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14 p, 4.3 MB N -Methyl--Aspartate Receptor Link to the MAP Kinase Pathway in Cortical and Hippocampal Neurons and Microglia Is Dependent on Calcium Sensors and Is Blocked by α-Synuclein, Tau, and Phospho-Tau in Non-transgenic and Transgenic APP Mice / Franco, Rafael (Universitat de Barcelona. Departament de Bioquímica i Biomedicina Molecular) ; Aguinaga Andrés, David (Universitat de Barcelona. Departament de Bioquímica i Biomedicina Molecular) ; Reyes Resina, Irene (Universitat de Barcelona. Departament de Bioquímica i Biomedicina Molecular) ; Canela, Enric I. (Universitat de Barcelona. Departament de Bioquímica i Biomedicina Molecular) ; Lillo Jové, Jaume (Universitat de Barcelona. Departament de Bioquímica i Biologia Molecular) ; Tarutani, Airi (Tokyo Metropolitan Institute of Medical Science. Department of Dementia and Higher Brain Function) ; Hasegawa, Masato (Tokyo Metropolitan Institute of Medical Science. Department of Dementia and Higher Brain Function) ; del Ser Badia, Anna (Universitat Autònoma de Barcelona. Departament de Bioquímica i de Biologia Molecular) ; del Rio, José A. (Universitat de Barcelona. Departament de Biologia Cel·lular, Fisiologia i Immunologia) ; Kreutz, Michael R. (University Medical Center Hamburg-Eppendorf) ; Saura Antolín, Carlos (Universitat Autònoma de Barcelona. Institut de Neurociències) ; Navarro Brugal, Gemma (Universitat de Barcelona. Departament de Bioquímica i Biologia Molecular)
N -methyl--aspartate receptors (NMDARs) respond to glutamate to allow the influx of calcium ions and the signaling to the mitogen-activated protein kinase (MAPK) cascade. Both MAPK- and Ca 2+ -mediated events are important for both neurotransmission and neural cell function and fate. [...]
2018 - 10.3389/fnmol.2018.00273
Frontiers in molecular neuroscience, Vol. 11 (August 2018) , art. 273  

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