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8 p, 958.4 KB Prediction of enzyme function by combining sequence similarity and protein interactions / Espadaler, Jordi (Universitat Pompeu Fabra. Departament de Ciències Experimentals i de la Salut) ; Eswar, Narayanan (University of California. Departments of Biopharmaceutical Sciences and Pharmaceutical Chemistry) ; Querol Murillo, Enrique (Universitat Autònoma de Barcelona. Departament de Bioquímica) ; Avilés, Francesc X. (Francesc Xavier) (Universitat Autònoma de Barcelona. Departament de Bioquímica i de Biologia Molecular) ; Sali, Andrej (University of California. Departments of Biopharmaceutical Sciences and Pharmaceutical Chemistry) ; Martí Renom, Marc A. (Centro de Investigación Príncipe Felipe (València)) ; Oliva Miguel, Baldomero (Universitat Pompeu Fabra. Departament de Ciències Experimentals i de la Salut)
Background: A number of studies have used protein interaction data alone for protein function prediction. Here, we introduce a computational approach for annotation of enzymes, based on the observation that similar protein sequences are more likely to perform the same function if they share similar interacting partners. [...]
2008 - 10.1186/1471-2105-9-249
BMC bioinformatics, Vol. 9, N. 249 (May 2008), p. 1-8
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