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1.
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15 p, 2.7 MB |
Targeting aberrant DNA methylation in mesenchymal stromal cells as a treatment for myeloma bone disease
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García Gómez, Antonio (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ;
Li, Tianlu (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ;
de la Calle-Fabregat, Carlos (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ;
Rodríguez-Ubreva, Javier (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ;
Ciudad, Laura (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ;
Català-Moll, Francesc (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ;
Godoy-Tena, Gerard (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ;
Martín Sánchez, Montserrat (Universidad de Salamanca) ;
San Segundo, Laura (Universidad de Salamanca) ;
Muntión, Sandra (Universidad de Salamanca) ;
Morales, Xabier (Universidad de Navarra) ;
Ortiz de Solórzano, Carlos (Universidad de Navarra) ;
Oyarzabal, Julen (Universidad de Navarra) ;
San José Enériz, Edurne (Universidad de Navarra) ;
Esteller, M (Universitat de Barcelona. Departament de Ciències Fisiològiques) ;
Agirre, Xabier (Universidad de Navarra) ;
Prosper, Felipe (Universidad de Navarra) ;
Garayoa, Mercedes (Universidad de Salamanca) ;
Ballestar, Esteban (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras)
Multiple myeloma (MM) progression and myeloma-associated bone disease (MBD) are highly dependent on bone marrow mesenchymal stromal cells (MSCs). MM-MSCs exhibit abnormal transcriptomes, suggesting the involvement of epigenetic mechanisms governing their tumor-promoting functions and prolonged osteoblast suppression. [...]
2021 -  10.1038/s41467-020-20715-x
Nature communications, Vol. 12 Núm. 1 (december 2021) , p. 421
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2.
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13 p, 766.7 KB |
Early surgery with neuraxial anaesthesia in patients on chronic antiplatelet therapy with a proximal femur fracture : Multicentric randomised clinical trial
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Anaya, Rafael (Institut d'Investigació Biomèdica Sant Pau) ;
Rodriguez Prieto, Mireia (Institut d'Investigació Biomèdica Sant Pau) ;
Millan, Angélica (Institut d'Investigació Biomèdica Sant Pau) ;
Reguant, Francesca (Fundació Althaia) ;
Llorca Garcia, Jordi (Fundació Althaia) ;
Guilabert, Patricia (Hospital Universitari Vall d'Hebron) ;
Ruiz Pardos, Ana (Hospital Clínic i Provincial de Barcelona) ;
Pantoja, Efrain (Institut d'Investigació Biomèdica Sant Pau) ;
Gil Sanchez, José María (Institut d'Investigació Biomèdica Sant Pau) ;
Moral, Victoria (Institut d'Investigació Biomèdica Sant Pau) ;
Merchán Galvis, Ángela María (Institut d'Investigació Biomèdica Sant Pau) ;
Martinez-Zapata, Maria José (Institut d'Investigació Biomèdica Sant Pau) ;
Universitat Autònoma de Barcelona
Background: Patients with proximal femur fracture on antiplatelet treatment benefit from early surgery. Our goal was to perform early surgery under neuraxial anaesthesia when indicated by the platelet function test. [...]
2021 - 10.3390/jcm10225371
Journal of clinical medicine, Vol. 10 Núm. 22 (11 2021) , p. 5371
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3.
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84 p, 17.4 MB |
Calcar femorale variation in extant and fossil hominids : Implications for identifying bipedal locomotion in fossil hominins
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Cazenave, Marine (University of Kent. Skeletal Biology Research Centre) ;
Kivell, Tracy L. (Max Planck Institute for Evolutionary Anthropology. Department of Human Evolution) ;
Pina, Marta (Institut Català de Paleontologia Miquel Crusafont) ;
Begun, David R. (University of Toronto. Department of Anthropology) ;
Skinner, Matthew M. (University of the Witwatersrand. Centre for the Exploration of the Deep Human Journey)
The calcar femorale is an internal bony structure of the proximal femur considered to be functionally related to bipedal locomotion. Among extant primates, the presence of a calcar femorale has been so far documented in extant humans and Pan and, among extinct hominins, in the Late Miocene Orrorin, in a Pliocene Australopithecus, and in a Middle Pleistocene Homo specimen. [...]
2022 - 10.1016/j.jhevol.2022.103183
Journal of human evolution, Vol. 167 (June 2022) , art. 103183
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58 p, 549.3 KB |
New femoral remains of Nacholapithecus kerioi: Implications for intraspecific variation and Miocene hominoid evolution
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Pina Miquel, Marta (Institut Català de Paleontologia Miquel Crusafont) ;
Kikuchi, Yasuhiro (Saga University. Department of Anatomy and Physiology (Japan)) ;
Nakatsukasa, Masato (Kyoto University. Laboratory of Physical Anthropology (Japan)) ;
Nakano, Yoshihiko (Osaka University. Department of Biological Anthropology (Japan)) ;
Kunimatsu, Yutaka (Ryukoku University. Department of Business Administration (Japan)) ;
Ogihara, Naomichi (The University of Tokyo. Department of Biological Sciences (Japan)) ;
Shimizu, Daisuke (Chubu Gakuin University. Faculty of Nursing and Rehabilitation (Japan)) ;
Takano, Tomo (Japan Monkey Centre (Japan)) ;
Tsujikawa, Hiroshi (Tohoku Bunka Gakuen University. Department of Rehabilitation (Japan)) ;
Ishida, Hidemi (Kyoto University (Japan))
The middle Miocene stem kenyapithecine Nacholapithecus kerioi (16-15 Ma; Nachola, Kenya) is represented by a large number of isolated fossil remains and one of the most complete skeletons in the hominoid fossil record (KNM-BG 35250). [...]
2021 - 10.1016/j.jhevol.2021.102982
Journal of human evolution, Vol. 155 (June 2021) , art. 102982
2 documents
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6.
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18 p, 26.7 MB |
Limb bone histology records birth in mammals
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Nacarino-Meneses, Carmen (Institut Català de Paleontologia Miquel Crusafont) ;
Köhler, Meike (Institut Català de Paleontologia Miquel Crusafont)
The annual cyclicality of cortical bone growth marks (BGMs) allows reconstruction of some important life history traits, such as longevity, growth rate or age at maturity. Little attention has been paid, however, to non-cyclical BGMs, though some record key life history events such as hatching (egg-laying vertebrates), metamorphosis (amphibians), or weaning (suggested for Microcebus and the hedgehog). [...]
2018 - 10.1371/journal.pone.0198511
PloS one, Vol. 13, Issue 6 (June 2018) , p. e0198511
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7.
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191 p, 5.6 MB |
Tratamiento con células madre mesenquimales en un modelo experimental ovino de osteonecrosis de cabeza femoral
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López Fernández, Alba ;
Aguirre Cañadell, M. (Màrius), (Màrius) dir. ;
Vélez Villa, Roberto, dir. ;
Seoane Suárez, Joan, dir. ;
Universitat Autònoma de Barcelona.
Departament de Bioquímica i de Biologia Molecular
La osteonecrosis de cabeza femoral (ONCF) se define como la muerte tisular asociada a un proceso isquémico y a la sucesiva destrucción del tejido óseo de la cabeza del fémur. Debido a las características anatómicas y vasculares, la articulación de la cadera presenta una propensión especial para la osteonecrosis. [...]
Osteonecrosis of the femoral head (ONFH) is defined as the ischemic process associated to tissue death and the successive bone tissue destruction in the femoral head. Because of its anatomical and vascular features, the hip joint has more propensity for its development. [...]
[Barcelona] : Universitat Autònoma de Barcelona, 2019
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201 p, 4.2 MB |
Osteonecrosis of the femoral head treatment with advanced cell therapy and biomaterials in an experimental sheep animal model
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Barro Ojeda, Víctor ;
Aguirre Cañadell, M. (Màrius), (Màrius) dir. ;
Vélez Villa, Roberto, dir. ;
Cáceres Palou, Enrique, dir. ;
Universitat Autònoma de Barcelona.
Departament de Cirurgia
Introducción: La osteonecrosis de la cabeza femoral (ONCF) afecta principalmente a pacientes jóvenes y activos, sin tratamiento, la entidad progresa en pocos años hacia la deformidad e incongruencia articular, presentando en su etapa avanzada cambios degenerativos articulares, dolor y discapacidad funcional, generando un importante impacto socioeconómico. [...]
Introduction: Femoral head osteonecrosis (ONCF) mainly affects young and active patients, without treatment, the entity progresses in a few years towards deformity and joint incongruity, presenting at its advanced stage joint degenerative changes, pain and functional disability, generating an important socioeconomic impact. [...]
[Barcelona] : Universitat Autònoma de Barcelona, 2019
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179 p, 2.0 MB |
Prevención del sangrado postoperatorio en fracturas subcapitales de fémur tratadas mediante sustitución protésica: eficacia y seguridad del ácido tranexámico y la cola de fibrina
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Jordán Sales, Marcos ;
Cáceres Palou, Enrique, dir. (Universitat Autònoma de Barcelona. Departament de Cirurgia) ;
Celaya Ibáñez, Fernando, dir. ;
Martínez Zapata, Mª José, dir. ;
Monllau García, Juan Carlos, dir. (Universitat Autònoma de Barcelona. Departament de Cirurgia) ;
Universitat Autònoma de Barcelona.
Departament de Cirurgia
Objetivos: El objetivo principal del estudio fue evaluar la eficacia y la seguridad del ácido tranexámico y de la cola de fibrina administrados vía tópica en pacientes intervenidos de fractura subcapital de fémur mediante artroplastia de cadera. [...]
Objectives: The main objective of the study was to evaluate the efficacy and safety of tranexamic acid and fibrin sealant administered topically in patients with a femoral neck fracture operated with a hip arthroplasty. [...]
[Barcelona] : Universitat Autònoma de Barcelona, 2017.
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