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UAB Digital Repository of Documents 13 records found  1 - 10next  jump to record: Search took 0.01 seconds. 
1.
9 p, 2.4 MB HPIPred : Host-pathogen interactome prediction with phenotypic scoring / Macho Rendón, Javier (Universitat Autònoma de Barcelona. Departament de Bioquímica i de Biologia Molecular) ; Rebollido-Ríos, Rocio (Universitat Autònoma de Barcelona. Departament de Bioquímica i de Biologia Molecular) ; Torrent Burgas, Marc (Universitat Autònoma de Barcelona. Departament de Bioquímica i de Biologia Molecular)
Protein-protein interactions (PPIs) are involved in most cellular processes. Unfortunately, current knowledge of host-pathogen interactomes is still very limited. Experimental methods used to detect PPIs have several limitations, including increasing complexity and economic cost in large-scale screenings. [...]
2022 - 10.1016/j.csbj.2022.11.026
Computational and Structural Biotechnology Journal, Vol. 20 (november 2022) , p. 6534-6542  
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2.
16 p, 3.1 MB Cross interactions between Apolipoprotein E and amyloid proteins in neurodegenerative diseases / Loch, Rolf Antonie (Scherrer Institute (Suïssa). Department of Biology and Chemistry) ; Wang, Hongzhi (Paul Scherrer Institute (Suïssa). Department of Biology and Chemistry) ; Peralvarez-Marin, Alex (Universitat Autònoma de Barcelona. Departament de Bioquímica i de Biologia Molecular) ; Berger, Philipp (Scherrer Institute (Suïssa). Department of Biology and Chemistry) ; Nielsen, Henrietta (Stockholm University. Department of Biochemistry and Biophysics) ; Chroni, Angeliki (National Center for Scientific Research 'Demokritos' (Grècia)) ; Luo, Jinghui (Scherrer Institute (Suïssa). Department of Biology and Chemistry)
Three common Apolipoprotein E isoforms, ApoE2, ApoE3, and ApoE4, are key regulators of lipid homeostasis, among other functions. Apolipoprotein E can interact with amyloid proteins. The isoforms differ by one or two residues at positions 112 and 158, and possess distinct structural conformations and functions, leading to isoform-specific roles in amyloid-based neurodegenerative diseases. [...]
2023 - 10.1016/j.csbj.2023.01.022
Computational and Structural Biotechnology Journal, Vol. 21 (january 2023) , p. 1189-1204  
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3.
8 p, 1.1 MB The dynamic landscape of peptide activity prediction / Bárcenas, Oriol (Universitat Autònoma de Barcelona. Institut de Biotecnologia i de Biomedicina "Vicent Villar Palasí") ; Pintado-Grima, Carlos (Universitat Autònoma de Barcelona. Institut de Biotecnologia i de Biomedicina "Vicent Villar Palasí") ; Sidorczuk, Katarzyna (University of Wrocław) ; Teufel, Felix (University of Copenhagen) ; Nielsen, Henrik (Technical University of Denmark) ; Ventura, Salvador (Universitat Autònoma de Barcelona. Institut de Biotecnologia i de Biomedicina "Vicent Villar Palasí") ; Burdukiewicz, Michał (Universitat Autònoma de Barcelona. Institut de Biotecnologia i de Biomedicina "Vicent Villar Palasí")
Peptides are known to possess a plethora of beneficial properties and activities: antimicrobial, anticancer, anti-inflammatory or the ability to cross the blood-brain barrier are only a few examples of their functional diversity. [...]
2022 - 10.1016/j.csbj.2022.11.043
Computational and Structural Biotechnology Journal, Vol. 20 (November 2022) , p. 6526-6533  
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4.
9 p, 1.5 MB Structural and biochemical characterization of the relaxosome auxiliary proteins encoded on the Bacillus subtilis plasmid pLS20 / Crespo, Isidro (ALBA Laboratori de Llum de Sincrotró) ; Bernardo, Nerea (ALBA Laboratori de Llum de Sincrotró) ; Cuppari, Anna (ALBA Laboratori de Llum de Sincrotró) ; Calisto, Bárbara Luísa Machado (ALBA Laboratori de Llum de Sincrotró) ; Val-Calvo, Jorge (Centro de Biología Molecular Severo Ochoa) ; Miguel-Arribas, Andrés (Centro de Biología Molecular Severo Ochoa) ; Meijer, Wilfried J. J. (Centro de Biología Molecular Severo Ochoa) ; Carpena, Xavi (ALBA Laboratori de Llum de Sincrotró) ; Gil-Ortiz, Fernando (ALBA Laboratori de Llum de Sincrotró) ; Malfois, Marc (ALBA Laboratori de Llum de Sincrotró) ; Boer, D. Roeland (ALBA Laboratori de Llum de Sincrotró)
Bacterial conjugation is an important route for horizontal gene transfer. The initial step in this process involves a macromolecular protein-DNA complex called the relaxosome, which in plasmids consists of the origin of transfer (oriT) and several proteins that prepare the transfer. [...]
2022 - 10.1016/j.csbj.2021.12.041
Computational and Structural Biotechnology Journal, Vol. 20 (January 2022) , p. 757-765  
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5.
11 p, 4.9 MB Dynorphin A induces membrane permeabilization by formation of proteolipidic pores. Insights from electrophysiology and computational simulations / Perini, D. Aurora (Laboratory of Molecular Biophysics. Department of Physics. Universitat Jaume I) ; Aguilella-Arzo, Marcel (Laboratory of Molecular Biophysics. Department of Physics. Universitat Jaume I) ; Alcaraz, Antonio (Laboratory of Molecular Biophysics. Department of Physics. Universitat Jaume I) ; Perálvarez-Marín, Alex (Universitat Autònoma de Barcelona. Institut de Neurociències) ; Queralt-Martín, María (Laboratory of Molecular Biophysics. Department of Physics. Universitat Jaume I)
Dynorphins are endogenous neuropeptides that function as ligands for the κ-opioid receptor. In addition to opioid activity, dynorphins can induce several pathological effects such as neurological dysfunctions and cell death. [...]
2021 - 10.1016/j.csbj.2021.12.021
Computational and Structural Biotechnology Journal, Vol. 20 (december 2021) , p. 230-240  
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6.
9 p, 2.1 MB Dysbiosis and relapse-related microbiome in inflammatory bowel disease : a shotgun metagenomic approach / Serrano-Gómez, Gerard (Hospital Universitari Vall d'Hebron. Institut de Recerca) ; Mayorga, Luis (Hospital Universitari Vall d'Hebron. Institut de Recerca) ; Oyarzun, Iñigo (Hospital Universitari Vall d'Hebron. Institut de Recerca) ; Roca, Joaquim (Consejo Superior de Investigaciones Científicas (Espanya)) ; Borruel, Natalia (Hospital Universitari Vall d'Hebron) ; Casellas, Francesc (Hospital Universitari Vall d'Hebron) ; Varela, Encarna (Hospital Universitari Vall d'Hebron. Institut de Recerca) ; Pozuelo, Marta (Hospital Universitari Vall d'Hebron. Institut de Recerca) ; Machiels, Kathleen (Translational Research Center for Gastrointestinal Disorders, Leuven, Belgium) ; Guarner, Francisco (Hospital Universitari Vall d'Hebron. Institut de Recerca) ; Vermeire, Severine (University Hospitals Leuven (Bèlgica)) ; Manichanh, Chaysavanh (Centro de Investigación Biomédica en Red de Enfermedades Hepáticas y Digestivas) ; Universitat Autònoma de Barcelona
Crohn's disease (CD) and ulcerative colitis (UC), the two main forms of inflammatory bowel disease (IBD), affect several million people worldwide. CD and UC are characterized by periods of clinical remission and relapse. [...]
2021 - 10.1016/j.csbj.2021.11.037
Computational and Structural Biotechnology Journal, Vol. 19 (december 2021) , p. 6481-6489  
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7.
10 p, 1.4 MB Metal utilization in genome-reduced bacteria : Do human mycoplasmas rely on iron? / Peralvarez-Marin, Alex (Universitat Autònoma de Barcelona. Departament de Bioquímica i de Biologia Molecular) ; Baranowski, Eric (Université de Toulouse. Interactions Hôtes-Agents Pathogènes) ; Bierge, Paula (Universitat Autònoma de Barcelona. Institut de Biotecnologia i de Biomedicina "Vicent Villar Palasí") ; Quijada Pich, Oscar (Universitat Autònoma de Barcelona. Departament de Bioquímica i de Biologia Molecular) ; Lebrette, Hugo (Stockholm University. Department of Biochemistry and Biophysics) ; Universitat Autònoma de Barcelona. Institut de Neurociències
Mycoplasmas are parasitic bacteria with streamlined genomes and complex nutritional requirements. Although iron is vital for almost all organisms, its utilization by mycoplasmas is controversial. Despite its minimalist nature, mycoplasmas can survive and persist within the host, where iron availability is rigorously restricted through nutritional immunity. [...]
2021 - 10.1016/j.csbj.2021.10.022
Computational and Structural Biotechnology Journal, Vol. 19 (2021) , p. 5752-5761  
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8.
15 p, 2.9 MB Cryptic amyloidogenic regions in intrinsically disordered proteins : Function and disease association / Santos, Jaime (Universitat Autònoma de Barcelona. Departament de Bioquímica i de Biologia Molecular) ; Pallarès i Goitiz, Irantzu (Universitat Autònoma de Barcelona. Institut de Biotecnologia i de Biomedicina "Vicent Villar Palasí") ; Iglesias, Valentin (Universitat Autònoma de Barcelona. Departament de Bioquímica i de Biologia Molecular) ; Ventura, Salvador (Universitat Autònoma de Barcelona. Institut de Biotecnologia i de Biomedicina "Vicent Villar Palasí")
The amyloid conformation is considered a fundamental state of proteins and the propensity to populate it a generic property of polypeptides. Multiple proteome-wide analyses addressed the presence of amyloidogenic regions in proteins, nurturing our understanding of their nature and biological implications. [...]
2021 - 10.1016/j.csbj.2021.07.019
Computational and Structural Biotechnology Journal, Vol. 19 (July 2021) , p. 4192-4206  
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9.
11 p, 1.4 MB Design of novel small molecule base-pair recognizers of toxic CUG RNA transcripts characteristics of DM1 / Ondono, Raul (Universitat Ramon Llull. Institut Químic de Sarrià-IQS) ; Lirio, Ángel (Universitat Ramon Llull. Institut Químic de Sarrià-IQS) ; Elvira, Carlos (Universitat Ramon Llull. Institut Químic de Sarrià-IQS) ; Álvarez Marimon, Elena (Universitat Autònoma de Barcelona. Departament de Bioquímica i de Biologia Molecular) ; Provenzano, Claudia (Consiglio Nazionale delle Ricerche. Istituto di Biochimica e Biologia Cellulare) ; Cardinali, Beatrice (Consiglio Nazionale delle Ricerche. Istituto di Biochimica e Biologia Cellulare) ; Pérez-Alonso, Manuel (Universitat de València) ; Peralvarez-Marin, Alex (Universitat Autònoma de Barcelona. Departament de Bioquímica i de Biologia Molecular) ; Borrell, José Ignacio (Universitat Ramon Llull. Institut Químic de Sarrià-IQS) ; Falcone, Germana (Consiglio Nazionale delle Ricerche. Istituto di Biochimica e Biologia Cellulare) ; Estrada-Tejedor, Roger (Universitat Ramon Llull. Institut Químic de Sarrià-IQS)
Myotonic Dystrophy type 1 (DM1) is an incurable neuromuscular disorder caused by toxic DMPK transcripts that carry CUG repeat expansions in the 3' untranslated region (3'UTR). The intrinsic complexity and lack of crystallographic data makes noncoding RNA regions challenging targets to study in the field of drug discovery. [...]
2021 - 10.1016/j.csbj.2020.11.053
Computational and Structural Biotechnology Journal, Vol. 19 (2021) , p. 51-61  
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10.
10 p, 2.0 MB Experimental and computational analysis of biased agonism on full-length and a C-terminally truncated adenosine A receptor / Navarro Brugal, Gemma (Universitat de Barcelona. Departament de Bioquímica i Fisiologia) ; Gonzalez, Angel (Universitat Autònoma de Barcelona. Departament de Pediatria, Obstetrícia i Ginecologia i Medicina Preventiva i Salut Pública) ; Campanacci, Stefano (Universitat de Barcelona. Departament de Bioquímica i Biomedicina Molecular) ; Rivas-Santisteban, Rafael (Universitat de Barcelona. Departament de Bioquímica i Biomedicina Molecular) ; Reyes-Resina, Irene (Universitat de Barcelona. Departament de Bioquímica i Biomedicina Molecular) ; Casajuana-Martin, Nil (Universitat Autònoma de Barcelona. Departament de Pediatria, Obstetrícia i Ginecologia i Medicina Preventiva i Salut Pública) ; Cordomí Montoya, Arnau (Universitat Autònoma de Barcelona. Departament de Pediatria, Obstetrícia i Ginecologia i Medicina Preventiva i Salut Pública) ; Pardo Carrasco, Leonardo (Universitat Autònoma de Barcelona. Departament de Pediatria, Obstetrícia i Ginecologia i Medicina Preventiva i Salut Pública) ; Franco, Rafael (Universitat de Barcelona. Facultat de Química)
Biased agonism, the ability of agonists to differentially activate downstream signaling pathways by stabilizing specific receptor conformations, is a key issue for G protein-coupled receptor (GPCR) signaling. [...]
2020 - 10.1016/j.csbj.2020.09.028
Computational and Structural Biotechnology Journal, Vol. 18 (september 2020) , p. 2723-2732  
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