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1.
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14 p, 4.5 MB |
The Miocene primate Pliobates is a pliopithecoid
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Bouchet, Florian (Institut Català de Paleontologia Miquel Crusafont) ;
Zanolli, Clément (Université de Bordeaux) ;
Urciuoli, Alessandro (Institut Català de Paleontologia Miquel Crusafont) ;
Almécija, Sergio (Institut Català de Paleontologia Miquel Crusafont) ;
Fortuny, Josep (Institut Català de Paleontologia Miquel Crusafont) ;
Robles, Josep M. (Institut Català de Paleontologia Miquel Crusafont) ;
Beaudet, Amélie (University of the Witwatersrand) ;
Moyà Solà, Salvador (Universitat Autònoma de Barcelona. Departament de Biologia Animal, de Biologia Vegetal i d'Ecologia) ;
Alba, David M. (Institut Català de Paleontologia Miquel Crusafont)
The systematic status of the small-bodied catarrhine primate Pliobates cataloniae, from the Miocene (11. 6 Ma) of Spain, is controversial because it displays a mosaic of primitive and derived features compared with extant hominoids (apes and humans). [...]
2024 -  10.1038/s41467-024-47034-9
Nature communications, Vol. 15 (April 2024) , art. 2822
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2.
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16 p, 3.7 MB |
An epigenetic switch controls an alternative NR2F2 isoform that unleashes a metastatic program in melanoma
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Davalos, Veronica (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ;
Lovell, Claudia D. (New York University School of Medicine, USA) ;
Von Itter, Richard (New York University School of Medicine, USA) ;
Dolgalev, Igor (New York University Grossman School of Medicine, USA) ;
Agrawal, Praveen (New York University Grossman School of Medicine, USA) ;
Baptiste, Gillian (New York University Grossman School of Medicine, USA) ;
Kahler, David J. (New York University Grossman School of Medicine, USA) ;
Sokolova, Elena (New York University Grossman School of Medicine, USA) ;
Moran, S (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ;
Piqué, Laia (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ;
Vega-Saenz de Miera, Eleazar (New York University School of Medicine, USA) ;
Fontanals-Cirera, Barbara (New York University School of Medicine, USA) ;
Karz, Alcida (New York University School of Medicine, USA) ;
Tsirigos, Aristotelis (New York University Grossman School of Medicine, USA) ;
Yun, Chi (New York University Grossman School of Medicine, USA) ;
Darvishian, Farbod (New York University Grossman School of Medicine, USA) ;
Etchevers, Heather C. (Aix-Marseille University, Marseille, France) ;
Osman, Iman (New York University Grossman School of Medicine, USA) ;
Esteller, Manel (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ;
Schober, Markus (New York University School of Medicine, USA) ;
Hernando, Eva (New York University Grossman School of Medicine, USA)
Metastatic melanoma develops once transformed melanocytic cells begin to de-differentiate into migratory and invasive melanoma cells with neural crest cell (NCC)-like and epithelial-to-mesenchymal transition (EMT)-like features. [...]
2023 - 10.1038/s41467-023-36967-2
Nature communications, Vol. 14 Núm. 1 (april 2023)
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3.
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15 p, 3.7 MB |
Large T cell clones expressing immune checkpoints increase during multiple myeloma evolution and predict treatment resistance
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Botta, Cirino (Clínica Universidad de Navarra) ;
Perez, Cristina (Clínica Universidad de Navarra) ;
Larrayoz, Marta (Clínica Universidad de Navarra) ;
Puig, Noemí (Hospital Universitario de Salamanca) ;
Cedena, María Teresa (Hospital Universitario 12 de Octubre) ;
Termini, Rosalinda (Clínica Universidad de Navarra) ;
Goicoechea, Ibai (Clínica Universidad de Navarra) ;
Rodriguez, Sara (Clínica Universidad de Navarra) ;
Zabaleta, Aintzane (Clínica Universidad de Navarra) ;
Lopez, Aitziber (Clínica Universidad de Navarra) ;
Sarvide, Sarai (Clínica Universidad de Navarra) ;
Blanco, Laura (Clínica Universidad de Navarra) ;
Papetti, Daniele Marco (Department of Informatics. University of Milano-Bicocca) ;
Nobile, M.S. (Biostatistics and Bioimaging Centre-B4) ;
Besozzi, Daniela (Biostatistics and Bioimaging Centre-B4) ;
Gentile, Massimo (Department of Oncohematology. "Annunziata" Hospital) ;
Correale, Pierpaolo (Great Metropolitan Hospital "Riuniti" of Reggio Calabria) ;
Siragusa, Sergio (Department of Health Promotion. University of Palermo) ;
Oriol, Albert (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ;
González-Garcia, Maria Esther (Hospital Universitario de Cabueñes (Gijón)) ;
Sureda, Anna (Institut d'Investigació Biomèdica de Bellvitge) ;
de Arriba, Felipe (Instituto Murciano de Investigación Biosanitaria) ;
Ríos-Tamayo, Rafael (Hospital Universitario Puerta de Hierro Majadahonda (Madrid)) ;
Moraleda, José María (Instituto Murciano de Investigación Biosanitaria) ;
Gironella, Mercedes (Hospital Universitari Vall d'Hebron) ;
Hernández, Miguel T. (Hospital Universitario de Canarias (Illes Canàries)) ;
Bargay, Joan (Hospital Universitari Son Llàtzer (Illes Balears)) ;
Palomera, Luís (Hospital Clínico Universitario "Lozano Blesa" de Zaragoza) ;
Pérez-Montaña, Albert (Hospital Universitari Son Espases (Illes Balears)) ;
Goldschmidt, Hartmut (Department of Internal Medicine V. University of Heidelberg) ;
Avet-Loiseau, Hervé (IUC-T Oncopole) ;
Roccaro, Aldo (Department of Hematology. ASST Spedali Civili di Brescia) ;
Orfao, Alberto (Universidad de Salamanca. Departament de Medicina) ;
Martinez-Lopez, Joaquín (Hospital Universitario 12 de Octubre) ;
Rosiñol, Laura (Institut d'Investigacions Biomèdiques August Pi i Sunyer) ;
Lahuerta, J. J (Hospital Universitario 12 de Octubre) ;
Bladé Creixenti, Juan (Institut d'Investigacions Biomèdiques August Pi i Sunyer) ;
Mateos, M. V (Hospital Universitario de SalamancaBiomedica de Salamanca (IBSAL). Centro de Investigación del Cancer (IBMCC-USAL. CSIC)) ;
San-Miguel, J (Clínica Universidad de Navarra) ;
Martinez Climent, Juan-José (Clínica Universidad de Navarra) ;
Paiva, Bruno (Clínica Universidad de Navarra)
Tumor recognition by T cells is essential for antitumor immunity. A comprehensive characterization of T cell diversity may be key to understanding the success of immunomodulatory drugs and failure of PD-1 blockade in tumors such as multiple myeloma (MM). [...]
2023 - 10.1038/s41467-023-41562-6
Nature communications, Vol. 14 Núm. 1 (december 2023) , p. 5825
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4.
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15 p, 2.7 MB |
ALPL-1 is a target for chimeric antigen receptor therapy in osteosarcoma
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Mensali, Nadia (Department of Cellular Therapy. Oslo University Hospital) ;
Köksal, Hakan (Oslo University Hospital) ;
Joaquina, Sandy (Oslo University Hospital) ;
Wernhoff, Patrick (Oslo University Hospital) ;
Casey, Nicholas P. (Oslo University Hospital) ;
Romecín, Paola Alejandra (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ;
Panisello, Carla (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ;
Rodríguez, René (Instituto de Salud Carlos III) ;
Vimeux, Lene (Université de Paris) ;
Juzeniene, Asta (Oslo University Hospital) ;
Myhre, Marit R. (Oslo University Hospital) ;
Fåne, Anne (Oslo University Hospital) ;
Castilla Ramírez, Caroline (Virgen del Rocio University Hospital) ;
Maggadottir, Solrun Melkork (Oslo University Hospital) ;
Duru, Adil Doganay (Nova Southeastern University) ;
Georgoudaki, Anna-Maria (Department of Oncology-Pathology. Karolinska Institutet) ;
Grad, Iwona (Oslo University Hospital) ;
Maturana, Andrés Daniel (Nagoya University) ;
Gaudernack, Gustav (Department of Cancer Immunology. Oslo University Hospital) ;
Kvalheim, Gunnar (Department of Cellular Therapy. Oslo University Hospital) ;
Carcaboso, Angel M. (Institut de Recerca Sant Joan de Déu) ;
De Álava, Enrique (Universidad de Sevilla) ;
Donnadieu, Emma (Université de Paris) ;
Bruland, Øyvind S (University of Oslo) ;
Menendez, Pablo (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ;
Inderberg, Else Marit (Oslo University Hospital) ;
Wälchli, Sébastien (Oslo University Hospital)
Osteosarcoma (OS) remains a dismal malignancy in children and young adults, with poor outcome for metastatic and recurrent disease. Immunotherapies in OS are not as promising as in some other cancer types due to intra-tumor heterogeneity and considerable off-target expression of the potentially targetable proteins. [...]
2023 - 10.1038/s41467-023-39097-x
Nature communications, Vol. 14 Núm. 1 (december 2023) , p. 3375
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5.
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18 p, 15.6 MB |
Macrophage and neutrophil heterogeneity at single-cell spatial resolution in human inflammatory bowel disease
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Garrido-Trigo, Alba (Institut d'Investigacions Biomèdiques August Pi i Sunyer) ;
Corraliza, Ana Maria (Institut d'Investigacions Biomèdiques August Pi i Sunyer) ;
Veny, Marisol (Institut d'Investigacions Biomèdiques August Pi i Sunyer) ;
Dotti, Isabella (Institut d'Investigacions Biomèdiques August Pi i Sunyer) ;
Melón-Ardanaz, Elisa (Institut d'Investigacions Biomèdiques August Pi i Sunyer) ;
Rill, Aina (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ;
Crowell, Helena L. (Department of Molecular Life Sciences. University of Zurich. Switzerland. SIB Swiss Institute of Bioinformatics) ;
Corbí, Ángel (Centro de Investigaciones Biológicas. Consejo Superior de Investigaciones Científicas (CSIC)) ;
Gudiño, Victoria (Institut d'Investigacions Biomèdiques August Pi i Sunyer) ;
Esteller, Miriam (Institut d'Investigacions Biomèdiques August Pi i Sunyer) ;
Álvarez-Teubel, Iris (Institut d'Investigacions Biomèdiques August Pi i Sunyer) ;
Aguilar, Daniel (Institut d'Investigacions Biomèdiques August Pi i Sunyer) ;
Masamunt, M.Carmen (Institut d'Investigacions Biomèdiques August Pi i Sunyer) ;
Killingbeck, E. (NanoString Technologies) ;
Kim, Youngmi (NanoString Technologies) ;
Leon, Michael (NanoString Technologies) ;
Visvanathan, Sudha (Translational Medicine and Clinical Pharmacology. Boehringer-Ingelheim Pharmaceuticals Inc) ;
Marchese, Domenica (Centre de Regulació Genòmica) ;
Caratù, Ginevra (Centre de Regulació Genòmica) ;
Martin Cardona, Albert (Hospital Universitari MútuaTerrassa (Terrassa, Catalunya)) ;
Esteve, Maria (Department of Gastroenterology. Hospital Universitari Mútua Terrassa. Universitat de Barcelona) ;
Panés, Julian (Centro de Investigación Biomédica en Red de Enfermedades Hepáticas y Digestivas) ;
Ricart, Elena (Centro de Investigación Biomédica en Red de Enfermedades Hepáticas y Digestivas) ;
Mereu, Elisabetta (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ;
Heyn, Holger (Universitat Pompeu Fabra) ;
Salas, Azucena (Centro de Investigación Biomédica en Red de Enfermedades Hepáticas y Digestivas)
Ulcerative colitis and Crohn's disease are chronic inflammatory intestinal diseases with perplexing heterogeneity in disease manifestation and response to treatment. While the molecular basis for this heterogeneity remains uncharacterized, single-cell technologies allow us to explore the transcriptional states within tissues at an unprecedented resolution which could further understanding of these complex diseases. [...]
2023 - 10.1038/s41467-023-40156-6
Nature communications, Vol. 14 Núm. 1 (december 2023) , p. 4506
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6.
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17 p, 3.1 MB |
The PENGUIN approach to reconstruct protein interactions at enhancer-promoter regions and its application to prostate cancer
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Armaos, Alexandros (Istituto Italiano di Tecnologia) ;
Serra, François (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ;
Núñez-Carpintero, Iker (Barcelona Supercomputing Center) ;
Seo, J.H.Ji-Heui (Department of Medical Oncology, Dana Farber Cancer Institute (Estats Units d'Amèrica)) ;
Baca, Sylvan C. (Department of Medical Oncology, Dana Farber Cancer Institute (Estats Units d'Amèrica)) ;
Gustincich, Stefano (Istituto Italiano di Tecnologia) ;
Valencia, Alfonso (Institució Catalana de Recerca i Estudis Avançats) ;
Freedman, Matthew L. (Broad Institute (Estats Units d'Amèrica)) ;
Cirillo, D. (Barcelona Supercomputing Center) ;
Giambartolomei, C. (Human Technopol (Itàlia)) ;
Tartaglia, G.G. (Istituto Italiano di Tecnologia (Itàlia))
We introduce Promoter-Enhancer-Guided Interaction Networks (PENGUIN), a method for studying protein-protein interaction (PPI) networks within enhancer-promoter interactions. PENGUIN integrates H3K27ac-HiChIP data with tissue-specific PPIs to define enhancer-promoter PPI networks (EPINs). [...]
2023 - 10.1038/s41467-023-43767-1
Nature communications, Vol. 14 Núm. 1 (december 2023) , p. 8084
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7.
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16 p, 3.4 MB |
Low input capture Hi-C (liCHi-C) identifies promoter-enhancer interactions at high-resolution
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Tomás Daza, Laureano (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ;
Rovirosa, Llorenç (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ;
López-Martí, Paula (Barcelona Supercomputing Center) ;
Nieto-Aliseda, Andrea (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ;
Serra, François (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ;
Planas-Riverola, Ainhoa (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ;
Molina, Oscar (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ;
McDonald, Rebecca (Wellcome-MRC Cambridge Stem Cell Institute) ;
Ghevaert, Cedric (NHS Blood and Transplant) ;
Cuatrecasas, Esther (Hospital Sant Joan de Déu (Manresa)) ;
Costa, Dolors (Cancer Network Biomedical Research Center) ;
Camós, Mireia (Instituto de Salud Carlos III) ;
Bueno, Clara (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ;
Menéndez, Pablo (Institució Catalana de Recerca i Estudis Avançats) ;
Valencia, Alonso (Institució Catalana de Recerca i Estudis Avançats) ;
Javierre, B. M (Institut Germans Trias i Pujol)
Long-range interactions between regulatory elements and promoters are key in gene transcriptional control; however, their study requires large amounts of starting material, which is not compatible with clinical scenarios nor the study of rare cell populations. [...]
2023 - 10.1038/s41467-023-35911-8
Nature communications, Vol. 14 Núm. 1 (december 2023) , p. 268
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8.
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13 p, 3.5 MB |
A monoclonal antibody targeting a large surface of the receptor binding motif shows pan-neutralizing SARS-CoV-2 activity
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de Campos-Mata, Leire (Karolinska Institutet (Estocolm, Suècia)) ;
Trinité, Benjamin (Institut Germans Trias i Pujol. Institut de Recerca de la Sida IrsiCaixa) ;
Modrego, Andrea (Centro Nacional de Biotecnología) ;
Tejedor Vaquero, Sonia (Hospital del Mar Research Institute (IMIM). Translational Clinical Research Program) ;
Pradenas, Edwards (Institut Germans Trias i Pujol. Institut de Recerca de la Sida IrsiCaixa) ;
Pons-Grífols, Anna (Institut Germans Trias i Pujol. Institut de Recerca de la Sida IrsiCaixa) ;
Rodrigo Melero, Natalia (Centre de Regulació Genòmica) ;
Carlero, Diego (Centro Nacional de Biotecnología) ;
Marfil, Sílvia (Institut Germans Trias i Pujol. Institut de Recerca de la Sida IrsiCaixa) ;
Santiago, César (Centro Nacional de Biotecnología) ;
Raïch-Regué, Dàlia (Institut Germans Trias i Pujol. Institut de Recerca de la Sida IrsiCaixa) ;
Bueno-Carrasco, María Teresa (Centro Nacional de Biotecnología) ;
Tarrés-Freixas, Ferran (Unitat mixta d'investigació IRTA-UAB en Sanitat Animal. Centre de Recerca en Sanitat Animal) ;
Abancó, Ferran (Institut Germans Trias i Pujol. Institut de Recerca de la Sida IrsiCaixa) ;
Urrea, Víctor (Institut Germans Trias i Pujol. Institut de Recerca de la Sida IrsiCaixa) ;
Izquierdo Useros, Nuria (ISCIII. CIBERINFEC) ;
Riveira-Muñoz, Eva (Institut Germans Trias i Pujol. Institut de Recerca de la Sida IrsiCaixa) ;
Ballana, Ester (Institut Germans Trias i Pujol) ;
Pérez, Mónica (Unitat mixta d'investigació IRTA-UAB en Sanitat Animal. Centre de Recerca en Sanitat Animal) ;
Vergara-Alert, Júlia (Unitat mixta d'investigació IRTA-UAB en Sanitat Animal. Centre de Recerca en Sanitat Animal) ;
Segalés Coma, Joaquim (Universitat Autònoma de Barcelona. Departament de Sanitat i d'Anatomia Animals) ;
Carolis, Carlo (Centre de Regulació Genòmica) ;
Arranz, Rocío (Centro Nacional de Biotecnología) ;
Blanco, Julià (University of Vic-Central University of Catalonia. Infectious Diseases and Immunity, Faculty of Medicine) ;
Magri, Giuliana (Universitat de Barcelona)
Here we report the characterization of 17T2, a SARS-CoV-2 pan-neutralizing human monoclonal antibody isolated from a COVID-19 convalescent individual infected during the first pandemic wave. 17T2 is a class 1 VH1-58/κ3-20 antibody, derived from a receptor binding domain (RBD)-specific IgA + memory B cell, with a broad neutralizing activity against former and new SARS-CoV-2 variants, including XBB. [...]
2024 - 10.1038/s41467-024-45171-9
Nature communications, Vol. 15 (february 2024)
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9.
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11 p, 1.2 MB |
Clinical outcome and biomarker assessments of a multi-centre phase II trial assessing niraparib with or without dostarlimab in recurrent endometrial carcinoma
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Madariaga, Ainhoa (Universitat Autònoma de Barcelona) ;
Garg, Swati (University Health Network, Toronto, Canada) ;
Tchrakian, Nairi (University Health Network, Toronto, Canada) ;
Dhani, Neesha C. (University of Toronto, Canada) ;
Jimenez, Waldo (Juravinski Cancer Centre, Hamilton, Canada) ;
Welch, Stephen (London Health Sciences Center, London, Canada) ;
MacKay, Helen (Odette Cancer Centre. Sunnybrook Health Sciences Centre, Toronto, Canada) ;
Ethier, Josee-Lyne (Kingston Health Sciences Cancer Centre, Kingston, Canada) ;
Gilbert, Lucy (Royal Victoria Hospital, Montréal, Canada) ;
Li, Xuan (University Health Network, Toronto, Canada) ;
Rodriguez, Angela (University Health Network, Toronto, Canada) ;
Chan, Lucy (University Health Network, Toronto, Canada) ;
Bowering, Valerie (University Health Network, Toronto, Canada) ;
Clarke, Blaise (University Health Network, Toronto, Canada) ;
Zhang, Tong (University of Toronto, Canada) ;
King, Ian (University of Toronto, Canada) ;
Downs, Gregory (University of Toronto, Canada) ;
Stockley, Tracy (University of Toronto, Canada) ;
Wang, Lisa (University of Toronto, Toronto, Canada) ;
Udagani, Smitha (University Health Network, Toronto, Canada) ;
Oza, Amit M. (University of Toronto, Canada) ;
Lheureux, Stephanie (University of Toronto, Canada)
This multi-centre, non-randomized, open-label, phase II trial (NCT03016338), assessed niraparib monotherapy (cohort 1, C1), or niraparib and dostarlimab (cohort 2, C2) in patients with recurrent serous or endometrioid endometrial carcinoma. [...]
2023 - 10.1038/s41467-023-37084-w
Nature communications, Vol. 14 (2023) , art. 1452
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10.
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14 p, 3.4 MB |
Structure of the homodimeric androgen receptor ligand-binding domain
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Nadal, Marta (Hospital de la Santa Creu i Sant Pau (Barcelona, Catalunya)) ;
Prekovic, Stefan (KU Leuven) ;
Gallastegui, Nerea (Agència de Gestió d'Ajuts Universitaris i de Recerca (AGAUR)) ;
Helsen, Christine (KU Leuven) ;
Abella, Montserrat (Agència de Gestió d'Ajuts Universitaris i de Recerca (AGAUR)) ;
Zielinska, Karolina (Universitat de Barcelona) ;
Gay, Marina (Barcelona Institute of Science and Technology (BIST)) ;
Vilaseca, Marta (Barcelona Institute of Science and Technology (BIST)) ;
Taulès, Marta (Universitat de Barcelona) ;
Houtsmuller, Adriaan B. (Erasmus Optical Imaging Centre) ;
Van Royen, Martin E. (Erasmus Optical Imaging Centre) ;
Claessens, Frank (KU Leuven) ;
Fuentes-Prior, Pablo (Institut d'Investigació Biomèdica Sant Pau) ;
Estébanez-Perpiñá, Eva (Bases Estructurals de Processos Fisiopatològics Fonamentals. Agència de Gestió d'Ajuts Universitaris i de Recerca (AGAUR)) ;
Universitat Autònoma de Barcelona
The androgen receptor (AR) plays a crucial role in normal physiology, development and metabolism as well as in the aetiology and treatment of diverse pathologies such as androgen insensitivity syndromes (AIS), male infertility and prostate cancer (PCa). [...]
2017 - 10.1038/ncomms14388
Nature communications, Vol. 8 (june 2017) , p. 14388
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