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47 p, 1.4 MB |
The benefits of voluntary physical exercise after traumatic brain injury on rat's object recognition memory : A comparison of different temporal schedules
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Amorós-Aguilar, Laura (Universitat Autònoma de Barcelona. Departament de Psicobiologia i Metodologia de les Ciències de la Salut) ;
Portell Cortés, Isabel (Universitat Autònoma de Barcelona. Institut de Neurociències) ;
Costa Miserachs, David (Universitat Autònoma de Barcelona. Institut de Neurociències) ;
Torras Garcia, Meritxell (Universitat Autònoma de Barcelona. Institut de Neurociències) ;
Riubugent-Camps, Èlia (Universitat Autònoma de Barcelona. Institut de Neurociències) ;
Almolda Ardid, Beatriz (Universitat Autònoma de Barcelona. Departament de Biologia Cel·lular, de Fisiologia i d'Immunologia) ;
Coll-Andreu, Margalida (Universitat Autònoma de Barcelona. Institut de Neurociències)
Physical exercise can reduce the cognitive decline associated with traumatic brain injury, yet little is known about the optimal administration schedules. Here, different protocols of voluntary wheel running were evaluated for their effects on object recognition memory (ORM), neuroprotection (NeuN+ cells), microglial reactivity (Iba1 staining) and neurogenesis (DCX+ cells) after controlled cortical impact injury (CCI). [...]
2020 -  10.1016/j.expneurol.2020.113178
Experimental Neurology, Vol. 326 (2020)
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11 p, 958.8 KB |
Effects of Mediterranean diet or mindfulness-based stress reduction on fetal and neonatal brain development : a secondary analysis of a randomized clinical trial
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Nakaki, Ayako (Hospital Clínic i Provincial de Barcelona) ;
Crovetto, Francesca (Hospital Clínic i Provincial de Barcelona) ;
Urru, Andrea (Universitat Pompeu Fabra) ;
Piella, Gemma (Universitat Pompeu Fabra) ;
Borras, Roger (Universitat Autònoma de Barcelona. Departament de Matemàtiques) ;
Comte, Valentin (Universitat Pompeu Fabra) ;
Vellvé, Kilian (Hospital Clínic i Provincial de Barcelona) ;
Paules, Cristina (Hospital Clínic i Provincial de Barcelona) ;
Segalés, Laura (Hospital Clínic i Provincial de Barcelona) ;
Dacal, Marta (Hospital Clínic i Provincial de Barcelona) ;
Gomez, Yvan (Hospital Clínic i Provincial de Barcelona) ;
Youssef, Lina (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ;
Casas, Rosa (Hospital Clínic i Provincial de Barcelona) ;
Castro-Barquero, Sara (Hospital Clínic i Provincial de Barcelona) ;
Martín-Asuero, Andrés (Instituto esMindfulness, Barcelona) ;
Oller Guzmán, Teresa (Instituto esMindfulness, Barcelona) ;
Morilla, I. (Hospital Clínic i Provincial de Barcelona) ;
Martínez-Àran, Anabel (Hospital Clínic i Provincial de Barcelona) ;
Camacho, Alba (Hospital Clínic i Provincial de Barcelona) ;
Pascual Tutusaus, Mireia (Hospital Clínic i Provincial de Barcelona) ;
Arranz, Angela (Hospital Clínic i Provincial de Barcelona) ;
Rebollo-Polo, Monica (Institut de Recerca Sant Joan de Dèu) ;
Gomez-Chiari, Marta (Hospital Sant Joan de Déu (Manresa)) ;
Bargalló, Núria (Hospital Clínic i Provincial de Barcelona) ;
Pozo, Óscar J. (Institut Hospital del Mar d'Investigacions Mèdiques) ;
Gomez-Gomez, A (Institut Hospital del Mar d'Investigacions Mèdiques) ;
Izquierdo Renau, Montserrat (Universitat de Barcelona) ;
Eixarch, Elisenda (Hospital Clínic i Provincial de Barcelona) ;
Vieta, Eduard (Hospital Clínic i Provincial de Barcelona) ;
Estruch, Ramon (Hospital Clínic i Provincial de Barcelona) ;
Crispi, Fatima (Hospital Clínic i Provincial de Barcelona) ;
Gonzalez-Ballester, Miguel Angel (Universitat Pompeu Fabra) ;
Gratacós, Eduard (Hospital Clínic i Provincial de Barcelona)
BACKGROUND: Maternal suboptimal nutrition and high stress levels are associated with adverse fetal and infant neurodevelopment. OBJECTIVE: This study aimed to investigate if structured lifestyle interventions involving a Mediterranean diet or mindfulness-based stress reduction during pregnancy are associated with differences in fetal and neonatal brain development. [...]
2023 - 10.1016/j.ajogmf.2023.101188
American journal of obstetrics & gynecology, maternal-fetal medicine, Vol. 5 Núm. 12 (december 2023)
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28 p, 796.7 KB |
Dissecting ultra-processed foods and drinks : Do they have a potential to impact the brain?
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Contreras Rodríguez, Oren (Universitat Autònoma de Barcelona. Departament de Psiquiatria i de Medicina Legal) ;
Solanas i Garcia, Montserrat (Universitat Autònoma de Barcelona. Departament de Biologia Cel·lular, de Fisiologia i d'Immunologia) ;
Escorihuela Agullo, Rosa Maria (Universitat Autònoma de Barcelona. Departament de Psiquiatria i de Medicina Legal)
Ultra-processed foods and drinks (UPF) are formulation of ingredients, mostly of exclusive industrial use, that result from a series of industrial processes. They usually have a low nutrient but high energy density, with a high content of saturated and trans fats, and added sugars. [...]
2022 - 10.1007/s11154-022-09711-2
Reviews in endocrine and metabolic disorders, Vol. 23 Núm. 4 (august 2022) , p. 697-717
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5.
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36 p, 1.1 MB |
New Pieces for an Old Puzzle : Approaching Parkinson's Disease from Translatable Animal Models, Gut Microbiota Modulation, and Lipidomics
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Ortega Moreno, Lorena (University Rey Juan Carlos) ;
Bagues, Ana (University Rey Juan Carlos) ;
Martínez Perea, Vicente (Universitat Autònoma de Barcelona. Departament de Biologia Cel·lular, de Fisiologia i d'Immunologia) ;
Abalo, Raquel (University Rey Juan Carlos) ;
Universitat Autònoma de Barcelona.
Institut de Neurociències
Parkinson's disease (PD) is a severe neurodegenerative disease characterized by disabling motor alterations that are diagnosed at a relatively late stage in its development, and non-motor symptoms, including those affecting the gastrointestinal tract (mainly constipation), which start much earlier than the motor symptoms. [...]
2023 - 10.3390/nu15122775
Nutrients, Vol. 15, Num. 12 (June 2023) , art. 2775
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6.
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40 p, 6.4 MB |
Roadmap on nanomedicine for the central nervous system
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Ciofani, Gianni (Italian Institute of Technology) ;
Campisi, Marco (Polytechnic University of Turin) ;
Mattu, Clara (Polytechnic University of Turin) ;
Kamm, Roger D. (Massachusetts Institute of Technology) ;
Chiono, Valeria (Polytechnic University of Turin) ;
Raynold, Aji Alex Moothedathu (University of Coimbra) ;
Freitas, João S. (University of Coimbra) ;
Redolfi Riva, Eugenio (Scuola Superiore Sant'Anna) ;
Micera, Silvestro (Scuola Superiore Sant'Anna) ;
Pucci, Carlotta (Italian Institute of Technology) ;
Novio Vázquez, Fernando (Universitat Autònoma de Barcelona. Departament de Química) ;
Lorenzo Rivera, Julia (Universitat Autònoma de Barcelona. Institut de Biotecnologia i de Biomedicina "Vicent Villar Palasí") ;
Ruiz-Molina, Daniel (Institut Català de Nanociència i Nanotecnologia) ;
Sierri, Giulia (University of Milano-Bicocca) ;
Re, Francesca (University of Milano-Bicocca) ;
Wunderlich, Hannah (Technical University of Munich) ;
Kumari, Prachi (Technical University of Munich) ;
Kozielski, Kristen L. (Technical University of Munich) ;
Chami, Mounia (Institut de Pharmacologie Moléculaire et Cellulaire) ;
Marino, Attilio (Italian Institute of Technology) ;
Ferreira, Lino (University of Coimbra) ;
Universitat Autònoma de Barcelona.
Departament de Bioquímica i de Biologia Molecular
In recent years, a great deal of effort has been undertaken with regards to treatment of pathologies at the level of the central nervous system (CNS). Here, the presence of the blood-brain barrier acts as an obstacle to the delivery of potentially effective drugs and makes accessibility to, and treatment of, the CNS one of the most significant challenges in medicine. [...]
2023 - 10.1088/2515-7639/acab88
JPhys materials, Vol. 6, Issue 2 (April 2023) , art. 22501
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18 p, 1.0 MB |
Polyoxometalate-Decorated Gold Nanoparticles Inhibit β-Amyloid Aggregation and Cross the Blood-Brain Barrier in a µphysiological Model
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Perxés Perich, Marta (Institut Català de Nanociència i Nanotecnologia) ;
Palma-Florez, Sujey (Institut de Ciència i Tecnologia de Barcelona) ;
Solé, Clara (Institut de Ciència i Tecnologia de Barcelona) ;
Goberna-Ferrón, Sara (Institut Català de Nanociència i Nanotecnologia) ;
Samitier, Josep (Institut de Ciència i Tecnologia de Barcelona) ;
Gómez-Romero, Pedro 1959- (Institut Català de Nanociència i Nanotecnologia) ;
Mir, Mònica (Institut de Ciència i Tecnologia de Barcelona) ;
Lagunas, Anna (Institut de Ciència i Tecnologia de Barcelona)
Alzheimer's disease is characterized by a combination of several neuropathological hallmarks, such as extracellular aggregates of beta amyloid (Aβ). Numerous alternatives have been studied for inhibiting Aβ aggregation but, at this time, there are no effective treatments available. [...]
2023 - 10.3390/nano13192697
Nanomaterials, Vol. 13, Issue 19 (October 2023) , art. 2697
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22 p, 475.4 KB |
Increased thin-spine density in frontal cortex pyramidal neurons in a genetic rat model of schizophrenia-relevant features
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Sánchez González, Ana (Universitat Autònoma de Barcelona. Departament de Psiquiatria i de Medicina Legal) ;
Thougaard, Estrid (Research Laboratory for Stereology and Neuroscience, Bispebjerg Copenhagen University Hospital) ;
Tapias-Espinosa, Carles (Universitat Autònoma de Barcelona. Departament de Psiquiatria i de Medicina Legal) ;
Cañete, Toni (Universitat Autònoma de Barcelona. Departament de Psiquiatria i de Medicina Legal) ;
Sampedro-Viana, Daniel (Universitat Autònoma de Barcelona. Departament de Psiquiatria i de Medicina Legal) ;
Saunders, Justin M. (Department of Physiology and Biophysics, Virginia Commonwealth University School of Medicine) ;
Toneatti, Rudy (Department of Physiology and Biophysics, Virginia Commonwealth University School of Medicine) ;
Tobeña, Adolf 1950- (Universitat Autònoma de Barcelona. Departament de Psiquiatria i de Medicina Legal) ;
Gonzalez-Maeso, Javier (Department of Physiology and Biophysics, Virginia Commonwealth University School of Medicine) ;
Aznar, Susana (Research Laboratory for Stereology and Neuroscience, Bispebjerg Copenhagen University Hospital) ;
Fernández-Teruel, Alberto (Universitat Autònoma de Barcelona. Departament de Psiquiatria i de Medicina Legal) ;
Universitat Autònoma de Barcelona.
Institut de Neurociències
The cellular mechanisms altered during brain wiring leading to cognitive disturbances in neurodevelopmental disorders remain unknown. We have previously reported altered cortical expression of neurodevelopmentally regulated synaptic markers in a genetic animal model of schizophrenia-relevant behavioral features, the Roman-High Avoidance rat strain (RHA-I). [...]
2021 - 10.1016/j.euroneuro.2021.01.006
European neuropsychopharmacology, Vol. 44 (March 2021) , p. 79-91
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51 p, 2.3 MB |
Rewarding deep brain stimulation at the medial forebrain bundle favours avoidance conditioned response in a remote memory test, hinders extinction and increases neurogenesis
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Huguet, Gemma (Universitat de Girona. Departament de Biologia) ;
Kádár, Elisabet (Universitat de Girona. Departament de Biologia) ;
Serrano, Noelia (Universitat Autònoma de Barcelona. Departament de Psicobiologia i de Metodologia de Ciències de la Salut) ;
Tapias-Espinosa, Carles (Universitat Autònoma de Barcelona. Departament de Psiquiatria i de Medicina Legal) ;
García-Brito, Soleil (Universitat Autònoma de Barcelona. Departament de Psicobiologia i de Metodologia de Ciències de la Salut) ;
Morgado-Bernal, Ignacio (Universitat Autònoma de Barcelona. Departament de Psicobiologia i de Metodologia de Ciències de la Salut) ;
Aldavert Vera, Laura (Universitat Autònoma de Barcelona. Departament de Psicobiologia i de Metodologia de Ciències de la Salut) ;
Segura Torres, Pilar (Universitat Autònoma de Barcelona. Departament de Psicobiologia i de Metodologia de Ciències de la Salut) ;
Universitat Autònoma de Barcelona.
Institut de Neurociències
Intracranial Self-Stimulation (ICSS) at the medial forebrain bundle consistently facilitates learning and memory in rats when administered post-training or when administered non-concurrent to training, but its scope regarding remote memory has not yet been studied. [...]
2020 - 10.1016/j.bbr.2019.112308
Behavioural Brain Research, Vol. 378 (2020) , p. 112308
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22 p, 986.7 KB |
Primary fatty amides in plasma associated with brain amyloid burden, hippocampal volume, and memory in the European Medical Information Framework for Alzheimer's Disease biomarker discovery cohort
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Kim, Min (Steno Diabetes Center Copenhagen) ;
Snowden, Stuart (University of Cambridge) ;
Suvitaival, Tommi (Steno Diabetes Center Copenhagen) ;
Ali, Ashfaq (Steno Diabetes Center Copenhagen) ;
Merkler, David J. (University of South Florida) ;
Ahmad, Tahmina (King's College London) ;
Westwood, Sarah (University of Oxford) ;
Baird, Alison (University of Oxford) ;
Proitsi, Petroula (King's College London) ;
Nevado-Holgado, Alejo (University of Oxford) ;
Hye, Abdul (Steno Diabetes Center Copenhagen) ;
Bos, Isabelle (Maastricht University) ;
Vos, Stephanie (Maastricht University) ;
Vandenberghe, Rik (University Hospitals Leuven (Bèlgica)) ;
Teunissen, Charlotte (Amsterdam Neuroscience) ;
ten Kate, Mara (Amsterdam Neuroscience) ;
Scheltens, Philip (Amsterdam UMC. University Medical Center) ;
Gabel, Silvy (KU Leuven) ;
Meersmans, Karen (KU Leuven) ;
Blin, Olivier ;
Richardson, Jill (GlaxoSmithKline R&D) ;
De Roeck, Ellen (University of Antwerp) ;
Sleegers, Kristel (VIB) ;
Bordet, Régis (University of Lille) ;
Rami Gonzalez, Lorena (Hospital Clínic i Provincial de Barcelona) ;
Kettunen, Petronella (John Radcliffe Hospital (Oxford, Regne Unit)) ;
Tsolaki, Magda (AHEPA University Hospital (Grècia)) ;
Verhey, Frans (Maastricht University) ;
Sala, Isabel (Institut d'Investigació Biomèdica Sant Pau) ;
Lleó, Alberto (Institut d'Investigació Biomèdica Sant Pau) ;
Peyratout, Gwendoline (Lausanne University Hospital) ;
Tainta, Mikel (CITA-Alzheimer Foundation) ;
Johannsen, Peter (Copenhagen University Hospital) ;
Freund-Levi, Yvonne (Karolinska University Hospital and Karolinska Institutet (Suecia)) ;
Frölich, Lutz (University of Heidelberg) ;
Dobricic, Valerija (University of Lübeck) ;
Engelborghs, Sebastiaan (University Hospital Antwerp (Bèlgica)) ;
Frisoni, Giovanni B. (University of Geneva) ;
Molinuevo, José Luis (Hospital Clínic i Provincial de Barcelona) ;
Wallin, Anders (University of Gothenburg) ;
Popp, Julius (Geneva University Hospitals) ;
Martinez-Lage, Pablo (CITA-Alzheimer Foundation) ;
Bertram, Lars (University of Lübeck) ;
Barkhof, Frederik (Amsterdam Neuroscience) ;
Ashton, Nicholas J (University of Gothenburg) ;
Blennow, Kaj (Sahlgrenska University Hospital (Suècia)) ;
Zetterberg, Henrik (UK Dementia Research Institute) ;
Streffer, Johannes (Janssen Pharmaceutical Companies) ;
Visser, Pieter J. (Amsterdam Neuroscience) ;
Lovestone, Simon (University of Oxford) ;
Legido-Quigley, Cristina (Steno Diabetes Center Copenhagen) ;
Universitat Autònoma de Barcelona
A critical and as-yet unmet need in Alzheimer's disease (AD) is the discovery of peripheral small molecule biomarkers. Given that brain pathology precedes clinical symptom onset, we set out to test whether metabolites in blood associated with pathology as indexed by cerebrospinal fluid (CSF) AD biomarkers. [...]
2019 - 10.1016/j.jalz.2019.03.004
Alzheimer's & Dementia, Vol. 15 Núm. 6 (june 2019) , p. 817-827
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