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21 p, 5.9 MB |
Oxidative Stress in Structural Valve Deterioration : A Longitudinal Clinical Study
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Galiñanes, Manuel (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Casós, Kelly (Hospital Universitari de Bellvitge) ;
Blasco-Lucas, Arnau (Hospital Universitari de Bellvitge) ;
Permanyer, Eduard (Centro Médico Teknon) ;
Máñez, Rafael (Hospital Universitari de Bellvitge) ;
Le Tourneau, Thierry (Université de Nantes) ;
Barquinero, Jordi (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Schwartz, Simon (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Bottio, Tomaso (University Hospital of Padova (Pàdua, Itàlia)) ;
Roussel, Jean Christian (CHU de Nantes) ;
Fellah-Hebia, Imen (CHU de Nantes) ;
Sénage, Thomas (Université de Nantes) ;
Evangelista Masip, Arturo (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Badano, Luigi P. (San Luca Hospital(Itàlia)) ;
Ruiz-Majoral, Alejandro (Hospital Universitari de Bellvitge) ;
Galli, Cesare (Avantea and Fondazione Avantea Onlus (Itàlia)) ;
Padler-Karavani, Vered (Tel Aviv University) ;
Soulillou, Jean-Paul (Centre Hospitalier Universitaire de Nantes) ;
Vidal Guitart, Xavier (Hospital Universitari Vall d'Hebron) ;
Cozzi, Emanuele (University Hospital of Padova (Pàdua, Itàlia)) ;
Costa, Cristina (Hospital Universitari de Bellvitge) ;
Universitat Autònoma de Barcelona
The cause of structural valve deterioration (SVD) is unclear. Therefore, we investigated oxidative stress markers in sera from patients with bioprosthetic heart valves (BHVs) and their association with SVD. [...]
2022 -  10.3390/biom12111606
Biomolecules, Vol. 12 (october 2022)
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2.
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14 p, 958.0 KB |
Response of the human myocardium to ischemic injury and preconditioning : The role of cardiac and comorbid conditions, medical treatment, and basal redox status
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Casós, Kelly (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Ferrer-Curriu, Gemma (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Soler-Ferrer, Paula (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Pérez, María-Llanos (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Permanyer, Eduard (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Blasco-Lucas, Arnau (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Gracia Baena, Juan Manuel (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Castro, Miguel A. (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Sureda, Carlos (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Barquinero, Jordi (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Galiñanes, Manuel (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Universitat Autònoma de Barcelona
The diseased human myocardium is highly susceptible to ischemia/reoxygenation (I/R)-induced injury but its response to protective interventions such as ischemic preconditioning (IPreC) is unclear. Cardiac and other pre-existing clinical conditions as well as previous or ongoing medical treatment may influence the myocardial response to I/R injury and protection. [...]
2017 - 10.1371/journal.pone.0174588
PloS one, Vol. 12 (april 2017)
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3.
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209 p, 15.0 MB |
Identificación de factores que favorecen la degeneración de las bioprótesis valvulares aórticas
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Blasco-Lucas, Arnau ;
Armengol Carrasco, Manuel, dir. ;
Galiñanes, Manuel, dir. ;
Permanyer Boada, Eduard, dir. ;
Universitat Autònoma de Barcelona.
Departament de Cirurgia
La calcificació és la causa més freqüent de la degeneració estructural de les biopròtesis valvulars aòrtiques. Tot i la seva importància, el mecanisme pel qual el teixit es calcifica segueix sent desconegut. [...]
La calcificación es la causa más frecuente de la degeneración estructural de las bioprótesis valvulares aórticas. A pesar de su importancia, el mecanismo por el cual el tejido se calcifica sigue siendo desconocido. [...]
The most common cause of structural valve degeneration is tissue calcification of the aortic bioprostheses. Despite its importance, the mechanisms that would explain this calcification are still not well understood. [...]
2020
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9 p, 925.7 KB |
The effect of intracoronary infusion of bone marrow-derived mononuclear cells on all-cause mortality in acute myocardial infarction : the BAMI trial
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Mathur, Anthony (Centre for Cardiovascular Medicine & Devices, Queen Mary University of London) ;
Fernández Avilés, F. (Hospital General Universitario Gregorio Marañón) ;
Bartunek, Jozef (Cardiovascular Center, OLV Hospital Aalst) ;
Belmans, Ann (KU) ;
Crea, Filippo (Fondazione Policlinico Universitario A. Gemelli IRCCS) ;
Dowlut, Sheik (Centre for Cardiovascular Medicine & Devices, Queen Mary University of London) ;
Galiñanes, Manuel (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Good, Marie-Claire (Queen Mary University of London) ;
Hartikainen, Juha (Kuopio University Hospital ( Finlàndia)) ;
Hauskeller, Christine (University of Exeter) ;
Janssens, Stefan (University Hospitals Leuven (Bèlgica)) ;
Kala, Petr (University Hospital Brno (República Txeca)) ;
Kastrup, Jens (University of Copenhagen) ;
Martin, John (University College London) ;
Menasché, Philippe (Department of Cardiovascular Surgery, Hôpital Européen Georges Pompidou and University of Paris) ;
Sanz-Ruiz, Ricardo (Hospital General Universitario Gregorio Marañón) ;
Ylä-Herttuala, Seppo (University of Eastern Finland) ;
Zeiher, Andreas Michael (Department of Medicine III, Goethe University of Frankfurt) ;
Universitat Autònoma de Barcelona
Bone marrow-derived mononuclear cell (BM-MNC) therapy may improve myocardial recovery in patients following acute myocardial infarction (AMI), though existing trial results are inconsistent. Originally an open-label, multicentre Phase III trial, BAMI was designed to demonstrate the safety and efficacy of intracoronary infusion of BM-MNCs in reducing the time to all-cause mortality in patients with reduced left ventricular ejection fraction (LVEF, ≤45%) after primary angioplasty (PPCI) for ST-elevation AMI. [...]
2020 - 10.1093/eurheartj/ehaa651
European heart journal, Vol. 41 (august 2020) , p. 3702-3710
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5.
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13 p, 4.6 MB |
Generation of cattle knockout for galactose-α1,3-galactose and N-glycolylneuraminic acid antigens
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Perota, Andrea (Laboratory of Reproductive Technologies) ;
Lagutina, Irina (Laboratory of Reproductive Technologies) ;
Duchi, Roberto (Laboratory of Reproductive Technologies) ;
Zanfrini, Elisa (Laboratory of Reproductive Technologies) ;
Lazzari, Giovanna (Fondazione Avantea) ;
Judor, Jean Paul (CHU Nantes) ;
Conchon, Sophie (CHU Nantes) ;
Bach, Jean-Marie (University of Nantes) ;
Bottio, Tomaso (Padova University School of Medicine) ;
Gerosa, Gino (Padova University School of Medicine) ;
Costa Farré, Cristina (Hospitalet de Llobregat) ;
Galiñanes, Manuel (Hospital Universitari Vall d'Hebron) ;
Roussel, Jean Christian (Nantes University Hospital (França)) ;
Padler-Karavani, Vered (Tel Aviv University) ;
Cozzi, Emanuele (University Hospital of Padova (Pàdua, Itàlia)) ;
Soulillou, Jean Paul (CHU Nantes) ;
Galli, Cesare (Fondazione Avantea) ;
Universitat Autònoma de Barcelona
Two well-characterized carbohydrate epitopes are absent in humans but present in other mammals. These are galactose-α1,3-galactose (αGal) and N -glycolylneuraminic acid (Neu5Gc) which are introduced by the activities of two enzymes including α(1,3) galactosyltransferase (encoded by the GGTA1 gene) and CMP-Neu5Gc hydroxylase (encoded by the CMAH gene) that are inactive in humans but present in cattle. [...]
2019 - 10.1111/xen.12524
Xenotransplantation, Vol. 26 (may 2019)
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6.
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6 p, 617.5 KB |
The effect of intracoronary infusion of bone marrow-derived mononuclear cells on all-cause mortality in acute myocardial infarction : rationale and design of the trial
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Mathur, Anthony (Queen Mary University of London) ;
Arnold, Roman (Hospital Clínico Universitario de Valladolid) ;
Assmus, Birgit (Johann-Wolfgang-Goethe University (Germany)) ;
Bartunek, Jozef (VZW Cardiovascular Research Center Aalst (Belgium)) ;
Belmans, Ann (KU Leuven-University of Leuven & Universiteit Hasselt (Belgium)) ;
Bönig, Halvard (Johann-Wolfgang-Goethe University (Germany)) ;
Crea, Filippo (Catholic University of the Sacred Heart (Italy)) ;
Dimmeler, Stefanie (Johann-Wolfgang-Goethe University (Germany)) ;
Dowlut, Sheik (Queen Mary University of London) ;
Fernández Avilés, F. (Hospital General Universitario Gregorio Marañón) ;
Galiñanes, Manuel (Hospital Universitari Vall d'Hebron) ;
García-Dorado, David (Hospital Universitari Vall d'Hebron) ;
Hartikainen, Juha (Kuopio University Hospital ( Finlàndia)) ;
Hill, Jonathan (King's College Hospital NHS Foundation Trust) ;
Hogardt-Noll, Annette (t2cure (Germany)) ;
Homsy, Christian (Celyad SA (Belgium)) ;
Janssens, Stefan (University Hospitals Leuven (Bèlgica)) ;
Kala, Petr (Faculty Hospital and Masaryk University (Czech Republic)) ;
Kastrup, Jens (University of Copenhagen) ;
Martin, John (University College London (UK)) ;
Menasche, Philippe (University Paris Descartes. Assistance Publique Hopitaux de Paris (France)) ;
Miklik, Roman (Faculty Hospital and Masaryk University (Czech Republic)) ;
Mozid, Abdul (Barts Heart Centre (UK)) ;
San Román, J. Alberto (Hospital Clínico Universitario de Valladolid) ;
Sanz-Ruiz, Ricardo (Hospital General Universitario Gregorio Marañón) ;
Tendera, Michal (Medical University of Silesia (Poland)) ;
Wojakowski, Wojtek (Medical University of Silesia (Poland)) ;
Ylä-Herttuala, Seppo (Kuopio University Hospital ( Finlàndia)) ;
Zeiher, Andreas Michael (Johann-Wolfgang-Goethe University (Germany)) ;
Universitat Autònoma de Barcelona
Over the past 13 years bone marrow-derived mononuclear cells () have been widely investigated for clinical efficacy in patients following acute myocardial infarction (). These early phase trials have used various surrogate markers to judge efficacy and, although promising, the results have been inconsistent. [...]
2017 - 10.1002/ejhf.829
European Journal of Heart Failure, Vol. 19, Issue 11 (November 2017) , p. 1545-1550
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7 p, 929.4 KB |
Ischemic postconditioning of the isolated human myocardium : role of the applied protocol
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Casós, Kelly (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Pérez, María-Llanos (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Blasco-Lucas, Arnau (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Ferrer-Curriu, Gemma (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Gracia Baena, Juan Manuel (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Sureda, Carlos (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Permanyer, Eduard (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Igual Barceló, Alberto (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Galiñanes, Manuel (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Universitat Autònoma de Barcelona
Ischemic postconditioning (IPostC), has been proposed as a useful approach to reduce infarct size in all species, but its clinical utility remains unclear. To investigate the role played by the protocol used on the efficacy of IPostC in protecting the diseased human myocardium. [...]
2015 - 10.1016/j.ijcha.2015.05.009
International journal of cardiology. Heart & vasculature, Vol. 8 (may 2015) , p. 55-61
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