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19 p, 5.8 MB |
Deep Learning Analyses to Delineate the Molecular Remodeling Process after Myocardial Infarction
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Iborra Egea, Oriol (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Gálvez-Montón, Carolina (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Prat-Vidal, Cristina (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Rudilla, F (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Soler-Botija, Carolina (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Revuelta-López, Elena (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Ferrer-Curriu, Gemma (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Segú-Vergés, Cristina (Anaxomics Biotech S.L.) ;
Mellado-Bergillos, Araceli (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Gomez-Puchades, Pol (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Gastelurrutia, Paloma (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Bayés-Genís, Antoni (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Universitat Autònoma de Barcelona
Specific proteins and processes have been identified in post-myocardial infarction (MI) pathological remodeling, but a comprehensive understanding of the complete molecular evolution is lacking. We generated microarray data from swine heart biopsies at baseline and 6, 30, and 45 days after infarction to feed machine-learning algorithms. [...]
2021 -  10.3390/cells10123268
Cells, Vol. 10 (november 2021)
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15 p, 4.3 MB |
Acellular cardiac scaffolds enriched with MSC-derived extracellular vesicles limit ventricular remodelling and exert local and systemic immunomodulation in a myocardial infarction porcine model
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Monguió-Tortajada, Marta (Institut Germans Trias i Pujol) ;
Prat-Vidal, Cristina (Banc de Sang i Teixits) ;
Martínez-Falguera, Daina (Universitat de Barcelona) ;
Teis, Albert (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Soler-Botija, Carolina (Instituto de Salud Carlos III) ;
Courageux, Yvan (Universitat Autònoma de Barcelona. Departament de Bioquímica i de Biologia Molecular) ;
Munizaga-Larroudé, Micaela (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Morón-Font, Miriam (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Bayés-Genís, Antoni (Universitat Autònoma de Barcelona. Departament de Medicina) ;
Borràs i Serres, Francesc Enric (Universitat de Barcelona. Departament de Biologia Cel·lular, Fisiologia i Immunologia) ;
Rudilla, F. (Institut d'Investigació Biomèdica de Bellvitge) ;
Gálvez-Montón, Carolina (Institut d'Investigació Biomèdica de Bellvitge)
Rationale: Extracellular vesicles (EVs) from mesenchymal stromal cell (MSC) are a potential therapy for cardiac healing after myocardial infarction (MI). Nevertheless, neither their efficient administration nor therapeutic mechanisms are fully elucidated. [...]
2022 - 10.7150/thno.72289
Theranostics, Vol. 12, Issue 10 (June 2022) , p. 4656-4670
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13 p, 3.5 MB |
Electrophysiological effects of adipose graft transposition procedure (AGTP) on the post-myocardial infarction scar : A multimodal characterization of arrhythmogenic substrate
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Adeliño, Raquel (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Martínez-Falguera, Daina (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Curiel, Carolina (Boston Scientific Department. Barcelona Delegation) ;
Teis, Albert (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Marsal, Roger (Boston Scientific Department. Barcelona Delegation) ;
Rodríguez-Leor, Oriol (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Prat-Vidal, Cristina (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Fadeuilhe, Edgar (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Aranyó, Júlia (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Revuelta-López, Elena (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Sarrias, Axel (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Bazán, Víctor (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Andrés-Cordón, Joan Francesc (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Roura, Santiago (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Villuendas-Sabaté, Roger (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Lupón, Josep (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Bayés-Genís, Antoni (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Gálvez-Montón, Carolina (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Bisbal, Felipe (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Universitat Autònoma de Barcelona
To assess the arrhythmic safety profile of the adipose graft transposition procedure (AGTP) and its electrophysiological effects on post-myocardial infarction (MI) scar. Myocardial repair is a promising treatment for patients with MI. [...]
2022 - 10.3389/fcvm.2022.983001
Frontiers in Cardiovascular Medicine, Vol. 9 (september 2022)
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7 p, 1.6 MB |
Neoinnervation and neovascularization of acellular pericardial-derived scaffolds in myocardial infarcts
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Gálvez-Montón, Carolina (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Fernandez-Figueras, M. Teresa (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Martí, Mercè (Centro de Investigación Biomédica en Red de Bioingeniería, Biomateriales y Nanomedicina) ;
Soler-Botija, Carolina (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Roura, Santiago (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Perea-Gil, Isaac (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Prat-Vidal, Cristina (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Llucià-Valldeperas, Aida (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Raya, Ángel (Institució Catalana de Recerca i Estudis Avançats) ;
Bayés-Genís, Antoni (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Universitat Autònoma de Barcelona.
Departament de Medicina
Engineered bioimplants for cardiac repair require functional vascularization and innervation for proper integration with the surrounding myocardium. The aim of this work was to study nerve sprouting and neovascularization in an acellular pericardial-derived scaffold used as a myocardial bioimplant. [...]
2015 - 10.1186/s13287-015-0101-6
Stem cell research & therapy, Vol. 6 (may 2015)
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13 p, 4.9 MB |
Head-to-head comparison of two engineered cardiac grafts for myocardial repair : From scaffold characterization to pre-clinical testing
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Perea-Gil, Isaac (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Gálvez-Montón, Carolina (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Prat-Vidal, Cristina (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Jorba, Ignasi (Universitat de Barcelona) ;
Segú-Vergés, Cristina (Anaxomics Biotech) ;
Roura, Santiago (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Soler-Botija, Carolina (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Iborra Egea, Oriol (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Revuelta-López, Elena (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Fernández, Marco A. (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Farré, Ramon (Institut d'Investigacions Biomèdiques August Pi i Sunyer) ;
Navajas, Daniel (Universitat de Barcelona) ;
Bayés-Genís, Antoni (Universitat Autònoma de Barcelona. Departament de Medicina)
Cardiac tissue engineering, which combines cells and supportive scaffolds, is an emerging treatment for restoring cardiac function after myocardial infarction (MI), although, the optimal construct remains a challenge. [...]
2018 - 10.1038/s41598-018-25115-2
Scientific reports, Vol. 8 (april 2018)
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1 p, 662.5 KB |
Author Correction : Unravelling the effects of mechanical physiological conditioning on cardiac adipose tissue-derived progenitor cells in vitro and in silico
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Llucià-Valldeperas, Aida (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Bragos, Ramon (Universitat Politècnica de Catalunya. Departament d'Enginyeria Electrònica) ;
Soler-Botija, Carolina (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Roura, Santiago (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Gálvez-Montón, Carolina (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Prat-Vidal, Cristina (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Perea-Gil, Isaac (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Bayés-Genís, Antoni (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Universitat Autònoma de Barcelona
2018 - 10.1038/s41598-018-24808-y
Scientific reports, Vol. 8 (april 2018)
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16 p, 1.3 MB |
Wharton's jelly mesenchymal stromal cells and derived extracellular vesicles as post-myocardial infarction therapeutic toolkit : an experienced view
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Muñoz-Domínguez, Noelia (Banc de Sang i Teixits) ;
Roura, Santiago (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Prat-Vidal, Cristina (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Vives Armengol, Joaquim (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Universitat Autònoma de Barcelona
Outstanding progress has been achieved in developing therapeutic options for reasonably alleviating symptoms and prolonging the lifespan of patients suffering from myocardial infarction (MI). Current treatments, however, only partially address the functional recovery of post-infarcted myocardium, which is in fact the major goal for effective primary care. [...]
2021 - 10.3390/pharmaceutics13091336
Pharmaceutics, Vol. 13 Núm. 9 (september 2021) , p. 1336
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