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9 p, 1012.4 KB |
Plasma Aβ42/40 ratio alone or combined with FDG-PET can accurately predict amyloid-PET positivity : A cross-sectional analysis from the AB255 Study
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Pérez-Grijalba, Virginia (Araclon Biotech S.L.) ;
Arbizu, Javier (Clínica Universidad de Navarra) ;
Romero, Judith (Araclon Biotech S.L.) ;
Prieto, Elena (Clínica Universidad de Navarra) ;
Pesini, Pedro (Araclon Biotech S.L.) ;
Sarasa, Leticia (Araclon Biotech S.L.) ;
Guillen, Fernando (Clínica Universidad de Navarra) ;
Monleón, Inmaculada (Araclon Biotech S.L.) ;
San-José, Itziar (Araclon Biotech S.L.) ;
Martínez-Lage, Pablo (Fundación CITA-Alzheimer) ;
Munuera, Josep (Institut de Recerca Sant Joan de Déu) ;
Hernández, Isabel (Instituto de Salud Carlos III) ;
Buendía, Mar (Universitat Internacional de Catalunya) ;
Sotolongo-Grau, Oscar (Universitat Internacional de Catalunya) ;
Alegret, Montserrat (Instituto de Salud Carlos III) ;
Ruiz, Agustín (Instituto de Salud Carlos III) ;
Tárraga, Lluís (Instituto de Salud Carlos III) ;
Boada, Mercè (Instituto de Salud Carlos III) ;
Sarasa, Manuel (Araclon Biotech S.L.) ;
Goñi Imízcoz, Miguel (Hospital Divino Vallés (Burgos)) ;
Pujadas, Francesc ;
Villarejo, Alberto ;
Frank, Ana ;
Peña-Casanova, Jordi ;
Fernández, Manuel ;
Piñol, Gerard ;
Blesa, Rafael (Institut d'Investigació Biomèdica Sant Pau) ;
Gil, Pedro ;
Pascual, Luis F. ;
Aguilar Barberà, Miquel ;
Frisoni, Giovanni B. ;
Matias-Guiu, Jorge ;
Andreasen, Niels ;
Antúnez, Carmen ;
Universitat Autònoma de Barcelona
To facilitate population screening and clinical trials of disease-modifying therapies for Alzheimer's disease, supportive biomarker information is necessary. This study was aimed to investigate the association of plasma amyloid-beta (Aβ) levels with the presence of pathological accumulation of Aβ in the brain measured by amyloid-PET. [...]
2019 -  10.1186/s13195-019-0549-1
Alzheimer's research & therapy, Vol. 11 Núm. 1 (january 2019) , p. 96
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16 p, 3.7 MB |
Altered brain metabolome is associated with memory impairment in the rTG4510 mouse model of tauopathy
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Tondo, Mireia (Institut d'Investigació Biomèdica Sant Pau) ;
Wasek, Brandi (Baylor Scott & White Research Institute) ;
Escolà-Gil, Joan Carles (Institut d'Investigació Biomèdica Sant Pau) ;
Gonzalo Calvo, David de (Hospital de la Santa Creu i Sant Pau (Barcelona, Catalunya)) ;
Harmon, Clinton (Baylor Scott & White Research Institute) ;
Arning, Erland (Baylor Scott & White Research Institute) ;
Bottiglieri, Teodoro (Baylor Scott & White Research Institute) ;
Universitat Autònoma de Barcelona
Alzheimer's disease (AD) is characterized, amongst other features, by the pathologic accumulation of abnormally phosphorylated tau filaments in neurons that lead to neurofibrillary tangles. However, the molecular mechanisms by which the abnormal processing of tau leads to neurodegeneration and cognitive impairment remain unknown. [...]
2020 - 10.3390/metabo10020069
Metabolites, Vol. 10 Núm. 2 (february 2020) , p. 69
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10 p, 876.7 KB |
Measuring cognitive impairment and monitoring cognitive decline in Huntington's disease : a comparison of assessment instruments
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Horta, Andrea (Universitat Autònoma de Barcelona. Departament de Medicina) ;
Martinez-Horta, Saul (Universitat Autònoma de Barcelona. Departament de Medicina) ;
Pérez-Pérez, Jesús (Universitat Autònoma de Barcelona. Departament de Medicina) ;
Puig-Davi, Arnau (Institut d'Investigació Biomèdica Sant Pau) ;
de Lucia, Natascia (University of Naples "Federico II", Naples, Italy) ;
de Michele, Giuseppe (University of Naples "Federico II", Naples, Italy) ;
Salvatore, Elena (University of Naples "Federico II", Naples, Italy) ;
Kehrer, Stefanie (Charité-Universitätsmedizin, Berlin, Germany) ;
Priller, Josef (Charité-Universitätsmedizin, Berlin, Germany) ;
Migliore, Simone (Fondazione IRCCS Casa Sollievo Della Sofferenza Research Hospital, San Giovanni Rotondo, Italy) ;
Squitieri, Ferdinando (Fondazione IRCCS Casa Sollievo Della Sofferenza Research Hospital, San Giovanni Rotondo, Italy) ;
Castaldo, Ana (Fondazione IRCCS Istituto Neurologico Carlo Besta, Milan, Italy) ;
Mariotti, Caterina (Fondazione IRCCS Istituto Neurologico Carlo Besta, Milan, Italy) ;
Mañanes, Verónica (Hospital Universitario Ramon Y Cajal) ;
Lopez-Sendon, José Luís (Hospital Universitario Ramon Y Cajal) ;
Rodriguez, Noelia (Fundación Jimenez Diaz) ;
Martinez-Descals, Asunción (Fundación Jimenez Diaz) ;
Júlio, Filipa (Coimbra University Hospital) ;
Januário, Cristina (Coimbra University Hospital) ;
Delussi, marianna (European Huntington's Disease Network (EHDN), Ulm, Germany) ;
de Tommaso, Marina (European Huntington's Disease Network (EHDN), Ulm, Germany) ;
Noguera, Sandra (Hospital Mare de Deu de La Mercè) ;
Ruiz-Idiago, Jesús (Hospital Mare de Deu de La Mercè) ;
Sitek, Emilia J. (St. Adalbert Hospital, Copernicus, Gdańsk, Poland) ;
Wallner, Renata (Medical University of Wroclaw, Wroclaw, Poland) ;
Nuzzi, Angela (European Huntington's Disease Network (EHDN), Ulm, Germany) ;
Pagonabarraga Mora, Javier (Universitat Autònoma de Barcelona. Departament de Medicina) ;
Kulisevsky, Jaime (Universitat Autònoma de Barcelona. Departament de Medicina)
Background: Progressive cognitive decline is an inevitable feature of Huntington's disease (HD) but specific criteria and instruments are still insufficiently developed to reliably classify patients into categories of cognitive severity and to monitor the progression of cognitive impairment. [...]
2023 - 10.1007/s00415-023-11804-0
Journal of Neurology, Vol. 270, Num. 11 (november 2023) , p. 5408-5417
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10 p, 841.1 KB |
Efficacy and safety clinical trial with efavirenz in patients diagnosed with adult Niemann-pick type C with cognitive impairment
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Gascon-Bayarri, Jordi (Hospital Universitari de Bellvitge) ;
Simon, Petru Cristian (Hospital Universitari de Bellvitge) ;
Llop, Roser (Hospital Universitari de Bellvitge) ;
Carnaval, Thiago (Hospital Universitari de Bellvitge) ;
Ledesma, María Dolores (Centro de Biología Molecular Severo Ochoa) ;
Rico, Imma (Hospital Universitari de Bellvitge) ;
Sánchez-Castañeda, Cristina (Hospital Universitari de Bellvitge) ;
Campdelacreu, Jaume (Hospital Universitari de Bellvitge) ;
Calvo-Malvar, Nahum (Hospital Universitari de Bellvitge) ;
Cos, Mònica (Hospital Universitari de Bellvitge) ;
de Lama, Eugenia (Hospital Universitari de Bellvitge) ;
Cortés-Romera, Montserrat (Hospital Universitari de Bellvitge) ;
Rodríguez-Bel, Laura (Hospital Universitari de Bellvitge) ;
Pérez-Sousa, Celia (Complejo Hospitalario Universitario de A Coruña) ;
Cerdán Sánchez, María (Hospital General Universitario Santa María del Rosell) ;
Muelas, Nuria (Hospital Universitari i Politècnic La Fe (València)) ;
Sevillano, María Dolores (Hospital Universitario de Salamanca) ;
Mir, Pablo (Universidad de Sevilla) ;
López de Munain, Adolfo (Hospital de Donostia (Sant Sebastià, País Basc)) ;
Ferrer, Anna (Hospital Universitari de Bellvitge) ;
Videla, Sebastián (Hospital Universitari de Bellvitge) ;
Universitat Autònoma de Barcelona
Niemann-Pick disease Type C (NPC) is a genetic, incurable, neurodegenerative disorder. This orphan disease is most frequently caused by mutations in the NPC1 protein, resulting in intralysossomal cholesterol accumulation. [...]
2022 - 10.1097/MD.0000000000031471
Medicine, Vol. 101 (december 2022)
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22 p, 3.7 MB |
A 3D deep learning model to predict the diagnosis of dementia with Lewy bodies, Alzheimer's disease, and mild cognitive impairment using brain 18F-FDG PET
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Etminani, Kobra (Center for Applied Intelligent Systems Research (CAISR). Halmstad University) ;
Soliman, Amira (Center for Applied Intelligent Systems Research (CAISR). Halmstad University) ;
Davidsson, Anette (Department of Clinical Physiology. Department of Health. Medicine and Caring Sciences. Linköping University) ;
Chang, Jose R. (National Cheng Kung University in Tainan) ;
Martínez-Sanchis, Begoña (Hospital Universitari i Politècnic La Fe (València)) ;
Byttner, Stefan (Center for Applied Intelligent Systems Research (CAISR). Halmstad University) ;
Camacho, Valle (Institut d'Investigació Biomèdica Sant Pau) ;
Bauckneht, Matteo (Nuclear Medicine Unit. IRCCS Ospedale Policlinico San Martino) ;
Stegeran, Roxana (Department of Diagnostic Radiology. Linköping University Hospital) ;
Ressner, Marcus (Department of Medical Physics. Linköping University Hospital) ;
Agudelo-Cifuentes, Marc (Hospital Universitari i Politècnic La Fe (València)) ;
Chincarini, Andrea (National Institute of Nuclear Physics (INFN)) ;
Brendel, Matthias (Department of Nuclear Medicine. University Hospital. LMU Munich) ;
Rominger, Axel (Department of Nuclear Medicine. Inselspital. University Hospital Bern) ;
Bruffaerts, Rose (Biomedical Research Institute. Hasselt University) ;
Vandenberghe, Rik (Neurology Department. University Hospitals Leuven) ;
Kramberger, Milica G. (Department of Neurology. University Medical Centre) ;
Trost, Maja (Univerza V Ljubljani) ;
Nicastro, Nicolas (Department of Clinical Neurosciences. Geneva University Hospitals) ;
Frisoni, Giovanni B. (LANVIE (Laboratoire de Neuroimagerie du Vieillissement). Department of Psychiatry. University Hospitals) ;
Lemstra, Afina W. (Department of Neurology. Alzheimer Center) ;
van Berckel, Bart N.M. (Department of Radiology & Nuclear Medicine. Amsterdam UMC. location VUmc) ;
Pilotto, Andrea (Parkinson's Disease Rehabilitation Centre) ;
Padovani, Alessandro (Neurology Unit. Department of Clinical and Experimental Sciences. University of Brescia) ;
Morbelli, Silvia (Department of Health Sciences. University of Genoa) ;
Aarsland, Dag (Department of Old Age Psychiatry. Institute of Psychiatry. Psychology and Neuroscience. King's College London) ;
Nobili, Flavio (Clinical Neurology. IRCCS Ospedale Policlinico San Martino) ;
Garibotto, Valentina (Division of Nuclear Medicine and Molecular Imaging. University Hospitals of Geneva and NIMTLab. Faculty of Medicine. University of Geneva) ;
Ochoa-Figueroa, Miguel (Center for Medical Image Science and Visualization (CMIV). Linköping University) ;
Universitat Autònoma de Barcelona
Purpose: The purpose of this study is to develop and validate a 3D deep learning model that predicts the final clinical diagnosis of Alzheimer's disease (AD), dementia with Lewy bodies (DLB), mild cognitive impairment due to Alzheimer's disease (MCI-AD), and cognitively normal (CN) using fluorine 18 fluorodeoxyglucose PET (18F-FDG PET) and compare model's performance to that of multiple expert nuclear medicine physicians' readers. [...]
2022 - 10.1007/s00259-021-05483-0
European Journal of Nuclear Medicine and Molecular Imaging, Vol. 49 Núm. 2 (january 2022) , p. 563-584
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19 p, 5.2 MB |
Plasma extracellular vesicles reveal early molecular differences in amyloid positive patients with early-onset mild cognitive impairment
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Cano, Amanda (Centro de Investigación Biomédica en Red sobre Enfermedades Neurodegenerativas) ;
Esteban-De Antonio, Ester (Universitat Internacional de Catalunya) ;
Bernuz, Mireia (Universitat Autònoma de Barcelona. Departament de Química) ;
Puerta, Raquel (Universitat Internacional de Catalunya) ;
García-González, Pablo (Centro de Investigación Biomédica en Red sobre Enfermedades Neurodegenerativas) ;
De Rojas, Itziar (Centro de Investigación Biomédica en Red sobre Enfermedades Neurodegenerativas) ;
Olivé, Claudia (Universitat Internacional de Catalunya. Ace Alzheimer Center Barcelona) ;
Pérez-Cordón, Alba (Universitat Internacional de Catalunya) ;
Montrreal, Laura (Universitat Internacional de Catalunya) ;
Núñez-Llaves, Raúl (Universitat Internacional de Catalunya) ;
Sotolongo Grau, Oscar (Universitat Internacional de Catalunya) ;
Alarcón-Martín, Emilio (Universitat Internacional de Catalunya) ;
Valero, Sergi (Centro de Investigación Biomédica en Red sobre Enfermedades Neurodegenerativas) ;
Alegret, Montserrat (Centro de Investigación Biomédica en Red sobre Enfermedades Neurodegenerativas) ;
Martín, Elvira (Universitat Internacional de Catalunya) ;
Martino-Adami, Pamela V. (University of Cologne. Department of Psychiatry and Psychotherapy) ;
Ettcheto, Miren (Universitat de Barcelona. Institut de Neurociències) ;
Camins, Antoni (Universitat de Barcelona. Institut de Neurociències) ;
Vivas, Assumpta (Clínica Corachan) ;
Gomez-Chiari, Marta (Clínica Corachan) ;
Tejero, Miguel Ángel (Clínica Corachan) ;
Orellana, Adelina (Centro de Investigación Biomédica en Red sobre Enfermedades Neurodegenerativas) ;
Tárraga, Lluís (Centro de Investigación Biomédica en Red sobre Enfermedades Neurodegenerativas) ;
Marquié, Marta (Centro de Investigación Biomédica en Red sobre Enfermedades Neurodegenerativas) ;
Ramirez, Alfredo (Cluster of Excellence Cellular Stress Responses in Aging-Associated Diseases (CECAD), University of Cologne) ;
Martí, Mercè (Universitat Autònoma de Barcelona. Departament de Química) ;
Pividori, María Isabel (Universitat Autònoma de Barcelona. Institut de Biotecnologia i de Biomedicina "Vicent Villar Palasí") ;
Boada, Mercè (Centro de Investigación Biomédica en Red sobre Enfermedades Neurodegenerativas) ;
Ruiz, Agustín (Centro de Investigación Biomédica en Red sobre Enfermedades Neurodegenerativas)
In the clinical course of Alzheimer's disease (AD) development, the dementia phase is commonly preceded by a prodromal AD phase, which is mainly characterized by reaching the highest levels of Aβ and p-tau-mediated neuronal injury and a mild cognitive impairment (MCI) clinical status. [...]
2023 - 10.1186/s12951-023-01793-7
Journal of nanobiotechnology, Vol. 21 (February 2023) , art. 54
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12 p, 1.4 MB |
Macular vessel density in the superficial plexus is not associated to cerebrospinal fluid core biomarkers for Alzheimer's disease in individuals with mild cognitive impairment : The NORFACE cohort
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Marquié, Marta (Centro de Investigación Biomédica en Red sobre Enfermedades Neurodegenerativas) ;
García-Sánchez, Ainhoa (Universitat Internacional de Catalunya) ;
Alarcón-Martín, Emilio (Universitat Internacional de Catalunya) ;
Martínez, Joan (Universitat Internacional de Catalunya) ;
Castilla Marti, Miguel (Clínica Oftalmológica Dr. Castilla) ;
Castilla-Martí, Luis (Universitat Autònoma de Barcelona. Departament de Cirurgia) ;
Orellana, Adelina (Centro de Investigación Biomédica en Red sobre Enfermedades Neurodegenerativas) ;
Montrreal, Laura (Universitat Internacional de Catalunya) ;
De Rojas, Itziar (Centro de Investigación Biomédica en Red sobre Enfermedades Neurodegenerativas) ;
García-González, Pablo (Centro de Investigación Biomédica en Red sobre Enfermedades Neurodegenerativas) ;
Puerta, Raquel (Universitat Internacional de Catalunya) ;
Olivé, Clàudia (Universitat Internacional de Catalunya) ;
Cano, Amanda (Centro de Investigación Biomédica en Red sobre Enfermedades Neurodegenerativas) ;
Hernández, Isabel (Universitat Internacional de Catalunya) ;
Rosende-Roca, Maitée (Universitat Internacional de Catalunya) ;
Vargas, Liliana (Universitat Internacional de Catalunya) ;
Tartari, Juan Pablo (Universitat Internacional de Catalunya) ;
Esteban-De Antonio, Ester (Universitat Internacional de Catalunya) ;
Bojaryn, Urszula (Universitat Internacional de Catalunya) ;
Ricciardi, Mario (Universitat Internacional de Catalunya) ;
Ariton, Diana María (Universitat Internacional de Catalunya) ;
Pytel, Vanesa (Universitat Internacional de Catalunya) ;
Alegret, Montserrat (Centro de Investigación Biomédica en Red sobre Enfermedades Neurodegenerativas) ;
Ortega, Gemma (Centro de Investigación Biomédica en Red sobre Enfermedades Neurodegenerativas) ;
Espinosa, Ana (Centro de Investigación Biomédica en Red sobre Enfermedades Neurodegenerativas) ;
Pérez-Cordón, Alba (Universitat Internacional de Catalunya) ;
Sanabria, Ángela (Centro de Investigación Biomédica en Red sobre Enfermedades Neurodegenerativas) ;
Muñoz, Nathalia (Universitat Internacional de Catalunya) ;
Lleonart, Núria (Universitat Internacional de Catalunya) ;
Aguilera, Núria (Universitat Internacional de Catalunya) ;
Tárraga, Lluís (Centro de Investigación Biomédica en Red sobre Enfermedades Neurodegenerativas) ;
Valero, Sergi (Centro de Investigación Biomédica en Red sobre Enfermedades Neurodegenerativas) ;
Ruiz, Agustín (Centro de Investigación Biomédica en Red sobre Enfermedades Neurodegenerativas) ;
Boada, Mercè (Centro de Investigación Biomédica en Red sobre Enfermedades Neurodegenerativas)
Optical coherence tomography angiography (OCT-A) is a novel method in the dementia field that allows the detection of retinal vascular changes. The comparison of OCT-A measures with established Alzheimer's disease (AD)-related biomarkers is essential to validate the former as a marker of cerebrovascular impairment in the AD continuum. [...]
2023 - 10.3389/fnins.2023.1076177
Frontiers in Neuroscience, Vol. 17 (february 2023)
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11 p, 2.4 MB |
The effects of white matter hyperintensities on MEG power spectra in population with mild cognitive impairment
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Torres-Simon, Lucia (Universidad Complutense de Madrid. Departamento de Psicología Experimental) ;
Cuesta, Pablo (Instituto de Investigación Sanitaria del Hospital Clínico San Carlos) ;
del Cerro-Leon, Alberto (Universidad Complutense de Madrid. Departamento de Psicología Experimental) ;
Chino, Brenda (Universitat Autònoma de Barcelona. Institut de Neurociències) ;
Orozco, Lucia H. (Universidad Complutense de Madrid. Centro de Neurociencia Cognitiva y Computacional) ;
Marsh, Elisabeth B. (Department of Neurology, The Johns Hopkins School of Medicine) ;
Gil Gregorio, Pedro (Hospital Universitario Clínico San Carlos (Madrid)) ;
Maestu, Fernando (Instituto de Investigación Sanitaria del Hospital Clínico San Carlos)
Cerebrovascular disease is responsible for up to 20% of cases of dementia worldwide, but also it is a major comorbid contributor to the progression of other neurodegenerative diseases, like Alzheimer's disease. [...]
2023 - 10.3389/fnhum.2023.1068216
Frontiers in human neuroscience, Vol. 17 (february 2023)
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