|
1.
|
|
15 p, 4.3 MB |
Acellular cardiac scaffolds enriched with MSC-derived extracellular vesicles limit ventricular remodelling and exert local and systemic immunomodulation in a myocardial infarction porcine model
/
Monguió-Tortajada, Marta (Institut Germans Trias i Pujol) ;
Prat-Vidal, Cristina (Banc de Sang i Teixits) ;
Martínez-Falguera, Daina (Universitat de Barcelona) ;
Teis, Albert (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Soler-Botija, Carolina (Instituto de Salud Carlos III) ;
Courageux, Yvan (Universitat Autònoma de Barcelona. Departament de Bioquímica i de Biologia Molecular) ;
Munizaga-Larroudé, Micaela (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Morón-Font, Miriam (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Bayés-Genís, Antoni (Universitat Autònoma de Barcelona. Departament de Medicina) ;
Borràs i Serres, Francesc Enric (Universitat de Barcelona. Departament de Biologia Cel·lular, Fisiologia i Immunologia) ;
Rudilla, F. (Institut d'Investigació Biomèdica de Bellvitge) ;
Gálvez-Montón, Carolina (Institut d'Investigació Biomèdica de Bellvitge)
Rationale: Extracellular vesicles (EVs) from mesenchymal stromal cell (MSC) are a potential therapy for cardiac healing after myocardial infarction (MI). Nevertheless, neither their efficient administration nor therapeutic mechanisms are fully elucidated. [...]
2022 -  10.7150/thno.72289
Theranostics, Vol. 12, Issue 10 (June 2022) , p. 4656-4670
|
|
|
2.
|
|
21 p, 2.4 MB |
Selective brain entry of lipid nanoparticles in haemorrhagic stroke is linked to biphasic blood-brain barrier disruption
/
Al-Ahmady, Zahraa S. (The University of Manchester. Nanomedicine Lab, Division of Pharmacy and Optometry) ;
Dickie, Ben R. (University of Manchester. Geoffrey Jefferson Brain Research Centre) ;
Aldred, Isabelle (The University of Manchester. Nanomedicine Lab, Division of Pharmacy and Optometry) ;
Jasim, Dhifaf A. (The University of Manchester. Nanomedicine Lab, Division of Pharmacy and Optometry) ;
Barrington, Jack (University of Manchester. Division of Neuroscience and Experimental Psychology) ;
Haley, Michael J (University of Manchester. Division of Neuroscience and Experimental Psychology) ;
Lemarchand, Eloise (University of Manchester. Division of Neuroscience and Experimental Psychology) ;
Coutts, Graham (University of Manchester. Division of Neuroscience and Experimental Psychology) ;
Kaur, Satinderdeep (Nottingham Trent University. Pharmacology Department) ;
Bates, Jessica (Nottingham Trent University. Pharmacology Department) ;
Curran, Sarah (Nottingham Trent University. Pharmacology Department) ;
Goddard, Ruth (Nottingham Trent University. Pharmacology Department) ;
Walker, Megan (Nottingham Trent University. Pharmacology Department) ;
Parry-jones, Adrian (University of Manchester. Geoffrey Jefferson Brain Research Centre) ;
Kostarelos, Kostas (Institut Català de Nanociència i Nanotecnologia) ;
Allan, Stuart M. (University of Manchester. Geoffrey Jefferson Brain Research Centre)
Haemorrhagic stroke represents a significant public health burden, yet our knowledge and ability to treat this type of stroke are lacking. Previously we showed that we can target ischaemic-stroke lesions by selective translocation of lipid nanoparticles through the site of blood-brain barrier (BBB) disruption. [...]
2022 - 10.7150/thno.72167
Theranostics, Vol. 12, Issue 10 (May 2022) , p. 4477-4497
|
|
|
3.
|
|
16 p, 1.9 MB |
Interleukin-4 and interleukin-13 induce different metabolic profiles in microglia and macrophages that relate with divergent outcomes after spinal cord injury
/
Amo Aparicio, Jesús (Universitat Autònoma de Barcelona. Institut de Neurociències) ;
Garcia Garcia, Joana (Universitat Autònoma de Barcelona. Institut de Neurociències) ;
Francos Quijorna, Isaac (King's College London. Wolfson Centre for Age-Related Diseases) ;
Urpi, Andrea (Universitat Autònoma de Barcelona. Institut de Neurociències) ;
Esteve-Codina, Anna (Universitat Pompeu Fabra) ;
Gut, Marta (Universitat Pompeu Fabra) ;
Quintana Romero, Albert (Universitat Autònoma de Barcelona. Institut de Neurociències) ;
Lopez-Vales, Ruben (Universitat Autònoma de Barcelona. Institut de Neurociències)
Background: Microglia and macrophages adopt a pro-inflammatory phenotype after spinal cord injury (SCI), what is thought to contribute to secondary tissue degeneration. We previously reported that this is due, in part, to the low levels of anti-inflammatory cytokines, such as IL-4. [...]
2021 - 10.7150/thno.65203
Theranostics, Vol. 11 Num. 20 (october 2021) , p. 9805-9820
|
|
|
4.
|
|
13 p, 1.5 MB |
IL-37 exerts therapeutic effects in experimental autoimmune encephalomyelitis through the receptor complex IL-1R5/IL-1R8
/
Sánchez Fernández, Alba (Universitat Autònoma de Barcelona. Institut de Neurociències) ;
Zandee, Stephanie (Université de Montréal. Department of Neuroscience) ;
Amo Aparicio, Jesús (Universitat Autònoma de Barcelona. Institut de Neurociències) ;
Charabati, Marc (Université de Montréal. Department of Neuroscience) ;
Prat, Alexandre (Université de Montréal. Department of Neuroscience) ;
Garlanda, Cecilia (Humanitas Clinical and Research Center) ;
Eisenmesser, Elan Z. (University of Colorado. Department of Biochemistry and Molecular Genetics) ;
Dinarello, Charles A. (Radboud University Medical Center. Department of Medicine) ;
López-Vales, Rubèn (Universitat Autònoma de Barcelona. Institut de Neurociències) ;
Universitat Autònoma de Barcelona.
Departament de Biologia Cel·lular, de Fisiologia i d'Immunologia
Background: Interleukin 37 (IL-37), a member of IL-1 family, broadly suppresses inflammation in many pathological conditions by acting as a dual-function cytokine in that IL-37 signals via the extracellular receptor complex IL1-R5/IL-1R8, but it can also translocate to the nucleus. [...]
2021 - 10.7150/thno.47435
Theranostics, Vol. 11 Núm. 1 (january 2021) , p. 1-13
|
|
|
5.
|
|
12 p, 2.7 MB |
Selective delivery of T22-PE24-H6 to CXCR4 + diffuse large B-cell lymphoma cells leads to wide therapeutic index in a disseminated mouse model
/
Falgàs, Aïda (Institut d'Investigació Biomèdica Sant Pau) ;
Pallarès, Victor (Institut d'Investigació Biomèdica Sant Pau) ;
Serna, Naroa (Universitat Autònoma de Barcelona. Institut de Biotecnologia i de Biomedicina "Vicent Villar Palasí") ;
Sánchez García, Laura 1992- (Universitat Autònoma de Barcelona. Institut de Biotecnologia i de Biomedicina "Vicent Villar Palasí") ;
Sierra, Jorge (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ;
Gallardo, Alberto (Institut d'Investigació Biomèdica Sant Pau) ;
Alba-Castellón, Lorena (Institut d'Investigació Biomèdica Sant Pau) ;
Álamo, Patricia (Institut d'Investigació Biomèdica Sant Pau) ;
Unzueta Elorza, Ugutz (Institut d'Investigació Biomèdica Sant Pau) ;
Villaverde Corrales, Antonio (Universitat Autònoma de Barcelona. Institut de Biotecnologia i de Biomedicina "Vicent Villar Palasí") ;
Vázquez Gómez, Esther (Universitat Autònoma de Barcelona. Institut de Biotecnologia i de Biomedicina "Vicent Villar Palasí") ;
Mangues, Ramon 1957- (Institut d'Investigació Biomèdica Sant Pau) ;
Casanova Rigat, Isolda (Institut d'Investigació Biomèdica Sant Pau) ;
Universitat Autònoma de Barcelona.
Departament de Genètica i de Microbiologia
Background : Novel therapeutic strategies are urgently needed to reduce relapse rates and enhance survival in Diffuse Large B-Cell Lymphoma (DLBCL) patients. CXCR4-overexpressing cancer cells are good targets for therapy because of their association with dissemination and relapse in R-CHOP treated DLBCL patients. [...]
2020 - 10.7150/thno.43231
Theranostics, Vol. 10, Issue 12 (April 2020) , p. 5169-5180
|
|
|
6.
|
|
|
7.
|
|
18 p, 2.7 MB |
Immunization with the Gly 1127 -Cys 1140 amino acid sequence of the LRP1 receptor reduces atherosclerosis in rabbits. Molecular, immunohistochemical and nuclear imaging studies
/
Bornachea, Olga (Institut d'Investigació Biomèdica Sant Pau) ;
Benitez Amaro, Aleyda (Institut d'Investigació Biomèdica Sant Pau) ;
Vea, Angela (Institut d'Investigació Biomèdica Sant Pau) ;
Nasarre, Laura (Institut d'Investigació Biomèdica Sant Pau) ;
Gonzalo Calvo, David de (Institut d'Investigació Biomèdica Sant Pau) ;
Escolà-Gil, Joan Carles (Institut d'Investigació Biomèdica Sant Pau) ;
Cedó, Lídia (Institut d'Investigació Biomèdica Sant Pau) ;
Iborra, Antoni (Universitat Autònoma de Barcelona. Servei de Cultius Cel·lulars, Producció d'Anticossos i Citometria) ;
Martinez-Martinez, Laura (Institut d'Investigació Biomèdica Sant Pau) ;
Juarez, Candido (Institut d'Investigació Biomèdica Sant Pau) ;
Cámara, Juan Antonio (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Espinet, Carina (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Borrell-Pages, Maria (Institut d'Investigació Biomèdica Sant Pau) ;
Badimon, Lina (Institut d'Investigació Biomèdica Sant Pau) ;
Castell-Conesa, Joan (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Llorente-Cortés, Vicenta (Institut d'Investigació Biomèdica Sant Pau) ;
Universitat Autònoma de Barcelona
Background : The LRP1 (CR9) domain and, in particular, the sequence Gly 1127 -Cys 1140 (P3) plays a critical role in the binding and internalization of aggregated LDL (agLDL). We aimed to evaluate whether immunization with P3 reduces high-fat diet (HFD)-induced atherosclerosis. [...]
2020 - 10.7150/thno.37305
Theranostics, Vol. 10 (february 2020) , p. 3263-3280
|
|
|
8.
|
|
15 p, 2.3 MB |
Nanosized UCMSC-derived extracellular vesicles but not conditioned medium exclusively inhibit the inflammatory response of stimulated T cells: implications for nanomedicine
/
Monguió Tortajada, Marta (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Rudilla, F. (Institut Germans Trias i Pujol) ;
Gálvez-Montón, Carolina (Institut Germans Trias i Pujol) ;
Pujal, Josep Maria (Universitat de Girona. Laboratori de processament cel·lular) ;
Aran, Gemma (Institut Germans Trias i Pujol) ;
Sanjurjo, Lucía (Institut Germans Trias i Pujol) ;
Franquesa, Marcella (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Sarrias, Maria-Rosa (Institut Germans Trias i Pujol) ;
Bayés-Genís, Antoni (Universitat Autònoma de Barcelona. Departament de Medicina) ;
Borràs i Serres, Francesc Enric (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol)
Undesired immune responses have drastically hampered outcomes after allogeneic organ transplantation and cell therapy, and also lead to inflammatory diseases and autoimmunity. Umbilical cord mesenchymal stem cells (UCMSCs) have powerful regenerative and immunomodulatory potential, and their secreted extracellular vesicles (EVs) are envisaged as a promising natural source of nanoparticles to increase outcomes in organ transplantation and control inflammatory diseases. [...]
2017 - 10.7150/thno.16154
Theranostics, Vol. 7 Núm. 2 (2017) , p. 270-284
|
|
|
9.
|
|
16 p, 2.9 MB |
In Vivo Theranostics at the Peri-Infarct Region in Cerebral Ischemia
/
Agulla, Jesús (Universidade de Santiago de Compostela) ;
Brea, David (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Campos, Francisco (Universidade de Santiago de Compostela) ;
Sobrino, Tomás (Universidade de Santiago de Compostela) ;
Argibay, Bárbara (Universidade de Santiago de Compostela) ;
Al-Soufi, Wajih (Universidade de Santiago de Compostela) ;
Blanco, Miguel (Universidade de Santiago de Compostela) ;
Castillo, José (Universidade de Santiago de Compostela) ;
Ramos-Cabrer, Pedro (Universidade de Santiago de Compostela)
The use of theranostics in neurosciences has been rare to date because of the limitations imposed on the free delivery of substances to the brain by the blood-brain barrier. Here we report the development of a theranostic system for the treatment of stroke, a leading cause of death and disability in developed countries. [...]
2013 - 10.7150/thno.7088
Theranostics, Vol. 4 (december 2013) , p. 90-105
|
|
guest ::
email alert
or subscribe to the 
RSS feed.
