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10 p, 922.8 KB |
The Role of the Complement System in Chronic Inflammatory Demyelinating Polyneuropathy : Implications for Complement-Targeted Therapies
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Querol, Luis (Institut d'Investigació Biomèdica Sant Pau) ;
Hartung, Hans-Peter (Palacky University Olomouc) ;
Lewis, Richard A. (Cedars Sinai Medical Center) ;
van Doorn, Pieter A. (University Medical Center) ;
Hammond, Timothy R. (Sanofi) ;
Atassi, Nazem (Sanofi) ;
Alonso-Alonso, Miguel (Sanofi) ;
Dalakas, Marinos C. (Neuroimmunology National and Kapodistrian University of Athens Medical School) ;
Universitat Autònoma de Barcelona
Chronic inflammatory demyelinating polyneuropathy (CIDP) is the most common, heterogeneous, immune-mediated neuropathy, characterized by predominant demyelination of motor and sensory nerves. CIDP follows a relapsing-remitting or a progressive course and causes substantial disability. [...]
2022 -  10.1007/s13311-022-01221-y
Neurotherapeutics, Vol. 19 Núm. 3 (april 2022) , p. 864-873
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10 p, 787.2 KB |
Granulocytes-Rich Thrombi in Cerebral Large Vessel Occlusion Are Associated with Increased Stiffness and Poorer Revascularization Outcomes
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Juega, Jesus (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Li, Jiahui (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Palacio-Garcia, Carlos (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Rodriguez, Maite (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Tiberi, Riccardo (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Piñana, Carlos (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Rodriguez-Luna, David (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Requena, Manuel (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
García-Tornel, Álvaro (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Rodriguez-Villatoro, Noelia (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Rubiera Del Fueyo, Marta A (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Muchada, Marian (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Olivé-Gadea, Marta (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Rizzo, Federica (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Hernandez, David (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Dios-Lascuevas, Marta (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Hernández-Pérez, María (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Dorado Bouix, Laura (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Quesada, Helena (Hospital Universitari de Bellvitge) ;
Cardona, Pere-Joan (Hospital Universitari de Bellvitge) ;
De La Torre, Carolina (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ;
Gallur, Laura (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Camacho, Jessica (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Ramón y Cajal, Santiago (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Tomasello, Alejandro (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Ribo, Marc (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Molina, Carlos A. (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Pagola, Jorge (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Universitat Autònoma de Barcelona
We aim to identify a profile of intracranial thrombus resistant to recanalization by mechanical thrombectomy (MT) in acute stroke treatment. The first extracted clot of each MT was analyzed by flow cytometry obtaining the composition of the main leukocyte populations: granulocytes, monocytes, and lymphocytes. [...]
2023 - 10.1007/s13311-023-01385-1
Neurotherapeutics, Vol. 20 (may 2023) , p. 1167-1176
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17 p, 1.8 MB |
Therapeutic Effect of IL-21 Blockage by Gene Therapy in Experimental Autoimmune Encephalomyelitis
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Edo Salvador, Ángel (Universitat Autònoma de Barcelona. Institut de Neurociències) ;
Calvo-Barreiro, Laura (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Eixarch, Herena (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Bosch i Merino, Assumpció (Universitat Autònoma de Barcelona. Institut de Neurociències) ;
Chillón Rodríguez, Miguel (Universitat Autònoma de Barcelona. Institut de Neurociències) ;
Espejo, Carmen (Hospital Universitari Vall d'Hebron. Institut de Recerca)
The pathogenic role of the interleukin 21 (IL-21) in diferent autoimmune diseases, such as multiple sclerosis (MS), has been extensively studied. However, its pleiotropic nature makes it a cytokine that may exhibit diferent activity depending on the immunological stage of the disease. [...]
2022 - 10.1007/s13311-022-01279-8
Neurotherapeutics, Vol. 19 (july 2022) , p. 1617-1633
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10 p, 2.6 MB |
Transcutaneous Spinal Neuromodulation Reorganizes Neural Networks in Patients with Cerebral Palsy
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Gad, Parag (University of California. Department of Neurobiology) ;
Hastings, Susan (Susan Hastings Pediatric Physical Therapy (San Jose, Estats Units d'Amèrica)) ;
Zhong, Hui (University of California. Department of Neurobiology) ;
Seth, Gaurav (Banaras Hindu University. Indian Institute of Technology) ;
Kandhari, Sachin (Institute of Brain and Spine (Nova Delhi, India)) ;
Edgerton, Victor (Institut Germans Trias i Pujol. Institut Guttmann) ;
Universitat Autònoma de Barcelona
Spinal neuromodulation and activity-based rehabilitation triggers neural network reorganization and enhances sensory-motor performances involving the lower limbs, the trunk, and the upper limbs. This study reports the acute efects of Transcutaneous Electrical Spinal Cord Neuromodulation (SCONE™, SpineX Inc. [...]
2021 - 10.1007/s13311-021-01087-6
Neurotherapeutics, Vol. 18 (july 2021) , p. 1953-1962
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18 p, 6.7 MB |
Selected Clostridia Strains from The Human Microbiota and their Metabolite, Butyrate, Improve Experimental Autoimmune Encephalomyelitis
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Calvo-Barreiro, Laura (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Eixarch, Herena (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Cornejo-Sánchez, Thais (Hospital Universitari Vall d'Hebron) ;
Costa, Carme (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Castillo, Mireia (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Mestre, Leyre (Instituto Cajal (Consejo Superior de Investigaciones Científicas)) ;
Guaza, Carmen (Instituto Cajal (Consejo Superior de Investigaciones Científicas)) ;
Martínez-Cuesta, María del Carmen (Consejo Superior de Investigaciones Científicas (Espanya). Instituto de Investigación en Ciencias de la Alimentación) ;
Tanoue, Takeshi (RIKEN Center for Integrative Medical Sciences) ;
Honda, Kenya (RIKEN Center for Integrative Medical Sciences) ;
González-López, Juanjo 1975- (Hospital Universitari Vall d'Hebron) ;
Montalban, Xavier (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Espejo, Carmen (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Universitat Autònoma de Barcelona
Gut microbiome studies in multiple sclerosis (MS) patients are unravelling some consistent but modest patterns of gut dysbiosis. Among these, a signifcant decrease of Clostridia cluster IV and XIVa has been reported. [...]
2021 - 10.1007/s13311-021-01016-7
Neurotherapeutics, Vol. 18 (april 2021) , p. 920-937
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19 p, 13.2 MB |
Angiotensin Type 1 Receptor Antagonists Protect Against Alpha-Synuclein-Induced Neuroinflammation and Dopaminergic Neuron Death
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Rodriguez-Perez, Ana I. (Centro de Investigación Biomédica en Red sobre Enfermedades Neurodegenerativas) ;
Sucunza, Diego (University of Navarra. Neurosciences Division, Centro de Investigación Médica Aplicada) ;
Pedrosa, Maria A. (Centro de Investigación Biomédica en Red sobre Enfermedades Neurodegenerativas) ;
Garrido-Gil, Pablo (Centro de Investigación Biomédica en Red sobre Enfermedades Neurodegenerativas) ;
Kulisevsky, Jaime (Institut d'Investigació Biomèdica Sant Pau) ;
Lanciego, Jose L. (University of Navarra. Neurosciences Division, Centro de Investigación Médica Aplicada) ;
Labandeira-Garcia, Jose L. (Centro de Investigación Biomédica en Red sobre Enfermedades Neurodegenerativas) ;
Universitat Autònoma de Barcelona
The loss of dopaminergic neurons and α-synuclein accumulation are major hallmarks of Parkinson's disease (PD), and it has been suggested that a major mechanism of α-synuclein toxicity is microglial activation. [...]
2018 - 10.1007/s13311-018-0646-z
Neurotherapeutics, Vol. 15 (july 2018) , p. 1063-1081
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12 p, 4.5 MB |
Clinical and Histopathological Amelioration of Experimental Autoimmune Encephalomyelitis by AAV Vectors Expressing a Soluble Interleukin-23 Receptor
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Miralles, Marta (Universitat Autònoma de Barcelona. Institut de Neurociències) ;
Eixarch, Herena (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Tejero Ambrosio, Marcos (Universitat Autònoma de Barcelona. Institut de Neurociències) ;
Costa, Carme (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Hirota, Keiji (National Institute for Medical Research) ;
Castaño, A. Raul (Universitat Autònoma de Barcelona. Institut de Biotecnologia i de Biomedicina "Vicent Villar Palasí") ;
Puig Ferrer, Meritxell (Universitat Autònoma de Barcelona. Institut de Neurociències) ;
Stockinger, Gitta (National Institute for Medical Research) ;
Montalban, Xavier (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Bosch i Merino, Assumpció (Universitat Autònoma de Barcelona. Institut de Neurociències) ;
Espejo, Carmen (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Chillón Rodríguez, Miguel (Universitat Autònoma de Barcelona. Institut de Neurociències) ;
Universitat Autònoma de Barcelona.
Departament de Bioquímica i de Biologia Molecular ;
Universitat Autònoma de Barcelona.
Departament de Biologia Cel·lular, de Fisiologia i d'Immunologia
The role of the T helper (Th)17 pathway has been clearly demonstrated in the onset and progression of autoimmune diseases, where interleukin (IL)-23 is a key molecule in maintaining the response mediated by Th17 cells. [...]
The online version of this article (doi:10. 1007/s13311-017-0545-8) contains supplementary material, which is available to authorized users.
2017 - 10.1007/s13311-017-0545-8
Neurotherapeutics, Vol. 14 (June 2017) , p. 1095-1106
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