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8 p, 801.4 KB |
Epigenetic clocks in relapse after a first episode of schizophrenia
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Segura, Àlex González (Institut d'investigacions Biomèdiques August Pi i Sunyer (IDIBAPs)) ;
Prohens, Llucia (Institut d'investigacions Biomèdiques August Pi i Sunyer (IDIBAPs)) ;
Mezquida, Gisela (Centro de Investigación Biomédica en Red de Salud Mental) ;
Amoretti, Silvia (Centro de Investigación Biomédica en Red de Salud Mental) ;
Bioque, Miquel (Universitat de Barcelona) ;
Ribeiro, María (Instituto de Investigación Sanitaria de Navarra) ;
Gurriarán-Bas, Xaquin (Hospital General Universitario Gregorio Marañón) ;
Rementería, Lide (Instituto de Investigación Sanitaria Bioaraba) ;
Bergé Baquero, Daniel (Institut Hospital del Mar d'Investigacions Mèdiques) ;
Rodriguez-Jimenez, Roberto (Universidad Complutense de Madrid) ;
Roldán, Alejandra (Institut d'Investigació Biomèdica Sant Pau) ;
Pomarol-Clotet, Edith (FIDMAG Germanes Hospitalàries Research Foundation) ;
Ibáñez, Angela (Universidad de Alcalá) ;
Usall, Judith (Institut de Recerca Sant Joan de Déu) ;
García-Portilla, Maria Paz (Instituto de Investigación Sanitaria del Principado de Asturias (ISPA)) ;
Cuesta, Manuel J. (Instituto de Investigación Sanitaria de Navarra) ;
Parellada, Mara (Hospital General Universitario Gregorio Marañón) ;
González-Pinto, Ana (Instituto de Investigación Sanitaria Bioaraba) ;
Berrocoso, Esther (Hospital Universitario Puerta del Mar) ;
Bernardo, Miquel (Universitat de Barcelona) ;
Mas, Sergi (Centro de Investigación Biomédica en Red de Salud Mental) ;
González-Díaz, Jairo (Hospital Clínic i Provincial de Barcelona) ;
Arbelo, Néstor (Hospital Clínic i Provincial de Barcelona) ;
González-Peñas, Jairo (Hospital General Universitario Gregorio Marañón) ;
Pina-Camacho, Laura (Hospital General Universitario Gregorio Marañón) ;
Diestre, Alba (Hospital de la Santa Creu i Sant Pau (Barcelona, Catalunya)) ;
Selma Gonzalez, Judit (Institut d'Investigació Biomèdica Sant Pau) ;
Zorrilla, Iñaki (Instituto de Investigación Sanitaria Bioaraba) ;
López, Purificación (Instituto de Investigación Sanitaria Bioaraba) ;
Trabsa, Amira (Institut Hospital del Mar d'Investigacions Mèdiques) ;
Monserrat, Clara (Parc de Salut MAR de Barcelona) ;
Sanchez-Pastor, Luis (Instituto de Investigación Sanitaria Hospital 12 de Octubre (i+12)) ;
Nuñez-Doyle, Aggie (Instituto de Investigación Sanitaria Hospital 12 de Octubre (i+12)) ;
Fatjó-Vilas, Mar (Universitat de Barcelona) ;
Sarró, Salvador (FIDMAG Germanes Hospitalàries Research Foundation) ;
Butjosa, Anna (Institut de Recerca Sant Joan de Déu) ;
Pardo, Marta (Institut de Recerca Sant Joan de Déu) ;
López-Ilundain, Jose M. (Instituto de Investigación Sanitaria de Navarra) ;
Sánchez Torres, Ana M. (Instituto de Investigación Sanitaria de Navarra) ;
Saiz-Ruiz, Jerónimo (Hospital Universitario Ramón y Cajal) ;
Ochoa-Mangado, Enriqueta (Hospital Universitario Ramón y Cajal) ;
Rlevero, Olga (Universitat de València) ;
De-la-Cámara, Concepción (Universidad de Zaragoza) ;
Echevarría, Rafael Segarra (Universidad del País Vasco) ;
González-Blanco, Leticia (Instituto de Investigación Sanitaria del Principado de Asturias (ISPA)) ;
Universitat Autònoma de Barcelona
The main objective of the present study was to investigate the association between several epigenetic clocks, covering different aspects of aging, with schizophrenia relapse evaluated over a 3-year follow-up period in a cohort of ninety-one first-episode schizophrenia patients. [...]
2022 -  10.1038/s41537-022-00268-2
Schizophrenia, Vol. 8 Núm. 1 (december 2022) , p. 61
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9 p, 871.1 KB |
Gene co-expression architecture in peripheral blood in a cohort of remitted first-episode schizophrenia patients
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Rodríguez, Natalia (Institut d'investigacions Biomèdiques August Pi i Sunyer (IDIBAPs)) ;
Gassó, Patricia (Centro de Investigación Biomédica en red en salud Mental (CIBERSAM)) ;
Martínez-Pinteño, Albert (Institut d'investigacions Biomèdiques August Pi i Sunyer (IDIBAPs)) ;
Segura, Àlex-González (Institut d'investigacions Biomèdiques August Pi i Sunyer (IDIBAPs)) ;
Mezquida, Gisela (Hospital Clínic i Provincial de Barcelona) ;
Moreno-Izco, Lucia (Instituto de Investigación Sanitaria de Navarra) ;
González-Peñas, Javier (Centro de Investigación Biomédica en Red de Salud Mental) ;
Zorrilla, Iñaki (Universidad del País Vasco) ;
Martin, Marta (Institut d'Investigació Biomèdica Sant Pau) ;
Rodriguez-Jimenez, Roberto (Universidad Complutense de Madrid) ;
Corripio, Iluminada (Universitat Autònoma de Barcelona) ;
Sarró, Salvador (Universitat Internacional de Catalunya) ;
Ibáñez, Angela (Hospital Universitario Ramón y Cajal) ;
Butjosa, Anna (Hospital Sant Joan de Déu (Manresa)) ;
Contreras, Fernando (Centro de Investigación Biomédica en red en salud Mental (CIBERSAM)) ;
Bioque, Miquel (Universitat de Barcelona) ;
Cuesta, Manuel-Jesús (Hospital General Universitario Gregorio Marañón) ;
Parellada, Mara (Centro de Investigación Biomédica en Red de Salud Mental) ;
González-Pinto, Ana (Universidad del País Vasco) ;
Berrocoso, Esther (Instituto de Investigación e Innovación Biomédica de Cádiz) ;
Bernardo, Miquel (Universitat de Barcelona) ;
Mas, Sergi (Centro de Investigación Biomédica en red en salud Mental (CIBERSAM)) ;
Amoretti S, Silvia (Hospital Clínic i Provincial de Barcelona) ;
Moren, Constanza (Centro deInvestigación Biomédica en Red (CIBER) de Enfermedades Raras (CIBERER)) ;
Stella, Carol (Centro de Investigación Biomédica en Red de Salud Mental) ;
Gurriarán, Xaquin (Centro de Investigación Biomédica en Red de Salud Mental) ;
Alonso-Solís, Anna (Universitat Autònoma de Barcelona) ;
Grasa, Eva (Universitat Autònoma de Barcelona) ;
Fernandez, Jessica (Universidad del País Vasco) ;
Gonzalez-Ortega, Itxaso (Universidad del País Vasco) ;
Casanovas, Francesc (Institut Hospital del Mar d'Investigacions Mèdiques) ;
Bulbuena, Antoni (Universitat Autònoma de Barcelona) ;
Núñez-Doyle, Ágatha (Instituto de Investigación Sanitaria Hospital 12 de Octubre (i+12)) ;
Jiménez-Rodríguez, Olga (Instituto de Investigación Sanitaria Hospital 12 de Octubre (i+12)) ;
Pomarol-Clotet, Edith (Centro de Investigación Biomédica en Red de Salud Mental) ;
Feria-Raposo, Isabel (Benito Menni CASM) ;
Usall, Judith (Institut de Recerca Sant Joan de Déu) ;
Muñoz-Samons, Daniel (Hospital Materno-Infantil Sant Joan de Déu) ;
Ilundain, Jose L. (Instituto de Investigación Sanitaria de Navarra) ;
Sánchez-Torres, Ana Maria (Instituto de Investigación Sanitaria de Navarra) ;
Saiz-Ruiz, Jeronimo (Universidad de Alcalá) ;
López-Torres, Isabel (Hospital Universitario Ramón y Cajal) ;
Nacher, Juan (Instituto de Investigación Sanitaria INCLIVA (València, Comunitat Valenciana)) ;
De-la-Cámara, Concepción (Centro de Investigación Biomédica en red en salud Mental (CIBERSAM)) ;
Gutiérrez, Miguel (Arabako Unibertsitate Ospitalea (Vitoria, País Basc)) ;
Sáiz, Pilar Alejandra (Instituto de Investigación Sanitaria del Principado de Asturias)
A better understanding of schizophrenia subtypes is necessary to stratify the patients according to clinical attributes. To explore the genomic architecture of schizophrenia symptomatology, we analyzed blood co-expression modules and their association with clinical data from patients in remission after a first episode of schizophrenia. [...]
2022 - 10.1038/s41537-022-00215-1
Schizophrenia, Vol. 8 Núm. 1 (december 2022) , p. 45
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10 p, 3.2 MB |
Extreme drought impacts have been underestimated in grasslands and shrublands globally
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Smith, Melinda D. (Colorado State University. Department of Biology) ;
Wilkins, Kate D. (Denver Zoo) ;
Holdrege, Martin (Utah State University. Department of Wildland Resource) ;
Wilfahrt, Peter (University of Minnesota. Department of Ecology, Evolution, and Behavior) ;
Collins, Scott L. (University of New Mexico. Department of Biology) ;
Knapp, Alan K. (Colorado State University. Department of Biology) ;
Sala, Osvaldo (Arizona State University) ;
Dukes, Jeffrey (Carnegie Institution for Science (Washington, Estats Units d'Amèrica)) ;
Phillips, Richard (Indiana University, Department of Biology) ;
Yahdjian, Laura (Instituto de Investigaciones Fisiológicas y Ecológicas Vinculadas a la Agricultura) ;
Gherardi, Laureano (University of California. Department of Environmental Science, Policy, and Management) ;
Timothy Ohlert (Colorado State University. Department of Biology) ;
Beierm, Claus (University of Copenhagen. Department of Geosciences and Natural Resource Management) ;
Fraser, Lauchlan (Thompson Rivers University. Department of Natural Resource Science) ;
Jentsch, Anke (University of Bayreuth. Department of Disturbance Ecology and Vegetation Dynamics) ;
Loik, Michael (University of California. Department of Environmental Studies) ;
Maestre, Fernando T (Universidad de Alicante. Departamento de Ecología) ;
Power, Sally (Western Sydney University) ;
Yu, Qiang (Beijing Forestry University) ;
Felton, Andrew (Montana State University. Department of Land Resources and Environmental Sciences) ;
Munson, Seth (Southwest Biological Science Center) ;
Luo, Yiqi (Cornell University. School of Integrative Plant Science) ;
Abdoli, Hamed (Tarbiat Modares University. Department of Range Management) ;
Abedi, Mehdi (Tarbiat Modares University. Department of Range Management) ;
Alados, Concepción (Instituto Pirenaico de Ecología. Departamento de Biodiversidad y Restauración) ;
Alberti, Juan (Consejo Nacional de Investigación Ciencia y Técnica) ;
Alon, Moshe (Tel Aviv University) ;
An, Hui (Ningxia University. School of Ecology and Environment) ;
Anacker, Brian (City of Boulder Open Space and Mountain Parks) ;
Anderson, Maggie (University of Minnesota. Department of Ecology, Evolution, and Behavior) ;
Auge, Harald (German Centre for Integrative Biodiversity Research (Halle-Jena-Leipzig, Alemanya)) ;
Bachle, Seton (Kansas State University) ;
Bahalkeh, Khadijeh (Tarbiat Modares University. Department of Range Management) ;
Bahn, Michael (University of Innsbruck. Department of Ecology) ;
Batbaatar, Amgaa (University of Alberta. Department of Biological Sciences) ;
Bauerle, Taryn (Cornell University) ;
Behn, Kai (University of Bonn. Department of Plant Nutrition.) ;
Beil, Ilka (University of Greifswald. Department of Experimental Plant Ecology.) ;
Biancari, Lucio (University of Buenos Aires) ;
Blindow, Irmgard (University of Greifswald. Department of Biology) ;
Bondaruk, Viviana (University of Buenos Aires) ;
Borer, Elizabeth (University of Minnesota. Department of Ecology, Evolution, Behavior) ;
Bork, Edward (University of Alberta. Department of Agricultural, Food and Nutritional Science) ;
Bruschetti, Martin (Universidad Nacional de Mar del Plata) ;
Byrne, Kerry (California State Polytechnic University. Department of Environmental Science and Management) ;
Cahill, James F. (University of Alberta. Department of Biological Sciences) ;
Calvo, Dianela (Universidad Nacional de Río Negro. Centro de Estudios Ambientales desde la NorPatagonia) ;
Carbognani, Michele (University of Parma. Department of Chemistry) ;
Cardoni, Augusto (Universidad Nacional de Mar de la Plata) ;
Carlyle, Cameron (University of Alberta. Department of Agricultural. Food and Nutritional Science) ;
Castillo Garcia, Miguel (Instituto Pirenaico de Ecología) ;
Chang, Scott X. (Department of Renewable Resources. University of Alberta) ;
Chieppa, Jeff (Western Sydney University. Hawkesbury Institute for the Environment) ;
Cianciaruso, Marcus V. (Universidade Federal de Goiás. Department of Ecology) ;
Cohen, Ofer (Tel Aviv University. School of Plant Sciences and Food Security) ;
Cordeiro, Amanda L. (Colorado State University. Department of Ecosystem Science and Sustainability) ;
Cusack, Daniela (Colorado State University. Department of Ecosystem Science and Sustainability) ;
Dahlke, Sven (University of Greifswald. Department of Biology) ;
Daleo, Pedro (Universidad Nacional de Mar del Plata) ;
D'Antonio, Carla (University of California. Department of Ecology, Evolution, Marine Biology) ;
Dietterich, Lee (US Army Engineer Research and Development Center) ;
Doherty, Tim S. (University of Sydney. School of Life and Environmental Sciences) ;
Dubbert, Maren (Isotope Biogeochemistry and GasFluxes) ;
Ebeling, Anne (Friedrich Schiller University Jena. Institute of Ecology and Evolution) ;
Eisenhauer, Nico (Institute of Biology. Leipzig University) ;
Fischer, Felícia M. (Universitat Valencia. Centro de Investigaciones sobre Desertificación) ;
Forte, T'ai G. W. (University of Parma. Department of Chemistry) ;
Gebauer, Tobias (University of Freiburg) ;
Gozalo, Beatriz (Universidad de Alicante. Instituto Multidisciplinar para el Estudio del Medio "Ramón Margalef") ;
Greenville, Aaron C. (University of Sydney. School of Life and Environmental Sciences) ;
Guidoni-Martins, Karlo (Universidade Federal de Goiás. Department of Ecology) ;
Hannusch, Heather J. (Texas A&M University. Department of Ecology and Conservation Biology) ;
Haugum, Siri Vatsø (University of Bergen. Department of Biological Sciences) ;
Hautier, Yann (Utrecht University. Department of Biology) ;
Hefting, Mariet (Utrecht University. Department of Biology) ;
Henry, H.A.L. (University of Western Ontario. Department of Biology) ;
Hoss, Daniela (Universidade Federal do Rio Grande do Sul. Department of Ecology) ;
Ingrisch, Johannes (University of Innsbruck. Department of Ecology) ;
Iribarne, Oscar (Universidad Nacional de Mar del Plata) ;
Isbell, Forest (Behavior. University of Minnesota. Department of Ecology. Evolution) ;
Johnson, Yari (U.S. Army Corps of Engineers) ;
Jordan, Samuel (Arizona State University. School of Life Sciences) ;
Kelly, Eugene F. (Colorado State University. Department of Soil and Crop Sciences) ;
Kimmel, Kaitlin (The University of Alabama) ;
Kreyling, Juergen (Institute of Botany and Landscape Ecology) ;
Kröel-Dulay, György (University of Greifswald) ;
Kröpfl, Alicia (Universidad Nacional del Comahue. Departamento de Gestión Agropecuaria) ;
Kübert, Angelika (Albert-Ludwig-University of Freiburg) ;
Kulmatiski, andrew (Utah State University. Department of Wildland Resource and the Ecology Center) ;
Lamb, Eric (University of Saskatchewan. Department of Plant Sciences) ;
Larsen, Klaus Steenberg (University of Copenhagen. Department of Geosciences and Natural Resource Management) ;
Larson, Julie (Eastern Oregon Agricultural Research Center. US Department of Agriculture) ;
Lawson, Jason (Brackenridge Field Laboratory. University of Texas) ;
Leder, Cintia (Universidad Nacional de Río Negro. Centro de Estudios Ambientales desde la NorPatagonia) ;
Linstädter, Anja (University of Potsdam. Department of Biodiversity Research and Systematic Botany) ;
Liu, Jielin (Heilongjiang Academy of Agricultural Sciences) ;
Liu, Shirong (Chinese Academy of Forestry) ;
Lodge, Alexandra G. (Texas A&M University. Department of Ecology and Conservation Biology) ;
Longo, Grisel (Universidade Federal da Paraíba) ;
Loydi, Alejandro (Universidad Nacional del Sur. Departamento de Biología. Bioquímica y Farmacia.) ;
Luan, Junwei (International Centre for Bamboo and Rattan) ;
Lubbe, Frederick (Institute of Botany) ;
Macfarlane, Craig (Commonwealth Scientific and Industrial Research Organization) ;
Mackie-Haas, Kathleen (Bern University of Applied Sciences) ;
Malyshev, Andrey V. (University of Greifswald. Department of Experimental Plant Ecology) ;
Maturano Ruiz, Adrián (Universidad de Alicante. Instituto Multidisciplinar para el Estudio del Medio "Ramón Margalef") ;
Merchant, Thomas (University of Colorado. Department of Ecology and Evolutionary Biology) ;
Metcalfe, Daniel B. (Umeå University. Department of Ecology and Environmental Science) ;
Mori, Akira S. (Yokohama National University. Graduate School of Environment and Information Sciences) ;
Mudongo, Edwin (Conservancy-Communities Living Among Wildlife Sustainably) ;
Newman, Greg (University of Oklahoma. School of Biological Sciences) ;
Nielsen, Uffe N. (Western Sydney University) ;
Nimmo, Dale (Charles Sturt University) ;
Niu, Yujie (University of Bayreuth. Department of Disturbance Ecology and Vegetation Dynamics) ;
Nobre, Paola (Universidade Federal de Goiás. Department of Ecology) ;
O'Connor, Rory C. (Eastern Oregon Agricultural Research Center) ;
Ogaya Inurrigarro, Romà (Centre de Recerca Ecològica i d'Aplicacions Forestals) ;
Oñatibia, Gastón R. (University of Buenos Aires. Instituto de Investigaciones Fisiológicas y Ecológicas Vinculadas a la Agricultura) ;
Orbán, Ildikó (University of Potsdam. Department of Biodiversity Research and Systematic Botany) ;
Osborne, Brooke (Utah State University. Department of Environment and Society) ;
Otfinowski, Rafael (University of Winnipeg. Department of Biology) ;
Pärtel, Meelis (University of Tartu. Institute of Ecology and Earth Sciences) ;
Peñuelas, Josep (Centre de Recerca Ecològica i d'Aplicacions Forestals) ;
Peri, Pablo Luis (Universidad Nacional d ela Patagonia Austral) ;
Peter, Guadalupe (Universidad Nacional de Río Negro. Centro de Estudios Ambientales desde la NorPatagonia) ;
Petraglia, Alessandro (University of Parma. Department of Chemistry) ;
Picon-Cochard, Catherine (Université Clermont Auvergne. National Research Institute for Agriculture) ;
Pillar, Valério (Universidade Federal do Rio Grande do Sul. Department of Ecology) ;
Piñeiro Guerra, juan (Universidade Federal da Paraíba. Departamento de Sistemática e Ecologia) ;
Ploughe, Laura W. (Purdue University. Department of Biological Sciences) ;
Plowes, Robert M. (University of Texas. Brackenridge Field Laboratory) ;
Portales-Reyes, Cristy (Saint Louis University. Department of Biology) ;
Prober, Suzanne M. (Commonwealth Scientific and Industrial Research Organization Australia) ;
Pueyo, Yolanda (Instituto Pirenaico de Ecología. Consejo Superior de Investigaciones Científicas) ;
Reed, Sasha C. (Southwest Biological Science Center) ;
Ritchie, Euan G. (Deakin University. Centre for Integrative Ecology) ;
Rodríguez, Dana Aylén (Universidad Nacional del Sur. Departamento de Biología. Bioquímica y Farmacia.) ;
Rogers, William (Texas A&M University. Department of Ecology and Conservation Biology) ;
Roscher, Christiane (Helmholtz-Centre for Environmental Research-UFZ. Department of Physiological Diversity) ;
Sánchez, Ana M. (Rey Juan Carlos University. Department of Biology and Geology) ;
Santos, Bráulio A (Universidade Federal da Paraíba. Departamento de Sistemática e Ecologia) ;
Scarfó, María Cecilia (Universidad Nacional del Sur. Departamento de Biología. Bioquímica y Farmacia) ;
Seabloom, Eric W. (University of Minnesota. Department of Ecology, Evolution, Behavior) ;
Shi, Baoku (Northeast Normal University) ;
Souza, Lara (University of Oklahoma. Oklahoma Biological Survey) ;
Stampfli, Andreas (University of Bern. Oeschger Center for Climate Change Research) ;
Standish, Rachel (Murdoch University. Environmental and Conservation Sciences) ;
Sternberg, Marcelo (Tel Aviv University. School of Plant Sciences and Food Security) ;
Sun, Wei (Northeast Normal University.) ;
Sünnemann, Marie (Leipzig University) ;
Tedder, Michelle (University of Kwazulu-Natal) ;
Thorvaldsen, Pål (Norwegian Institute of Bioeconomy Research. Department of Landscape and Biodiversity) ;
Tian, Dashuan (Chinese Academy of Sciences) ;
Tielbörger, Katja (University of Tübingen. Department of Biology) ;
Valdecantos, Alejandro (Universidad de Alicante) ;
van den Brink, Liesbeth (University of Tübingen. Department of Biology) ;
Vandvik, Vigdis (University of Bergen. Department of Biological Sciences) ;
Vankoughnett, Mathew R. (Nova Scotia Community College) ;
Guri Velle, Liv (Møreforsking) ;
Wang, Changhui (Shanxi Agricultural University) ;
Wang, Yi (International Centre for Bamboo and Rattan) ;
Wardle, Glenda (University of Sydney. School of Life and Environmental Sciences) ;
Werner, Christiane (Albert-Ludwig-University of Freiburg.) ;
Wei, Cunzheng (Chinese Academy of Sciences) ;
Wiehl, Georg (Commonwealth Scientific and Industrial Research Organization) ;
Williams, Jennifer L. (University of British Columbia. Department of Geography and Biodiversity Research Centre) ;
Wolf, Amelia A. (University of Texas. Department of Integrative Biology) ;
Zeiter, Michaela (University of Bern) ;
Zhang, Fawei (Chinese Academy of Sciences) ;
Zhu, Juntao (Chinese Academy of Sciences) ;
Zong, Ning (Chinese Academy of Sciences) ;
Zuo, Xiaoan (Chinese Academy of Science)
Climate change is increasing the frequency and severity of short-term (~1 y) drought events-the most common duration of drought-globally. Yet the impact of this intensification of drought on ecosystem functioning remains poorly resolved. [...]
2024 - 10.1073/pnas.2309881120
PNAS, Vol. 121, Issue 4 (January 2024) , art. e2309881120
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5 p, 3.7 MB |
Decreased activation of parvalbumin interneurons in the medial prefrontal cortex in intact inbred Roman rats with schizophrenia-like reduced sensorimotor gating
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Tapias-Espinosa, Carles (Universitat Autònoma de Barcelona. Departament de Psiquiatria i de Medicina Legal) ;
Sánchez González, Ana (Universitat Autònoma de Barcelona. Departament de Psiquiatria i de Medicina Legal) ;
Cañete, Toni (Universitat Autònoma de Barcelona. Departament de Psiquiatria i de Medicina Legal) ;
Sampedro-Viana, Daniel (Universitat Autònoma de Barcelona. Departament de Psiquiatria i de Medicina Legal) ;
Castillo-Ruiz, Mª del Mar (Universitat Autònoma de Barcelona. Institut de Neurociències) ;
Tobeña, Adolf 1950- (Universitat Autònoma de Barcelona. Departament de Psiquiatria i de Medicina Legal) ;
Oliveras, Ignasi ;
Fernández-Teruel, Alberto (Universitat Autònoma de Barcelona. Departament de Psiquiatria i de Medicina Legal) ;
Aznar, Susana (Research Laboratory for Stereology and Neuroscience, Bispebjerg Copenhagen University Hospital)
Prepulse inhibition (PPI) allows assessing schizophrenia-like sensorimotor gating deficits in rodents. Previous studies indicate that PPI is modulated by the medial prefrontal cortex (mPFC), which is in agreement with our findings showing that PPI differences in the Roman rats are associated with divergences in mPFC activity. [...]
2023 - 10.1016/j.bbr.2022.114113
Behavioural Brain Research, Vol. 437 (Feb. 2023) , art. 114113
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104 p, 1.6 MB |
Neurobehavioral and neurodevelopmental profiles of a heuristic genetic model of differential schizophrenia- and addiction-relevant features: The RHA vs. RLA rats
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Fernández-Teruel, Alberto (Universitat Autònoma de Barcelona. Departament de Psiquiatria i de Medicina Legal) ;
Oliveras, Ignasi (Universitat Autònoma de Barcelona. Departament de Psiquiatria i de Medicina Legal) ;
Cañete, Toni (Universitat Autònoma de Barcelona. Departament de Psiquiatria i de Medicina Legal) ;
Rio-Álamos, Cristóbal (Universidad Austral de Chile. Departamento de Psicologia) ;
Tapias-Espinosa, Carles (Universitat Autònoma de Barcelona. Departament de Psiquiatria i de Medicina Legal) ;
Sampedro-Viana, Daniel (Universitat Autònoma de Barcelona. Departament de Psiquiatria i de Medicina Legal) ;
Sánchez-González, Ana (Universitat Autònoma de Barcelona. Departament de Psiquiatria i de Medicina Legal) ;
Sanna, Francesco (Universitá di Cagliari. Dipartimento di Scienze della vita e dell'ambiente) ;
Torrúbia, Rafael (Universitat Autònoma de Barcelona. Departament de Psiquiatria i de Medicina Legal) ;
González-Maeso, Javier (Virginia Commonwealth University School of Medicine. Department of Physiology and Biophysics) ;
Driscoll, Peter ;
Morón, Ignacio (Universidad de Granada. Departamento de Psicobiologia) ;
Torres, Carmen (Universidad de Jaén. Departamento de Psicología) ;
Aznar, Susana (Bispebjerg Copenhagen University Hospital) ;
Tobeña, Adolf 1950- (Universitat Autònoma de Barcelona. Departament de Psiquiatria i de Medicina Legal) ;
Corda, Maria G. (Universitá di Cagliari. Dipartimento di Scienze della vita e dell'ambiente) ;
Giorgi, Osvaldo (Universitá di Cagliari. Dipartimento di Scienze della vita e dell'ambiente) ;
Universitat Autònoma de Barcelona.
Institut de Neurociències
The Roman High- (RHA) and Low-(RLA) avoidance rat lines/strains were generated through bidirectional selective breeding for rapid (RHA) vs. extremely poor (RLA) two-way active avoidance acquisition. [...]
2021 - 10.1016/j.neubiorev.2021.09.042
Neuroscience and Biobehavioral Reviews, Vol. 131 (2021) , p. 597-617
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22 p, 475.4 KB |
Increased thin-spine density in frontal cortex pyramidal neurons in a genetic rat model of schizophrenia-relevant features
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Sánchez González, Ana (Universitat Autònoma de Barcelona. Departament de Psiquiatria i de Medicina Legal) ;
Thougaard, Estrid (Research Laboratory for Stereology and Neuroscience, Bispebjerg Copenhagen University Hospital) ;
Tapias-Espinosa, Carles (Universitat Autònoma de Barcelona. Departament de Psiquiatria i de Medicina Legal) ;
Cañete, Toni (Universitat Autònoma de Barcelona. Departament de Psiquiatria i de Medicina Legal) ;
Sampedro-Viana, Daniel (Universitat Autònoma de Barcelona. Departament de Psiquiatria i de Medicina Legal) ;
Saunders, Justin M. (Department of Physiology and Biophysics, Virginia Commonwealth University School of Medicine) ;
Toneatti, Rudy (Department of Physiology and Biophysics, Virginia Commonwealth University School of Medicine) ;
Tobeña, Adolf 1950- (Universitat Autònoma de Barcelona. Departament de Psiquiatria i de Medicina Legal) ;
Gonzalez-Maeso, Javier (Department of Physiology and Biophysics, Virginia Commonwealth University School of Medicine) ;
Aznar, Susana (Research Laboratory for Stereology and Neuroscience, Bispebjerg Copenhagen University Hospital) ;
Fernández-Teruel, Alberto (Universitat Autònoma de Barcelona. Departament de Psiquiatria i de Medicina Legal) ;
Universitat Autònoma de Barcelona.
Institut de Neurociències
The cellular mechanisms altered during brain wiring leading to cognitive disturbances in neurodevelopmental disorders remain unknown. We have previously reported altered cortical expression of neurodevelopmentally regulated synaptic markers in a genetic animal model of schizophrenia-relevant behavioral features, the Roman-High Avoidance rat strain (RHA-I). [...]
2021 - 10.1016/j.euroneuro.2021.01.006
European neuropsychopharmacology, Vol. 44 (March 2021) , p. 79-91
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33 p, 1.2 MB |
Metabotropic Glutamate Receptor 2 and Dopamine Receptor 2 Gene Expression Predict Sensorimotor Gating Response in the Genetically Heterogeneous NIH-HS Rat Strain
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Østerbøg, Tina Becher (Research Laboratory for Stereology and Neuroscience. Bispebjerg and Frederiksberg Hospitals. Copenhagen) ;
On, Doan Minh (Department of Physiology and Biophysics. Virginia Commonwealth University School of Medicine) ;
Oliveras, Ignasi (Universitat Autònoma de Barcelona. Departament de Psiquiatria i de Medicina Legal) ;
Río-Álamos, Cristobal (Universitat Autònoma de Barcelona. Departament de Psiquiatria i de Medicina Legal) ;
Sánchez González, Ana (Universitat Autònoma de Barcelona. Departament de Psiquiatria i de Medicina Legal) ;
Tapias-Espinosa, Carles (Departamento de Psiquiatría y Medicina Legal.) ;
Tobeña, Adolf 1950- (Universitat Autònoma de Barcelona. Departament de Psiquiatria i de Medicina Legal) ;
Gonzalez-Maeso, Javier (Department of Physiology and Biophysics, Virginia Commonwealth University School of Medicine) ;
Fernández-Teruel, Alberto (Universitat Autònoma de Barcelona. Departament de Psiquiatria i de Medicina Legal) ;
Aznar, Susana (Bispebjerg and Frederiksberg Hospitals (Copenhagen, Dinamarca))
Disruption of sensorimotor gating causes "flooding" of irrelevant sensory input and is considered a congenital trait in several neurodevelopmental disorders. Prepulse inhibition of acoustic startle response (PPI) is the operational measurement and has a high translational validity. [...]
2020 - 10.1007/s12035-019-01829-w
Molecular neurobiology, Vol. 57 Núm. 3 (March 2020) , p. 1516-1528
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42 p, 1.6 MB |
Volumetric brain differences between the Roman rat strains: Neonatal handling effects, sensorimotor gating and working memory
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Río-Álamos, Cristóbal (Austral University of Chile) ;
Piludu, Maria A. (Universitat Autònoma de Barcelona. Departament de Psiquiatria i de Medicina Legal) ;
Gerbolés, Cristina (Universitat Autònoma de Barcelona. Departament de Psiquiatria i de Medicina Legal) ;
Barroso, Didac (Universitat Autònoma de Barcelona. Departament de Psiquiatria i de Medicina Legal) ;
Oliveras, Ignasi (Universitat Autònoma de Barcelona. Departament de Psiquiatria i de Medicina Legal) ;
Sánchez-González, Ana (Universitat Autònoma de Barcelona. Institut de Neurociències) ;
Cañete, Toni (Universitat Autònoma de Barcelona. Institut de Neurociències) ;
Tapias-Espinosa, Carles (Universitat Autònoma de Barcelona. Departament de Psiquiatria i de Medicina Legal) ;
Sampedro-Viana, Daniel (Universitat Autònoma de Barcelona. Departament de Psiquiatria i de Medicina Legal) ;
Torrubia, Rafael (Universitat Autònoma de Barcelona. Departament de Psiquiatria i de Medicina Legal) ;
Tobeña, Adolf 1950- (Universitat Autònoma de Barcelona. Departament de Psiquiatria i de Medicina Legal) ;
Fernández-Teruel, Alberto (Universitat Autònoma de Barcelona. Departament de Psiquiatria i de Medicina Legal)
The present work was devoted to evaluate whether the differences between the Roman high-(RHA) and low-avoidance (RLA) rat strains in novelty-induced behavioural inhibition/disinhibition, sensorimotor gating (prepulse inhibition, PPI) and spatial learning/memory are paralleled by differences in the volume of relevant brain areas (measured through magnetic resonance image, MRI) related to these behavioural phenotypes. [...]
2019 - 10.1016/j.bbr.2018.12.033
Behavioural Brain Research, 2019
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36 p, 1.6 MB |
Schizophrenia-like reduced sensorimotor gating in intact inbred and outbred rats is associated with decreased medial prefrontal cortex activity and volume
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Tapias-Espinosa, Carles (Universitat Autònoma de Barcelona. Departament de Psiquiatria i de Medicina Legal) ;
Río-Álamos, Cristobal (Universidad Austral de Chile. Departamento de Psicologia) ;
Sánchez González, Ana (Universitat Autònoma de Barcelona. Departament de Psiquiatria i de Medicina Legal) ;
Oliveras, Ignasi (Universitat Autònoma de Barcelona. Departament de Psiquiatria i de Medicina Legal) ;
Sampedro-Viana, Daniel (Universitat Autònoma de Barcelona. Departament de Psiquiatria i de Medicina Legal) ;
Castillo-Ruiz, Mª del Mar (Universitat Autònoma de Barcelona. Institut de Neurociències) ;
Cañete, Toni (Universitat Autònoma de Barcelona. Departament de Psiquiatria i de Medicina Legal) ;
Tobeña, Adolf 1950- (Universitat Autònoma de Barcelona. Departament de Psiquiatria i de Medicina Legal) ;
Fernández-Teruel, Alberto (Universitat Autònoma de Barcelona. Departament de Psiquiatria i de Medicina Legal)
Prepulse inhibition (PPI) of startle response is a measure of sensorimotor gating that is impaired in schizophrenia and in many other clinical conditions. Rat models using pharmacological or surgical strategies reveal that PPI is modulated by the cortico-striatal-pallido-thalamic (CSPT) circuit. [...]
2019 - 10.1038/s41386-019-0392-x
Neuropsychopharmacology, Vol. 44 Núm. 11 (2019) , p. 1975-1984
Neuropsychopharmacology, 2019
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30 p, 681.2 KB |
Increased exploratory activity in rats with deficient sensorimotor gating: a study of schizophrenia-relevant symptoms with genetically heterogeneous NIH-HS and Roman rat strains
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Tapias-Espinosa, Carles (Universitat Autònoma de Barcelona. Departament de Psiquiatria i de Medicina Legal) ;
Río-Álamos, Cristobal (Universitat Autònoma de Barcelona. Departament de Psiquiatria i de Medicina Legal) ;
Sampedro-Viana, Daniel (Universitat Autònoma de Barcelona. Departament de Psiquiatria i de Medicina Legal) ;
Gerbolés, Cristina (Universitat Autònoma de Barcelona. Departament de Psiquiatria i de Medicina Legal) ;
Oliveras, Ignasi (Universitat Autònoma de Barcelona. Departament de Psiquiatria i de Medicina Legal) ;
Sánchez González, Ana (Universitat Autònoma de Barcelona. Departament de Psiquiatria i de Medicina Legal) ;
Tobeña, Adolf 1950- (Universitat Autònoma de Barcelona. Departament de Psiquiatria i de Medicina Legal) ;
Fernández-Teruel, Alberto (Universitat Autònoma de Barcelona. Departament de Psiquiatria i de Medicina Legal) ;
Universitat Autònoma de Barcelona.
Institut de Neurociències
Schizophrenia involves positive, negative and cognitive symptoms, as well as comorbidity with anxiety and obsessive-compulsive disorder. Prepulse inhibition (PPI) of the startle response is a measure of sensorimotor gating that is impaired in schizophrenia and animal models of the disease. [...]
2018 - 10.1016/j.beproc.2018.03.019
Behavioural Processes, Vol. 151 (june 2018) , p. 96-103
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