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138 p, 2.6 MB LKB1/ AMPK / TSC2 signaling pathway alterations in non-small-cell-lung-carcinoma / de Aguirre, Itziar ; Vertino, Paula, dir. ; Rosell i Costa, Rafael, dir. ; Universitat Autònoma de Barcelona. Departament de Mitjans, Comunicació i Cultura
El gen supresor tumoral LKB1/STK11b, codifica una serina/treonina quinasa. Las mutaciones de línea germinal en LKB1 están asociadas al síndrome de Peutz-Jeghers (PJS), trastorno dominante autosómico caracterizado por el crecimiento de pólipos en el tracto gastrointestinal, y depósitos de melanina mucocutánea, aumentando el riesgo de ciertos cánceres, incluido el de pulmón. [...]
LKB1, also known as STK11b, is a serine/threonine kinase that functions as a suppressor of tumor growth. Germ line mutations in LKB1 are associated with the Peutz-Jeghers syndrome (PJS), an autosomal dominant disorder characterized by benign hemartomas of the gastrointestinal tract and mucocutaneous melanin deposits and an increased risk of certain cancers, including lung. [...]
[Barcelona] : Universitat Autònoma de Barcelona, 2014  
Detailed record - Creative Commons

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