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29.
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8 p, 1.4 MB |
Immunomodulatory effect of MSC on B cells is independent of secreted extracellular vesicles
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Carreras-Planella, Laura (Universitat Autònoma de Barcelona. Departament de Biologia Cel·lular, de Fisiologia i d'Immunologia) ;
Monguió-Tortajada, Marta (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Borràs i Serres, Francesc Enric (Universitat Autònoma de Barcelona. Departament de Biologia Cel·lular, de Fisiologia i d'Immunologia) ;
Franquesa, Marcella (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol)
Mesenchymal stem or stromal cells (MSC) have proven immunomodulatory properties toward B cell activation and induce regulatory B cells (Breg), through a dual mechanism of action that relies both on cell contact and secreted factors. [...]
2019 -  10.3389/fimmu.2019.01288
Frontiers in immunology, Vol. 10 (June 2019) , art. 1288
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30.
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13 p, 3.2 MB |
Comprehensive proteomic profiling of plasma-derived Extracellular Vesicles from dementia with Lewy Bodies patients
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Gámez-Valero, Ana (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Campdelacreu, Jaume (Hospital Universitari de Bellvitge) ;
Reñé, Ramón (Hospital Universitari de Bellvitge) ;
Beyer, Katrin (Institut Germans Trias i Pujol) ;
Borràs i Serres, Francesc Enric (Universitat Autònoma de Barcelona. Departament de Biologia Cel·lular, de Fisiologia i d'Immunologia)
Proteins and nucleic acids contained in extracellular vesicles (EVs) are considered a feasible source of putative biomarkers for physiological and pathological conditions. Within the nervous system, not only neurons but also other brain cells are able to produce EVs, which have been involved in their physiological processes and also in the development and course of several neurodegenerative diseases. [...]
2019 - 10.1038/s41598-019-49668-y
Scientific reports, Vol. 9 (September 2019) , art. 13282
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31.
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171 p, 3.9 MB |
Vesículas extracelulares en orina como fuente no invasiva de material biológico para la monitorización de pacientes trasplantados
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Bancu, Ioana ;
Lauzurica, Ricardo, dir. ;
Borràs i Serres, Francesc Enric, dir. ;
Tor Aguilera, Jordi, dir. ;
Universitat Autònoma de Barcelona.
Departament de Medicina
El trasplante renal es el tratamiento de elección para los pacientes con enfermedad renal crónica avanzada. Aunque la tasa de supervivencia del injerto renal al año supera el 90%, se ha estimado que a los 5 años una cuarta parte de los pacientes trasplantados no tendrán un injerto renal funcionante. [...]
Kidney transplantation is the treatment of choice for patients with advanced chronic kidney disease. Although the renal graft survival at one year exceeds 90%, it has been estimated that at 5 years a quarter of the transplanted patients will not have a functioning renal graft. [...]
[Barcelona] : Universitat Autònoma de Barcelona, 2019.
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32.
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33.
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198 p, 5.7 MB |
Immunomodulation by mesenchymal stem cells for myocardial regeneration : cellular mechanisms and extracellular vesicles
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Monguió Tortajada, Marta ;
Borràs i Serres, Francesc Enric, dir. ;
Jaraquemada, Dolores, dir. ;
Universitat Autònoma de Barcelona.
Departament de Biologia Cel·lular, de Fisiologia i d'Immunologia
Les respostes immunològiques descontrolades obstaculitzen la regeneració de teixits danyats i el transplantament d'òrgans, i provoquen al·lèrgies i trastorns autoimmunitaris, causant morbiditat i mortalitat. [...]
Exacerbated immune responses hamper regeneration of injured tissues and organ transplantation, and lead to allergies and autoimmune disorders causing morbidity and mortality. One of these scenarios is the ischaemia-reperfusion injury (IRI) occurring upon myocardial infarction (MI). [...]
[Barcelona] : Universitat Autònoma de Barcelona, 2019.
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34.
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138 p, 3.1 MB |
Perfil transcriptómico y proteómico de las vesículas extracelulares de orina: diferencias entre donante renal y paciente trasplantado normo-funcional
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Lozano Ramos, Sara Inés ;
Borràs i Serres, Francesc Enric, dir. ;
Jaraquemada, Dolores, dir. ;
Universitat Autònoma de Barcelona.
Departament de Biologia Cel·lular, de Fisiologia i d'Immunologia
El trasplante renal (TR) es la mejor aproximación terapéutica para la enfermedad renal crónica (ERC) en estado terminal. Sin embargo, en la práctica clínica, la monitorización de la función renal se realiza, principalmente, mediante métodos indirectos. [...]
Kidney transplantation (KT) is the best therapeutic approach for chronic kidney diseases (CKD) leading to an irreversible kidney failure. However, the follow-up of kidney function is still delicate. [...]
[Barcelona] : Universitat Autònoma de Barcelona, 2019.
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35.
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13 p, 6.0 MB |
Mesenchymal stem cells induce expression of cD73 in human monocytes in vitro and in a swine model of myocardial infarction in vivo
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Monguió-Tortajada, Marta (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Rudilla, F. (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Gálvez-Montón, Carolina (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Franquesa, Marcella (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Bayés-Genís, Antoni (Universitat Autònoma de Barcelona. Departament de Medicina) ;
Borràs i Serres, Francesc Enric (Universitat Autònoma de Barcelona. Departament de Biologia Cel·lular, de Fisiologia i d'Immunologia)
The ectoenzymes CD39 and CD73 regulate the purinergic signaling through the hydrolysis of adenosine triphosphate (ATP)/ADP to AMP and to adenosine (Ado), respectively. This shifts the pro-inflammatory milieu induced by extracellular ATP to the anti- inflammatory regulation by Ado. [...]
2017 - 10.3389/fimmu.2017.01577
Frontiers in immunology, Vol. 8 (november 2017) , p. 1-13
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36.
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11 p, 2.5 MB |
A bead-assisted flow cytometry method for the semi-quantitative analysis of Extracellular Vesicles
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Suárez, Henar (Instituto de Investigación Hospital Universitario de la Princesa) ;
Gámez-Valero, Ana (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Reyes, Raquel (Centro de Biología Molecular Severo Ochoa) ;
López-Martín, Soraya (Instituto de Investigación Hospital Universitario de la Princesa) ;
Rodríguez, María Josefa (Centro Nacional de Biotecnología-Consejo Superior de Investigaciones Científicas) ;
Carrascosa, José L. (Centro Nacional de Biotecnología-Consejo Superior de Investigaciones Científicas) ;
Cabañas, Carlos (Centro de Biología Molecular Severo Ochoa) ;
Borràs i Serres, Francesc Enric (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Yáñez-Mó, María (Instituto de Investigación Hospital Universitario de la Princesa) ;
Universitat Autònoma de Barcelona
Most experimental approaches commonly employed for the characterization and quantitation of EVs are time consuming, require of specialized instrumentation and often are rather inaccurate. To circumvent the caveats imposed by EV small size, we used general and specific membrane markers in bead assisted flow cytometry, to provide a semi-quantitative measure of EV content in a given sample. [...]
2017 - 10.1038/s41598-017-11249-2
Scientific reports, Vol. 7 (september 2017) , p. 1-11
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37.
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13 p, 6.6 MB |
Inflammatory conditions dictate the effect of Mesenchymal stem or Stromal cells on B cell function
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Luk, Franka (Erasmus University Medical Center, Rotterdam) ;
Carreras-Planella, Laura (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Korevaar, Sander S. (Erasmus University Medical Center, Rotterdam) ;
de Witte, Samantha F. H. (Erasmus University Medical Center, Rotterdam) ;
Borràs i Serres, Francesc Enric (Universitat Autònoma de Barcelona. Departament de Biologia Cel·lular, de Fisiologia i d'Immunologia) ;
Betjes, Michiel G. H. (Erasmus University Medical Center, Rotterdam) ;
Baan, Carla C. (Erasmus University Medical Center, Rotterdam) ;
Hoogduijn, Martin J. (Erasmus University Medical Center, Rotterdam) ;
Franquesa, Marcella (Erasmus University Medical Center, Rotterdam)
The immunomodulatory capacity of mesenchymal stem or stromal cells (MSC) makes them a promising tool for treatment of immune disease and organ transplantation. The effects of MSC on B cells are characterized by an abrogation of plasmablast formation and induction of regulatory B cells (Bregs). [...]
2017 - 10.3389/fimmu.2017.01042
Frontiers in immunology, Vol. 8 (august 2017) , p. 1-13
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38.
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20 p, 9.7 MB |
Characterization and proteomic profile of extracellular vesicles from peritoneal dialysis efflux
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Carreras-Planella, Laura (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Soler Majoral, Jordi (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Rubio Esteve, Cristina (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Lozano Ramos, Sara Inés (Universitat Autònoma de Barcelona. Departament de Biologia Cel·lular, de Fisiologia i d'Immunologia) ;
Franquesa, Marcella (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Bonet Sol, Josep (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Troya Saborido, Maria Isabel (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Borràs i Serres, Francesc Enric (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol)
Peritoneal Dialysis (PD) is considered the best option for a cost-effective mid-term dialysis in patients with Chronic Renal Failure. However, functional failure of the peritoneal membrane (PM) force many patients to stop PD treatment and start haemodialysis. [...]
2017 - 10.1371/journal.pone.0176987
PloS one, Vol. 12 Núm. 5 (2017) , p. 1-20
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