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22 p, 2.7 MB |
Effect of Resistant Dextrin on Intestinal Gas Homeostasis and Microbiota
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Barber, Claudia (Universitat Autònoma de Barcelona. Departament de Medicina) ;
Sabater, Carlos (Health Research Institute of Asturias) ;
Ávila-Gálvez, María Ángeles (Laboratory of Food & Health, Group of Quality, Safety, and Bioactivity of Plant Foods (Múrcia)) ;
Vallejo, Fernando (Metabolomics Service (Múrcia)) ;
Bendezú García, Rogger Álvaro (Hospital General de Catalunya) ;
Guérin-Deremaux, Laetitia (Roquette Frères) ;
Guarner, Francisco (Hospital Universitari Vall d'Hebron) ;
Espín, Juan Carlos (Laboratory of Food & Health, Group of Quality, Safety, and Bioactivity of Plant Foods (Múrcia)) ;
Margolles, Abelardo (Health Research Institute of Asturias) ;
Azpiroz Vidaur, Fernando (Universitat Autònoma de Barcelona. Departament de Medicina)
Previous studies have shown that a resistant dextrin soluble fibre has prebiotic properties with related health benefits on blood glucose management and satiety. Our aim was to demonstrate the effects of continuous administration of resistant dextrin on intestinal gas production, digestive sensations, and gut microbiota metabolism and composition. [...]
2022 -  10.3390/nu14214611
Nutrients, Vol. 14 (november 2022)
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12 p, 2.1 MB |
A fermented milk product containing B. lactis CNCM i-2494 improves the tolerance of a plant-based diet in patients with disorders of gut-brain interactions
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Le Nevé, Boris (Danone Nutricia Research) ;
Martinez-De la Torre, Adrian (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Tap, Julien (Danone Nutricia Research) ;
Nieto Ruiz, Adoración (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Derrien, Muriel (Danone Nutricia Research) ;
Cotillard, Aurélie (Danone Nutricia Research) ;
Faurie, Jean-Michel (Danone Nutricia Research) ;
Barba Orozco, Elizabeth (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Mego Silva, Marianela (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Dornic, Quentin (Danone Nutricia Research) ;
Butler, John (Lawson Health Research Institute) ;
Merino, Xavier (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Lobo Álvarez, Beatriz (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Pinsach Batet, Ferran (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Pozuelo, Marta (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Santos, Javier (Centro de Investigación Biomédica en Red de Enfermedades Hepáticas y Digestivas) ;
Guarner, Francisco (Universitat Autònoma de Barcelona. Departament de Medicina) ;
Manichanh, Chaysavanh (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Azpiroz Vidaur, Fernando (Universitat Autònoma de Barcelona. Departament de Medicina)
Healthy, plant-based diets, rich in fermentable residues, may induce gas-related symptoms. The aim of this exploratory study was to assess the effects of a fermented milk product, containing probiotics, on the tolerance of a healthy diet in patients with disorders of gut-brain interactions (DGBI), complaining of excessive flatulence. [...]
2021 - 10.3390/nu13124542
Nutrients, Vol. 13 Núm. 12 (december 2021) , p. 4542
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13 p, 1.5 MB |
Evaluation of an O 2-Substituted (1-3)-β-D-Glucan, Produced by Pediococcus parvulus 2.6, in ex vivo Models of Crohn's Disease
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Notararigo, Sara (Instituto de Investigación Sanitaria de Santiago (IDIS)) ;
Varela, Encarnación (Centro de Investigación Biomédica en Red de Enfermedades Hepáticas y Digestivas) ;
Otal, Anna (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Cristobo, Iván (Centro de Investigaciones Biológicas (Madrid)) ;
Antolín, María (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Guarner, Francisco (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Prieto, Alicia (Centro de Investigaciones Biológicas (Madrid)) ;
López, Paloma (Centro de Investigaciones Biológicas (Madrid)) ;
Universitat Autònoma de Barcelona
1,3-β-glucans are extracellular polysaccharides synthesized by microorganisms and plants, with therapeutic potential. Among them, the O 2-substituted-(1-3)-β-D-glucan, synthesized by some lactic acid bacteria (LAB), has a prebiotic effect on probiotic strains, an immunomodulatory effect on monocyte-derived macrophages, and potentiates the ability of the producer strain to adhere to Caco-2 cells differentiated to enterocytes. [...]
2021 - 10.3389/fmicb.2021.621280
Frontiers in microbiology, Vol. 12 (february 2021)
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20 p, 22.6 MB |
Differential effects of western and mediterranean-type diets on gut microbiota : a metagenomics and metabolomics approach
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Barber, Claudia (Universitat Autònoma de Barcelona. Departament de Medicina) ;
Mego Silva, Marianela (Universitat Autònoma de Barcelona. Departament de Medicina) ;
Sabater, Carlos (Instituto de Investigación Sanitaria del Principado de Asturias) ;
Vallejo, Fernando (Centro de Edafologia y Biologia Aplicada del Segura-CSIC) ;
Bendezú García, Rogger Álvaro (Universitat Autònoma de Barcelona. Departament de Medicina) ;
Masihy, Marcela (Universitat Autònoma de Barcelona. Departament de Medicina) ;
Guarner, Francisco (Universitat Autònoma de Barcelona. Departament de Medicina) ;
Espín, Juan Carlos (Centro de Edafologia y Biologia Aplicada del Segura-CSIC) ;
Margolles, Abelardo (Instituto de Investigación Sanitaria del Principado de Asturias) ;
Azpiroz Vidaur, Fernando (Hospital Universitari Vall d'Hebron. Institut de Recerca)
Our aim was to determine the effect of diet on gut microbiota, digestive function and sensations, using an integrated clinical, metagenomics and metabolomics approach. We conducted a cross-over, randomised study on the effects of a Western-type diet versus a fibre-enriched Mediterranean diet. [...]
2021 - 10.3390/nu13082638
Nutrients, Vol. 13 Núm. 8 (august 2021) , p. 2638
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9 p, 2.1 MB |
Dysbiosis and relapse-related microbiome in inflammatory bowel disease : a shotgun metagenomic approach
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Serrano-Gómez, Gerard (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Mayorga, Luis (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Oyarzun, Iñigo (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Roca, Joaquim (Consejo Superior de Investigaciones Científicas (Espanya)) ;
Borruel, Natalia (Hospital Universitari Vall d'Hebron) ;
Casellas, Francesc (Hospital Universitari Vall d'Hebron) ;
Varela, Encarna (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Pozuelo, Marta (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Machiels, Kathleen (Translational Research Center for Gastrointestinal Disorders, Leuven, Belgium) ;
Guarner, Francisco (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Vermeire, Severine (University Hospitals Leuven (Bèlgica)) ;
Manichanh, Chaysavanh (Centro de Investigación Biomédica en Red de Enfermedades Hepáticas y Digestivas) ;
Universitat Autònoma de Barcelona
Crohn's disease (CD) and ulcerative colitis (UC), the two main forms of inflammatory bowel disease (IBD), affect several million people worldwide. CD and UC are characterized by periods of clinical remission and relapse. [...]
2021 - 10.1016/j.csbj.2021.11.037
Computational and Structural Biotechnology Journal, Vol. 19 (december 2021) , p. 6481-6489
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7 p, 797.7 KB |
Abdominal distension after eating lettuce : The role of intestinal gas evaluated in vitro and by abdominal CT imaging
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Barba Orozco, Elizabeth (Hospital Universitari Vall d'Hebron) ;
Sánchez, Borja (Instituto de Investigación Sanitaria del Principado de Asturias) ;
Burri, Emanuel (Kantonsspital Baselland) ;
Accarino, Ana María (Universitat Autònoma de Barcelona. Departament de Medicina) ;
Monclus, Eva (Universitat Politècnica de Catalunya) ;
Navazo, Isabel (Universitat Politècnica de Catalunya) ;
Guarner, Francisco (Universitat Autònoma de Barcelona. Departament de Medicina) ;
Margolles, Abelardo (Instituto de Investigación Sanitaria del Principado de Asturias) ;
Azpiroz Vidaur, Fernando (Universitat Autònoma de Barcelona. Departament de Medicina)
Some patients complain that eating lettuce, gives them gas and abdominal distention. Our aim was to determine to what extent the patients' assertion is sustained by evidence. An in vitro study measured the amount of gas produced during the process of fermentation by a preparation of human colonic microbiota (n = 3) of predigested lettuce, as compared to beans, a high gas-releasing substrate, to meat, a low gas-releasing substrate, and to a nutrient-free negative control. [...]
2019 - 10.1111/nmo.13703
Neurogastroenterology and Motility, Vol. 31 (august 2019)
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132 p, 3.4 MB |
Microbiota intestinal y colitis ulcerosa, abordaje metagenómico
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Robles Alonso, Virginia ;
Guarner, Francisco, dir. ;
Universitat Autònoma de Barcelona.
Departament de Medicina
Se han evidenciado cambios en la composición de la microbiota fecal en pacientes con CU en actividad frente a sanos, pero no queda claramente establecido si los cambios disbióticos son secundarios a la enfermedad o por el contrario pueden jugar cierto papel en la fisiopatología de la inflamación intestinal. [...]
There have been described changes in fecal microbiota composition in patients with UC with inflammatory activity versus healthy individual, but it is not clear whether the dysbiotic changes are secondary to the disease itself or, on the contrary, may play a role in the pathophysiology of intestinal inflammation. [...]
[Bellaterra] : Universitat Autònoma de Barcelona, 2017.
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