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52 p, 705.6 KB |
Role of Amyloid-β and Tau Proteins in Alzheimer's Disease : Confuting the Amyloid Cascade
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Gulisano, W. (Department of Biomedical and Biotechnological Sciences. Section of Physiology. University of Catania) ;
Maugeri, Daniele (Department of Biomedical and Biotechnological Sciences. Section of Physiology. University of Catania) ;
Baltrons Soler, Ma. Antonia (Universitat Autònoma de Barcelona. Departament de Bioquímica i de Biologia Molecular) ;
Fà, Mauro (Taub Institute for Research on Alzheimer's Disease and the Aging Brain. Department of Medicine. Columbia University) ;
Amato, Arianna (Department of Anaesthesiology. Università Cattolica Del Sacro Cuore) ;
Palmeri, Agostino (Department of Biomedical and Biotechnological Sciences. Section of Physiology. University of Catania) ;
D'Adamio, Luciano (Department of Pharmacology. Physiology and Neuroscience. Rutgers University) ;
Grassi, Claudio (Institute of Human Physiology. Università Cattolica Del Sacro Cuore) ;
Devanand, D.P. (Department of Psychiatry. Columbia University. College of Phys. and Surg.) ;
Honig, Lawrence S. (Department of Neurology. Columbia University. College of Phys. and Surg.) ;
Puzzo, Daniela (Department of Biomedical and Biotechnological Sciences. Section of Physiology. University of Catania) ;
Arancio, Ottavio (Taub Institute for Research on Alzheimer's Disease and the Aging Brain. Department of Medicine. Columbia University)
The "Amyloid Cascade Hypothesis" has dominated the Alzheimer's disease (AD) field in the last 25 years. It posits that the increase of amyloid-β (Aβ) is the key event in AD that triggers tau pathology followed by neuronal death and eventually, the disease. [...]
2018 -  10.3233/JAD-179935
Journal of Alzheimer's disease, Vol. 64 Núm. s1 (2018) , p. S611-S631
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13 p, 162.5 KB |
Validation of plasma proteomic biomarkers relating to brain amyloid burden in the EMIF-Alzheimer's disease multimodal biomarker discovery cohort
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Westwood, Sarah (University of Oxford) ;
Baird, Alison L (University of Oxford) ;
Anand, Sneha N. (University of Oxford) ;
Nevado-Holgado, Alejo (University of Oxford) ;
Kormilitzin, Andrey (University of Oxford) ;
Shi, Liu (University of Oxford) ;
Hye, Abdul (King's College London) ;
Ashton, Nicholas J (University of Gothenburg) ;
Morgan, Angharad R. (Cardiff University) ;
Bos, Isabelle (Maastricht University) ;
Vos, Stephanie J.B. (Maastricht University) ;
Baker, Susan (Janssen R and D) ;
Buckley, Noel J (University of Oxford) ;
Ten Kate, Mara (Vrije Universiteit University Medical Center) ;
Scheltens, Philip (Vrije Universiteit University Medical Center) ;
Teunissen, Charlotte E. (Vrije Universiteit University Medical Center) ;
Vandenberghe, Rik (University Hospitals Leuven (Bèlgica)) ;
Gabel, Silvy (Ku Leuven) ;
Meersmans, Karen (Ku Leuven) ;
Engelborghs, Sebastiaan (Vrije Universiteit Brussel (VUB)) ;
De Roeck, Ellen E. (Vrije Universiteit Brussel (VUB)) ;
Sleegers, Kristel (Center for Molecular Neurology) ;
Frisoni, Giovanni B. (Irccs Istituto Centro San Giovanni di Dio Fatebenefratelli) ;
Blin, Olivier (Aix-Marseille Université) ;
Richardson, Jill C. (GlaxoSmithKline R and D) ;
Bordet, Régis (University of Lille) ;
Molinuevo, José Luis (Hospital Clínic i Provincial de Barcelona) ;
Rami, Lorena (Universitat Pompeu Fabra) ;
Wallin, Anders (Sahlgrenska Academy at University of Gothenburg) ;
Kettunen, Petronella (Sahlgrenska Academy at University of Gothenburg) ;
Tsolaki, Magda (AHEPA University Hospital (Grècia)) ;
Verhey, Frans (Maastricht University) ;
Lleó, Alberto (Institut d'Investigació Biomèdica Sant Pau) ;
Sala, Isabel (Institut d'Investigació Biomèdica Sant Pau) ;
Popp, Julius (Geneva University Hospitals) ;
Peyratout, Gwendoline (Lausanne University Hospital) ;
Martinez-Lage, Pablo (Geneva University Hospitals) ;
Tainta, Mikel (CITA-Alzheimer Foundation) ;
Johannsen, Peter (Copenhagen University Hospital) ;
Freund-Levi, Yvonne (Karolinska Institutet (Estocolm, Suècia)) ;
Frölich, Lutz (University of Heidelberg) ;
Dobricic, Valerija (University of Lübeck) ;
Legido-Quigley, Cristina (Steno Diabetes Center) ;
Bertram, Lars (University of Oslo) ;
Barkhof, Frederik (Ucl Institutes of Neurology and Healthcare Engineering) ;
Zetterberg, Henrik (Ucl Institute of Neurology) ;
Morgan, B.Paul (Cardiff University) ;
Streffer, Johannes (Janssen R and D. Llc) ;
Visser, Pieter Jelle (Vu University Medical Center) ;
Lovestone, Simon (Janssen R and D) ;
Universitat Autònoma de Barcelona
We have previously investigated, discovered, and replicated plasma protein biomarkers for use to triage potential trials participants for PET or cerebrospinal fluid measures of Alzheimer's disease (AD) pathology. [...]
2020 - 10.3233/JAD-190434
Journal of Alzheimer's disease, Vol. 74 Núm. 1 (2020) , p. 213-225
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12 p, 801.4 KB |
Different Inflammatory Signatures in Alzheimer's Disease and Frontotemporal Dementia Cerebrospinal Fluid
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Boström, Gustaf (Department of Public Health and Caring Sciences. Geriatrics. Uppsala University) ;
Freyhult, Eva (Department of Medical Sciences. Science for Life Laboratory. National Bioinformatics Infrastructure Sweden. Uppsala University) ;
Virhammar, Johan (Department of Neuroscience. Neurology. Uppsala University Hospital) ;
Alcolea, Daniel (Institut d'Investigació Biomèdica Sant Pau) ;
Tumani, Hayrettin (Department of Neurology. Ulm University Hospital) ;
Otto, Markus (Department of Neurology. Ulm University Hospital) ;
Brundin, Rose-Marie (Department of Public Health and Caring Sciences. Geriatrics. Uppsala University) ;
Kilander, Lena (Department of Public Health and Caring Sciences. Geriatrics. Uppsala University) ;
Löwenmark, Malin (Department of Public Health and Caring Sciences. Geriatrics. Uppsala University) ;
Giedraitis, Vilmantas (Department of Public Health and Caring Sciences. Geriatrics. Uppsala University) ;
Lleó, Alberto (Institut d'Investigació Biomèdica Sant Pau) ;
Von Arnim, Christine A.F. (Department of Geriatric Medicine. University Medical Center Göttingen. Georg-August-University) ;
Kultima, Kim (Department of Medical Sciences. Clinical Chemistry. Uppsala University) ;
Ingelsson, Martin (Department of Public Health and Caring Sciences. Geriatrics. Uppsala University)
Background: Neuroinflammatory processes are common in neurodegenerative diseases such as Alzheimer's disease (AD) and frontotemporal dementia (FTD), but current knowledge is limited as to whether cerebrospinal fluid (CSF) levels of neuroinflammatory proteins are altered in these diseases. [...]
2021 - 10.3233/jad-201565
Journal of Alzheimer's disease, Vol. 81 Núm. 2 (2021) , p. 629-640
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23 p, 1.1 MB |
The Behavioral and Psychological Symptoms of Dementia in down Syndrome Scale (BPSD-DS II) : Optimization and Further Validation
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Dekker, Alain D. (Department of Practice-oriented Scientific Research (PWO). Alliade Care Group) ;
Ulgiati, Aurora M. (Department of Practice-oriented Scientific Research (PWO). Alliade Care Group) ;
Groen, Henk (Department of Epidemiology. University of Groningen. University Medical Center Groningen) ;
Boxelaar, Vicent A. (Center for Information Technology. University of Groningen) ;
Sacco, Silvia (Institut Jérôme Lejeune) ;
Falquero, Ségolène (Institut Jérôme Lejeune) ;
Carfi, Angelo (Policlinico Universitario Agostino Gemelli IRCCS (Roma, Itàlia)) ;
Di Paola, Antonella (Department of Geriatrics. Fondazione Policlinico Universitario Gemelli Irccs) ;
Benejam, Bessy (Barcelona Down Medical Center. Fundació Catalana Síndrome de Down) ;
Valldeneu, Silvia (Institut d'Investigació Biomèdica Sant Pau) ;
Fopma, Roelie (Department of Practice-oriented Scientific Research (PWO). Alliade Care Group) ;
Oosterik, Marjo (Aveleijn) ;
Hermelink, Marloes (De Twentse Zorgcentra) ;
Beugelsdijk, Gonny (Ipse de Bruggen) ;
Schippers, Mieke (Ipse de Bruggen) ;
Henstra, Hepie (Nieuw Woelwijck) ;
Scholten-Kuiper, Martine (Philadelphia Zorg) ;
Willink-Vos, Judith (Severinus) ;
De Ruiter, Lisa (Sherpa) ;
Willems, Liesbeth (Sprank) ;
Loonstra-De Jong, Anneke (Vanboeijen) ;
Coppus, Antonia (Dichterbij) ;
Tollenaere, Marleen (Department of Neurology and Memory Clinic. Hospital Network Antwerp (ZNA) Middelheim and Hoge Beuken) ;
Fortea, Juan (Institut d'Investigació Biomèdica Sant Pau) ;
Onder, Graziano (Department of Cardiovascular. Endocrine-metabolic Diseases and Aging. Istituto Superiore di Sanitá) ;
Rebillat, Anne-Sophie (Institut Jérôme Lejeune) ;
Van Dam, Debby (Laboratory of Neurochemistry and Behavior. Department of Biomedical Sciences and Institute Born-Bunge. University of Antwerp) ;
De Deyn, Peter Paul (University Hospital Antwerp (Bèlgica))
Background: People with Down syndrome (DS) are at high risk to develop Alzheimer's disease dementia (AD). Behavioral and psychological symptoms of dementia (BPSD) are common and may also serve as early signals for dementia. [...]
2021 - 10.3233/JAD-201427
Journal of Alzheimer's disease, Vol. 81 Núm. 4 (2021) , p. 1505-1527
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13 p, 610.0 KB |
White Matter Hyperintensities Are No Major Confounder for Alzheimer's Disease Cerebrospinal Fluid Biomarkers
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van Waalwijk van Doorn, Linda J. C. ;
Ghafoorian, Mohsen ;
van Leijsen, Esther M. C. ;
Claassen, Jurgen A. H. R. ;
Arighi, Andrea ;
Bozzali, Marco ;
Cannas, Jorge ;
Cavedo, Enrica ;
Eusebi, Paolo ;
Farotti, Lucia ;
Fenoglio, Chiara ;
Fortea, Juan (Institut d'Investigació Biomèdica Sant Pau) ;
Frisoni, Giovanni B. ;
Galimberti, Daniela ;
Greco, Viviana ;
Herukka, Sanna-Kaisa ;
Liu, Yawu ;
Lleó, Alberto (Institut d'Investigació Biomèdica Sant Pau) ;
de Mendonça, Alexandre ;
Nobili, Flavio M. ;
Parnetti, Lucilla ;
Picco, Agnese ;
Pikkarainen, Maria ;
Salvadori, Nicola ;
Scarpini, Elio ;
Soininen, Hilkka ;
Tarducci, Roberto ;
Urbani, Andrea ;
Vilaplana, Eduard (Institut d'Investigació Biomèdica Sant Pau) ;
Meulenbroek, Olga ;
Platel, Bram ;
Verbeek, Marcel M. ;
Kuiperij, H. Bea ;
Universitat Autònoma de Barcelona
The cerebrospinal fluid (CSF) biomarkers amyloid-β 1-42 (Aβ), total and phosphorylated tau (t-tau, p-tau) are increasingly used to assist in the clinical diagnosis of Alzheimer's disease (AD). However, CSF biomarker levels can be affected by confounding factors. [...]
2021 - 10.3233/JAD-200496
Journal of Alzheimer's disease, Vol. 79 (january 2021) , p. 163-175
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16 p, 903.0 KB |
Dickkopf-1 Overexpression in vitro Nominates Candidate Blood Biomarkers Relating to Alzheimer's Disease Pathology
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Shi, Liu (University of Oxford) ;
Winchester, Laura M. (University of Oxford) ;
Liu, Benjamine Y. (University of Oxford) ;
Killick, Richard (Maurice Wohl Institute Clinical Neuroscience Institute) ;
Ribe, Elena M. (University of Oxford) ;
Westwood, Sarah (University of Oxford) ;
Baird, Alison L. (University of Oxford) ;
Buckley, Noel J. (University of Oxford) ;
Hong, Shengjun (University of Lübeck) ;
Dobricic, Valerija (University of Lübeck) ;
Kilpert, Fabian (University of Lübeck) ;
Franke, Andre (Christian-Albrechts-University of Kiel) ;
Kiddle, Steven (King's College London) ;
Sattlecker, Martina (King's College London) ;
Dobson, Richard (University College London) ;
Cuadrado, Antonio ("Victor Babes" National Institute of Pathology) ;
Hye, Abdul (Maurice Wohl Institute Clinical Neuroscience Institute) ;
Ashton, Nicholas J. (University of Gothenburg) ;
Morgan, Angharad R. (Cardiff University) ;
Bos, Isabelle (Amsterdam UMC. University Medical Center) ;
Vos, Stephanie J. B. (Maastricht University) ;
ten Kate, Mara (Amsterdam UMC. University Medical Center) ;
Scheltens, Philip (Amsterdam UMC. University Medical Center) ;
Vandenberghe, Rik (University Hospitals Leuven (Bèlgica)) ;
Gabel, Silvy (Laboratory for Cognitive Neurology) ;
Meersmans, Karen (Laboratory for Cognitive Neurology) ;
Engelborghs, Sebastiaan (Universitair Ziekenhuis Brussel-UZ Brussel. Department of Neurology) ;
De Roeck, Ellen E. (University of Antwerp) ;
Sleegers, Kristel (Center for Molecular Neurology) ;
Frisoni, Giovanni B. (IRCCS Istituto Centro San Giovanni di Dio Fatebenefratelli) ;
Blin, Olivier (Aix-Marseille Université) ;
Richardson, Jill C. (GlaxoSmithKline R&D. Neurosciences Therapeutic Area) ;
Bordet, Régis (University of Lille) ;
Molinuevo, José Luis (Barcelonaβeta Brain Research Center (BBRC)) ;
Rami Gonzalez, Lorena (Barcelonaβeta Brain Research Center (BBRC)) ;
Wallin, Anders (Sahlgrenska University Hospital (Suècia)) ;
Kettunen, Petronella (University of Oxford) ;
Tsolaki, Magda (Aristotle University of Thessaloniki) ;
Verhey, Frans (Maastricht University) ;
Lleó, Alberto (Institut d'Investigació Biomèdica Sant Pau) ;
Alcolea, Daniel (Institut d'Investigació Biomèdica Sant Pau) ;
Popp, Julius (University of Geneva) ;
Peyratout, Gwendoline (Lausanne University Hospital) ;
Martinez-Lage, Pablo (CITA-Alzheimer Foundation (San Sebastian)) ;
Tainta, Mikel (Organización Sanitaria Integrada Goierri) ;
Johannsen, Peter (Copenhagen University Hospital) ;
Teunissen, Charlotte E. (Amsterdam UMC. University Medical Center) ;
Freund-Levi, Yvonne (Department of Psychiatry, Örebro Universitetssjukhus) ;
Frölich, Lutz (University of Heidelberg) ;
Legido-Quigley, Cristina (Steno Diabetes Center Copenhagen) ;
Barkhof, Frederik (UCL Institutes of Neurology and Healthcare Engineering) ;
Blennow, Kaj (Sahlgrenska University Hospital (Suècia)) ;
Rasmussen, Katrine Laura (University of Copenhagen) ;
Nordestgaard, Børge Grønne (Copenhagen University Hospital) ;
Frikke-Schmidt, Ruth (University of Copenhagen) ;
Nielsen, Sune Fallgaard (Copenhagen University Hospital) ;
Soininen, Hilkka (University of Eastern Finland) ;
Vellas, Bruno (Univeriste Paul Sabatier) ;
Kloszewska, Iwona (Medical University of Lodz) ;
Mecocci, Patrizia (University of Perugia (Itàlia)) ;
Zetterberg, Henrik (UCL Institute of Neurology (Regne Unit)) ;
Morgan, B. Paul (Cardiff University) ;
Streffer, Johannes (UCB Pharma (Braine-l'Alleud, Bèlgica)) ;
Visser, Pieter Jelle (Karolinska Institutet (Estocolm, Suècia)) ;
Bertram, Lars (University of Oslo) ;
Nevado-Holgado, Alejo (University of Oxford) ;
Lovestone, Simon (University of Oxford) ;
Universitat Autònoma de Barcelona
Previous studies suggest that Dickkopf-1 (DKK1), an inhibitor of Wnt signaling, plays a role in amyloid-induced toxicity and hence Alzheimer's disease (AD). However, the effect of DKK1 expression on protein expression, and whether such proteins are altered in disease, is unknown. [...]
2020 - 10.3233/JAD-200208
Journal of Alzheimer's disease, Vol. 77 (september 2020) , p. 1353-1368
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9 p, 306.3 KB |
Vibrating Tail, Digging, Body/Face Interaction, and Lack of Barbering : Sex-Dependent Behavioral Signatures of Social Dysfunction in 3xTg-AD Mice as Compared to Mice with Normal Aging
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Torres-Lista, Virginia (Universitat Autònoma de Barcelona. Institut de Neurociències) ;
Gimenez-Llort, Lydia (Universitat Autònoma de Barcelona. Institut de Neurociències)
Modeling of Alzheimer's disease (AD), classically focused on the subject-environment interaction, foresees current social neuroscience efforts as improving the predictive validity of new strategies. Here we studied social functioning among congeners in 13-14-month-old mice with normal aging in naturalistic and experimental conditions and depicted behavioral signatures of dysfunction in age-matched 3xTg-AD mice. [...]
2019 - 10.3233/JAD-190253
Journal of Alzheimer's disease, Vol. 69 (june 2019) , p. 969-977
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23 p, 1.3 MB |
The behavioral and psychological symptoms of dementia in Down syndrome (BPSD-DS) scale : comprehensive assessment of psychopathology in Down syndrome
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Dekker, Alain D. (Universitair Medisch Centrum Groningen) ;
Sacco, Silvia (Institut Jérôme Lejeune) ;
Carfi, Angelo (Universitá Cattolica del Sacro Cuore) ;
Benejam, Bessy (Fundació Catalana Síndrome de Down) ;
Vermeiren, Yannick (Universitair Medisch Centrum Groningen) ;
Beugelsdijk, Gonny (Ipse de Bruggen) ;
Schippers, Mieke (Ipse de Bruggen) ;
Hassefras, Lyanne (Ipse de Bruggen) ;
Eleveld, José (Cosis (Groningen)) ;
Grefelman, Sharina (Cosis (Groningen)) ;
Fopma, Roelie (Talant (Heerenveen)) ;
Bomer-Veenboer, Monique (Pameijer (Rotterdam)) ;
Botí, M (Fundació Catalana Síndrome de Down) ;
Oosterling, G. Danielle E. (Aveleijn (Borne)) ;
Scholten, Esther (Elver (Nieuw-Wehl)) ;
Tollenaere, Marleen (Institute Born-Bunge) ;
Checkley, Laura (University College London. Division of Psychiatry) ;
Strydom, André (University College London. Division of Psychiatry) ;
Van Goethem, Gert (Het GielsBos (Gierle)) ;
Onder, Graziano (Universitá Cattolica del Sacro Cuore) ;
Blesa, Rafael (Institut d'Investigació Biomèdica Sant Pau) ;
zu Eulenburg, Christine (Universitair Medisch Centrum Groningen) ;
Coppus, Antonia (Dichterbij (Gennep)) ;
Rebillat, Anne-Sophie (Institut Jérôme Lejeune) ;
Fortea, Juan (Fundació Catalana Síndrome de Down) ;
De Deyn, Peter Paul (Universitair Medisch Centrum Groningen) ;
Universitat Autònoma de Barcelona
People with Down syndrome (DS) are prone to develop Alzheimer's disease (AD). Behavioral and psychological symptoms of dementia (BPSD) are core features, but have not been comprehensively evaluated in DS. [...]
2018 - 10.3233/JAD-170920
Journal of Alzheimer's disease, Vol. 63, issue 2 (2018) , p. 797-819
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