ; Gomis, Roger R.. (Institució Catalana de Recerca i Estudis Avançats) ; Carracedo, Arkaitz (Ikerbasque, Basque Foundation for Science (Bilbao, País Basc))
This study unravels an unprecedented murine model of lethal metastatic prostate cancer, based on the combined deletion of Pten and Lkb1. Importantly, minimal activity of LKB1 is sufficient to hamper prostate cancer cell aggressiveness, thus redefining the relationship between gene dosage and tumor suppression. [...]
2020 - 10.1084/jem.20191787
The journal of experimental medicine, Vol. 217 (march 2020)  
3.
11 p, 3.4 MB Low-dose statin treatment increases prostate cancer aggressiveness / Caro-Maldonado, Alfredo (CIC bioGUNE, Bizkaia Technology Park, Derio, Spain) ; Camacho, Laura (Biochemistry and Molecular Biology Department, University of the Basque Country, Bilbao, Spain) ; Zabala-Letona, Amaia (Centro de Investigación Biomédica en Red de Cáncer) ; Torrano, Verónica (Centro de Investigación Biomédica en Red de Cáncer) ; Fernández Ruiz, Sonia (Centro de Investigación Biomédica en Red de Cáncer) ; Zamacola-Bascaran, Kepa (CIC bioGUNE, Bizkaia Technology Park, Derio, Spain) ; Arreal, Leire (CIC bioGUNE, Bizkaia Technology Park, Derio, Spain) ; Valcárcel-Jiménez, Lorea (CIC bioGUNE, Bizkaia Technology Park, Derio, Spain) ; Martín-Martín, Natalia (Centro de Investigación Biomédica en Red de Cáncer) ; Flores, Juana M. (Department of Animal Medicine and Surgery, School of Veterinary Medicine, Complutense University of Madrid, Madrid, Spain) ; Cortazar, Ana Rosa (CIC bioGUNE, Bizkaia Technology Park, Derio, Spain) ; Zúñiga-García, Patricia (CIC bioGUNE, Bizkaia Technology Park, Derio, Spain) ; Arruabarrena-Aristorena, Amaia (CIC bioGUNE, Bizkaia Technology Park, Derio, Spain) ; Guillaumond, Fabienne (Université Aix-Marseille, Marseille, France) ; Cabrera, Diana (CIC bioGUNE, Bizkaia Technology Park, Derio, Spain) ; Falcón-Perez, Juan M. (IKERBASQUE, Basque foundation for science, Bilbao, Spain) ; Aransay, Ana M. (Centro de Investigación Biomédica en Red de Enfermedades Hepáticas y Digestivas) ; Gomez Muñoz, Antonio (Biochemistry and Molecular Biology Department, University of the Basque Country, Bilbao, Spain) ; Olivan, M. (Hospital Universitari Vall d'Hebron. Institut de Recerca) ; Morote Robles, Juan (Hospital Universitari Vall d'Hebron. Institut de Recerca) ; Carracedo, Arkaitz (IKERBASQUE, Basque foundation for science, Bilbao, Spain) ; Universitat Autònoma de Barcelona
Prostate cancer is diagnosed late in life, when co-morbidities are frequent. Among them, hypertension, hypercholesterolemia, diabetes or metabolic syndrome exhibit an elevated incidence. In turn, prostate cancer patients frequently undergo chronic pharmacological treatments that could alter disease initiation, progression and therapy response. [...]
2017 - 10.18632/oncotarget.22217
Oncotarget, Vol. 9 (october 2017) , p. 1494-1504  
4.
24 p, 5.3 MB Therapeutic effects of telomerase in mice with pulmonary fibrosis induced by damage to the lungs and short telomeres / Povedano, Juan Manuel ; Martinez, Paula ; Serrano, Rosa ; Tejera, Águeda ; Gómez-López, Gonzalo ; Bobadilla, Maria ; Flores, Juana Maria (Universitat Autònoma de Barcelona. Departament de Bioquímica i de Biologia Molecular) ; Bosch i Tubert, Fàtima ; Blasco, María A.
Pulmonary fibrosis is a fatal lung disease characterized by fibrotic foci and inflammatory infiltrates. Short telomeres can impair tissue regeneration and are found both in hereditary and sporadic cases. [...]
2018 - 10.7554/eLife.31299
eLife, Vol. 7 (january 2018)  
5.
13 p, 5.0 MB Constitutive Cyclin O deficiency results in penetrant hydrocephalus, impaired growth and infertility / Núnez-Ollé, Marc (Institut Hospital del Mar d'Investigacions Mèdiques) ; Jung, Carole (Universitat Pompeu Fabra. Laboratori de Fisiologia Molecular) ; Terré, Berta (Institute for Research in Biomedicine (IRB Barcelona)) ; Balsiger, Norman A. (Institut Hospital del Mar d'Investigacions Mèdiques) ; Plata, Cristina (Universitat Pompeu Fabra. Laboratori de Fisiologia Molecular) ; Roset, Ramon (Institut Hospital del Mar d'Investigacions Mèdiques) ; Pardo-Pastor, Carlos (Universitat Pompeu Fabra. Laboratori de Fisiologia Molecular) ; Garrido, Marta (Institut Hospital del Mar d'Investigacions Mèdiques) ; Rojas, Santiago (Universitat Autònoma de Barcelona. Departament de Ciències Morfològiques) ; Alameda, Francesc (Institut Hospital del Mar d'Investigacions Mèdiques) ; Lloreta, Josep 1958- (Institut Hospital del Mar d'Investigacions Mèdiques) ; Martín-Caballero, Juan (Parc de Recerca Biomèdica de Barcelona (PRBB)) ; Flores, Juana M. (Universidad Complutense de Madrid. Departamento de Medicina y Cirugía Animal) ; Stracker, Travis H. (Institute for Research in Biomedicine (IRB Barcelona)) ; Valverde, Miguel A. (Universitat Pompeu Fabra. Laboratori de Fisiologia Molecular) ; Muñoz, Francisco J. (Universitat Pompeu Fabra. Laboratori de Fisiologia Molecular) ; Gil-Gómez, Gabriel (Institut Hospital del Mar d'Investigacions Mèdiques) ; Universitat Autònoma de Barcelona
Cyclin O (encoded by CCNO) is a member of the cyclin family with regulatory functions in ciliogenesis and apoptosis. Homozygous CCNO mutations have been identified in human patients with Reduced Generation of Multiple Motile Cilia (RGMC) and conditional inactivation of Ccno in the mouse recapitulates some of the pathologies associated with the human disease. [...]
2017 - 10.18632/oncotarget.21818
Oncotarget, Vol. 8 (october 2017) , p. 99261-99273  

Interested in being notified about new results for this query?
Set up a personal email alert or subscribe to the RSS feed.