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6 p, 558.0 KB Mutations in Escherichia coli aceE and ribB genes allow survival of strains defective in the first step of the isoprenoid biosynthesis pathway / Pérez-Gil, Jordi (Centre de Recerca en Agrigenòmica) ; Uros, Eva Maria (Centre de Recerca en Agrigenòmica) ; Sauret-Güeto, Susanna (Centre de Recerca en Agrigenòmica) ; Lois, L. Maria (Centre de Recerca en Agrigenòmica) ; Kirby, James (Joint BioEnergy Institute) ; Nishimoto, Minobu (Joint BioEnergy Institute) ; Baidoo, Edward E. K. (Joint BioEnergy Institute) ; Keasling, Jay D. (Joint BioEnergy Institute) ; Boronat i Margosa, Albert (Centre de Recerca en Agrigenòmica) ; Rodríguez Concepción, Manuel (Centre de Recerca en Agrigenòmica)
A functional 2-C-methyl-D-erythritol 4-phosphate (MEP) pathway is required for isoprenoid biosynthesis and hence survival in Escherichia coli and most other bacteria. In the first two steps of the pathway, MEP is produced from the central metabolic intermediates pyruvate and glyceraldehyde 3-phosphate via 1-deoxy-D-xylulose 5-phosphate (DXP) by the activity of the enzymes DXP synthase (DXS) and DXP reductoisomerase (DXR). [...]
2012 - 10.1371/journal.pone.0043775
PloS one, Vol. 7, issue 8 (Aug. 2012) , e43775  

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