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UAB Digital Repository of Documents 28 records found  previous11 - 20next  jump to record: Search took 0.01 seconds. 
11.
16 p, 9.5 MB Characterization of Soft Amyloid Cores in Human Prion-Like Proteins / Batlle Carreras, Cristina (Universitat Autònoma de Barcelona. Institut de Biotecnologia i de Biomedicina "Vicent Villar Palasí") ; Sánchez de Groot, Natalia (Centre de Regulació Genòmica) ; Iglesias, Valentin (Universitat Autònoma de Barcelona. Institut de Biotecnologia i de Biomedicina "Vicent Villar Palasí") ; Navarro, Susanna (Universitat Autònoma de Barcelona. Institut de Biotecnologia i de Biomedicina "Vicent Villar Palasí") ; Ventura, Salvador (Universitat Autònoma de Barcelona. Departament de Bioquímica i de Biologia Molecular)
Prion-like behaviour is attracting much attention due to the growing evidences that amyloid-like self-assembly may reach beyond neurodegeneration and be a conserved functional mechanism. The best characterized functional prions correspond to a subset of yeast proteins involved in translation or transcription. [...]
2017 - 10.1038/s41598-017-09714-z
Scientific reports, Vol. 7 (2017) , art. 12134  
Detailed record - Creative Commons
12.
13 p, 5.2 MB Discovering putative prion-like proteins in Plasmodium falciparum : a computational and experimental analysis / Pallarès i Goitiz, Irantzu (Universitat Autònoma de Barcelona. Departament de Bioquímica i de Biologia Molecular) ; Sánchez de Groot, Natalia (Centre de Regulació Genòmica) ; Iglesias, Valentin (Universitat Autònoma de Barcelona. Institut de Biotecnologia i de Biomedicina "Vicent Villar Palasí") ; Sant'Anna, Ricardo (Universitat Autònoma de Barcelona. Institut de Biotecnologia i de Biomedicina "Vicent Villar Palasí") ; Biosca, Arnau (Institut de Bioenginyeria de Catalunya) ; Fernàndez-Busquets, Xavier (Institut de Bioenginyeria de Catalunya) ; Ventura, Salvador (Universitat Autònoma de Barcelona. Departament de Bioquímica i de Biologia Molecular)
Prions are a singular subset of proteins able to switch between a soluble conformation and a self-perpetuating amyloid state. Traditionally associated with neurodegenerative diseases, increasing evidence indicates that organisms exploit prion-like mechanisms for beneficial purposes. [...]
2018 - 10.3389/fmicb.2018.01737
Frontiers in microbiology, Vol. 9 (Aug. 2018) , art. 1737  
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13.
13 p, 7.9 MB Computational analysis of candidate prion-like proteins in bacteria and their role / Iglesias, Valentin (Universitat Autònoma de Barcelona. Institut de Biotecnologia i de Biomedicina "Vicent Villar Palasí") ; Sánchez de Groot, Natalia (Universitat Autònoma de Barcelona. Institut de Biotecnologia i de Biomedicina "Vicent Villar Palasí") ; Ventura, Salvador (Universitat Autònoma de Barcelona. Departament de Bioquímica i de Biologia Molecular)
Prion proteins were initially associated with diseases such as Creutzfeldt Jakob and transmissible spongiform encephalopathies. However, deeper research revealed them as versatile tools, exploited by the cells to execute fascinating functions, acting as epigenetic elements or building membrane free compartments in eukaryotes. [...]
2015 - 10.3389/fmicb.2015.01123
Frontiers in microbiology, Vol. 6 (Oct. 2015) , art. 1123  
Detailed record - Creative Commons
14.
8 p, 1.3 MB Amyloid fibril formation by bovine cytochrome c / Sánchez de Groot, Natalia (Universitat Autònoma de Barcelona. Institut de Biotecnologia i de Biomedicina "Vicent Villar Palasí") ; Ventura, Salvador (Universitat Autònoma de Barcelona. Departament de Bioquímica i de Biologia Molecular)
Bovine heart cytochrome c is an all-α globular protein containing a covalently bound heme group. Prolonged incubation at 75°C in mild alkaline solution damages the prosthetic group and results in permanent unfolding of the polypeptide chain. [...]
2005 - 10.1155/2005/104348
Spectroscopy, Vol. 19 (2005) , p. 199-205  
Detailed record - Creative Commons
15.
20 p, 3.5 MB The fitness cost and benefit of phase-separated protein deposits / Sánchez de Groot, Natalia (Centre de Regulació Genòmica) ; Torrent Burgas, Marc (Universitat Autònoma de Barcelona. Departament de Bioquímica i de Biologia Molecular) ; Ravarani, Charles N. J. (Medical Research Council Laboratory of Molecular Biology) ; Trusina, Ala (Niels Bohr Institute) ; Ventura, Salvador (Universitat Autònoma de Barcelona. Institut de Biotecnologia i de Biomedicina "Vicent Villar Palasí") ; Babu, Madam M (Medical Research Council Laboratory of Molecular Biology)
Phase separation of soluble proteins into insoluble deposits is associated with numerous diseases. However, protein deposits can also function as membrane-less compartments for many cellular processes. [...]
2019 - 10.15252/msb.20178075
Molecular systems biology, Vol. 15, issue 4 (April 2019) , art. e8075  
Detailed record - Creative Commons
16.
12 p, 2.4 MB A coordinated response at the transcriptome and interactome level is required to ensure uropathogenic escherichia coli survival during bacteremia / Sánchez de Groot, Natalia (Centre de Regulació Genòmica) ; Torrent Burgas, Marc (Universitat Autònoma de Barcelona. Departament de Bioquímica i de Biologia Molecular)
Localized infections or disruption of the skin barrier can enable the entry of bacteria into the bloodstream, possibly leading to acute inflammation and sepsis. There is currently no holistic view on how bacteria can survive and spread in the bloodstream. [...]
2019 - 10.3390/microorganisms7090292
Microorganisms, Vol. 7, Issue 9 (September 2019) , art. 292  
Detailed record - Creative Commons
17.
10 p, 1.3 MB Characterization of Amyloid Cores in Prion Domains / Sant'Anna, Ricardo (Universitat Autònoma de Barcelona. Institut de Biotecnologia i de Biomedicina "Vicent Villar Palasí") ; Fernández Gallegos, María Rosario (Universitat Autònoma de Barcelona. Departament de Bioquímica i de Biologia Molecular) ; Batlle Carreras, Cristina (Universitat Autònoma de Barcelona. Departament de Bioquímica i de Biologia Molecular) ; Navarro, Susanna (Universitat Autònoma de Barcelona. Departament de Bioquímica i de Biologia Molecular) ; Sánchez de Groot, Natalia (Universitat Autònoma de Barcelona. Departament de Bioquímica i de Biologia Molecular) ; Serpell, Louise (University of Sussex. School of Life Sciences) ; Ventura, Salvador (Universitat Autònoma de Barcelona. Departament de Bioquímica i de Biologia Molecular)
Amyloids consist of repetitions of a specific polypeptide chain in a regular cross-β-sheet conformation. Amyloid propensity is largely determined by the protein sequence, the aggregation process being nucleated by specific and short segments. [...]
2016 - 10.1038/srep34274
Scientific reports, Vol. 6 (2016) , art. 34274  
Detailed record - Creative Commons
18.
13 p, 1.1 MB Protein aggregation into insoluble deposits protects from oxidative stress / Carija, Anita (Universitat Autònoma de Barcelona. Institut de Biotecnologia i de Biomedicina "Vicent Villar Palasí") ; Navarro, Susanna (Universitat Autònoma de Barcelona. Departament de Bioquímica i de Biologia Molecular) ; Sánchez de Groot, Natalia (Centre de Regulació Genòmica) ; Ventura, Salvador (Universitat Autònoma de Barcelona. Institut de Biotecnologia i de Biomedicina "Vicent Villar Palasí")
Protein misfolding and aggregation have been associated with the onset of neurodegenerative disorders. Recent studies demonstrate that the aggregation process can result in a high diversity of protein conformational states, however the identity of the specific species responsible for the cellular damage is still unclear. [...]
2017 - 10.1016/j.redox.2017.03.027
Redox biology, Vol. 12 (Aug. 2017) , p. 699-711  
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19.
6 p, 5.8 MB Centrality in the host-pathogen interactome is associated with pathogen fitness during infection / Crua Asensio, Núria (Hospital Universitari Vall d'Hebron) ; Muñoz Giner, Elisabet (Hospital Universitari Vall d'Hebron) ; Sánchez de Groot, Natalia (Universitat Pompeu Fabra) ; Torrent Burgas, Marc (Universitat Autònoma de Barcelona. Departament de Bioquímica i de Biologia Molecular)
To perform their functions proteins must interact with each other, but how these interactions influence bacterial infection remains elusive. Here we demonstrate that connectivity in the host-pathogen interactome is directly related to pathogen fitness during infection. [...]
2017 - 10.1038/ncomms14092
Nature communications, Vol. 8 (January 2017) , art. 14092  
Detailed record - Creative Commons
20.
11 p, 2.0 MB Is membrane homeostasis the missing link between inflammation and neurodegenerative diseases? / Sánchez de Groot, Natalia (Laboratory of Molecular Biology. Medical Research Council) ; Torrent Burgas, Marc (Laboratory of Molecular Biology. Medical Research Council) ; Universitat Autònoma de Barcelona. Departament de Bioquímica i de Biologia Molecular
Systemic inflammation and infections are associated with neurodegenerative diseases. Unfortunately, the molecular bases of this link are still largely undiscovered. We, therefore, review how inflammatory processes can imbalance membrane homeostasis and theorize how this may have an effect on the aggregation behavior of the proteins implicated in such diseases. [...]
2015 - 10.1007/s00018-015-2038-4
Cellular and Molecular Life Sciences, Vol. 72, Issue 24 (December 2015) , p. 4795-4805  
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