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1.
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18 p, 1.8 MB |
Serum DNA methylome of the colorectal cancer serrated pathway enables non-invasive detection
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Gallardo-Gómez, María (Universidade de Vigo) ;
Costas-Ríos, Lara (Universidade de Vigo) ;
García-Prieto, Carlos A (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ;
Álvarez-Rodríguez, Lara (Universidade de Vigo) ;
Bujanda, Luis (Universidad del País Vasco (UPV/EHU)) ;
Barrero, Maialen (Hospital Universitario Donostia) ;
Castells, Antoni (Hospital Clínic i Provincial de Barcelona) ;
Balaguer, Francesc (Hospital Clínic i Provincial de Barcelona) ;
Jover, Rodrigo (Universidad Miguel Hernández, Alicante) ;
Esteller, Manel (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ;
Tardío Baiges, Antoni (Instituto de Investigación Biomédica Galicia Sur) ;
González-Carreró Fojón, Joaquín (Instituto de Investigación Biomédica Galicia Sur) ;
Cubiella, Joaquín (Centro de Investigación Biomédica en Red de Enfermedades Hepáticas y Digestivas (CIBERehd), Ourense) ;
De Chiara, Loretta (Universidade de Vigo)
The clinical relevance of the colorectal cancer serrated pathway is evident, but the screening of serrated lesions remains challenging. We aimed to characterize the serum methylome of the serrated pathway and to evaluate circulating cell-free DNA (cfDNA) methylomes as a potential source of biomarkers for the non-invasive detection of serrated lesions. [...]
2023 -  10.1002/1878-0261.13573
Molecular Oncology, 2023
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2.
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10 p, 2.6 MB |
Epigenetic Profiling and Response to CD19 Chimeric Antigen Receptor T-Cell Therapy in B-Cell Malignancies
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García-Prieto, Carlos A (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ;
Villanueva, Lorea (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ;
Bueno-Costa, Alberto (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ;
Davalos, Veronica (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ;
González-Navarro, Europa Azucena (Department of Immunology. Hospital Clinic) ;
Juan, Manuel (Institut d'Investigacions Biomèdiques August Pi i Sunyer) ;
Urbano-Ispizua, Álvaro (Department of Hematology. University of Barcelona) ;
Delgado, Julia (Centro de Investigación Biomedica en Red de Cancer) ;
Ortiz-Maldonado, Valetín (Institut d'Investigacions Biomèdiques August Pi i Sunyer) ;
Del Bufalo, Francesca (Department of Paediatric Haematology and Oncology. Bambino Gesù Children's Hospital) ;
Locatelli, Franco (Sapienza University of Rome) ;
Quintarelli, Concetta (Department of Clinical Medicine and Surgery. University of Naples Federico II) ;
Sinibaldi, Matilde (Department of Paediatric Haematology and Oncology. Bambino Gesù Children's Hospital) ;
Soler, Marta (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ;
Castro De Moura, Manuel (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ;
Ferrer, Gerardo (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ;
Urdinguio, Rocío G. (Universidad de Oviedo) ;
Fernandez, A.F. (Universidad de Oviedo) ;
Fraga, Mario F. (Universidad de Oviedo) ;
Bar, Diana (The Edmond and Lily Safra Children's Hospital) ;
Meir, Agustín (The Edmond and Lily Safra Children's Hospital) ;
Itzhaki, Orit (Ella Lemelbaum Institute for Immuno Oncology) ;
Besser, MichalJ. (Tel Aviv University) ;
Avigdor, Abraham (Sheba Medical Center) ;
Jacoby, Elad (Tel Aviv University) ;
Esteller, Manel (Universitat de Barcelona. Departament de Ciències Fisiològiques)
Background: Chimeric antigen receptor (CAR) T cells directed against CD19 (CART19) are effective in B-cell malignancies, but little is known about the molecular factors predicting clinical outcome of CART19 therapy. [...]
2022 - 10.1093/jnci/djab194
Journal of the National Cancer Institute, Vol. 114 Núm. 3 (january 2022) , p. 436-445
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3.
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15 p, 4.7 MB |
Epigenetic inactivation of the 5-methylcytosine RNA methyltransferase NSUN7 is associated with clinical outcome and therapeutic vulnerability in liver cancer
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Ortiz-Barahona, Vanessa (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ;
Soler, Marta (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ;
Davalos, Veronica (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ;
García-Prieto, Carlos A. (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ;
Janin, Maxime (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ;
Setien, Fernando (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ;
Fernández-Rebollo, Irene (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ;
Bech-Serra, Joan J. (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ;
De La Torre, Carolina (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ;
Guil, Sonia (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ;
Villanueva, Alberto (Institut d'Investigació Biomèdica de Bellvitge) ;
Zhang, Pei Hong (Fudan University, Shanghai, China) ;
Yang, Li (Fudan University, Shanghai, China) ;
Guarnacci, Marco (Australian National University, Canberra, Australia) ;
Schumann, Ulrike (Australian National University, Canberra, Australia) ;
Preiss, Thomas (Australian National University, Canberra, Australia) ;
Balaseviciute, Ugne (Hospital Clínic i Provincial de Barcelona) ;
Montal, Robert (Universitat de Lleida) ;
Llovet, Josep M. (Hospital Clínic i Provincial de Barcelona) ;
Esteller, Manel (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras)
Background: RNA modifications are important regulators of transcript activity and an increasingly emerging body of data suggests that the epitranscriptome and its associated enzymes are altered in human tumors. [...]
2023 - 10.1186/s12943-023-01785-z
Molecular cancer, Vol. 22 Núm. 1 (may 2023)
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4.
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11 p, 4.4 MB |
Culture expansion of CAR T cells results in aberrant DNA methylation that is associated with adverse clinical outcome
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Salz, Lucia (RWTH Aachen University Medical School, Germany) ;
Seitz, Alexander (Miltenyi Biotec B.V. & Co. KG, Gladbach, Germany) ;
Schäfer, Daniel (Miltenyi Biotec B.V. & Co. KG, Gladbach, Germany) ;
Franzen, Julia (RWTH Aachen University Medical School, Germany) ;
Holzer, Tatjana (Miltenyi Biotec B.V. & Co. KG, Gladbach, Germany) ;
García-Prieto, Carlos A (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ;
Bürger, Iris (Miltenyi Biotec B.V. & Co. KG, Gladbach, Germany) ;
Hardt, Olaf (Miltenyi Biotec B.V. & Co. KG, Gladbach, Germany) ;
Esteller, Manel (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ;
Wagner, Wolfgang (RWTH Aachen University Medical School, Germany)
Chimeric antigen receptor (CAR) T cells provide new perspectives for treatment of hematological malignancies. Manufacturing of these cellular products includes culture expansion procedures, which may affect cellular integrity and therapeutic outcome. [...]
2023 - 10.1038/s41375-023-01966-1
Leukemia, Vol. 37 Núm. 9 (july 2023) , p. 1868-1878
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5.
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4 p, 1.4 MB |
Remodeling of the m6A RNA landscape in the conversion of acute lymphoblastic leukemia cells to macrophages
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Bueno-Costa, Alberto (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ;
Piñeyro, David (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ;
García-Prieto, Carlos A. (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ;
Ortiz-Barahona, Vanessa (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ;
Martinez-Verbo, Laura (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ;
Webster, Natalie A. (STORM Therapeutics Ltd, UK) ;
Andrews, Byron (STORM Therapeutics Ltd, UK) ;
Kol, Nitzan (Tel Aviv University, Israel) ;
Avrahami, Chen (Tel Aviv University, Israel) ;
Moshitch-Moshkovitz, Sharon (Tel Aviv University, Israel) ;
Rechavi, Gideon (Tel Aviv University, Israel) ;
Esteller, M (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras)
2022 - 10.1038/s41375-022-01621-1
Leukemia, Vol. 36 Núm. 8 (august 2022) , p. 2121-2124
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6.
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9 p, 1.5 MB |
Validation of a DNA methylation microarray for 285,000 CpG sites in the mouse genome
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García-Prieto, Carlos A (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ;
Álvarez-Errico, Damiana (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ;
Musulen, Eva (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ;
Bueno-Costa, Alberto (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ;
Vazquez Prat, Berta Nieves (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ;
Vaquero, Alejandro (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ;
Esteller, M (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras)
Mouse has been extensively used as a model organism in many studies to characterize biological pathways and drug effects and to mimic human diseases. Similar DNA sequences between both species facilitate these types of experiments. [...]
2022 - 10.1080/15592294.2022.2053816
Epigenetics, Vol. 17 Núm. 12 (december 2022) , p. 1677-1685
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7.
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8.
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11 p, 1.3 MB |
Detection of oncogenic and clinically actionable mutations in cancer genomes critically depends on variant calling tools
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García-Prieto, Carlos A (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ;
Martínez Jiménez, Francisco (Institute for Research in Biomedicine (IRB Barcelona)) ;
Valencia, Alfonso (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ;
Porta-Pardo, Eduard (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras)
Motivation: The analysis of cancer genomes provides fundamental information about its etiology, the processes driving cell transformation or potential treatments. While researchers and clinicians are often only interested in the identification of oncogenic mutations, actionable variants or mutational signatures, the first crucial step in the analysis of any tumor genome is the identification of somatic variants in cancer cells (i. [...]
2022 - 10.1093/bioinformatics/btac306
Bioinformatics, Vol. 38 Núm. 12 (15 2022) , p. 3181-3191
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9.
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13 p, 453.4 KB |
Phenotypic Characteristics and Copy Number Variants in a Cohort of Colombian Patients with VACTERL Association
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Moreno, Olga M. (Pontificia Universidad Javeriana) ;
Sanchez, Ana I. (Centro Medico Imbanaco de Cali) ;
Herreño, Angélica (Pontificia Universidad Javeriana) ;
Giraldo, Gustavo (Pontificia Universidad Javeriana) ;
Suarez, Fernando (Hospital Universitario de San Ignacio) ;
Prieto, Juan Carlos (Pontificia Universidad Javeriana) ;
Clavijo, Ana Shaia (Pontificia Universidad Javeriana) ;
Olaya, Mercedes (Hospital Universitario de San Ignacio) ;
Vargas, Yaris (Hospital Universitario de San Ignacio) ;
Benítez, Javier (CNIO: Centro Nacional de Investigaciones Oncologicas) ;
Surrallés i Calonge, Jordi (Institut d'Investigació Biomèdica Sant Pau) ;
Rojas, Adriana (Pontificia Universidad Javeriana) ;
Universitat Autònoma de Barcelona
VACTERL association (OMIM 192350) is a heterogeneous clinical condition characterized by congenital structural defects that include at least 3 of the following features: vertebral abnormalities, anal atresia, heart defects, tracheoesophageal fistula, renal malformations, and limb defects. [...]
2020 - 10.1159/000510910
Molecular Syndromology, Vol. 11 Núm. 5-6 (december 2020) , p. 271-283
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10.
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12 p, 844.6 KB |
Epigenetic profiling linked to multisystem inflammatory syndrome in children (MIS-C) : A multicenter, retrospective study
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Davalos, Veronica (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ;
García-Prieto, Carlos A (Barcelona Supercomputing Center) ;
Ferrer, Gerardo (Centro de Investigación Biomédica en Red de Cáncer) ;
Aguilera-Albesa, Sergio (Complejo Hospitalario de Navarra) ;
Valencia-Ramos, Juan (Hospital Universitario de Burgos) ;
Rodríguez-Palmero, Agustí (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Ruiz, Montserrat (Centro de Investigación Biomédica en Red de Enfermedades Raras) ;
Planas-Serra, Laura (Centro de Investigación Biomédica en Red de Enfermedades Raras) ;
Jordán García, Iolanda (Hospital Sant Joan de Déu (Barcelona, Catalunya)) ;
Alegría, Iosune (Complejo Hospitalario de Navarra) ;
Flores-Pérez, Patricia (Pediatrics Department. Hospital Universitario Niño Jesús) ;
Cantarín, Verónica (Pediatrics Department. Hospital Universitario Niño Jesús) ;
Fumadó, Victoria (Unitat de Malalties Infeccioses i Importades. Servei de Pediatría. Infectious and Imported Diseases. Pediatric Unit. Hospital Universitari Sant Joan de Deú) ;
Viadero, Maria Teresa (Hospital Universitario Marqués de Valdecilla (Santander, Cantabria)) ;
Rodrigo, Carlos (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Méndez-Hernández, Maria (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
López-Granados, Eduardo (Instituto de Investigación Sanitaria del Hospital Universitario La Paz) ;
Colobrán Oriol, Roger (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Rivière, Jacques G.. (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Soler-Palacín, Pere (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Pujol, Aurora 1968- (Institució Catalana de Recerca i Estudis Avançats) ;
Esteller, M (Universitat de Barcelona. Departament de Ciències Fisiològiques) ;
Universitat Autònoma de Barcelona.
Departament de Pediatria, d'Obstetrícia i Ginecologia i de Medicina Preventiva
Background: Most children and adolescents infected with the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) remain asymptomatic or develop a mild coronavirus disease 2019 (COVID-19) that usually does not require medical intervention. [...]
2022 - 10.1016/j.eclinm.2022.101515
EClinicalMedicine, Vol. 50 (august 2022) , art. 101515
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