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15 p, 1.4 MB |
Comparative anti-fracture effectiveness of different oral anti-osteoporosis therapies based on "real-world" data : a meta-analysis of propensity-matched cohort findings from the UK Clinical Practice Research Database and the Catalan SIDIAP Database
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Khalid, Sara (University of Oxford. NIHR Biomedical Research Centre) ;
Calderon-Larrañaga, Sara (Family and Community Medicine Teaching Unit of Granada. Cartuja University Health Centre. Andalusian Health Service (SAS), Granada, Spain) ;
Hawley, Samuel (University of Oxford. NIHR Biomedical Research Centre) ;
Ali, M. Sanni (London School of Hygiene and Tropical Medicine, London, United Kingdom) ;
Judge, Andrew (Bristol NIHR Biomedical Research Centre (Bristol, Regne Unit)) ;
Arden, N. K (University of Oxford. Arthritis Research UK Centre for Sport, Exercise, and Osteoarthritis) ;
van Staa, Tjeerd (Utrecht Institute for Pharmaceutical Sciences, Utrecht University, Utrecht, the Netherlands) ;
Cooper, Cyrus (NIHR Southampton Biomedical Research Centre, University of Southampton and University Hospital Southampton NHS Foundation Trust, Southampton, United Kingdom) ;
Javaid, Muhammad Kassim (University of Oxford. NIHR Biomedical Research Centre) ;
Prieto-Alhambra, Daniel (Institut Universitari d'Investigació en Atenció Primària Jordi Gol) ;
Universitat Autònoma de Barcelona
This paper aims to compare the clinical effectiveness of oral anti-osteoporosis drugs based on the observed risk of fracture while on treatment in primary care actual practice. We investigated two primary care records databases covering UK National Health Service (Clinical Practice Research Datalink, CPRD) and Catalan healthcare (Information System for Research in Primary Care, SIDIAP) patients during 1995-2014 and 2006-2014, respectivey. [...]
2018 -  10.2147/CLEP.S164112
Clinical Epidemiology, Vol. 10 (october 2018) , p. 1417-1431
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8 p, 2.2 MB |
Prevalence and Mortality of Individuals With X-Linked Hypophosphatemia : A United Kingdom Real-World Data Analysis
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Hawley, Samuel (University of Oxford. Nuffield Department of Orthopaedics, Rheumatology and Musculoskeletal Sciences) ;
Shaw, Nick J. (Institute of Metabolism & Systems Research, University of Birmingham) ;
Delmestri, Antonella (Nuffield Department of Orthopaedics, Rheumatology and Musculoskeletal Sciences, University of Oxford) ;
Prieto-Alhambra, Daniel (Universitat Autònoma de Barcelona) ;
Cooper, Cyrus (MRC Lifecourse Epidemiology Unit, University of Southampton) ;
Pinedo-Villanueva, Rafael (Nuffield Department of Orthopaedics, Rheumatology and Musculoskeletal Sciences, University of Oxford) ;
Javaid, M. Kassim (MRC Lifecourse Epidemiology Unit, University of Southampton)
X-linked hypophosphatemia (XLH) is a rare multisystemic disease with a prominent musculoskeletal phenotype. We aim here to improve understanding of the prevalence of XLH across the life course and of overall survival among people with XLH. [...]
2020 - 10.1210/clinem/dgz203
The journal of clinical endocrinology & metabolism, Vol. 105 Num. 3 (March 2020)
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9 p, 441.3 KB |
Sample size and power considerations for ordinary least squares interrupted time series analysis : a simulation study
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Hawley, Samuel (University of Oxford. Centre for Statistics in Medicine) ;
Ali, M. Sanni (Faculty of Epidemiology and Population Health, London School of Hygiene and Tropical Medicine) ;
Berencsi, Klara (University of Oxford. Nuffield Department of Orthopaedics, Rheumatology, and Musculoskeletal Sciences (NDORMS)) ;
Judge, Andrew (Department of Translational Health Sciences, University of Bristol, Bristol, UK) ;
Prieto-Alhambra, Daniel (Universitat Autònoma de Barcelona)
Interrupted time series (ITS) analysis is being increasingly used in epidemiology. Despite its growing popularity, there is a scarcity of guidance on power and sample size considerations within the ITS framework. [...]
2019 - 10.2147/CLEP.S176723
Clinical Epidemiology, Vol. 11 (2019) , p. 197-205
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4.
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8 p, 182.5 KB |
Impact of TNF inhibitor therapy on joint replacement rates in rheumatoid arthritis : a matched cohort analysis of BSRBR-RA UK registry data
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Hawley, Samuel (University of Oxford. Centre for Statistics in Medicine) ;
Ali, M. Sanni (Faculty of Epidemiology and Population Health, London School of Hygiene and Tropical Medicine, London, UK) ;
Cordtz, René (The Parker Institute, Copenhagen University Hospital Copenhagen) ;
Dreyer, Lene (Department of Clinical Medicine, Aalborg University, Aalborg, Denmark) ;
Edwards, Christopher J. (University Hospital Southampton NHS Foundation Trust (Regne Unit)) ;
Arden, N. K (MRC Lifecourse Epidemiology Unit, University of Southampton, Southampton) ;
Cooper, Cyrus (MRC Lifecourse Epidemiology Unit, University of Southampton, Southampton) ;
Judge, Andrew (Translational Health Sciences, University of Bristol, Bristol) ;
Hyrich, Kimme (University of Manchester) ;
Prieto-Alhambra, Daniel (Universitat Autònoma de Barcelona)
Previous ecological data suggest a decline in the need for joint replacements in RA patients following the introduction of TNF inhibitor (TNFi) therapy, although patient-level data are lacking. Our primary aim was to estimate the association between TNFi use and subsequent incidence of total hip replacement (THR) and total knee replacement. [...]
2019 - 10.1093/rheumatology/key424
Rheumatology, Vol. 58 (january 2019) , p. 1168-1175
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5.
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9 p, 1.3 MB |
Insulin use and Excess Fracture Risk in Patients with Type 2 Diabetes: A Propensity-Matched cohort analysis
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Losada-Grande, Eladio (Universitat Autònoma de Barcelona. Departament de Medicina) ;
Hawley, Samuel (University of Oxford) ;
Soldevila i Madorell, Berta (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Martínez-Laguna, Daniel (Institut Universitari d'Investigació en Atenció Primària Jordi Gol) ;
Nogués Solán, Xavier (Institut Hospital del Mar d'Investigacions Mèdiques) ;
Díez Pérez, Adolfo (Institut Hospital del Mar d'Investigacions Mèdiques) ;
Puig Domingo, Manuel (Universitat Autònoma de Barcelona. Departament de Medicina) ;
Mauricio Puente, Dídac (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Prieto-Alhambra, Daniel (University of Oxford)
Despite normal to high bone mineral density, patients with type 2 diabetes (T2DM) have an increased fracture risk. T2DM medications could partially account for this excess risk. The aim of this study was to assess the association between insulin use and bone fracture risk in T2DM patients. [...]
2017 - 10.1038/s41598-017-03748-z
Scientific reports, Vol. 3 Núm. 378 (june 2017) , p. 1-9
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7 p, 376.1 KB |
Clinical effectiveness of orthogeriatric and fracture liaison service models of care for hip fracture patients : population-based longitudinal study
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Hawley, Samuel (University of Oxford) ;
Javaid, M. Kassim (MRC Lifecourse Epidemiology Unit, University of Southampton) ;
Prieto-Alhambra, Daniel (Institut Hospital del Mar d'Investigacions Mèdiques) ;
Lippett, Janet (Royal Berkshire NHS Foundation Trust, Reading) ;
Sheard, Sally (University of Oxford) ;
Arden, N. K (MRC Lifecourse Epidemiology Unit, University of Southampton) ;
Cooper, Cyrus (MRC Lifecourse Epidemiology Unit, University of Southampton) ;
Judge, Andrew (MRC Lifecourse Epidemiology Unit, University of Southampton) ;
Universitat Autònoma de Barcelona
Objectives: to evaluate orthogeriatric and nurse-led fracture liaison service (FLS) models of post-hip fracture care in terms of impact on mortality (30 days and 1 year) and second hip fracture (2 years). [...]
2016 - 10.1093/ageing/afv204
Age and Ageing, Vol. 45 (january 2016) , p. 236-242
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