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1.
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253 p, 10.6 MB |
Identification of novel candidate biomarkers of response to chemotherapeutic agents in patients with colorectal cancer
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Li, Jing ;
Arango, Diego, dir. ;
Martínez Barriocana, Águeda, dir. ;
Meseguer Navarro, Anna, dir.
El càncer colorectal és el tercer tipus de càncer més comú a tot el món. La majoria dels pacients amb càncer colorectal reben tractament quimioterapèutic durant el curs de la seva malaltia. Tot i això, l'eficàcia dels compostos quimioterapèutics com a agents únics no supera el 30%. [...]
El cáncer colorrectal es el tercer tipo de cáncer más común en todo el mundo. La mayoría de los pacientes con cáncer colorrectal reciben tratamiento quimioterapéutico durante el curso de su enfermedad. [...]
Colorectal cancer (CRC) is the third most common type of cancer worldwide. Most CRC patients receive chemotherapeutic treatment during the course of their disease. However, the efficacy of chemotherapeutic compounds as single agents is not greater than 30%. [...]
2023 -  10.1186/s13690-023-01104-4
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2.
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13 p, 31.6 MB |
Extracellular vesicles secreted by triple-negative breast cancer stem cells trigger premetastatic niche remodeling and metastatic growth in the lungs
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González-Callejo, Patricia (Instituto de Salud Carlos III) ;
Gener, Petra (Instituto de Salud Carlos III) ;
Díaz Riascos, Zamira Vanessa (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Conti, Sefora (Institut de Bioenginyeria de Catalunya) ;
Cámara-Sánchez, Patricia (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Riera Brillas, Roger (Department of Biomedical Engineering. Eindhoven University of Technology) ;
Mancilla, Sandra (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
García-Gabilondo, Miguel (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Peg, Vicente (Centro de Investigación Biomédica en Red de Cáncer) ;
Arango, Diego (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Rosell Novel, Anna (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Labernadie, Anna (Institut de Bioenginyeria de Catalunya) ;
Trepat, Xavier (Institució Catalana de Recerca i Estudis Avançats) ;
Albertazzi, Lorenzo (Department of Biomedical Engineering. Eindhoven University of Technology) ;
Schwartz, S. (Instituto de Salud Carlos III) ;
Seras-Franzoso, Joaquin (Universitat Autònoma de Barcelona. Departament de Genètica i de Microbiologia) ;
Abasolo, Ibane (Hospital Universitari Vall d'Hebron. Institut de Recerca)
Tumor secreted extracellular vesicles (EVs) are potent intercellular signaling platforms. They are responsible for the accommodation of the premetastatic niche (PMN) to support cancer cell engraftment and metastatic growth. [...]
2023 - 10.1002/ijc.34447
International Journal of Cancer, Vol. 152 Núm. 10 (15 2023) , p. 2153-2165
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3.
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2 p, 760.6 KB |
Author Correction : DUSP5 is methylated in CIMP-high colorectal cancer but is not a major regulator of intestinal cell proliferation and tumorigenesis
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Tögel, Lars (La Trobe University School of Cancer Medicine) ;
Nightingale, Rebecca (La Trobe University School of Cancer Medicine) ;
Wu, Rui (Ludwig Institute for Cancer Research) ;
Chüeh, Anderly C. (Ludwig Institute for Cancer Research) ;
Al-Obaidi, Sheren (Ludwig Institute for Cancer Research) ;
Luk, Ian (La Trobe University School of Cancer Medicine) ;
Dávalos-Salas, Mercedes (La Trobe University School of Cancer Medicine) ;
Chionh, Fiona (La Trobe University School of Cancer Medicine) ;
Murone, Carmel (La Trobe University School of Cancer Medicine) ;
Buchanan, Daniel D. (The University of Melbourne. Department of Pathology) ;
Chatterton, Zac (The University of Melbourne. Department of Pathology) ;
Sieber, Oliver M. (The Walter and Eliza Hall Institute of Medical Research. Systems Biology and Personalised Medicine Division) ;
Arango, Diego (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Tebbutt, Niall C. (La Trobe University School of Cancer Medicine) ;
Williams, David (La Trobe University School of Cancer Medicine) ;
Dhillon, Amardeep S. (La Trobe University School of Cancer Medicine) ;
Mariadason, John M. (Ludwig Institute for Cancer Research)
2023 - 10.1038/s41598-023-29328-y
Scientific reports, Vol. 13 (february 2023)
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4.
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237 p, 5.6 MB |
The Small GTPase RHOA in cancer
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Anguita, Estefanía ;
Arango, Diego, dir. ;
Martínez Barriocanal, Agueda, dir. ;
Dopeso Gonzalez, Jose Higinio, dir.
RhoA és una proteïna GTPasa amb un paper rellevant en importants processos cel·lulars. Els nivells d'expressió de RhoA i/o la seva activitat es troben alterats en molts tipus de càncer, però curiosament s'han trobat mutacions recurrents i específiques de tumor en càncer gàstric de tipus difús (CGD), carcinoma de cèl·lules escamoses de cap i coll (CCECC), limfoma de Burkitt, leucèmia/limfoma T de l'adult i limfoma T angioimmunoblàstic, suggerint un paper diferent y depenent de tumor per cada proteïna mutant. [...]
RhoA es una proteína GTPasa con un papel relevante en importantes procesos celulares. Los niveles de expresión de RhoA y/o su actividad se encuentran alterados en muchos tipos de cáncer, pero curiosamente, se han encontrado mutaciones recurrentes y específicas de tumor en cáncer gástrico de tipo difuso (CGD), carcinoma de células escamosas de cabeza y cuello (CCECC), linfoma de Burkitt, leucemia/linfoma T del adulto y linfoma T angioinmunoblástico, sugiriendo un papel distinto y dependiente de tumor para cada proteína mutante. [...]
RhoA is a small GTPase with an important role in key cellular processes. RhoA expression levels and/or activity are altered in multiple cancers, but interestingly, recurrent and tissue-specific hotspot mutations have been recently identified in diffuse gastric cancer (DGC), head and neck squamous cell carcinoma (HNSCC), Burkitt lymphoma, adult T-cell leukemia/lymphoma and angioimmunoblastic T-cell lymphoma, suggesting a distinctive and tumor-dependent role of each mutant protein. [...]
2022
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5.
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13 p, 1.3 MB |
Identification of ZBTB18 as a novel colorectal tumor suppressor gene through genome-wide promoter hypermethylation analysis
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Bazzocco, Sarah (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Dopeso, Higinio (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Martínez-Barriocanal, Águeda (IRBLleida. Group of Molecular Oncology) ;
Anguita, Estefanía (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Nieto Raya, Rocio (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Li, Jing (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Garcia-Vidal, Elia (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Maggio, Valentina (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Rodrigues, Paulo (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
de Marcondes, Priscila Guimarães (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Schwartz, Simon (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Aaltonen, Lauri A. (University of Helsinki) ;
Sánchez, Alex (Universitat de Barcelona. Departament d'Estadística) ;
Mariadason, John M. (La Trobe University. School of Cancer Medicine) ;
Arango, Diego (IRBLleida. Group of Molecular Oncology)
Cancer initiation and progression are driven by genetic and epigenetic changes. Although genome/exome sequencing has significantly contributed to the characterization of the genetic driver alterations, further investigation is required to systematically identify cancer driver genes regulated by promoter hypermethylation. [...]
2021 - 10.1186/s13148-021-01070-0
Clinical Epigenetics, Vol. 13 (april 2021)
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6.
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10 p, 2.5 MB |
Myo5b knockout mice as a model of microvillus inclusion disease
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Cartón-Garcia, Fernando (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Overeem, Arend W. (University Medical Center Groningen) ;
Nieto Raya, Rocio (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Bazzocco, Sarah (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Dopeso, Higinio (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Macaya, Irati (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Bilic Zimmermann, Josipa (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Landolfi, Stefania (Hospital Universitari Vall d'Hebron) ;
Hernandez-Losa, Javier (Hospital Universitari Vall d'Hebron) ;
Schwartz, Simo (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Ramon y Cajal, Santiago (Hospital Universitari Vall d'Hebron) ;
van Ijzendoorn, Sven C. D. (University Medical Center Groningen) ;
Arango, Diego (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Universitat Autònoma de Barcelona
Inherited MYO5B mutations have recently been associated with microvillus inclusion disease (MVID), an autosomal recessive syndrome characterized by intractable, life-threatening, watery diarrhea appearing shortly after birth. [...]
2015 - 10.1038/srep12312
Scientific reports, Vol. 5 (07 2015)
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7.
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12 p, 2.3 MB |
Loss of the EPH receptor B6 contributes to colorectal cancer metastasis
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Mateo-Lozano, Silvia (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Bazzocco, Sarah (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Rodrigues, Paulo (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Mazzolini, Rocco (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Andretta, Elena (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Dopeso, Higinio (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Fernández Caparrós, Yolanda (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
del Llano, Edgar (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Bilic Zimmermann, Josipa (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Suárez-López, Lucía (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Macaya, Irati (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Cartón-Garcia, Fernando (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Nieto Raya, Rocio (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Jimenez-Flores, Lizbeth M. (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
de Marcondes, Priscila Guimarães (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Nuñez, Yaiza (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Afonso, Elsa (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Cacci, Karina (Hospital Universitari Vall d'Hebron) ;
Hernandez-Losa, Javier (Hospital Universitari Vall d'Hebron) ;
Landolfi, Stefania (Hospital Universitari Vall d'Hebron) ;
Abasolo, Ibane (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Ramón y Cajal, Santiago (Hospital Universitari Vall d'Hebron) ;
Mariadason, John M. (La Trobe University) ;
Schwartz, Simo (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Matsui, Toshimitsu (Kobe University Graduate School of Medicine) ;
Arango, Diego (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Universitat Autònoma de Barcelona
Although deregulation of EPHB signaling has been shown to be an important step in colorectal tumorigenesis, the role of EPHB6 in this process has not been investigated. We found here that manipulation of EPHB6 levels in colon cancer cell lines has no effect on their motility and growth on a solid substrate, soft agar or in a xenograft mouse model. [...]
2017 - 10.1038/srep43702
Scientific reports, Vol. 7 (03 2017)
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8.
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14 p, 2.1 MB |
Investigation of the role of tyrosine kinase receptor EPHA3 in colorectal cancer
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Andretta, Elena (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Cartón-Garcia, Fernando (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Martínez-Barriocanal, Águeda (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
de Marcondes, Priscila Guimarães (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Jimenez-Flores, Lizbeth M. (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Macaya, Irati (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Bazzocco, Sarah (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Bilic Zimmermann, Josipa (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Rodrigues, Paulo (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Nieto Raya, Rocio (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Landolfi, Stefania (Hospital Universitari Vall d'Hebron) ;
Ramon y Cajal, Santiago (Hospital Universitari Vall d'Hebron) ;
Schwartz, Simo (Centro de Investigación Biomédica en Red de Bioingeniería, Biomateriales y Nanomedicina) ;
Brown, Arthur (Robarts Research Institute) ;
Dopeso, Higinio (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Arango, Diego (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Universitat Autònoma de Barcelona
EPH signaling deregulation has been shown to be important for colorectal carcinogenesis and genome-wide sequencing efforts have identified EPHA3 as one of the most frequently mutated genes in these tumors. [...]
2017 - 10.1038/srep41576
Scientific reports, Vol. 7 (02 2017)
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9.
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12 p, 2.8 MB |
Dynamism, Sensitivity, and Consequences of Mesenchymal and Stem-Like Phenotype of Cancer Cells
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Gener, Petra (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Seras-Franzoso, Joaquin (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Callejo, Patricia González (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Andrade, Fernanda (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Rafael, Diana (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Martínez, Francesc (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Montero, Sara (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Arango, Diego (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Sayós, Joan (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Abasolo, Ibane (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Schwartz, Simon (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Universitat Autònoma de Barcelona
There are remarkable similarities in the description of cancer stem cells (CSCs) and cancer cells with mesenchymal phenotype. Both cell types are highly tumorigenic, resistant against common anticancer treatment, and thought to cause metastatic growth. [...]
2018 - 10.1155/2018/4516454
Stem Cells International, Vol. 2018 (october 2018)
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10.
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11 p, 6.9 MB |
DUSP5 is methylated in CIMP-high colorectal cancer but is not a major regulator of intestinal cell proliferation and tumorigenesis
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Tögel, Lars (La Trobe University School of Cancer Medicine) ;
Nightingale, Rebecca (La Trobe University School of Cancer Medicine) ;
Wu, Rui (Ludwig Institute for Cancer Research) ;
Chüeh, Anderly C. (Ludwig Institute for Cancer Research) ;
Al-Obaidi, Sheren (Ludwig Institute for Cancer Research) ;
Luk, Ian (La Trobe University School of Cancer Medicine) ;
Dávalos-Salas, Mercedes (La Trobe University School of Cancer Medicine) ;
Chionh, Fiona (La Trobe University School of Cancer Medicine) ;
Murone, Carmel (La Trobe University School of Cancer Medicine) ;
Buchanan, Daniel D. (The University of Melbourne) ;
Chatterton, Zac (The University of Melbourne) ;
Sieber, Oliver M. (The Walter and Eliza Hall Institute of Medical Research) ;
Arango, Diego (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Tebbutt, Niall C. (La Trobe University School of Cancer Medicine) ;
Williams, David (La Trobe University School of Cancer Medicine) ;
Dhillon, Amardeep S. (La Trobe University School of Cancer Medicine) ;
Mariadason, John M. (Ludwig Institute for Cancer Research) ;
Universitat Autònoma de Barcelona
The ERK signalling pathway regulates key cell fate decisions in the intestinal epithelium and is frequently dysregulated in colorectal cancers (CRCs). Variations in the dynamics of ERK activation can induce different biological outcomes and are regulated by multiple mechanisms, including activation of negative feedback loops involving transcriptional induction of dual-specificity phosphatases (DUSPs). [...]
2018 - 10.1038/s41598-018-20176-9
Scientific reports, Vol. 8 (january 2018)
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