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7 p, 191.5 KB Paracetamol in therapeutic dosages and acute liver injury : causality assessment in a prospective case series / Sabaté, Mònica (Vall d'Hebron Hospitals) ; Ibáñez Mora, Luisa (Vall d'Hebron Hospitals) ; Pérez, Eulàlia (Vall d'Hebron Hospitals) ; Vidal Guitart, Xavier (Vall d'Hebron Hospitals) ; Buti, Maria (Vall d'Hebron Hospitals) ; Xiol, Xavier (Hospital Universitari Prínceps d'Espanya de Bellvitge) ; Mas, Antoni (Hospital Clínic i Provincial de Barcelona) ; Guarner, Carlos (Institut d'Investigació Biomèdica Sant Pau) ; Forné, Montserrat (Hospital de Mútua (Terrassa, Catalunya)) ; Solà Lamoglia, Ricard (Hospital del Mar (Barcelona, Catalunya)) ; Castellote, José (Hospital Universitari Prínceps d'Espanya de Bellvitge) ; Rigau, Joaquim (Hospital General (Granollers, Catalunya)) ; Laporte Rosselló, Joan-Ramón (Vall d'Hebron Hospitals) ; Universitat Autònoma de Barcelona
Background: Acute liver injury (ALI) induced by paracetamol overdose is a well known cause of emergency hospital admission and death. However, there is debate regarding the risk of ALI after therapeutic dosages of the drug. [...]
Our results indicate that paracetamol in therapeutic dosages may be considered in the causality assessment in non-alcoholic patients with liver injury, even if the estimated incidence of ALI related to paracetamol appears to be low.

2011 - 10.1186/1471-230X-11-80
BMC Gastroenterology, Vol. 11, N. 80 (July 2011) , p. 1-7  

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