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14 p, 7.4 MB

Chromatin insulation orchestrates matrix metalloproteinase gene cluster expression reprogramming in aggressive breast cancer tumors / Llinàs-Arias, Pere (Institut d'Investigació Sanitària Illes Balears) ; Ensenyat-Mendez, Miquel (Cancer Epigenetics Laboratory. Health Research Institute of the Balearic Islands (IdISBa)) ; Íñiguez-Muñoz, Sandra (Cancer Epigenetics Laboratory. Health Research Institute of the Balearic Islands (IdISBa)) ; Orozco, Javier I.J. (Saint John's Cancer Institute, Providence Saint John's Health Center, Santa Monica, CA, USA) ; Valdez, Betsy (Saint John's Cancer Institute, Providence Saint John's Health Center, Santa Monica, CA, USA.) ; Salomon, Matthew P. (University of Southern California, Los Angeles, USA) ; Matsuba, Chikako (University of Southern California, Los Angeles, USA) ; Solivellas-Pieras, Maria (Cancer Epigenetics Laboratory. Health Research Institute of the Balearic Islands (IdISBa)) ; Bedoya-López, Andrés F. (Cancer Epigenetics Laboratory. Health Research Institute of the Balearic Islands (IdISBa)) ; Sesé, Borja (Cancer Epigenetics Laboratory. Health Research Institute of the Balearic Islands (IdISBa)) ; Mezger, Anja (Science for Life Laboratory, Solna, Sweden) ; Ormestad, Mattias (Science for Life Laboratory, Solna, Sweden) ; Unzueta, Fernando (Universitat de Barcelona) ; Strand, Siri H. (Stanford University School of Medicine, Stanford, USA) ; Boiko, Alexander D. (Samuel Oschin Comprehensive Cancer Institute, Los Angeles, USA) ; Hwang, E.Shelley (Duke University School of Medicine, Durham, USA) ; Cortés, Javier (Universidad Europea de Madrid) ; DiNome, Maggie L. (Duke University School of Medicine, Durham, USA) ; Esteller, Manel (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ; Lupien, Mathieu (University of Toronto) ; Marzese, Diego M. (Cancer Epigenetics Laboratory, Health Research Institute of the Balearic Islands (IdISBa))
Background: Triple-negative breast cancer (TNBC) is an aggressive subtype that exhibits a high incidence of distant metastases and lacks targeted therapeutic options. Here we explored how the epigenome contributes to matrix metalloprotease (MMP) dysregulation impacting tumor invasion, which is the first step of the metastatic process. [...]
2023 - DOI (Digital Object Identifier)