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7 p, 1000.2 KB |
Spontaneous reperfusion enhances succinate concentration in peripheral blood from stemi patients but its levels does not correlate with myocardial infarct size or area at risk
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Consegal, Marta (Hospital Universitari Vall d'Hebron) ;
Barba, Ignasi (Hospital Universitari Vall d'Hebron) ;
García del Blanco, Bruno (Hospital Universitari Vall d'Hebron) ;
Otaegui, Imanol (Hospital Universitari Vall d'Hebron) ;
Rodriguez-Palomares, Jose F (Hospital Universitari Vall d'Hebron) ;
Martí Balaguer, Gerard (Hospital Universitari Vall d'Hebron) ;
Serra-Vidal, Bernat (Hospital Universitari Vall d'Hebron) ;
Bellera Gotarda, Neus (Hospital Universitari Vall d'Hebron) ;
Ojeda-Ramos, Manuel (Hospital Universitari Vall d'Hebron) ;
Valente, Filipa (Hospital Universitari Vall d'Hebron) ;
Carmona, Maria Ángeles (Hospital Universitari Vall d'Hebron) ;
Miró-Casas, Elisabet (Hospital Universitari Vall d'Hebron) ;
Sambola, Antonia (Hospital Universitari Vall d'Hebron) ;
Lidón, Rosa María (Hospital Universitari Vall d'Hebron) ;
Bañeras, Jordi (Hospital Universitari Vall d'Hebron) ;
Barrabés, José A (Hospital Universitari Vall d'Hebron) ;
Rodríguez, Cristina (Institut d'Investigació Biomèdica Sant Pau) ;
Benito, Begoña (Hospital Universitari Vall d'Hebron) ;
Ruiz Meana, Marisol (Hospital Universitari Vall d'Hebron) ;
Inserte Igual, Javier (Hospital Universitari Vall d'Hebron) ;
Ferreira-Gonzalez, Ignacio (Hospital Universitari Vall d'Hebron) ;
Rodríguez-Sinovas, Antonio (Hospital Universitari Vall d'Hebron) ;
Universitat Autònoma de Barcelona
Succinate is enhanced during initial reperfusion in blood from the coronary sinus in ST-segment elevation myocardial infarction (STEMI) patients and in pigs submitted to transient coronary occlusion. [...]
2023 -  10.1038/s41598-023-34196-7
Scientific reports, Vol. 13 (april 2023)
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23 p, 2.2 MB |
Nr4a3 : A key nuclear receptor in vascular biology, cardiovascular remodeling and beyond
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Martínez-González, José (Institut d'Investigació Biomèdica Sant Pau) ;
Cañes Esteve, Laia (Institut d'Investigació Biomèdica Sant Pau) ;
Alonso Nieto, Judith (Institut d'Investigació Biomèdica Sant Pau) ;
Ballester-Servera, Carme (Institut d'Investigació Biomèdica Sant Pau) ;
Rodríguez-Sinovas, Antonio (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Corrales Insa, Irene (Banc de Sang i Teixits (Barcelona, Catalunya)) ;
Rodríguez, Cristina (Institut d'Investigació Biomèdica Sant Pau) ;
Universitat Autònoma de Barcelona
The mechanisms committed in the activation and response of vascular and inflammatory immune cells play a major role in tissue remodeling in cardiovascular diseases (CVDs) such as atherosclerosis, pulmonary arterial hypertension, and abdominal aortic aneurysm. [...]
2021 - 10.3390/ijms222111371
International journal of molecular sciences, Vol. 22 Núm. 21 (2021) , p. 11371
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18 p, 4.8 MB |
Citric Acid Cycle Metabolites Predict Infarct Size in Pigs Submitted to Transient Coronary Artery Occlusion and Treated with Succinate Dehydrogenase Inhibitors or Remote Ischemic Perconditioning
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Consegal, Marta (Universitat Autònoma de Barcelona. Departament de Medicina) ;
Núñez, Norberto (Universitat Autònoma de Barcelona. Departament de Medicina) ;
Barba, Ignasi (Universitat Autònoma de Barcelona. Departament de Medicina) ;
Benito, Begoña (Universitat Autònoma de Barcelona. Departament de Medicina) ;
Ruiz Meana, Marisol (Universitat Autònoma de Barcelona. Departament de Medicina) ;
Inserte, Javier (Universitat Autònoma de Barcelona. Departament de Medicina) ;
Ferreira-Gonzalez, Ignacio (Universitat Autònoma de Barcelona. Departament de Medicina) ;
Rodríguez-Sinovas, Antonio (Universitat Autònoma de Barcelona. Departament de Medicina)
Succinate dehydrogenase (SDH) inhibition with malonate during reperfusion reduced myocardial infarction in animals, whereas its endogenous substrate, succinate, is detected in plasma from STEMI patients. [...]
2021 - 10.3390/ijms22084151
International journal of molecular sciences, Vol. 22 (april 2021)
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15 p, 2.0 MB |
Effects of the Selective Stretch-Activated Channel Blocker GsMtx4 on Stretch-Induced Changes in Refractoriness in Isolated Rat Hearts and on Ventricular Premature Beats and Arrhythmias after Coronary Occlusion in Swine
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Barrabés, José A.. (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Inserte, Javier (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Agulló, Luis (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Rodríguez-Sinovas, Antonio (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Alburquerque-Béjar, Juan Jos. (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
García-Dorado, David (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Universitat Autònoma de Barcelona
Mechanical factors may contribute to ischemic ventricular arrhythmias. GsMtx4 peptide, a selective stretch-activated channel blocker, inhibits stretch-induced atrial arrhythmias. We aimed to assess whether GsMtx4 protects against ventricular ectopy and arrhythmias following coronary occlusion in swine. [...]
2015 - 10.1371/journal.pone.0125753
PloS one, Vol. 10 (may 2015)
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12 p, 1.9 MB |
Cardiotoxic Effects of Short-Term Doxorubicin Administration : Involvement of Connexin 43 in Calcium Impairment
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Pecoraro, Michela (University of Salerno) ;
Rodríguez-Sinovas, Antonio (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Marzocco, Stefania (University of Salerno) ;
Ciccarelli, Michele (University of Salerno) ;
Iaccarino, Guido (University of Salerno) ;
Pinto, Aldo (University of Salerno) ;
Popolo, Ada (University of Salerno) ;
Universitat Autònoma de Barcelona
The use of Doxorubicin (DOXO), a potent antineoplastic agent, is limited by the development of cardiotoxicity. DOXO-induced cardiotoxicity is multifactorial, although alterations in calcium homeostasis, seem to be involved. [...]
2017 - 10.3390/ijms18102121
International journal of molecular sciences, Vol. 18 (october 2017)
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10 p, 1.3 MB |
1 H NMR serum metabolomic profiling of patients at risk of cardiovascular diseases performing stress test
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Lema, Camila (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Andrés Villareal, Mireia (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Aguadé-Bruix, Santiago (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Consegal, Marta (Centro de Investigación Biomédica en Red en Enfermedades Cardiovasculares) ;
Rodriguez-Sinovas, Antonio (Centro de Investigación Biomédica en Red en Enfermedades Cardiovasculares) ;
Benito, Begoña (Centro de Investigación Biomédica en Red en Enfermedades Cardiovasculares) ;
Ferreira-Gonzalez, Ignacio (Centro de Investigación Biomédica en Red de Epidemiología y Salud Pública) ;
Barba, Ignasi (Vall d'Hebron Institut d'Oncologia) ;
Universitat Autònoma de Barcelona
Cardiovascular diseases are the leading cause of death worldwide. Changes in lifestyle and/or pharmacological treatment are able to reduce the burden of coronary artery diseases (CAD) and early diagnosis is crucial for the timely and optimal management of the disease. [...]
2020 - 10.1038/s41598-020-74880-6
Scientific reports, Vol. 10 (october 2020)
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