|
1.
|
|
12 p, 1.2 MB |
Plasma biomarkers for amyloid, tau, and cytokines in Down syndrome and sporadic Alzheimer's disease
/
Startin, Carla M. (LonDownS Consortium (London Down Syndrome Consortium)) ;
Ashton, Nicholas J. (University of Gothenburg) ;
Hamburg, Sarah (LonDownS Consortium (London Down Syndrome Consortium)) ;
Hithersay, Rosalyn (LonDownS Consortium (London Down Syndrome Consortium)) ;
Wiseman, Frances K. (University College London) ;
Mok, Kin Y. (Hong Kong University of Science and Technology) ;
Hardy, John (University College London) ;
Lleó, Alberto (Institut d'Investigació Biomèdica Sant Pau) ;
Lovestone, Simon (University of Oxford) ;
Parnetti, Lucilla (University of Perugia) ;
Zetterberg, Henrik (UCL Institute of Neurology (Regne Unit)) ;
Hye, Abdul (Maudsley NHS Foundation) ;
Fisher, Elisabeth ;
Nizetic, Dean ;
Tybulewicz, Victor ;
Karmiloff-Smith, Anette ;
Al-Janabi, Tamara ;
Zhang, David ;
Strydom, André (LonDownS Consortium (London Down Syndrome Consortium)) ;
Universitat Autònoma de Barcelona
Down syndrome (DS), caused by chromosome 21 trisomy, is associated with an ultra-high risk of dementia due to Alzheimer's disease (AD), driven by amyloid precursor protein (APP) gene triplication. Understanding relevant molecular differences between those with DS, those with sporadic AD (sAD) without DS, and controls will aid in understanding AD development in DS. [...]
2019 -  10.1186/s13195-019-0477-0
Alzheimer's research & therapy, Vol. 11 Núm. 1 (21 2019) , p. 26
|
|
|
2.
|
|
10 p, 497.8 KB |
The AT(N) framework for Alzheimer's disease in adults with Down syndrome
/
Rafii, Michael S. (University of Southern California) ;
Ances, Beau M. (Washington University School of Medicine in St. Louis) ;
Schupf, Nicole (Columbia University Medical Center) ;
Krinsky-McHale, Sharon J. (NYS Institute for Basic Research in Developmental Disabilities) ;
Mapstone, Mark (University of California) ;
Silverman, Wayne (University of California) ;
Lott, Ira (University of California) ;
Klunk, Willian (University of Pittsburgh) ;
Head, Elizabeth (University of California) ;
Christian, Brad (University of Wisconsin Madison) ;
Lai, Florence (Massachusetts General Hospital) ;
Rosas, H.Diana (Harvard Medical School) ;
Zaman, Shahid (Cambridgeshire and Peterborough NHS Foundation Trust) ;
Petersen, Melissa E. (University of North Texas Health Science Center) ;
Strydom, Andre (King's College London) ;
Fortea, Juan (Institut d'Investigació Biomèdica Sant Pau) ;
Handen, Benjamin (University of Pittsburgh) ;
O'Bryant, Sid (University of North Texas Health Science Center) ;
Universitat Autònoma de Barcelona
The National Institute on Aging in conjunction with the Alzheimer's Association (NIA-AA) recently proposed a biological framework for defining the Alzheimer's disease (AD) continuum. This new framework is based upon the key AD biomarkers (amyloid, tau, neurodegeneration, AT[N]) instead of clinical symptoms and represents the latest understanding that the pathological processes underlying AD begin decades before the manifestation of symptoms. [...]
2020 - 10.1002/dad2.12062
Alzheimer's & Dementia : Diagnosis, Assessment & Disease Monitoring, Vol. 12 Núm. 1 (2020) , p. e12062
|
|
|
3.
|
|
10 p, 344.1 KB |
Markers of early changes in cognition across cohorts of adults with down syndrome at risk of alzheimer's disease
/
Aschenbrenner, A.J. (Washington University in St. Louis. Department of Neurology) ;
Asaad Baksh, R. (The London Down Syndrome (LonDownS) Consortium) ;
Benejam, Bessy (Barcelona Down Medical Center. Fundació Catalana Síndrome de Down) ;
Beresford-Webb, J.A. (Cambridge Intellectual and Developmental Disabilities Research Group. Department of Psychiatry. University of Cambridge) ;
Coppus, Antonia (Department of Primary and Community Care. Radboud University Medical Center) ;
Fortea, Juan (Institut d'Investigació Biomèdica Sant Pau) ;
Handen, Benjamin L (Department of Psychiatry. University of Pittsburgh) ;
Hartley, S. (Department of Human Development & Family Studies. University of Wisconsin-Madison) ;
Head, E. (Department of Pathology & Laboratory Medicine. University of California) ;
Jaeger, J. (Deptment of Psychiatry and Behavioral Sciences. Albert Einstein College of Medicine) ;
Levin, J. (Munich Cluster for Systems Neurology (SyNergy)) ;
Loosli, S.V. (Department of Neurology. Ludwig-Maximilians-UniversitätMünchen) ;
Rebillat, A.S. (Jerome Lejeune Institute) ;
Sacco, S. (Jerome Lejeune Institute) ;
Schmitt, F.A. (Departments of Neurology. Neurosurgery. Behavioral Science. Psychology. Psychiatry. University of Kentucky) ;
Thurlow, K.E. (King's College London. Institute of Psychiatry, Psychology & Neuroscience) ;
Zaman, S. (Cambridgeshire & Peterborough NHS Foundation Trust) ;
Hassenstab, J. (Washington University in St. Louis. Department of Neurology) ;
Strydom, A. (South London and the Maudsley NHS Foundation Trust)
Introduction: Down syndrome (DS), a genetic variant of early onset Alzheimer's disease (AD), lacks a suitable outcome measure for prevention trials targeting predementia stages. Methods: We used cognitive test data collected in several longitudinal aging studies internationally from 312 participants with DS without dementia to identify composites that were sensitive to change over time. [...]
2021 - 10.1002/dad2.12184
Alzheimer's & Dementia : Diagnosis, Assessment & Disease Monitoring, Vol. 13 Núm. 1 (2021) , p. e12184
|
|
|
4.
|
|
28 p, 1.9 MB |
The clinical and neuropathological features of sporadic (Late-onset) and genetic forms of alzheimer's disease
/
Rujeedawa, T. (Cambridge Intellectual & Developmental Disabilities Research Group. Department of Psychiatry. University of Cambridge) ;
Félez, E.C. (Cambridge Intellectual & Developmental Disabilities Research Group. Department of Psychiatry. University of Cambridge) ;
Clare, I.C.H. (Cambridgeshire and Peterborough Foundation NHS Trust) ;
Fortea, Juan (Institut d'Investigació Biomèdica Sant Pau) ;
Strydom, A. (South London and the Maudsley NHS Foundation Trust. The LonDowns Consortium) ;
Rebillat, A.S. (Geriatrics. Institut Jérôme Lejeune) ;
Coppus, Antonia (Department of Primary and Community Care (149 ELG). Radboud University Nijmegen Medical Center) ;
Levin, J. (Munich Cluster for Systems Neurology (SyNergy)) ;
Zaman, S.H. (Cambridgeshire and Peterborough Foundation NHS Trust) ;
Universitat Autònoma de Barcelona
The purpose of this review is to compare and highlight the clinical and pathological aspects of genetic versus acquired Alzheimer's disease: Down syndrome-associated Alzheimer's disease in (DSAD) and Autosomal Dominant Alzheimer's disease (ADAD) are compared with the late-onset form of the disease (LOAD). [...]
2021 - 10.3390/jcm10194582
Journal of clinical medicine, Vol. 10 Núm. 19 (October 2021) , p. 4582
|
|
|
5.
|
|
12 p, 2.0 MB |
A multicentre validation study of the diagnostic value of plasma neurofilament light
/
Ashton, Nicholas J. (NIHR Biomedical Research Centre for Mental Health (Londres, Regne Unit)) ;
Janelidze, Shorena (Clinical Memory Research Unit. Department of Clinical Sciences Malmö. Lund University) ;
Al Khleifat, Ahmad (Department of Basic and Clinical Neuroscience. Maurice Wohl Clinical Neuroscience Institute. King's College London) ;
Leuzy, Antoine (Clinical Memory Research Unit. Department of Clinical Sciences Malmö. Lund University) ;
van der Ende, Emma L. (Alzheimer Center Rotterdam and Dept. of Neurology. Erasmus University Medical Center) ;
Karikari, Thomas K (Department of Psychiatry and Neurochemistry. Institute of Neuroscience & Physiology. The Sahlgrenska Academy at the University of Gothenburg) ;
Benedet, AndreaL. (Montreal Neurological Institute) ;
Pascoal, Tharick A. (Montreal Neurological Institute) ;
Lleó, Alberto (Institut d'Investigació Biomèdica Sant Pau) ;
Parnetti, Lucilla (Laboratory of Clinical Neurochemistry. Neurology Clinic. University of Perugia) ;
Galimberti, Daniela (University of Milan) ;
Bonanni, Laura (Department of Neuroscience. Imaging and Clinical Sciences. University G.d'Annunzio of Chieti-Pescara) ;
Pilotto, Andrea (Parkinson's Disease Rehabilitation Centre. FERB ONLUS) ;
Padovani, Alessandro (Neurology Unit. Department of Clinical and Experimental Sciences. University of Brescia) ;
Lycke, Jan (Sahlgrenska University Hospital (Suècia)) ;
Novakova, Lenka (Sahlgrenska University Hospital (Suècia)) ;
Axelsson, Markus (Sahlgrenska University Hospital (Suècia)) ;
Velayudhan, Latha (Department of Health Sciences. University of Leicester) ;
Rabinovici, Gil D. (Department of Radiology & Biomedical Imaging. University of California) ;
Miller, Bruce L. (University of California San Francisco. Memory and Aging Center) ;
Pariante, Carmine M (Stress. Psychiatry and Immunology Lab & Perinatal Psychiatry. Maurice Wohl Clinical Neuroscience Institute. King's College London) ;
Nikkheslat, Naghmeh (King's College London (Regne Unit)) ;
Resnick, Susan M. (Brain Aging and Behavior Section. Laboratory of Behavioral Neuroscience. National Institute on Aging. National Institutes of Health) ;
Thambisetty, Madhav (Clinical and Translational Neuroscience Section. Laboratory of Behavioral Neuroscience. National Institute on Aging. National Institutes of Health) ;
Schöll, Michael (Department of Neurodegenerative Disease. Queen Square Institute of Neurology. University College London) ;
Fernández-Eulate, Gorka (Department of Neurology. Donostia University Hospital. Osakidetza) ;
Gil-Bea, Francisco J. (Centro de Investigación Biomédica en Red sobre Enfermedades Neurodegenerativas) ;
López de Munain, Adolfo (Universidad del País Vasco. Departamento de Neurociencias) ;
Al-Chalabi, Ammar (King's College Hospital NHS Foundation Trust) ;
Rosa-Neto, Pedro (Montreal Neurological Institute) ;
Strydom, Andre (London Down Syndrome Consortium (LonDowns)) ;
Svenningsson, Per (Karolinska Institutet (Estocolm, Suècia). Department of Clinical Neuroscience) ;
Stomrud, Erik (Skåne University Hospital (Suècia)) ;
Santillo, Alexander (Lund University. Department of Clinical Sciences Malmö) ;
Aarsland, Dag (Stavanger University Hospital) ;
van Swieten, John C. (Erasmus University Medical Center) ;
Palmqvist, Sebastian (Lund University. Skåne University Hospital) ;
Zetterberg, Henrik (University College London. UK Dementia Research Institute) ;
Blennow, Kaj (Sahlgrenska University Hospital (Suècia)) ;
Hye, Abdul (Stavanger University Hospital) ;
Hansson, Oskar (Skåne University Hospital (Suècia))
Increased cerebrospinal fluid neurofilament light (NfL) is a recognized biomarker for neurodegeneration that can also be assessed in blood. Here, we investigate plasma NfL as a marker of neurodegeneration in 13 neurodegenerative disorders, Down syndrome, depression and cognitively unimpaired controls from two multicenter cohorts: King's College London (n = 805) and the Swedish BioFINDER study (n = 1,464). [...]
2021 - 10.1038/s41467-021-23620-z
Nature communications, Vol. 12 Núm. 1 (january 2021) , p. 3400
|
|
|
6.
|
|
11 p, 712.3 KB |
Comparison of covid-19 and non-covid-19 pneumonia in down syndrome
/
Real de Asua, Diego (Instituto de Investigación Hospital Universitario de la Princesa) ;
Mayer, Miguel Angel (Universitat Pompeu Fabra. Departament de Ciències Experimentals i de la Salut) ;
Del Carmen Ortega, María (Instituto de Investigación Sanitaria Hospital 12 de Octubre (i+12)) ;
Borrel, Jose M. (Down España Huesca) ;
de Jesús Bermejo, Teresa (Unidad de Neuropediatría. Instituto Hispalense de Pediatría) ;
González-lamuño, Domingo (Instituto de Investigación Sanitaria Valdecilla (Santander, Cantàbria)) ;
Manso, Coral (Down España) ;
Moldenhauer, Fernando (Instituto de Investigación Hospital Universitario de la Princesa) ;
Carmona Iragui, María (Institut d'Investigació Biomèdica Sant Pau) ;
Hüls, Anke (Department of Epidemiology and Gangarosa. Department of Environmental Health. Rollins School of Public Health. Emory University) ;
Sherman, Stephanie L. (Department of Human Genetics. School of Medicine. Emory University) ;
Strydom, Andre (The London Down Syndrome (LonDownS) Consortium. London. United Kingdom and South London and the Maudsley NHS Foundation Trust) ;
De La Torre, Rafael (Centro de Investigación Biomédica en Red de Fisiopatología de la Obesidad y Nutrición) ;
Dierssen, Mara (Biomedical Research Networking Center for Rare Diseases (CIBERER)) ;
Universitat Autònoma de Barcelona
Whether the increased risk for coronavirus disease 2019 (COVID-19) hospitalization and death observed in Down syndrome (DS) are disease specific or also occur in individuals with DS and non-COVID-19 pneumonias is unknown. [...]
2021 - 10.3390/jcm10163748
Journal of clinical medicine, Vol. 10 Núm. 16 (february 2021) , p. 3748
|
|
|
7.
|
|
9 p, 938.4 KB |
Conducting clinical trials in persons with Down syndrome : summary from the NIH INCLUDE Down syndrome clinical trials readiness working group
/
Baumer, Nicole (Boston Children's Hospital (Boston, Estats Units d'Amèrica)) ;
Becker, Mara L. (Duke University School of Medicine) ;
Capone, George (The Johns Hopkins School of Medicine) ;
Egan, Kathleen (Parent/Advocate, Virginia, USA) ;
Fortea, Juan (Institut d'Investigació Biomèdica Sant Pau) ;
Handen, Benjamin L. (University of Pittsburgh) ;
Head, Elizabeth (University of California) ;
Hendrix, James E. (LuMind IDSC Foundation, Burlington, USA) ;
Litovsky, Ruth Y. (University of Wisconsin) ;
Strydom, Andre (King's College London) ;
Tapia, Ignacio E. (University of Pennsylvania) ;
Rafii, Michael S. (University of Southern California) ;
Universitat Autònoma de Barcelona
The recent National Institute of Health (NIH) INCLUDE (INvestigation of Co-occurring conditions across the Lifespan to Understand Down syndromE) initiative has bolstered capacity for the current increase in clinical trials involving individuals with Down syndrome (DS). [...]
2022 - 10.1186/s11689-022-09435-z
Journal of Neurodevelopmental Disorders, Vol. 14 (march 2022)
|
|
|
8.
|
|
20 p, 1.6 MB |
Immune Dysregulation and the Increased Risk of Complications and Mortality Following Respiratory Tract Infections in Adults With Down Syndrome
/
Illouz, Tomer (Bar-Ilan University) ;
Biragyn, Arya (National Institute on Aging, National Institute of Health, Baltimore) ;
Iulita, M. Florencia (Institut d'Investigació Biomèdica Sant Pau) ;
Flores-Aguilar, Lisi (McGill University) ;
Dierssen, Mara (Centro de Investigación Biomédica en Red de Enfermedades Raras) ;
De Toma, Ilario (Centro de Investigación Biomédica en Red de Enfermedades Raras) ;
Antonarakis, Stylianos E. (iGE3 Institute of Genetics and Genomics of Geneva) ;
Yu, Eugene (State University of New York at Buffalo) ;
Herault, Yann (Université de Strasbourg) ;
Potier, Marie-Claude (Paris Brain Institute (ICM)) ;
Botté, Alexandra (Paris Brain Institute (ICM)) ;
Roper, Randall (Indiana University-Purdue University Indianapolis) ;
Sredni, Benjamin (Bar-Ilan University) ;
London, Jacqueline (Université de Paris) ;
Mobley, William (University of California, San Diego) ;
Strydom, Andre (South London and Maudsley NHS Foundation Trust) ;
Okun, Eitan (Bar-Ilan University) ;
Universitat Autònoma de Barcelona
The risk of severe outcomes following respiratory tract infections is significantly increased in individuals over 60 years, especially in those with chronic medical conditions, i. e. , hypertension, diabetes, cardiovascular disease, dementia, chronic respiratory disease, and cancer. [...]
2021 - 10.3389/fimmu.2021.621440
Frontiers in immunology, Vol. 12 (june 2021)
|
|
|
9.
|
|
2 p, 347.5 KB |
Correction to : Specific Susceptibility to COVID-19 in Adults with Down Syndrome
/
Illouz, Tomer (Bar-Ilan University) ;
Biragyn, Arya (NIA. Laboratory of Molecular Biology and Immunology) ;
Frenkel-Morgenstern, Milana (Bar-Ilan University) ;
Weissberg, Orly (Bar-Ilan University) ;
Gorohovski, Alessandro (Bar-Ilan University) ;
Merzon, Eugene (Tel Aviv University) ;
Green, Ilan (Tel Aviv University) ;
Iulita, M. Florencia (Institut d'Investigació Biomèdica Sant Pau) ;
Flores-Aguilar, Lisi (McGill University) ;
Dierssen, Mara (Centro de Investigación Biomédica en Red de Enfermedades Raras) ;
De Toma, Ilario (Centro de Investigación Biomédica en Red de Enfermedades Raras) ;
Lifshitz, Hefziba (Bar-Ilan University) ;
Antonarakis, Stylianos E. (iGE3 Institute of Genetics and Genomics of Geneva) ;
Yu, Eugene (State University of New York At Buffalo) ;
Herault, Yann (Université de Strasbourg) ;
Potier, Marie-Claude (Sorbonne Université) ;
Botté, Alexandra (Sorbonne Université) ;
Roper, Randall (Indiana University-Purdue University Indianapolis) ;
Sredni, Benjamin (Bar-Ilan University) ;
Sarid, Ronit (Sorbonne Université) ;
London, Jacqueline (Université de Paris) ;
Mobley, William (University of California) ;
Strydom, Andre (South London and Maudsley NHS Foundation Trust) ;
Okun, Eitan (Bar-Ilan University) ;
Universitat Autònoma de Barcelona
2021 - 10.1007/s12017-021-08695-7
Neuromolecular Medicine, may 2021, p. 1-2
|
|
|
10.
|
|
11 p, 935.0 KB |
Specific Susceptibility to COVID-19 in Adults with Down Syndrome
/
Illouz, Tomer (Bar-Ilan University. The Paul Feder Laboratory On Alzheimer's Disease Research) ;
Biragyn, Arya (NIA. Laboratory of Molecular Biology and Immunology) ;
Frenkel-Morgenstern, Milana (Bar-Ilan University. Cancer Genomics and BioComputing of Complex Diseases Lab, Azrieli Faculty of Medicine) ;
Weissberg, Orly (Bar-Ilan University. Cancer Genomics and BioComputing of Complex Diseases Lab, Azrieli Faculty of Medicine) ;
Gorohovski, Alessandro (Bar-Ilan University. Cancer Genomics and BioComputing of Complex Diseases Lab, Azrieli Faculty of Medicine) ;
Merzon, Eugene (Tel Aviv University. Leumit Health Services, Department of Family Medicine, Sackler School of Medicine) ;
Green, Ilan (Tel Aviv University. Leumit Health Services, Department of Family Medicine, Sackler School of Medicine) ;
Iulita, M. Florencia (Institut d'Investigació Biomèdica Sant Pau) ;
Flores-Aguilar, Lisi (McGill University. Department of Anatomy and Cell Biology) ;
del Mar Dierssen Sotos, Maria (Centro de Investigación Biomédica en Red de Enfermedades Raras) ;
De Toma, Ilario (Centro de Investigación Biomédica en Red de Enfermedades Raras) ;
Lifshitz, Hefziba (Bar-Ilan University. School of Education) ;
Antonarakis, Stylianos E. (iGE3 Institute of Genetics and Genomics of Geneva, 1211 Geneva, Switzerland) ;
Yu, Eugene (State University of New York At Buffalo. Genetics, Genomics and Bioinformatics Program) ;
Herault, Yann (IGBMC-UMR. Université de Strasbourg, CNRS, INSERM, Institut de Génétique Biologie Moléculaire Et Cellulaire) ;
Potier, Marie-Claude (Sorbonne Université, Hôpital de La Pitié-Salpêtrière. Paris Brain Institute (ICM), CNRS UMR7225, INSERM U1127) ;
Botté, Alexandra (Sorbonne Université, Hôpital de La Pitié-Salpêtrière. Paris Brain Institute (ICM), CNRS UMR7225, INSERM U1127) ;
Roper, Randall (Indiana University-Purdue University Indianapolis. Department of Biology) ;
Sredni, Benjamin (Bar-Ilan University. The Mina and Everard Goodman Faculty of Life Sciences) ;
Sarid, Ronit (Bar-Ilan University. The Mina and Everard Goodman Faculty of Life Sciences) ;
London, Jacqueline (CNRS. Université de Paris, BFA, UMR 8251) ;
Mobley, William (University of California. Department of Neurosciences) ;
Strydom, Andre (South London and Maudsley NHS Foundation Trust) ;
Okun, Eitan (Bar-Ilan University. The Mina and Everard Goodman Faculty of Life Sciences) ;
Universitat Autònoma de Barcelona
The current SARS-CoV-2 outbreak, which causes COVID-19, is particularly devastating for individuals with chronic medical conditions, in particular those with Down Syndrome (DS) who often exhibit a higher prevalence of respiratory tract infections, immune dysregulation and potential complications. [...]
2021 - 10.1007/s12017-021-08651-5
Neuromolecular Medicine, march 2021, p. 1-11
|
|
guest ::
email alert
or subscribe to the 
RSS feed.
