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UAB Digital Repository of Documents 3 records found  Search took 0.00 seconds. 
1.
18 p, 851.1 KB Clinical outcome measures in dementia with Lewy bodies trials : critique and recommendations / Rodriguez-Porcel, Federico (Medical University of South Carolina) ; Wyman-Chick, Kathryn A. (HealthPartners) ; Abdelnour, Carla (Universitat Autònoma de Barcelona) ; Toledo, Jon B. (University of Florida) ; Ferreira, Daniel (Mayo Clinic) ; Urwyler, Prabitha (University of Bern) ; Weil, Rimona S. (University College London) ; Kane, Joseph (Queen's University) ; Pilotto, Andrea (University of Brescia) ; Rongve, Arvid (The University of Bergen) ; Boeve, Bradley (Mayo Clinic) ; Taylor, John-Paul (Newcastle University) ; McKeith, Ian (Newcastle University) ; Aarsland, Dag (King's College London) ; Lewis, Simon J. G. (University of Sydney)
The selection of appropriate outcome measures is fundamental to the design of any successful clinical trial. Although dementia with Lewy bodies (DLB) is one of the most common neurodegenerative conditions, assessment of therapeutic benefit in clinical trials often relies on tools developed for other conditions, such as Alzheimer's or Parkinson's disease. [...]
2022 - 10.1186/s40035-022-00299-w
Translational Neurodegeneration, Vol. 11 (may 2022)  
Detailed record - Creative Commons
2.
1 p, 574.4 KB Correction : Clinical outcome measures in dementia with Lewy bodies trials: critique and recommendations / Rodriguez-Porcel, Federico (Medical University of South Carolina) ; Wyman-Chick, Kathryn A. (HealthPartners) ; Abdelnour, Carla (Universitat Autònoma de Barcelona) ; Toledo, Jon B. (University of Florida) ; Ferreira, Daniel (Mayo Clinic) ; Urwyler, Prabitha (University of Bern) ; Weil, Rimona S. (University College London) ; Kane, Joseph (Queen's University) ; Pilotto, Andrea (University of Brescia) ; Rongve, Arvid (The University of Bergen) ; Boeve, Bradley (Mayo Clinic) ; Taylor, John-Paul (Newcastle University) ; McKeith, Ian (Newcastle University) ; Aarsland, Dag (King's College London) ; Lewis, Simon J. G. (University of Sydney)
The selection of appropriate outcome measures is fundamental to the design of any successful clinical trial. Although dementia with Lewy bodies (DLB) is one of the most common neurodegenerative conditions, assessment of therapeutic benefit in clinical trials often relies on tools developed for other conditions, such as Alzheimer's or Parkinson's disease. [...]
2022 - 10.1186/s40035-022-00306-0
Translational Neurodegeneration, Vol. 11 (may 2022)  
Detailed record - Creative Commons
3.
18 p, 3.6 MB hnRNPDL phase separation is regulated by alternative splicing and disease-causing mutations accelerate its aggregation / Batlle Carreras, Cristina (Universitat Autònoma de Barcelona. Institut de Biotecnologia i de Biomedicina "Vicent Villar Palasí") ; Yang, Peiguo (St. Jude Children's Research Hospital (Memphis, Estats Units d'Amèrica)) ; Coughlin, Maura (St. Jude Children's Research Hospital (Memphis, Estats Units d'Amèrica)) ; Messing, James (Howard Hughes Medical Institute) ; Pesarrodona Roches, Mireia (Institut de Recerca Biomèdica de Lleida) ; Szulc, Elzbieta (Institut de Recerca Biomèdica de Lleida) ; Salvatella, Xavier (Institut de Recerca Biomèdica de Lleida) ; Kim, Hong Joo (St. Jude Children's Research Hospital (Memphis, Estats Units d'Amèrica)) ; Taylor, J. Paul (Howard Hughes Medical Institute) ; Ventura, Salvador (Universitat Autònoma de Barcelona. Departament de Bioquímica i de Biologia Molecular)
Prion-like proteins form multivalent assemblies and phase separate into membraneless organelles. Heterogeneous ribonucleoprotein D-like (hnRNPDL) is a RNA-processing prion-like protein with three alternative splicing (AS) isoforms, which lack none, one, or both of its two disordered domains. [...]
2020 - 10.1016/j.celrep.2019.12.080
Cell reports, Vol. 30, issue 4 (Jan. 2020) , p. 1117-1128  
Detailed record - Creative Commons

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