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18 p, 3.4 MB Learning improvement after PI3K activation correlates with de novo formation of functional small spines / Enriquez-Barreto, Lilian (Universitat Autònoma de Barcelona. Institut de Neurociències) ; Cuesto, Germán (Centro de Investigación Biomédica (La Rioja)) ; Dominguez-Iturza, Nuria (Centro de Investigación Biomédica (La Rioja)) ; Gavilán, Elena (Universidad de Sevilla. Instituto de Biomedicina de Sevilla) ; Ruano, Diego (Universidad de Sevilla. Instituto de Biomedicina de Sevilla) ; Sandi, Carmen (École Polytechnique Fédérale de Lausanne. Brain Mind Institute) ; Fernández-Ruiz, Antonio (Instituto Cajal-CSIC) ; Martín-Vázquez, Gonzalo (Instituto Cajal-CSIC) ; Herreras, Oscar (Instituto Cajal-CSIC) ; Morales, Miguel (Centro de Investigación Biomédica (La Rioja)) ; Universitat Autònoma de Barcelona. Departament de Bioquímica i Biologia Molecular
PI3K activation promotes the formation of synaptic contacts and dendritic spines, morphological features of glutamatergic synapses that are commonly known to be related to learning processes. In this report, we show that in vivo administration of a peptide that activates the PI3K signaling pathway increases spine density in the rat hippocampus and enhances the animals' cognitive abilities, while in vivo electrophysiological recordings show that PI3K activation results in synaptic enhancement of Schaffer and stratum lacunosum moleculare inputs. [...]
2014 - 10.3389/fnmol.2013.00054
Frontiers in Molecular Neuroscience, Vol. 6 (January 2014) , art. 54  

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