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1.
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12 p, 1.4 MB |
Study of CD27, CD38, HLA-DR and Ki-67 immune profiles for the characterization of active tuberculosis, latent infection and end of treatment
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Díaz-Fernández, Sergio (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Villar-Hernández, Raquel (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Stojanovic, Zoran (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Fernández, Marco A (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
De Souza Galvão, Maria Luiza (Hospital Universitari Vall d'Hebron) ;
Tolosa, Guillermo (Universidad de la Frontera) ;
Sánchez-Montalva, Adrián (Hospital Universitari Vall d'Hebron) ;
Abad Capa, Jorge (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Jiménez-Fuentes, María Ángeles (Hospital Universitari Vall d'Hebron) ;
Safont Gonzalez, Guillem (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Romero i Andrada, Iris (Universitat Autònoma de Barcelona. Departament de Genètica i de Microbiologia) ;
Sabrià, Josefina (Hospital de Sant Joan Despí Moisès Broggi) ;
Prat i Aymerich, Cristina (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Domínguez, José (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Latorre, Irene (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol)
Current blood-based diagnostic tools for TB are insufficient to properly characterize the distinct stages of TB, from the latent infection (LTBI) to its active form (aTB); nor can they assess treatment efficacy. [...]
2022 -  10.3389/fmicb.2022.885312
Frontiers in microbiology, Vol. 13 (july 2022)
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2.
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12 p, 995.8 KB |
Tobacco Smoking and Second-Hand Smoke Exposure Impact on Tuberculosis in Children
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Altet, Neus (Unitat Clínica de Tractament Directament Observat de la Tuberculosi (Barcelona)) ;
Latorre, Irene (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Jiménez-Fuentes, María Ángeles (Hospital Universitari Vall d'Hebron) ;
Soriano-Arandes, Antoni (Hospital Universitari Vall d'Hebron) ;
Villar-Hernández, Raquel (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Milà, Celia (Hospital Universitari Vall d'Hebron) ;
Rodríguez-Fernández, Pablo (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Muriel-Moreno, Beatriz (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Comella-del-Barrio, Patricia (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Godoy, Pere (Institut de Recerca Biomèdica de Lleida) ;
Millet, Joan-Pau (Centro de Investigación Biomédica en Red de Epidemiología y Salud Pública) ;
De Souza Galvão, Maria Luiza (Hospital Universitari Vall d'Hebron) ;
Jiménez-Ruiz, Carlos A. (Comunidad Autónoma de Madrid. Unidad de Tabaquismo) ;
Domínguez, José (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol)
Little is known about whether second-hand smoke (SHS) exposure affects tuberculosis (TB). Here, we investigate the association of cigarette smoke exposure with active TB and latent TB infection (LTBI) in children, analyzing Interferon-Gamma Release Assays' (IGRAs) performance and cytokine immune responses. [...]
2022 - 10.3390/jcm11072000
Journal of clinical medicine, Vol. 11 (april 2022)
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3.
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13 p, 1.6 MB |
Immunogenicity of 60 novel latency-related antigens of Mycobacterium tuberculosis
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Serra-Vidal, Mᵃdel Mar (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Latorre, Irene (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Franken, Kees L. C. M. (Department of Immunohematology and Blood Transfusion/Department of Infectious Diseases, Leiden University Medical Center) ;
Díaz, Jéssica (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
De Souza Galvão, Maria Luiza (Hospital Universitari Vall d'Hebron) ;
Casas, Irma (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Maldonado, José (Serveis Clínics (Barcelona)) ;
Milà, Celia (Hospital Universitari Vall d'Hebron) ;
Solsona, Jordi (Hospital Universitari Vall d'Hebron) ;
Jimenez-Fuentes, M. Ángeles (Hospital Universitari Vall d'Hebron) ;
Altet, Neus (Hospital Universitari Vall d'Hebron) ;
Lacoma, Alicia (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Ruiz-Manzano, Juan (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Ausina, Vicente (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Prat i Aymerich, Cristina (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Ottenhoff, Tom H. M. (Department of Immunohematology and Blood Transfusion/Department of Infectious Diseases, Leiden University Medical Center) ;
Domínguez, José (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol)
The aim of our work here was to evaluate the immunogenicity of 60 mycobacterial antigens, some of which have not been previously assessed, notably a novel series of in vivo -expressed Mycobacterium tuberculosis (IVE-TB) antigens. [...]
2014 - 10.3389/fmicb.2014.00517
Frontiers in microbiology, Vol. 5 (october 2014)
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4.
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13 p, 2.4 MB |
Discovery and validation of an NMR-based metabolomic profile in urine as TB biomarker
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Izquierdo-Garcia, José Luis (Universidad Complutense de Madrid) ;
Comella-del-Barrio, Patricia (Universitat Autònoma de Barcelona. Departament de Genètica i de Microbiologia) ;
Campos-Olivas, Ramón (Centro Nacional de Investigaciones Oncológicas) ;
Villar-Hernández, Raquel (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Prat i Aymerich, Cristina (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
De Souza Galvão, Maria Luiza (Hospital Universitari Vall d'Hebron) ;
Jiménez-Fuentes, Maria Angeles (Hospital Universitari Vall d'Hebron) ;
Ruiz-Manzano, Juan (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Stojanovic, Zoran (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
González, Adela (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Serra-Vidal, Mar (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
García-García, Esther (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Muriel-Moreno, Beatriz (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Millet, Joan-Pau (Centro de Investigación Biomédica en Red de Epidemiología y Salud Pública) ;
Molina-Pinargote, Israel (Unitat Clínica de Tractament Directament Observat de la Tuberculosi (Barcelona)) ;
Casas, Xavier (Unitat Clínica de Tractament Directament Observat de la Tuberculosi (Barcelona)) ;
Santiago, Javier (Unitat Clínica de Tractament Directament Observat de la Tuberculosi (Barcelona)) ;
Sabriá, Fina (Hospital de Sant Joan Despí Moisès Broggi) ;
Martos, Carmen (Hospital de Sant Joan Despí Moisès Broggi) ;
Herzmann, Christian (Research Center Borstel. Center for Clinical Studies, Germany) ;
Ruiz-Cabello, Jesús (IKERBASQUE, Basque Foundation for Science) ;
Domínguez, José (Universitat Autònoma de Barcelona. Departament de Genètica i de Microbiologia)
Despite efforts to improve tuberculosis (TB) detection, limitations in access, quality and timeliness of diagnostic services in low- and middle-income countries are challenging for current TB diagnostics. [...]
2020 - 10.1038/s41598-020-78999-4
Scientific reports, Vol. 10 (december 2020)
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5.
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11 p, 1.8 MB |
Diagnostic benefits of adding EspC, EspF and Rv2348-B to the QuantiFERON Gold In-tube antigen combination
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Villar-Hernández, Raquel (Universitat Autònoma de Barcelona) ;
Blauenfeldt, Thomas (Statens Serum Institut) ;
García-García, Esther (Universitat Autònoma de Barcelona) ;
Muriel-Moreno, Beatriz (Universitat Autònoma de Barcelona) ;
De Souza Galvão, Maria Luiza (Hospital Universitari Vall d'Hebron) ;
Millet, Joan-Pau (Centro de Investigación Biomédica en Red de Epidemiología y Salud Pública) ;
Sabriá, Fina (Hospital de Sant Joan Despí Moisès Broggi) ;
Sánchez-Montalvá, Adrian (Hospital Universitari Vall d'Hebron) ;
Ruiz-Manzano, Juan (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Pilarte, J. (Hospital Universitari Vall d'Hebron) ;
Jiménez, M. A. (Hospital Universitari Vall d'Hebron) ;
Centeno Clemente, Carmen Angela (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Martos, Carmen (Hospital de Sant Joan Despí Moisès Broggi) ;
Molina-Pinargote, Israel (Unitat Clínica de Tractament Directament Observat de la Tuberculosi (Barcelona)) ;
González-Díaz, Yoel D. (Unitat Clínica de Tractament Directament Observat de la Tuberculosi (Barcelona)) ;
Santiago, Javier (Unitat Clínica de Tractament Directament Observat de la Tuberculosi (Barcelona)) ;
Cantos, Adela (Hospital Universitari Vall d'Hebron) ;
Casas, Irma (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Guerola, Rosa (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Prat Aymerich, Cristina (Utrecht University) ;
Andersen, Peter Lawætz (Statens Serum Institut) ;
Latorre, Irene (Universitat Autònoma de Barcelona) ;
Ruhwald, Morten (Statens Serum Institut) ;
Domínguez, Jose (Universitat Autònoma de Barcelona)
Interferon (IFN)-γ release assays (IGRAs) are used to diagnose latent tuberculosis (TB) infection (LTBI). To improve the accuracy of these tests, different approaches, such as alternative cytokine detection and using different antigens, are considered. [...]
2020 - 10.1038/s41598-020-70204-w
Scientific reports, Vol. 10 (august 2020)
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6.
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1.5 MB |
Cell-Mediated Immune Responses to in vivo -Expressed and Stage-Specific Mycobacterium tuberculosis Antigens in Latent and Active Tuberculosis Across Different Age Groups
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Coppola, Mariateresa (Leiden University Medical Center) ;
Villar-Hernández, Raquel (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
van Meijgaarden, Krista E. (Leiden University Medical Center) ;
Latorre, Irene (Universitat Autònoma de Barcelona. Departament de Genètica i de Microbiologia) ;
Muriel-Moreno, Beatriz (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
García-García, Esther (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Franken, Kees L. M. C. (Leiden University Medical Center) ;
Prat i Aymerich, Cristina (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Stojanovic, Zoran (Universitat Autònoma de Barcelona. Departament de Medicina) ;
De Souza Galvão, Maria Luiza (Hospital Universitari Vall d'Hebron) ;
Millet, Joan-Pau (CIBER de Epidemiología y Salud Pública (CIBEREESP)) ;
Sabriá, Josefina (Hospital de Sant Joan Despí Moisès Broggi) ;
Sánchez-Montalva, Adrián (Hospital Universitari Vall d'Hebron) ;
Noguera-Julian, Antoni (Institut de Recerca Sant Joan de Déu) ;
Geluk, Annemieke (Leiden University Medical Center) ;
Domínguez, José (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Ottenhoff, Tom H. M. (Leiden University Medical Center)
A quarter of the global human population is estimated to be latently infected by Mycobacterium tuberculosis (Mtb), the causative agent of tuberculosis (TB). TB remains the global leading cause of death by a single pathogen and ranks among the top-10 causes of overall global mortality. [...]
2020 - 10.3389/fimmu.2020.00103
Frontiers in immunology, Vol. 11 (february 2020)
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7.
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11 p, 1.7 MB |
Use of IP-10 detection in dried plasma spots for latent tuberculosis infection diagnosis in contacts via mail
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Villar-Hernández, Raquel (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Latorre, Irene (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
De Souza Galvão, Maria Luiza (Hospital Universitari Vall d'Hebron) ;
Jiménez, María A. (Hospital Universitari Vall d'Hebron) ;
Ruiz Manzano, J (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Pilarte, Jose (Hospital Universitari Vall d'Hebron) ;
García-García, Esther (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Muriel-Moreno, Beatriz (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Cantos, Adela (Hospital Universitari Vall d'Hebron) ;
Altet, Neus (Hospital Universitari Vall d'Hebron) ;
Millet, Joan-Pau (Centro de Investigación Biomédica en Red de Epidemiología y Salud Pública) ;
González-Díaz, Yoel D. (Unidad Clínica de Tratamiento Directamente Observado "Serveis Clinics") ;
Molina-Pinargote, Israel (Unidad Clínica de Tratamiento Directamente Observado "Serveis Clinics") ;
Prat i Aymerich, Cristina (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Ruhwald, Morten (Statens Serum Institut (Copenhagen, Dinamarca). Department of Infectious Disease Immunology) ;
Domínguez, José (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Universitat Autònoma de Barcelona
The aim of this study was to test the use of IP-10 detection in dried plasma from contact studies individuals (contacts of smear positive patients), by comparing it with IP-10 and IFN-γ detection in direct plasma, to establish IP-10 detection in DPS as a useful assay for LTBI diagnosis. [...]
2019 - 10.1038/s41598-019-40778-1
Scientific reports, Vol. 9 Núm. 1 (january 2019) , p. 3943
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8.
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11 p, 1.2 MB |
Study of CD27 and CCR4 markers on specific CD4+ T-cells as immune tools for active and latent tuberculosis management
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Latorre, Irene (Universitat Autònoma de Barcelona. Departament de Genètica i de Microbiologia) ;
Fernández Sanmartin, Marco Antonio (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Muriel-Moreno, Beatriz (Universitat Autònoma de Barcelona. Departament de Genètica i de Microbiologia) ;
Villar-Hernández, Raquel (Universitat Autònoma de Barcelona. Departament de Genètica i de Microbiologia) ;
Vila, Sergi (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
De Souza Galvão, Maria Luiza (Hospital Universitari Vall d'Hebron) ;
Stojanovic, Zoran (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Jiménez-Fuentes, María A. (Hospital Universitari Vall d'Hebron) ;
Centeno, Carmen (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Ruiz-Manzano, Juan (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Millet, Joan-Pau (Centro de Investigación Biomédica en Red de Epidemiología y Salud Pública) ;
Molina-Pinargote, Israael (Serveis Clínics. Unitat Clínica de Tractament Directament Observat de la Tuberculosi) ;
González-Díaz, Yoel D. (Serveis Clínics. Unitat Clínica de Tractament Directament Observat de la Tuberculosi) ;
Lacoma, Alicia (Universitat Autònoma de Barcelona. Departament de Genètica i de Microbiologia) ;
Luque-Chacón, Lydia (Hospital de Sant Joan Despí Moisès Broggi) ;
Sabriá, Josefina (Hospital de Sant Joan Despí Moisès Broggi) ;
Prat i Aymerich, Cristina (Universitat Autònoma de Barcelona. Departament de Genètica i de Microbiologia) ;
Domínguez, José (Universitat Autònoma de Barcelona. Departament de Genètica i de Microbiologia)
The immunological characterization of different cell markers has opened the possibility of considering them as immune tools for tuberculosis (TB) management, as they could correlate with TB latency/disease status and outcome. [...]
2019 - 10.3389/fimmu.2018.03094
Frontiers in immunology, Vol. 9 (Jan. 2019) , art. 3094
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9.
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17 p, 1.5 MB |
Assessment of the influence of direct tobacco smoke on infection and active TB management
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Altet, Neus (Hospital Universitari Vall d'Hebron) ;
Latorre, Irene (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Jiménez-Fuentes, María Ángeles (Hospital Universitari Vall d'Hebron) ;
Maldonado, José (Unitat Clínica de Tractament Directament Observat de la Tuberculosi (Barcelona)) ;
Molina Romero, Israel (Unitat Clínica de Tractament Directament Observat de la Tuberculosi (Barcelona)) ;
González-Díaz, Yoel (Unitat Clínica de Tractament Directament Observat de la Tuberculosi (Barcelona)) ;
Milà, Celia (Hospital Universitari Vall d'Hebron) ;
García-García, Esther (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Muriel-Moreno, Beatriz (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Villar-Hernández, Raquel (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Laabei, Maisem (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Gómez Camacho, Andromeda Celeste (Universitat Autònoma de Barcelona. Institut de Biotecnologia i de Biomedicina "Vicent Villar Palasí") ;
Godoy, Pere (Generalitat de Catalunya. Departament de Salut) ;
De Souza Galvão, Maria Luiza (Hospital Universitari Vall d'Hebron) ;
Solano Reina, Segismundo (Hospital General Universitario Gregorio Marañón) ;
Jiménez-Ruiz, Carlos A. (Comunidad Autónoma de Madrid. Unidad de Tabaquismo) ;
Domínguez, José (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
PII Smoking SEPAR Working Group
Background. Smoking is a risk factor for tuberculosis (TB) infection and disease progression. Tobacco smoking increases susceptibility to TB in a variety of ways, one of which is due to a reduction of the IFN-γ response. [...]
2017 - 10.1371/journal.pone.0182998
PloS one, Vol. 12 Núm. 8 (august 2017) , p. 1
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10.
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117 p, 5.6 MB |
Aplicabilitat clínica de les tècniques de detecció in vitro de l'interferó-gamma en la infecció i la malaltia tuberculosa
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De Souza Galvão, Maria Luiza ;
Domínguez Benítez, José Antonio, dir. ;
Altet Gómez, María Neus, dir. ;
Ruíz Manzano, Juan, dir. ;
Universitat Autònoma de Barcelona.
Departament de Medicina
Les tècniques dels IGRAs (Interferon-gamma release assays) Quantiferon-TB Gold in Tube (QFN-G-IT) així com el T-SPOT. TB, quantifiquen la resposta cel·lular immune a través de la detecció de l' Interferó-gamma (IF-γ) produït per les cèl·lules T sensibilitzades prèviament, en resposta a una estimulació in vitro amb antígens específics: l'ESAT-6, CFP-10 i TB7. [...]
Interferon-γ (IF-γ) release assays (IGRAs), Quantiferon-TB Gold in Tube (QFN-G-IT) as well as T-SPOT. TB quantify the cellular immune response by detecting IF-γ, produced by T-cells sensitized previously, in response to in vitro stimulation with specific antigens: ESAT-6, CFP-10 and TB7. [...]
[Barcelona] : Universitat Autònoma de Barcelona, 2015
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