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12 p, 280.0 KB |
Alzheimer's disease research progress in the Mediterranean region : The Alzheimer's Association International Conference Satellite Symposium
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Sexton, Claire (Alzheimer's Association (Illinois, Estats Units)) ;
Solis, Michele (Freelance science writer (Washington, Estats Units)) ;
Aharon-Peretz, Judith (Rappapaort School of Medicine (Haifa, Israel)) ;
Alexopoulos, Panagiotis (University of Patras (Grècia)) ;
Apostolova, Liana G. (Indiana University (Bloomington, Estats Units)) ;
Bayen, Eléonore (University of California San Francisco (California, Estats Units)) ;
Birkenhager, Betty (University Medical Center Groningen (Groningen, Països Baixos)) ;
Cappa, Stefano (IRCCS Mondino Foundation (Pavia, Itàlia)) ;
Constantinidou, Fofi (University of Cyprus (Nicosia, Xipre)) ;
Fortea, Juan (Institut d'Investigació Biomèdica Sant Pau) ;
Gerritsen, Debby L. (Radboud Medical Center Nijmegen (Nijmegen, Països Baixos)) ;
Hassanin, Hany I. (Ain Shams University (El Caire, Egipte)) ;
Ibáñez, Agustín (Universidad de San Andres & National Scientific and Technical Research Council (CONICET) (Buenos Aires, Argentina)) ;
Ioannidis, Panagiotis (Aristotle University of Thessaloniki (Thessaloniki, Grècia)) ;
Karageorgiou, Elissaios (Neurological Institute of Athens (Atenes, Grècia)) ;
Korczyn, Amos (Tel Aviv University (Tel Aviv, Israel)) ;
Leroi, Iracema (Trinity College Dublin (Dublín, Irlanda)) ;
Lichtwarck, Bjorn (Innlandet Hospital Trust (Ottestad, Noruega)) ;
Logroscino, Giancarlo (University Aldo Moro Bari (Bari, Itàlia)) ;
Lynch, Chris (Alzheimer's Disease International (Londres, Regne Unit))) ;
Mecocci, Patrizia (University of Perugia (Perugia, Itàlia)) ;
Molinuevo, José Luis (Barcelonaβeta Brain Research Center (BBRC)) ;
Papatriantafyllou, John (Ana Aslan International Foundation) ;
Papegeorgiou, Sokratis (National and Kapodistrian University of Athens (Atenes, Grècia)) ;
Politis, Antonis (National and Kapodistrian University of Athens (Atenes, Grècia)) ;
Raman, Rema (University of Southern California (California, Estats Units)) ;
Ritchie, Karen (Institut National de la Santé et de la Recherche Médicale (França)) ;
Sanchez-Juan, Pascual (Hospital Universitario Marqués de Valdecilla (Santander, Cantabria)) ;
Sano, Mary (The Mount Sinai Hospital (New York, Estats Units)) ;
Scarmeas, Nikolas (Columbia University (New York, Estats Units)) ;
Spiru, Luiza (Ana Aslan International Foundation) ;
Stathi, Afroditi (University of Birmingham (Regne Unit)) ;
Tsolaki, Magda (Aristotle University of Thessaloniki (Macedonia, Grècia)) ;
Yener, Gorsev (Izmir University of Economics (Izmir, Turquia)) ;
Zaganas, Ioannis (University of Crete (Creta, Grècia)) ;
Zygouris, Stelios (Centre for Research and Technology Hellas/ Information Technologies Institute (Thessaloniki, Grècia)) ;
Carrillo, Maria (Alzheimer's Association (Illinois, Estats Units)) ;
Universitat Autònoma de Barcelona
As research and services in the Mediterranean region continue to increase, so do opportunities for global collaboration. To support such collaborations, the Alzheimer's Association was due to hold its seventh Alzheimer's Association International Conference Satellite Symposium in Athens, Greece in 2021. [...]
2022 -  10.1002/alz.12588
Alzheimer's & Dementia, Vol. 18 Núm. 10 (october 2022) , p. 1957-1968
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24 p, 6.3 MB |
CD300f immune receptor contributes to healthy aging by regulating inflammaging, metabolism, and cognitive decline
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Evans, Frances (Instituto Pasteur de Montevideo) ;
Alí-Ruiz, Daniela (Instituto Pasteur de Montevideo) ;
Rego, Natalia (Instituto Pasteur de Montevideo) ;
Negro-Demontel, Maria Luciana (Instituto Pasteur de Montevideo) ;
Lago, Natalia (Universitat Autònoma de Barcelona. Departament de Biologia Cel·lular, de Fisiologia i d'Immunologia) ;
Cawen, Fabio Andrés (Instituto Pasteur de Montevideo) ;
Pannunzio, Bruno (Instituto Pasteur de Montevideo) ;
Sanchez-Molina, Paula (Universitat Autònoma de Barcelona. Departament de Biologia Cel·lular, de Fisiologia i d'Immunologia) ;
Reyes, Laura (Centro Uruguayo de Imagenología Molecular) ;
Paolino, Andrea (Centro Uruguayo de Imagenología Molecular) ;
Rodríguez-Duarte, Jorge (Instituto Pasteur de Montevideo) ;
Pérez-Torrado, Valentina (Instituto Pasteur de Montevideo) ;
Chicote-González, Almudena (Universitat de Barcelona. Departament de Biomedicina) ;
Quijano, Celia (Universidad de la República. Departamento de Bioquímica (Montevideo, Uruguay)) ;
Marmisolle, Inés (Universidad de la República. Departamento de Bioquímica (Montevideo, Uruguay)) ;
Mulet, Ana Paula (Instituto Pasteur de Montevideo) ;
Schlapp, Geraldine (Instituto Pasteur de Montevideo) ;
Meikle, Maria Noel (Instituto Pasteur de Montevideo) ;
Bresque, Mariana (Instituto Pasteur de Montevideo) ;
Crispo, Martina (Instituto Pasteur de Montevideo) ;
Savio, Eduardo (Centro Uruguayo de Imagenología Molecular) ;
Malagelada, Cristina (Universitat de Barcelona. Departament de Biomedicina) ;
Escande, Carlos (Instituto Pasteur de Montevideo) ;
Peluffo, Hugo (Instituto Pasteur de Montevideo) ;
Universitat Autònoma de Barcelona.
Institut de Neurociències
Emerging evidence suggests that immune receptors may participate in many aging-related processes such as energy metabolism, inflammation, and cognitive decline. CD300f, a TREM2-like lipid-sensing immune receptor, is an exceptional receptor as it integrates activating and inhibitory cell-signaling pathways that modulate inflammation, efferocytosis, and microglial metabolic fitness. [...]
2023 - 10.1016/j.celrep.2023.113269
Cell reports, Vol. 42 Núm. 10 (2023) , p. 113269
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135 p, 1.9 MB |
Cerebrospinal fluid and blood biomarkers for neurodegenerative dementias : An update of the Consensus of the Task Force on Biological Markers in Psychiatry of the World Federation of Societies of Biological Psychiatry
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Lewczuk, Piotr (University Hospital of Białystok) ;
Riederer, Peter (University Hospital Würzburg) ;
O'Bryant, Sid E. (University of North Texas Health Science Center) ;
Verbeek, Marcel M. (Radboud Alzheimer center) ;
Dubois, Bruno (Salpêtrièrie Hospital) ;
Visser, Pieter Jelle (Vrije Universiteit Amsterdam) ;
Jellinger, Kurt A. (Institute of Clinical Neurobiology) ;
Engelborghs, Sebastiaan (University Hospital Antwerp (Bèlgica)) ;
Ramirez, Alfredo (University of Cologne) ;
Parnetti, Lucilla (University of Perugia) ;
Jack Jr, Clifford R. (Mayo Clinic) ;
Teunissen, Charlotte E. (VU University Medical Center Amsterdam) ;
Hampel, Harald (heimer (IM2A). Hôpital Pitié-Salpêtrière) ;
Lleó, Alberto (Institut d'Investigació Biomèdica Sant Pau) ;
Jessen, Frank (German Center for Neurodegenerative Disorders (DZNE)) ;
Glodzik, Lidia (NYU Langone Medical Center) ;
de Leon, Mony J. (NYU Langone Medical Center) ;
Fagan, Anne M. (Washington University School of Medicine) ;
Molinuevo, José Luis (Hospital Clínic i Provincial de Barcelona) ;
Jansen, Willemijn J. (Maastricht University) ;
Winblad, Bengt (Karolinska Institutet (Estocolm, Suècia)) ;
Shaw, Leslie M. (University of Pennsylvania) ;
Andreasson, Ulf (The Sahlgrenska Academy at the University of Gothenburg) ;
Otto, Markus (University of Ulm) ;
Mollenhauer, Brit (Kassel and University Medical Center Göttingen) ;
Wiltfang, Jens (University of Aveiro) ;
Turner, Martin R. (University of Oxford) ;
Zerr, Inga (German Center for Neurodegenerative Diseases) ;
Handels, Ron (Karolinska Institutet (Estocolm, Suècia)) ;
Thompson, Alexander G. (University of Oxford) ;
Johansson, Gunilla (Karolinska Institutet (Estocolm, Suècia)) ;
Ermann, Natalia (Universitätsklinikum Erlangen. and Friedrich-Alexander Universität Erlangen-Nürnberg) ;
Trojanowski, John Q. (University of Pennsylvania) ;
Karaca, Ilker (University of Bonn) ;
Wagner, Holger (University of Bonn) ;
Oeckl, Patrick (University of Ulm) ;
van Waalwijk van Doorn, Linda (Radboud Alzheimer center) ;
Bjerke, Maria (University of Antwerp) ;
Kapogiannis, Dimitrios (National Institute on Aging/National Institutes of Health (NIA/NIH)) ;
Kuiperij, H.Bea (Radboud Alzheimer center) ;
Farotti, Lucia (University of Perugia) ;
Li, Yi (NYU Langone Medical Center) ;
Gordon, Brian A. (Washington University School of Medicine) ;
Epelbaum, Stéphane (Institut de la Mémoire et de la Maladie d'Alzheimer (IM2A)) ;
Vos, Stephanie J.B. (Maastricht University) ;
Klijn, Catharina J.M. (Radboud Alzheimer Center) ;
Van Nostrand, William E. (Stony Brook University) ;
Minguillon, Carolina (Fundació Pasqual Maragall) ;
Schmitz, Matthias (University Medical School) ;
Gallo, Carla (Universidad Peruana Cayetano Heredia) ;
Lopez Mato, Andrea (Maimonides University) ;
Thibaut, Florence (University Hospital Cochin-Site Tarnier 89 rue d'Assas) ;
Lista, Simone (heimer (IM2A). Hôpital Pitié-Salpêtrière) ;
Alcolea, Daniel (Institut d'Investigació Biomèdica Sant Pau) ;
Zetterberg, Henrik (UCL Institute of Neurology (Regne Unit)) ;
Blennow, Kaj (Sahlgrenska University Hospital (Suècia)) ;
Kornhuber, Johannes (Universitätsklinikum Erlangen) ;
Universitat Autònoma de Barcelona
In the 12 years since the publication of the first Consensus Paper of the WFSBP on biomarkers of neurodegenerative dementias, enormous advancement has taken place in the field, and the Task Force takes now the opportunity to extend and update the original paper. [...]
2018 - 10.1080/15622975.2017.1375556
World Journal of Biological Psychiatry, Vol. 19 Núm. 4 (19 2018) , p. 244-328
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7 p, 663.7 KB |
Common and rare TBK1 variants in early-onset Alzheimer disease in a European cohort
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Verheijen, Jan (University of Antwerp) ;
van der Zee, Julie (University of Antwerp) ;
Gijselinck, Ilse (University of Antwerp) ;
Van den Bossche, Tobi (University Hospital Antwerp (Bèlgica)) ;
Dillen, Lubina (University of Antwerp) ;
Heeman, Bavo (University of Antwerp) ;
Gómez-Tortosa, Estrella (Hospital Universitario Fundación Jiménez Díaz) ;
Lladó, Albert (Hospital Clínic i Provincial de Barcelona) ;
Sanchez-Valle, Raquel (Hospital Clínic i Provincial de Barcelona) ;
Graff, Caroline (Karolinska University Hospital and Karolinska Institutet (Suecia)) ;
Pastor, Pau (Centro de Investigación Biomédica en Red sobre Enfermedades Neurodegenerativas) ;
Pastor, Maria A. (Clínica Universidad de Navarra) ;
Benussi, Luisa (Istituto Centro San Giovanni di Dio-Fatebenefratelli) ;
Ghidoni, Roberta (Istituto Centro San Giovanni di Dio-Fatebenefratelli) ;
Binetti, Giuliano (Istituto Centro San Giovanni di Dio-Fatebenefratelli) ;
Clarimón, Jordi (Hospital de la Santa Creu i Sant Pau (Barcelona, Catalunya)) ;
de Mendonça, Alexandre (University of Lisbon) ;
Gelpi, Ellen (Hospital Clínic i Provincial de Barcelona) ;
Tsolaki, Magda (Aristotle University of Thessaloniki) ;
Diehl-Schmid, Janine (Technische Universität München) ;
Nacmias, Benedetta (University of Florence) ;
Almeida, Maria Rosário (University of Coimbra) ;
Borroni, Barbara (University of Brescia) ;
Matej, Radoslav (Thomayer Hospital in Prague) ;
Ruiz, Agustín (Fundació ACE) ;
Engelborghs, Sebastiaan (University Hospital Antwerp (Bèlgica)) ;
Vandenberghe, Rik (University Hospitals Leuven (Bèlgica)) ;
De Deyn, Peter P. (University Hospital Antwerp (Bèlgica)) ;
Cruts, Marc (University of Antwerp) ;
Van Broeckhoven, Christine (University of Antwerp) ;
Sleegers, Kristel (University of Antwerp) ;
Goeman, Johan ;
Nuytten, Dirk ;
Vandenbulcke, Mathieu ;
Santens, Patrick 700 1_ ;
Sieben, Anne ;
Dermaut, Bart ;
Versijpt, Jan ;
Michotte, Alex ;
Deryck, Olivier ;
Bergmans, Bruno ;
Willems, Christiana ;
Ivanoiu, Adrian ;
Salmon, Eric ;
Alexopoulos, Panagiotis (Technische Universität München) ;
Sorbi, Sandro ;
Bessi, Valentina ;
Bagnoli, Silvia ;
Santana, Isabel ;
Simões do Couto, Frederico ;
Martins, Madalena ;
Thonberg, Häkan ;
Fratiglioni, Laura ;
Padovani, Alessandro ;
Rohan, Zdenek ;
Razquin, Cristina ;
Lorenzo, Elena ;
Iglesias, Elena ;
Seijo-Martínez, Manuel ;
Rene, Ramon ;
Gascon, Jordi ;
Campdelacreu, Jaume ;
Koutroumani, Maria ;
Lleó, Alberto (Institut d'Investigació Biomèdica Sant Pau) ;
Fortea, Juan (Institut d'Investigació Biomèdica Sant Pau) ;
Blesa, Rafael (Institut d'Investigació Biomèdica Sant Pau) ;
Universitat Autònoma de Barcelona
TANK-binding kinase 1 (TBK1) loss-of-function (LoF) mutations are known to cause frontotemporal dementia (FTD) and amyotrophic lateral sclerosis (ALS), often combined with memory deficits early in the disease course. [...]
2018 - 10.1016/j.neurobiolaging.2017.10.012
Neurobiology of Aging, Vol. 62 (february 2018) , p. 245.e1-245.e7
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11 p, 1.1 MB |
Atrophy in the thalamus but not cerebellum is specific for C9orf72 FTD and ALS patients - An atlas-based volumetric MRI study
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Schönecker, Sonja (Ludwig-Maximilians-Universität) ;
Neuhofer, Christiane (Ludwig-Maximilians-Universität) ;
Otto, Markus (University of Ulm) ;
Ludolph, Albert (University of Ulm) ;
Kassubek, Jan (University of Ulm) ;
Landwehrmeyer, Bernhard (University of Ulm) ;
Anderl-Straub, Sarah (University of Ulm) ;
Semler, Elisa (University of Ulm) ;
Diehl-Schmid, Janine (Technical University of Munich) ;
Prix, Catharina (Ludwig-Maximilians-Universität) ;
Vollmar, Christian (Ludwig-Maximilians-Universität) ;
Fortea, Juan (Institut d'Investigació Sant Pau) ;
Huppertz, Hans-Jürgen (Swiss Epilepsy Clinic) ;
Arzberger, Thomas (Ludwig-Maximilians-Universität) ;
Edbauer, Dieter (Munich Cluster for Systems Neurology (SyNergy)) ;
Feddersen, Berend (Ludwig-Maximilians-Universität) ;
Dieterich, Marianne (Munich Cluster for Systems Neurology (SyNergy)) ;
Schroeter, Matthias L. (University Hospital Leipzig) ;
Volk, Alexander E. (University Medical Center Hamburg-Eppendorf) ;
Fließbach, Klaus (University Hospital Bonn (Bonn, Alemanya)) ;
Schneider, Anja (University Hospital Bonn (Bonn, Alemanya)) ;
Kornhuber, Johannes (Friedrich-Alexander University Erlangen-Nürnberg) ;
Maler, Manuel (Friedrich-Alexander University Erlangen-Nürnberg) ;
Prudlo, Johannes (German Center for Neurodegenerative Diseases (DZNE)) ;
Jahn, Holger (AMEOS Klinikum Heiligenhafen) ;
Boeckh-Behrens, Tobias (Technical University of Munich) ;
Danek, Adrian (Ludwig-Maximilians-Universität) ;
Klopstock, Thomas (Ludwig-Maximilians-Universität) ;
Levin, Johannes (German Center for Neurodegenerative Diseases (DZNE)) ;
Universitat Autònoma de Barcelona
The neuropathology of patients with frontotemporal dementia (FTD) or amyotrophic lateral sclerosis (ALS) due to a C9orf72 mutation is characterized by two distinct types of characteristic protein depositions containing either TDP-43 or so-called dipeptide repeat proteins that extend beyond frontal and temporal regions. [...]
2018 - 10.3389/fnagi.2018.00045
Frontiers in aging neuroscience, Vol. 10 Núm. FEB (15 2018) , p. 45
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8 p, 667.2 KB |
Rare nonsynonymous variants in SORT1 are associated with increased risk for frontotemporal dementia
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Philtjens, Stéphanie (University of Antwerp) ;
Van Mossevelde, Sara (Antwerp University Hospital (UZA)) ;
Van der Zee, Julie (University of Antwerp) ;
Wauters, Eline (University of Antwerp) ;
Dillen, Lubina (University of Antwerp) ;
Vandenbulcke, Mathieu (University Hospitals Leuven (Bèlgica)) ;
Vandenberghe, Rik (University Hospitals Leuven (Bèlgica)) ;
Ivanoiu, Adrian (Université Catholique de Louvain) ;
Sieben, Anne (Universitair Ziekenhuis Gent) ;
Willems, Christiana (Jessa Hospital) ;
Benussi, Luisa (Istituto Centro San Giovanni di Dio-Fatebenefratelli) ;
Ghidoni, Roberta (Istituto Centro San Giovanni di Dio-Fatebenefratelli) ;
Binetti, Giuliano (Istituto Centro San Giovanni di Dio-Fatebenefratelli) ;
Borroni, Barbara (University of Brescia) ;
Padovani, Alessandro (University of Brescia) ;
Pastor, Pau (Instituto de Salud Carlos III) ;
Diez-Fairen, Monica (Instituto de Salud Carlos III) ;
Aguilar, Miquel (Instituto de Salud Carlos III) ;
de Mendonça, Alexandre (University of Lisbon) ;
Miltenberger-Miltényi, Gabriel (University of Lisbon) ;
Hernández, Isabel (Universitat Internacional de Catalunya. Institut Català de Neurociències Aplicades) ;
Boada, M. (Universitat Internacional de Catalunya. Institut Català de Neurociències Aplicades) ;
Ruiz, A. (Universitat Internacional de Catalunya. Institut Català de Neurociències Aplicades) ;
Nacmias, B. (University of Florence) ;
Sorbi, S. (IRCCS Don Gnocchi) ;
Almeida, M.Rosario (University of Coimbra) ;
Santana, Isabel (University of Coimbra) ;
Clarimón, Jordi (Hospital de la Santa Creu i Sant Pau (Barcelona, Catalunya)) ;
Lleó, Alberto (Institut d'Investigació Biomèdica Sant Pau) ;
Frisoni, Giovanni B. (IRCCS Fatebenefratelli) ;
Sanchez-Valle, Raquel (Hospital Clínic i Provincial de Barcelona) ;
Llado Plarrumani, Albert (Hospital Clínic i Provincial de Barcelona) ;
Gómez-Tortosa, Estrella (Hospital Universitario Fundación Jiménez Díaz) ;
Gelpi, Ellen (Institut d'Investigacions Biomèdiques August Pi i Sunyer) ;
Van den Broeck, Marleen (University of Antwerp) ;
Peeters, Karin (University of Antwerp) ;
Cras, Patrick (Antwerp University Hospital (UZA)) ;
De Deyn, Peter P. (Middelheim and Hoge Beuken) ;
Engelborghs, Sebastiaan (Middelheim and Hoge Beuken) ;
Cruts, Marc (University of Antwerp) ;
Van Broeckhoven, Christine (University of Antwerp) ;
Universitat Autònoma de Barcelona
We investigated the genetic role of sortilin (SORT1) in frontotemporal dementia (FTD). SORT1 is the neuronal receptor for granulin, encoded by the progranulin gene (GRN), a major causal gene for inherited FTD. [...]
2018 - 10.1016/j.neurobiolaging.2018.02.011
Neurobiology of Aging, Vol. 66 (june 2018) , p. 181.e3-181.e10
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12 p, 1.2 MB |
Plasma biomarkers for amyloid, tau, and cytokines in Down syndrome and sporadic Alzheimer's disease
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Startin, Carla M. (LonDownS Consortium (London Down Syndrome Consortium)) ;
Ashton, Nicholas J. (University of Gothenburg) ;
Hamburg, Sarah (LonDownS Consortium (London Down Syndrome Consortium)) ;
Hithersay, Rosalyn (LonDownS Consortium (London Down Syndrome Consortium)) ;
Wiseman, Frances K. (University College London) ;
Mok, Kin Y. (Hong Kong University of Science and Technology) ;
Hardy, John (University College London) ;
Lleó, Alberto (Institut d'Investigació Biomèdica Sant Pau) ;
Lovestone, Simon (University of Oxford) ;
Parnetti, Lucilla (University of Perugia) ;
Zetterberg, Henrik (UCL Institute of Neurology (Regne Unit)) ;
Hye, Abdul (Maudsley NHS Foundation) ;
Fisher, Elisabeth ;
Nizetic, Dean ;
Tybulewicz, Victor ;
Karmiloff-Smith, Anette ;
Al-Janabi, Tamara ;
Zhang, David ;
Strydom, André (LonDownS Consortium (London Down Syndrome Consortium)) ;
Universitat Autònoma de Barcelona
Down syndrome (DS), caused by chromosome 21 trisomy, is associated with an ultra-high risk of dementia due to Alzheimer's disease (AD), driven by amyloid precursor protein (APP) gene triplication. Understanding relevant molecular differences between those with DS, those with sporadic AD (sAD) without DS, and controls will aid in understanding AD development in DS. [...]
2019 - 10.1186/s13195-019-0477-0
Alzheimer's research & therapy, Vol. 11 Núm. 1 (21 2019) , p. 26
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Primary fatty amides in plasma associated with brain amyloid burden, hippocampal volume, and memory in the European Medical Information Framework for Alzheimer's Disease biomarker discovery cohort
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Kim, Min (Steno Diabetes Center Copenhagen) ;
Snowden, Stuart (University of Cambridge) ;
Suvitaival, Tommi (Steno Diabetes Center Copenhagen) ;
Ali, Ashfaq (Steno Diabetes Center Copenhagen) ;
Merkler, David J. (University of South Florida) ;
Ahmad, Tahmina (King's College London) ;
Westwood, Sarah (University of Oxford) ;
Baird, Alison (University of Oxford) ;
Proitsi, Petroula (King's College London) ;
Nevado-Holgado, Alejo (University of Oxford) ;
Hye, Abdul (Steno Diabetes Center Copenhagen) ;
Bos, Isabelle (Maastricht University) ;
Vos, Stephanie (Maastricht University) ;
Vandenberghe, Rik (University Hospitals Leuven (Bèlgica)) ;
Teunissen, Charlotte (Amsterdam Neuroscience) ;
ten Kate, Mara (Amsterdam Neuroscience) ;
Scheltens, Philip (Amsterdam UMC. University Medical Center) ;
Gabel, Silvy (KU Leuven) ;
Meersmans, Karen (KU Leuven) ;
Blin, Olivier ;
Richardson, Jill (GlaxoSmithKline R&D) ;
De Roeck, Ellen (University of Antwerp) ;
Sleegers, Kristel (VIB) ;
Bordet, Régis (University of Lille) ;
Rami Gonzalez, Lorena (Hospital Clínic i Provincial de Barcelona) ;
Kettunen, Petronella (John Radcliffe Hospital (Oxford, Regne Unit)) ;
Tsolaki, Magda (AHEPA University Hospital (Grècia)) ;
Verhey, Frans (Maastricht University) ;
Sala, Isabel (Institut d'Investigació Biomèdica Sant Pau) ;
Lleó, Alberto (Institut d'Investigació Biomèdica Sant Pau) ;
Peyratout, Gwendoline (Lausanne University Hospital) ;
Tainta, Mikel (CITA-Alzheimer Foundation) ;
Johannsen, Peter (Copenhagen University Hospital) ;
Freund-Levi, Yvonne (Karolinska University Hospital and Karolinska Institutet (Suecia)) ;
Frölich, Lutz (University of Heidelberg) ;
Dobricic, Valerija (University of Lübeck) ;
Engelborghs, Sebastiaan (University Hospital Antwerp (Bèlgica)) ;
Frisoni, Giovanni B. (University of Geneva) ;
Molinuevo, José Luis (Hospital Clínic i Provincial de Barcelona) ;
Wallin, Anders (University of Gothenburg) ;
Popp, Julius (Geneva University Hospitals) ;
Martinez-Lage, Pablo (CITA-Alzheimer Foundation) ;
Bertram, Lars (University of Lübeck) ;
Barkhof, Frederik (Amsterdam Neuroscience) ;
Ashton, Nicholas J (University of Gothenburg) ;
Blennow, Kaj (Sahlgrenska University Hospital (Suècia)) ;
Zetterberg, Henrik (UK Dementia Research Institute) ;
Streffer, Johannes (Janssen Pharmaceutical Companies) ;
Visser, Pieter J. (Amsterdam Neuroscience) ;
Lovestone, Simon (University of Oxford) ;
Legido-Quigley, Cristina (Steno Diabetes Center Copenhagen) ;
Universitat Autònoma de Barcelona
A critical and as-yet unmet need in Alzheimer's disease (AD) is the discovery of peripheral small molecule biomarkers. Given that brain pathology precedes clinical symptom onset, we set out to test whether metabolites in blood associated with pathology as indexed by cerebrospinal fluid (CSF) AD biomarkers. [...]
2019 - 10.1016/j.jalz.2019.03.004
Alzheimer's & Dementia, Vol. 15 Núm. 6 (june 2019) , p. 817-827
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18 p, 851.1 KB |
Clinical outcome measures in dementia with Lewy bodies trials : critique and recommendations
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Rodriguez-Porcel, Federico (Medical University of South Carolina) ;
Wyman-Chick, Kathryn A. (HealthPartners) ;
Abdelnour, Carla (Universitat Autònoma de Barcelona) ;
Toledo, Jon B. (University of Florida) ;
Ferreira, Daniel (Mayo Clinic) ;
Urwyler, Prabitha (University of Bern) ;
Weil, Rimona S. (University College London) ;
Kane, Joseph (Queen's University) ;
Pilotto, Andrea (University of Brescia) ;
Rongve, Arvid (The University of Bergen) ;
Boeve, Bradley (Mayo Clinic) ;
Taylor, John-Paul (Newcastle University) ;
McKeith, Ian (Newcastle University) ;
Aarsland, Dag (King's College London) ;
Lewis, Simon J. G. (University of Sydney)
The selection of appropriate outcome measures is fundamental to the design of any successful clinical trial. Although dementia with Lewy bodies (DLB) is one of the most common neurodegenerative conditions, assessment of therapeutic benefit in clinical trials often relies on tools developed for other conditions, such as Alzheimer's or Parkinson's disease. [...]
2022 - 10.1186/s40035-022-00299-w
Translational Neurodegeneration, Vol. 11 (may 2022)
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Correction : Clinical outcome measures in dementia with Lewy bodies trials: critique and recommendations
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Rodriguez-Porcel, Federico (Medical University of South Carolina) ;
Wyman-Chick, Kathryn A. (HealthPartners) ;
Abdelnour, Carla (Universitat Autònoma de Barcelona) ;
Toledo, Jon B. (University of Florida) ;
Ferreira, Daniel (Mayo Clinic) ;
Urwyler, Prabitha (University of Bern) ;
Weil, Rimona S. (University College London) ;
Kane, Joseph (Queen's University) ;
Pilotto, Andrea (University of Brescia) ;
Rongve, Arvid (The University of Bergen) ;
Boeve, Bradley (Mayo Clinic) ;
Taylor, John-Paul (Newcastle University) ;
McKeith, Ian (Newcastle University) ;
Aarsland, Dag (King's College London) ;
Lewis, Simon J. G. (University of Sydney)
The selection of appropriate outcome measures is fundamental to the design of any successful clinical trial. Although dementia with Lewy bodies (DLB) is one of the most common neurodegenerative conditions, assessment of therapeutic benefit in clinical trials often relies on tools developed for other conditions, such as Alzheimer's or Parkinson's disease. [...]
2022 - 10.1186/s40035-022-00306-0
Translational Neurodegeneration, Vol. 11 (may 2022)
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