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19 p, 7.0 MB |
Exposing and Overcoming Limitations of Clinical Laboratory Tests in COVID-19 by Adding Immunological Parameters; A Retrospective Cohort Analysis and Pilot Study
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Sánchez-Montalvá, Adrián (Hospital Universitari Vall d'Hebron) ;
Álvarez-Sierra, Daniel (Hospital Universitari Vall d'Hebron) ;
Martínez Gallo, Mónica (Hospital Universitari Vall d'Hebron) ;
Perurena-Prieto, Janire (Hospital Universitari Vall d'Hebron) ;
Arrese-Muñoz, Iria (Hospital Universitari Vall d'Hebron) ;
Ruiz-Rodriguez, Juan Carlos (Hospital Universitari Vall d'Hebron) ;
Espinosa-Pereiro, Juan (Hospital Universitari Vall d'Hebron) ;
Bosch-Nicolau, Pau (Hospital Universitari Vall d'Hebron) ;
Martínez Gómez, Xavier (Hospital Universitari Vall d'Hebron) ;
Antón, Andrés (Hospital Universitari Vall d'Hebron) ;
Martínez-Valle, Ferran (Hospital Universitari Vall d'Hebron) ;
Riveiro Barciela, Mar (Hospital Universitari Vall d'Hebron) ;
Blanco-Grau, Albert (Hospital Universitari Vall d'Hebron) ;
Rodríguez Frías, Francisco (Hospital Universitari Vall d'Hebron) ;
Castellano-Escuder, Pol (Universitat de Barcelona) ;
Poyatos Cantón, E (Hospital Universitari de Bellvitge) ;
Bas, Jordi (Hospital Universitari de Bellvitge) ;
Martínez Cáceres, Eva María (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Sánchez, Alex (Hospital Universitari Vall d'Hebron) ;
Zurera Egea, Coral (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Teniente Serra, Aina (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Hernández-González, Manuel (Hospital Universitari Vall d'Hebron) ;
Pujol-Borrell, Ricardo (Hospital Universitari Vall d'Hebron) ;
Universitat Autònoma de Barcelona
Two years since the onset of the COVID-19 pandemic no predictive algorithm has been generally adopted for clinical management and in most algorithms the contribution of laboratory variables is limited. [...]
2022 -  10.3389/fimmu.2022.902837
Frontiers in immunology, Vol. 13 (june 2022)
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15 p, 3.2 MB |
p53 wild-type colorectal cancer cells that express a fetal gene signature are associated with metastasis and poor prognosis
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Solé Font, Laura (Instituto de Salud Carlos III) ;
Lobo-Jarne, Teresa (Instituto de Salud Carlos III) ;
Álvarez-Villanueva, Daniel (Institut Català d'Oncologia) ;
Alonso-Marañón, Josune (Institut Hospital del Mar d'Investigacions Mèdiques) ;
Guillén, Yolanda (Institut Hospital del Mar d'Investigacions Mèdiques) ;
Guix, Marta (Universitat Pompeu Fabra) ;
Sangrador, Irene (Institut Hospital del Mar d'Investigacions Mèdiques) ;
Rozalén, Catalina (Institut Hospital del Mar d'Investigacions Mèdiques) ;
Vert, Anna (Institut Hospital del Mar d'Investigacions Mèdiques) ;
Barbachano, Antonio (Universidad Autónoma de Madrid) ;
Lop Gros, Joan (Institut Hospital del Mar d'Investigacions Mèdiques) ;
Salido, Marta (Institut Hospital del Mar d'Investigacions Mèdiques) ;
Bellosillo Paricio, Beatriz (Institut Hospital del Mar d'Investigacions Mèdiques) ;
García-Romero, Raquel (Institut Hospital del Mar d'Investigacions Mèdiques) ;
Garrido, Marta (Institut Hospital del Mar d'Investigacions Mèdiques) ;
González Miranda, Jessica (Institut Hospital del Mar d'Investigacions Mèdiques) ;
Martínez-Iniesta, María (Institut Català d'Oncologia) ;
López-Arribillaga, Erika (Group of Biomedical Genomics) ;
Salazar, Ramón. (Institut Català d'Oncologia) ;
Torres, Ferran (Universitat Autònoma de Barcelona. Departament de Pediatria, Obstetrícia i Ginecologia i Medicina Preventiva i Salut Pública) ;
Iglesias, Mar (Institut Hospital del Mar d'Investigacions Mèdiques) ;
Celià-Terrassa, Toni (Institut Hospital del Mar d'Investigacions Mèdiques) ;
Munoz, Alberto (Instituto de Salud Carlos III) ;
Villanueva, Alberto (Institut Català d'Oncologia) ;
Bigas Salvans, Anna (Instituto de Salud Carlos III) ;
Espinosa, Lluís (Instituto de Salud Carlos III) ;
Universitat Autònoma de Barcelona
Current therapy against colorectal cancer (CRC) is based on DNA-damaging agents that remain ineffective in a proportion of patients. Whether and how non-curative DNA damage-based treatment affects tumor cell behavior and patient outcome is primarily unstudied. [...]
2022 - 10.1038/s41467-022-30382-9
Nature communications, Vol. 13 Núm. 1 (december 2022) , p. 2866
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13 p, 7.0 MB |
Stratification of hospitalized COVID-19 patients into clinical severity progression groups by immuno-phenotyping and machine learning
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Mueller, Yvonne M. (Erasmus University Medical Center) ;
Schrama, Thijs J. (Erasmus University Medical Center) ;
Ruijten, Rik (Erasmus University Medical Center) ;
Schreurs, Marco W. J. (Erasmus University Medical Center) ;
Grashof, Dwin G. B. (Erasmus University Medical Center) ;
van de Werken, Harmen J. G. (Erasmus University Medical Center) ;
Lasinio, Giovanna Jona (University of Rome "La Sapienza") ;
Álvarez-Sierra, Daniel (Hospital Universitari Vall d'Hebron) ;
Kiernan, Caoimhe H. (Erasmus University Medical Center) ;
Castro Eiro, Melisa D. (Erasmus University Medical Center) ;
van Meurs, Marjan (Erasmus University Medical Center) ;
Brouwers-Haspels, Inge (Erasmus University Medical Center) ;
Zhao, Manzhi (Erasmus University Medical Center) ;
Li, Ling (Erasmus University Medical Center) ;
de Wit, Harm (Erasmus University Medical Center) ;
Ouzounis, Christos A. (Chemical Process & Energy Resources Institute, Centre for Research & Technology Hellas, Thermi) ;
Wilmsen, Merel E. P. (Erasmus University Medical Center) ;
Alofs, Tessa M. (Erasmus University Medical Center) ;
Laport, Danique A. (Erasmus University Medical Center) ;
van Wees, Tamara (Erasmus University Medical Center) ;
Kraker, Geoffrey (Cytek Biosciences, Fremont, CA USA) ;
Jaimes, Maria C. (Cytek Biosciences, Fremont, CA USA) ;
Van Bockstael, Sebastiaan (Cytek Biosciences, Fremont, CA USA) ;
Hernández-González, Manuel (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Rokx, Casper (Erasmus University Medical Center) ;
Rijnders, Bart J. A. (Erasmus University Medical Center) ;
Pujol-Borrell, Ricardo (Vall d'Hebron Institut d'Oncologia) ;
Katsikis, Peter D. (Erasmus University Medical Center) ;
Universitat Autònoma de Barcelona
Quantitative or qualitative differences in immunity may drive clinical severity in COVID-19. Although longitudinal studies to record the course of immunological changes are ample, they do not necessarily predict clinical progression at the time of hospital admission. [...]
2022 - 10.1038/s41467-022-28621-0
Nature communications, Vol. 13 (february 2022)
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17 p, 3.2 MB |
Peripheral and lung resident memory T cell responses against SARS-CoV-2
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Grau Expósito, Judith (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Sánchez-Gaona, Nerea (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Massana, Núria (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Suppi, Marina (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Astorga-Gamaza, Antonio (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Perea, David (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Rosado Rodríguez, Joel (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Falcó, Anna (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Kirkegaard, Cristina (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Torrella Domingo, Adriana (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Planas, Bibiana (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Navarro, Jordi (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Suanzes, Paula (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Álvarez-Sierra, Daniel (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Ayora, Alfonso (Hospital Universitari Vall d'Hebron) ;
Sansano, Irene (Universitat Autònoma de Barcelona. Departament de Ciències Morfològiques) ;
Esperalba, Juliana (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Andrés, Cristina (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Antón, Andrés (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Ramón y Cajal, Santiago (Universitat Autònoma de Barcelona. Departament de Ciències Morfològiques) ;
Almirante Gragera, Benito (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Pujol-Borrell, Ricardo (Hospital Universitari Vall d'Hebron) ;
Falcó, Vicenç (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Burgos, Joaquín (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Buzón, Maria José (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Genescà Ferrer, Meritxell (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Universitat Autònoma de Barcelona
Resident memory T cells (T) positioned within the respiratory tract are probably required to limit SARS-CoV-2 spread and COVID-19. Importantly, T are mostly non-recirculating, which reduces the window of opportunity to examine these cells in the blood as they move to the lung parenchyma. [...]
2021 - 10.1038/s41467-021-23333-3
Nature communications, Vol. 12 (may 2021)
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7 p, 799.9 KB |
A Rapid Test for Soy Aeroallergens Exposure Assessment
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Álvarez-Simón, Daniel (Universitat Autònoma de Barcelona. Departament de Medicina) ;
Cruz Carmona, María Jesús (Universitat Autònoma de Barcelona. Departament de Medicina) ;
Untoria, María-Dolores (Hospital Universitari Vall d'Hebron) ;
Muñoz Gall, Xavier (Universitat Autònoma de Barcelona. Departament de Biologia Cel·lular, de Fisiologia i d'Immunologia) ;
Villalbí, Joan Ramón (Institut d'Investigació Biomèdica Sant Pau) ;
Morell Brotad, Ferran 1944- (Universitat Autònoma de Barcelona. Departament de Medicina) ;
Gómez-Ollés, Susana (Universitat Autònoma de Barcelona. Departament de Medicina)
Determining soy aeroallergens levels is extremely important in the assessment of health risks due to these airborne substances. Currently, soy aeroallergens exposure in the environment is monitored using enzyme immunoassays (EIA) which must be evaluated in a specialized laboratory by skilled personnel. [...]
2014 - 10.1371/journal.pone.0088676
PloS one, Vol. 9, Issue 2 (February 2014) , art. e88676
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14 p, 6.3 MB |
Effects of diesel exhaust particle exposure on a murine model of asthma due to soybean
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Álvarez-Simón, Daniel (Universitat Autònoma de Barcelona. Departament de Medicina) ;
Gómez-Ollés, Susana (Centro de Investigación Biomédica en Red de Enfermedades Respiratorias) ;
de Homdedeu, Miquel (Hospital Universitari Vall d'Hebron) ;
Untoria, María-Dolores (Centro de Investigación Biomédica en Red de Enfermedades Respiratorias) ;
Cruz Carmona, María Jesús (Centro de Investigación Biomédica en Red de Enfermedades Respiratorias) ;
Muñoz Gall, Xavier (Universitat Autònoma de Barcelona. Departament de Biologia Cel·lular, de Fisiologia i d'Immunologia)
Exposure to soybean allergens has been linked to asthma outbreaks. Exposure to diesel exhaust particles (DEP) has been associated with an increase in the risk of asthma and asthma exacerbation; however, in both cases the underlying mechanisms remain poorly understood, as does the possible interaction between the two entities. [...]
2017 - 10.1371/journal.pone.0179569
PloS one, Vol. 12 (june 2017)
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10 p, 342.4 KB |
Validation of an Asbestos Exposure Questionnaire (QEAS-7) for Clinical Practice
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Ferrer Sancho, Jaume 1958- (Universitat Autònoma de Barcelona. Departament de Medicina) ;
Granados, Galo (Universitat Autònoma de Barcelona. Departament de Medicina) ;
Hernández, Santos (Institut Català de Seguretat i Salut Laboral, Departament de Treball, Afers Socials i Famílies) ;
Cruz Carmona, María Jesús (Hospital Universitari Vall d'Hebron) ;
Sampol, Júlia (Institut Català de Seguretat i Salut Laboral, Departament de Treball, Afers Socials i Famílies) ;
Álvarez-Simón, Daniel (Hospital Universitari Vall d'Hebron) ;
Ramada Rodilla, José María (Centro de Investigación Biomédica en Red de Epidemiología y Salud Pública)
Introduction: The seven-item QEAS-7 questionnaire (exposure to asbestos questionnaire) has been designed as a useful and simple tool to establish the probability of exposure to asbestos. The objective of the present study is to validate the QEAS-7 following the recommended methodology. [...]
2020 - 10.3390/ijerph17249167
International journal of environmental research and public health, Vol. 17 (december 2020)
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