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19 p, 3.9 MB Increasing polarity in tacrine and huprine derivatives : potent anticholinesterase agents for the treatment of myasthenia gravis / Galdeano, Carles (Universitat de Barcelona. Laboratori de Química Farmacèutica) ; Coquelle, Nicolas (Large-Scale Structures Group. Institut Laue-Langevin) ; Cieslikiewicz-Bouet, Monika (Institut National des Sciences Appliquées-INSA (Rouen, França)) ; Bartolini, Manuela (Department of Pharmacy and Biotechnology. Alma Mater Studiorum University of Bologna) ; Pérez, Belén (Universitat Autònoma de Barcelona. Institut de Neurociències) ; Clos, Victòria (Universitat Autònoma de Barcelona. Institut de Neurociències) ; Silman, Israel (Weizmann Institute of Science (Israel). Department of Neurobiology) ; Jean, Ludovic (Institut National des Sciences Appliquées-INSA (Rouen, França)) ; Colletier, Jacques Phillippe (Université Grenoble Alpes. Institut de Biologie Structurale) ; Renard, Pierre Yves (Institut National des Sciences Appliquées-INSA (Rouen, França)) ; Muñoz-Torrero López-Ibarra, Diego (Universitat de Barcelona. Laboratori de Química Farmacèutica)
Symptomatic treatment of myasthenia gravis is based on the use of peripherally-acting acetylcholinesterase (AChE) inhibitors that, in some cases, must be discontinued due to the occurrence of a number of side-effects. [...]
2018 - 10.3390/molecules23030634
Molecules, Vol. 23 Núm. 3 (2018) , p. 634  
Detailed record - Creative Commons

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