UAB Digital Repository of Documents 5 records found  Search took 0.01 seconds. 
1.
11 p, 548.2 KB Estimating the Incidence and Key Risk Factors of Cardiovascular Disease in Patients at High Risk of Imminent Fracture Using Routinely Collected Real-World Data From the / Pineda-Moncusí, Marta (University of Oxford) ; El-Hussein, Leena (University of Oxford) ; Delmestri, Antonella (University of Oxford) ; Cooper, Cyrus (University of Southampton) ; Moayyeri, Alireza (UCB Biopharma Sprl) ; Libanati, Cesar (UCB Biopharma Sprl) ; Toth, Emese (UCB Biopharma Sprl) ; Prieto-Alhambra, Daniel (Institut Universitari d'Investigació en Atenció Primària Jordi Gol) ; Khalid, Sara (University of Oxford) ; Universitat Autònoma de Barcelona
The objective of this work was to estimate the incidence rate of cardiovascular disease (CVD) events (myocardial infarction, stroke, or CVD death) at 1 year among three cohorts of patients at high risk of fracture (osteoporosis, previous fracture, and anti-osteoporosis medication) and to identify the key risk factors of CVD events in these three cohorts. [...]
2022 - 10.1002/jbmr.4648
Journal of Bone and Mineral Research, Vol. 37 (september 2022) , p. 1986-1996  
2.
15 p, 1.4 MB One- and 2-year incidence of osteoporotic fracture : a multi-cohort observational study using routinely collected real-world data / Khalid, Sara (Nuffield Orthopaedic Centre. Nuffield Department of Orthopaedics, Rheumatology and Musculoskeletal Sciences, Centre for Statistics in Medicine) ; Reyes, Carlen (Institut Universitari d'Investigació en Atenció Primària Jordi Gol) ; Ernst, Martin (University of Southern Denmark. Department of Public Health, Clinical Pharmacology and Pharmacy) ; Delmestri, Antonella (Nuffield Orthopaedic Centre. Nuffield Department of Orthopaedics, Rheumatology and Musculoskeletal Sciences, Centre for Statistics in Medicine) ; Toth, Emese (UCB Biopharma Sprl) ; Libanati, Cesar (UCB Biopharma Sprl) ; Abrahamsen, Bo (Holbæk Hospital (Dinamarca)) ; Prieto-Alhambra, Daniel (Universitat Autònoma de Barcelona)
We estimated and characterized the imminent fracture risk (1-2 years) of high-risk fracture patients through a multinational (UK, Spain, Denmark) cohort study. Older individuals with newly diagnosed osteoporosis and individuals who had a fracture while on treatment with a bisphosphonate were at a high risk of imminent fracture. [...]
2021 - 10.1007/s00198-021-06077-0
Osteoporosis International, Vol. 33 (2022) , p. 123-137  
3.
11 p, 810.9 KB The treatment gap after major osteoporotic fractures in Denmark 2005-2014 : a combined analysis including both prescription-based and hospital-administered anti-osteoporosis medications / Skjødt, M. K. (Holbæk Hospital (Dinamarca)) ; Ernst, M. T. (University of Southern Denmark. Department of Public Health, Clinical Pharmacology, Pharmacy and Environmental Medicine) ; Khalid, Sara (Oxford University Hospitals. Nuffield Department of Orthopaedics, Rheumatology and Musculoskeletal Sciences) ; Libanati, C. (UCB Pharma) ; Cooper, Cyrus (University of Southampton) ; Delmestri, Antonella (Oxford University Hospitals. Nuffield Department of Orthopaedics, Rheumatology and Musculoskeletal Sciences) ; Rubin, K. H. (University of Southern Denmark) ; Javaid, M. K. (Oxford University Hospitals. Nuffield Department of Orthopaedics, Rheumatology and Musculoskeletal Sciences) ; Martínez-Laguna, Daniel (Institut Universitari d'Investigació en Atenció Primària Jordi Gol) ; Prieto-Alhambra, Daniel (Oxford University Hospitals. Nuffield Department of Orthopaedics, Rheumatology and Musculoskeletal Sciences) ; Abrahamsen, Bo (Oxford University Hospitals. Nuffield Department of Orthopaedics, Rheumatology and Musculoskeletal Sciences) ; Universitat Autònoma de Barcelona
This study demonstrates a substantial and persistent anti-osteoporosis treatment gap in men and women ≥50 years old who sustained major osteoporotic fracture(s) between 2005 and 2014 in Denmark. This was not substantially reduced by including hospital-administered anti-osteoporosis treatments. [...]
2021 - 10.1007/s00198-021-05890-x
Osteoporosis International, Vol. 32 (march 2021) , p. 1961-1971  
4.
10 p, 780.0 KB Secular trends in the initiation of therapy in secondary fracture prevention in Europe : a multi-national cohort study including data from Denmark, Catalonia, and the United Kingdom / Skjødt, M. K. (Odense University Hospital (Dinamarca)) ; Khalid, Sara (Oxford University Hospitals. Nuffield Orthopaedic Centre) ; Ernst, M. (University of Southern Denmark. Department of Public Health, Clinical Pharmacology and Pharmacy) ; Rubin, K. H. (Odense University Hospital (Dinamarca)) ; Martínez-Laguna, Daniel (Universitat Autònoma de Barcelona. Departament de Medicina) ; Delmestri, Antonella (Oxford University Hospitals. Nuffield Orthopaedic Centre) ; Javaid, M. K. (Oxford University Hospitals. Nuffield Orthopaedic Centre) ; Cooper, Cyrus (University Hospital Southampton NHS Foundation Trust (Regne Unit)) ; Libanati, C. (UCB Pharma) ; Toth, E. (UCB Pharma) ; Abrahamsen, Bo (Oxford University Hospitals. Nuffield Orthopaedic Centre) ; Prieto-Alhambra, Daniel (Oxford University Hospitals. Nuffield Orthopaedic Centre)
This paper demonstrates a large post-fracture anti-osteoporosis treatment gap in the period 2005 to 2015. The gap was stable in Denmark at around 88-90%, increased in Catalonia from 80 to 88%, and started to increase in the UK towards the end of our study. [...]
2020 - 10.1007/s00198-020-05358-4
Osteoporosis International, Vol. 31 (march 2020) , p. 1535-1544  
5.
15 p, 1.4 MB Comparative anti-fracture effectiveness of different oral anti-osteoporosis therapies based on "real-world" data : a meta-analysis of propensity-matched cohort findings from the UK Clinical Practice Research Database and the Catalan SIDIAP Database / Khalid, Sara (University of Oxford. NIHR Biomedical Research Centre) ; Calderon-Larrañaga, Sara (Family and Community Medicine Teaching Unit of Granada. Cartuja University Health Centre. Andalusian Health Service (SAS), Granada, Spain) ; Hawley, Samuel (University of Oxford. NIHR Biomedical Research Centre) ; Ali, M. Sanni (London School of Hygiene and Tropical Medicine, London, United Kingdom) ; Judge, Andrew (Bristol NIHR Biomedical Research Centre (Bristol, Regne Unit)) ; Arden, N. K (University of Oxford. Arthritis Research UK Centre for Sport, Exercise, and Osteoarthritis) ; van Staa, Tjeerd (Utrecht Institute for Pharmaceutical Sciences, Utrecht University, Utrecht, the Netherlands) ; Cooper, Cyrus (NIHR Southampton Biomedical Research Centre, University of Southampton and University Hospital Southampton NHS Foundation Trust, Southampton, United Kingdom) ; Javaid, Muhammad Kassim (University of Oxford. NIHR Biomedical Research Centre) ; Prieto-Alhambra, Daniel (Institut Universitari d'Investigació en Atenció Primària Jordi Gol) ; Universitat Autònoma de Barcelona
This paper aims to compare the clinical effectiveness of oral anti-osteoporosis drugs based on the observed risk of fracture while on treatment in primary care actual practice. We investigated two primary care records databases covering UK National Health Service (Clinical Practice Research Datalink, CPRD) and Catalan healthcare (Information System for Research in Primary Care, SIDIAP) patients during 1995-2014 and 2006-2014, respectivey. [...]
2018 - 10.2147/CLEP.S164112
Clinical Epidemiology, Vol. 10 (october 2018) , p. 1417-1431  

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