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1.
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10 p, 2.3 MB |
Global and Regional Deep Learning Models for Multiple Sclerosis Stratification From MRI
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Coll, Llucia (Hospital Universitari Vall d'Hebron) ;
Pareto, Deborah (Hospital Universitari Vall d'Hebron) ;
Carbonell-Mirabent, Pere (Hospital Universitari Vall d'Hebron) ;
Cobo-Calvo, Álvaro (Hospital Universitari Vall d'Hebron) ;
Arrambide, Georgina (Hospital Universitari Vall d'Hebron) ;
Vidal-Jordana, Angela (Hospital Universitari Vall d'Hebron) ;
Comabella, Manuel (Hospital Universitari Vall d'Hebron) ;
Castilló, Joaquin (Hospital Universitari Vall d'Hebron) ;
Rodríguez-Acevedo, Breogán (Hospital Universitari Vall d'Hebron) ;
Zabalza, Ana (Hospital Universitari Vall d'Hebron) ;
Galan, Ingrid (Hospital Universitari Vall d'Hebron) ;
Midaglia, Luciana (Hospital Universitari Vall d'Hebron) ;
Nos, Carlos (Hospital Universitari Vall d'Hebron) ;
Auger, Cristina (Universitat Autònoma de Barcelona. Departament de Medicina) ;
Alberich, Manel (Hospital Universitari Vall d'Hebron) ;
Río, Jordi (Hospital Universitari Vall d'Hebron) ;
Sastre-Garriga, Jaume (Hospital Universitari Vall d'Hebron) ;
Oliver, Arnau (Universitat de Girona) ;
Montalban, Xavier (Universitat Autònoma de Barcelona. Departament de Medicina) ;
Rovira, Alex (Hospital Universitari Vall d'Hebron) ;
Tintoré, Mar (Hospital Universitari Vall d'Hebron) ;
Lladó, Xavier (Universitat de Girona) ;
Tur, Carmen (Universitat Autònoma de Barcelona. Departament de Medicina)
Background: The combination of anatomical MRI and deep learning-based methods such as convolutional neural networks (CNNs) is a promising strategy to build predictive models of multiple sclerosis (MS) prognosis. [...]
2023 -  10.1002/jmri.29046
Journal of Magnetic Resonance Imaging
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2.
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231 p, 7.7 MB |
Clinical monitoring of multiple sclerosis patients using digital technology
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Midaglia Fernández, Luciana ;
Montalbán Gairín, Xavier, dir. ;
Sastre Garriga, Jaume, dir. ;
Fonollosa Pla, Vicent, dir.
La tesi es basa en lús de la tecnologia digital, en aquest cas una aplicació, per al seguiment clínic de pacients amb esclerosi múltiple. La intenció final d'aquesta aplicació és alertar el clínic sobre l'aparició de símptomes subclínics i, per tant, la progressió de la malaltia.
La tesis se basa en el uso de la tecnología digital, en este caso una aplicación, para el seguimiento clínico de pacientes con esclerosis múltiple. La intención final de esta aplicación es alertar al clínico sobre la aparición de síntomas subclínicos y, por tanto, sobre la progresión de la enfermedad.
The thesis is based on the use of digital technology, in this case an application, for the clinical monitoring of patients with multiple sclerosis. The final intention of this application is to alert the clinician about the appearance of subclinical symptoms and, therefore, about the progression of the disease.
2023
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3.
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9 p, 730.3 KB |
Clinical monitoring of multiple sclerosis patients by means of digital technology, a field in the midst of a revolution Monitorización clínica del paciente con esclerosis múltiple a través de la tecnología digital, un campo en plena revolución
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Midaglia, Luciana (Hospital Universitari Vall d'Hebron) ;
Sastre-Garriga, Jaume (Hospital Universitari Vall d'Hebron) ;
Montalban, Xavier (Hospital Universitari Vall d'Hebron) ;
Universitat Autònoma de Barcelona
Introduction. Despite the great advances that have occurred in the diagnosis and treatment of multiple sclerosis (MS), few changes have taken place in terms of clinical monitoring. The lack of time and space in clinical practice limits the assessment of invisible symptoms and certain motor symptoms as manual dexterity and walking ability, which have a clear impact on the patient functional situation. [...]
2021 - 10.33588/RN.7306.2021136
Revista de neurología, Vol. 73 Núm. 6 (sep. 2021) , p. 210-218
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4.
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8 p, 1.6 MB |
T1/T2-weighted ratio in multiple sclerosis : A longitudinal study with clinical associations
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Boaventura de Oliveira, Mateus (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Sastre-Garriga, Jaume (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Garcia-Vidal, Aran (Hospital Universitari Vall d'Hebron) ;
Vidal-Jordana, Angela (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Quartana, Davide (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Carvajal-Junco, René (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Auger, Cristina (Hospital Universitari Vall d'Hebron) ;
Alberich, Manel (Hospital Universitari Vall d'Hebron) ;
Tintoré, Mar (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Rovira, Alex (Hospital Universitari Vall d'Hebron) ;
Montalban, Xavier (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Pareto, Deborah (Hospital Universitari Vall d'Hebron) ;
Universitat Autònoma de Barcelona
Background: T1w/T2-w ratio has been proposed as a clinically feasible MRI biomarker to assess tissue integrity in multiple sclerosis. However, no data is available in the earliest stages of the disease and longitudinal studies analysing clinical associations are scarce. [...]
2022 - 10.1016/j.nicl.2022.102967
NeuroImage, Vol. 34 (2022) , p. 102967
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5.
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12 p, 623.0 KB |
CSF Chitinase 3-Like 2 Is Associated With Long-term Disability Progression in Patients With Progressive Multiple Sclerosis
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Comabella, Manuel (Hospital Universitari Vall d'Hebron) ;
Sastre-Garriga, Jaume (Hospital Universitari Vall d'Hebron) ;
Borràs, Eva (Universitat Pompeu Fabra) ;
Villar, Luisa M. (Hospital Universitario Ramón y Cajal (Madrid)) ;
Saiz, Albert (Hospital Clínic i Provincial de Barcelona) ;
Martínez-Yélamos, Sergio (Hospital Universitari de Bellvitge) ;
García-Merino, Juan Antonio (Hospital Universitario Puerta de Hierro Majadahonda (Madrid)) ;
Pinteac, Rucsanda (Hospital Universitari Vall d'Hebron) ;
Fissolo, Nicolás (Hospital Universitari Vall d'Hebron) ;
Sánchez López, Antonio J. (Hospital Universitario Puerta de Hierro Majadahonda (Madrid)) ;
Costa-Frossard, Lucienne (Hospital Universitario Ramón y Cajal (Madrid)) ;
Blanco, Yolanda (Hospital Clínic i Provincial de Barcelona) ;
Llufriu, Sara (Hospital Clínic i Provincial de Barcelona) ;
Vidal-Jordana, Angela (Hospital Universitari Vall d'Hebron) ;
Sabidó, Eduard (Centre de Regulació Genòmica) ;
Montalban, Xavier (Universitat Autònoma de Barcelona. Departament de Medicina)
OBJECTIVE: This study aimed to identify long-term prognostic protein biomarkers associated with disease progression in patients with progressive multiple sclerosis (MS). METHODS: CSF samples were collected from a discovery cohort of 28 patients with progressive MS who participated in a clinical trial with interferon beta. [...]
2021 - 10.1212/NXI.0000000000001082
Neurology® neuroimmunology & neuroinflammation, Vol. 8 Núm. 6 (2021)
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6.
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12 p, 4.0 MB |
Deciphering multiple sclerosis disability with deep learning attention maps on clinical MRI
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Coll, Llucia (Hospital Universitari Vall d'Hebron) ;
Pareto, Deborah (Hospital Universitari Vall d'Hebron) ;
Carbonell-Mirabent, Pere (Hospital Universitari Vall d'Hebron) ;
Cobo-Calvo, Álvaro (Hospital Universitari Vall d'Hebron) ;
Arrambide, Georgina (Hospital Universitari Vall d'Hebron) ;
Vidal-Jordana, Angela (Hospital Universitari Vall d'Hebron) ;
Comabella, Manuel (Hospital Universitari Vall d'Hebron) ;
Castilló, Joaquín (Hospital Universitari Vall d'Hebron) ;
Rodríguez Acevedo, Breogán (Hospital Universitari Vall d'Hebron) ;
Zabalza, Ana (Hospital Universitari Vall d'Hebron) ;
Galan, Ingrid (Hospital Universitari Vall d'Hebron) ;
Midaglia, Luciana (Hospital Universitari Vall d'Hebron) ;
Nos, Carlos (Hospital Universitari Vall d'Hebron) ;
Salerno, Annalaura (Hospital Universitari Vall d'Hebron) ;
Auger, Cristina (Hospital Universitari Vall d'Hebron) ;
Alberich, Manel (Hospital Universitari Vall d'Hebron) ;
Río, Jordi (Hospital Universitari Vall d'Hebron) ;
Sastre-Garriga, Jaume (Hospital Universitari Vall d'Hebron) ;
Oliver, Arnau (Universitat de Girona. Institut de recerca en visió per computador i robòtica (VICOROB)) ;
Montalban, Xavier (Hospital Universitari Vall d'Hebron) ;
Rovira, Alex (Hospital Universitari Vall d'Hebron) ;
Tintoré, Mar (Hospital Universitari Vall d'Hebron) ;
Lladó, Xavier (Universitat de Girona. Institut de recerca en visió per computador i robòtica (VICOROB)) ;
Tur, Carmen (Hospital Universitari Vall d'Hebron) ;
Universitat Autònoma de Barcelona
The application of convolutional neural networks (CNNs) to MRI data has emerged as a promising approach to achieving unprecedented levels of accuracy when predicting the course of neurological conditions, including multiple sclerosis, by means of extracting image features not detectable through conventional methods. [...]
2023 - 10.1016/j.nicl.2023.103376
NeuroImage, Vol. 38 (march 2023)
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7.
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12 p, 1.3 MB |
An expert patient program to improve the empowerment and quality of life of people with multiple sclerosis : protocol for a multicenter pre-post intervention study
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Robles-Sanchez, Miguel Angel (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Amil-Bujan, Paloma (Expert Patient Program Catalonia, Generalitat de Catalunya) ;
Bosch-Farré, Cristina (Universitat de Girona) ;
Coll-Martínez, Clàudia (Hospital de Santa Caterina (Salt, Girona)) ;
Arévalo, María Jesús (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Anglada, Elisenda (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Menéndez, Rebeca (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Montalban, Xavier (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Sastre-Garriga, Jaume (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Ramió-Torrentà, Lluís (Universitat de Girona) ;
Bertran-Noguer, Carme (Universitat de Girona) ;
Universitat Autònoma de Barcelona.
Departament de Medicina
Multiple sclerosis (MS) causes a progressive disability, which substantially impacts the quality of life (QoL). Health interventions that meet the needs and demands of people with MS are essential to minimize QoL impairment. [...]
2023 - 10.3389/fneur.2023.1172640
Frontiers in neurology, Vol. 14 (may 2023)
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8.
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8 p, 871.8 KB |
Oral contraceptives do not modify the risk of a second attack and disability accrual in a prospective cohort of women with a clinically isolated syndrome and early multiple sclerosis
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Otero-Romero, Susana (Hospital Universitari Vall d'Hebron) ;
Carbonell-Mirabent, Pere (Hospital Universitari Vall d'Hebron) ;
Midaglia, Luciana (Hospital Universitari Vall d'Hebron) ;
Zuluaga Rodas, María Isabel (Hospital Universitari Vall d'Hebron) ;
Galan, Ingrid (Hospital Universitari Vall d'Hebron) ;
Cobo-Calvo, Álvaro (Hospital Universitari Vall d'Hebron) ;
Río, Jordi (Hospital Universitari Vall d'Hebron) ;
Arrambide, Georgina (Hospital Universitari Vall d'Hebron) ;
Vidal-Jordana, Angela (Hospital Universitari Vall d'Hebron) ;
Castilló, Joaquín (Hospital Universitari Vall d'Hebron) ;
Rodríguez Acevedo, Breogán (Hospital Universitari Vall d'Hebron) ;
Comabella, Manuel (Hospital Universitari Vall d'Hebron) ;
Rodríguez, Marta (Hospital Universitari Vall d'Hebron) ;
Tur, Carmen (Hospital Universitari Vall d'Hebron) ;
Auger, Cristina (Hospital Universitari Vall d'Hebron) ;
Rovira, Alex (Hospital Universitari Vall d'Hebron) ;
Sastre-Garriga, Jaume (Hospital Universitari Vall d'Hebron) ;
Montalban, Xavier (Hospital Universitari Vall d'Hebron) ;
Tintoré, Mar (Hospital Universitari Vall d'Hebron) ;
Universitat Autònoma de Barcelona
To evaluate whether oral contraceptive (OC) use is associated with the risk of a second attack and disability accrual in women with a clinically isolated syndrome (CIS) and early multiple sclerosis (MS). [...]
2021 - 10.1177/13524585211053001
Multiple sclerosis, Vol. 28 (november 2021) , p. 950-957
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9.
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8 p, 1.4 MB |
Detection of lesions in the optic nerve with magnetic resonance imaging using a 3D convolutional neural network
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Martí-Juan, Gerard (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Frías, Marcos (BCN Medtech) ;
Garcia-Vidal, Aran (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Vidal-Jordana, Angela (Hospital Universitari Vall d'Hebron) ;
Alberich, Manel (Hospital Universitari Vall d'Hebron) ;
Calderon, Willem (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Piella, Gemma (BCN Medtech) ;
Camara, Oscar (BCN Medtech) ;
Montalban, Xavier (Hospital Universitari Vall d'Hebron) ;
Sastre-Garriga, Jaume (Hospital Universitari Vall d'Hebron) ;
Rovira, Alex (Hospital Universitari Vall d'Hebron) ;
Pareto, Deborah (Hospital Universitari Vall d'Hebron) ;
Universitat Autònoma de Barcelona
Optic neuritis (ON) is one of the first manifestations of multiple sclerosis, a disabling disease with rising prevalence. Detecting optic nerve lesions could be a relevant diagnostic marker in patients with multiple sclerosis. [...]
2022 - 10.1016/j.nicl.2022.103187
NeuroImage, Vol. 36 (september 2022)
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10.
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10 p, 509.3 KB |
Association of Early Progression Independent of Relapse Activity With Long-term Disability After a First Demyelinating Event in Multiple Sclerosis
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Tur, Carmen (Hospital Universitari Vall d'Hebron) ;
Carbonell-Mirabent, Pere (Hospital Universitari Vall d'Hebron) ;
Cobo-Calvo, Álvaro (Hospital Universitari Vall d'Hebron) ;
Otero-Romero, Susana (Hospital Universitari Vall d'Hebron) ;
Arrambide, Georgina (Hospital Universitari Vall d'Hebron) ;
Midaglia, Luciana (Hospital Universitari Vall d'Hebron) ;
Castilló, Joaquín (Hospital Universitari Vall d'Hebron) ;
Vidal-Jordana, Angela (Hospital Universitari Vall d'Hebron) ;
Rodríguez Acevedo, Breogán (Hospital Universitari Vall d'Hebron) ;
Zabalza, Ana (Hospital Universitari Vall d'Hebron) ;
Galan, Ingrid (Hospital Universitari Vall d'Hebron) ;
Nos, Carlos (Hospital Universitari Vall d'Hebron) ;
Salerno, Annalaura (Hospital Universitari Vall d'Hebron) ;
Auger, Cristina (Hospital Universitari Vall d'Hebron) ;
Pareto, Deborah (Hospital Universitari Vall d'Hebron) ;
Comabella, Manuel (Hospital Universitari Vall d'Hebron) ;
Río, Jordi (Hospital Universitari Vall d'Hebron) ;
Sastre-Garriga, Jaume (Hospital Universitari Vall d'Hebron) ;
Rovira, Alex (Hospital Universitari Vall d'Hebron) ;
Tintoré, Mar (Hospital Universitari Vall d'Hebron) ;
Montalban, Xavier (Hospital Universitari Vall d'Hebron) ;
Universitat Autònoma de Barcelona
This cohort study investigates the long-term outcomes of patients who develop progression independent of relapse activity after a first demyelinating event in multiple sclerosis. What are the long-term outcomes of patients developing progression independent of relapse activity (PIRA) after a first demyelinating event in multiple sclerosis? In this longitudinal cohort study including 1128 patients with a first demyelinating event in multiple sclerosis, presenting with PIRA was associated with significantly shorter times to developing severe disability compared with not presenting with PIRA. [...]
2022 - 10.1001/jamaneurol.2022.4655
JAMA Neurology, Vol. 80 (december 2022) , p. 151-160
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