UAB Digital Repository of Documents 131 records found  1 - 10nextend  jump to record: Search took 0.00 seconds. 
1.
13 p, 1.2 MB Peripheral inflammation preceeding ischemia impairs neuronal survival through mechanisms involving miR-127 in aged animals / Loppi, Sanna (University of Arizona) ; Korhonen, Paula (University of Eastern Finland) ; Bouvy-Liivrand, Maria (University of Eastern Finland) ; Caligola, Simone (University of Verona) ; Turunen, Tiia A. (University of Eastern Finland) ; Turunen, Mikko P. (University of Eastern Finland) ; Hernandez de Sande, Ana (University of Eastern Finland) ; Kołosowska, Natalia (University of Eastern Finland) ; Scoyni, Flavia (University of Eastern Finland) ; Rosell Novel, Anna (Hospital Universitari Vall d'Hebron. Institut de Recerca) ; García-Berrocoso, Teresa (Hospital Universitari Vall d'Hebron. Institut de Recerca) ; Lemarchant, Sighild (University of Eastern Finland) ; Dhungana, Hiramani (University of Helsinki) ; Montaner, Joan (Hospital Universitari Vall d'Hebron. Institut de Recerca) ; Koistinaho, Jari (University of Helsinki) ; Kanninen, Katja M. (University of Eastern Finland) ; Kaikkonen, Minna U. (University of Eastern Finland) ; Giugno, Rosalba (University of Verona) ; Heinäniemi, Merja (University of Eastern Finland) ; Malm, Tarja (University of Eastern Finland) ; Universitat Autònoma de Barcelona
Ischemic stroke, the third leading cause of death in the Western world, affects mainly the elderly and is strongly associated with comorbid conditions such as atherosclerosis or diabetes, which are pathologically characterized by increased inflammation and are known to influence the outcome of stroke. [...]
2020 - 10.1111/acel.13287
Aging Cell, Vol. 20 (december 2020)  
2.
21 p, 7.3 MB Telomerase treatment prevents lung profibrotic pathologies associated with physiological aging / Piñeiro-Hermida, Sergio (Spanish National Cancer Centre. Telomeres and Telomerase Group. Molecular Oncology Program) ; Autilio, Chiara (Universidad Complutense de Madrid. Departamento de Bioquímica y Biología Molecular) ; Martínez, Paula (Spanish National Cancer Centre. Telomeres and Telomerase Group. Molecular Oncology Program) ; Bosch i Tubert, Fàtima (Universitat Autònoma de Barcelona. Departament de Bioquímica i de Biologia Molecular) ; Pérez-Gil, Jesús (Universidad Complutense de Madrid. Departamento de Bioquímica y Biología Molecular) ; Blasco, María A (Spanish National Cancer Centre. Telomeres and Telomerase Group. Molecular Oncology Program)
Here, we show that physiological aging in mice leads to degenerative and fibrotic-like pathologies in the lung and that telomerase gene therapy prevents the onset of these pathologies. Our findings highlight telomerase activation as a potential therapeutic strategy for lung degenerative pathologies associated with aging. [...]
2020 - 10.1083/jcb.202002120
The Journal of Cell Biology, Vol. 219 (august 2020)  
3.
15 p, 4.2 MB GATA2 Promotes Hematopoietic Development and Represses Cardiac Differentiation of Human Mesoderm / Castaño Cardoso, Julio (Center for Networked Biomedical Research on Bioengineering. Biomaterials. and Nanomedicine (CIBER-BBN)) ; Aranda, S. (Center for Genomic Regulation (CRG). The Barcelona Institute of Science and Technology. Universitat Pompeu Fabra) ; Bueno, Clara (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ; Calero-Nieto, F.J. (Department of Hematology. Wellcome and MRC Cambridge Stem Cell Institute and Cambridge Institute for Medical Research. University of Cambridge) ; Mejia-Ramirez, E. (Center of Regenerative Medicine in Barcelona (CMRB). Hospital Duran i Reynals) ; Mosquera, J.L. (Institut d'Investigació Biomèdica de Bellvitge) ; Blanco, E. (Center for Genomic Regulation (CRG). The Barcelona Institute of Science and Technology. Universitat Pompeu Fabra) ; Wang, X. (Department of Hematology. Wellcome and MRC Cambridge Stem Cell Institute and Cambridge Institute for Medical Research. University of Cambridge) ; Prieto, Cristina (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ; Zabaleta, L. (Laboratory of Hematological Diseases. Fundación Inbiomed) ; Mereu, E. (CNAG-CRG. Center for Genomic Regulation (CRG). Barcelona Institute of Science and Technology (BIST)) ; Rovira, M. (Center of Regenerative Medicine in Barcelona (CMRB). Hospital Duran i Reynals) ; Jiménez-Delgado, S. (Center of Regenerative Medicine in Barcelona (CMRB). Hospital Duran i Reynals) ; Matson, D.R. (Department of Cell and Regenerative Biology. UW-Madison Blood Research Program. Carbone Cancer Center. University of Wisconsin School of Medicine and Public Health) ; Heyn, H. (Universitat Pompeu Fabra) ; Bresnick, E.H. (Department of Cell and Regenerative Biology. UW-Madison Blood Research Program. Carbone Cancer Center. University of Wisconsin School of Medicine and Public Health) ; Göttgens, Berthold (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ; Di Croce, L. (Institució Catalana de Recerca i Estudis Avançats (ICREA)) ; Menéndez, Pablo (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ; Raya, A. (Institució Catalana de Recerca i Estudis Avançats (ICREA)) ; Giorgetti, A. (Center of Regenerative Medicine in Barcelona (CMRB). Hospital Duran i Reynals) ; Universitat Autònoma de Barcelona
In vertebrates, GATA2 is a master regulator of hematopoiesis and is expressed throughout embryo development and in adult life. Although the essential role of GATA2 in mouse hematopoiesis is well established, its involvement during early human hematopoietic development is not clear. [...]
2019 - 10.1016/j.stemcr.2019.07.009
Stem cell reports, Vol. 13 Núm. 3 (october 2019) , p. 515-529  
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13 p, 2.4 MB Histone variant MacroH2A1 is downregulated in prostate cancer and influences malignant cell phenotype / Vieira-Silva, T.S. (Cancer Biology and Epigenetics Group. Research Center (CI-IPOP). Portuguese Oncology Institute of Porto (IPO Porto). Research Center-LAB 3) ; Monteiro-Reis, S. (Cancer Biology and Epigenetics Group. Research Center (CI-IPOP). Portuguese Oncology Institute of Porto (IPO Porto). Research Center-LAB 3) ; Barros-Silva, D. (Cancer Biology and Epigenetics Group. Research Center (CI-IPOP). Portuguese Oncology Institute of Porto (IPO Porto). Research Center-LAB 3) ; Ramalho-Carvalho, J. (Cancer Biology and Epigenetics Group. Research Center (CI-IPOP). Portuguese Oncology Institute of Porto (IPO Porto). Research Center-LAB 3) ; Graça, I. (Cancer Biology and Epigenetics Group. Research Center (CI-IPOP). Portuguese Oncology Institute of Porto (IPO Porto). Research Center-LAB 3) ; Carneiro, I. (Department of Pathology. Portuguese Oncology Institute of Porto (IPO Porto)) ; Martins, A.T. (Department of Pathology. Portuguese Oncology Institute of Porto (IPO Porto)) ; Oliveira, J. (Department of Urology. Portuguese Oncology Institute of Porto (IPO Porto)) ; Antunes, L. (Department of Epidemiology. Portuguese Oncology Institute of Porto (IPO Porto)) ; Hurtado-Bagès, Sarah (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ; Buschbeck, Marcus (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ; Henrique, R. (Department of Pathology and Molecular Immunology. Institute of Biomedical Sciences Abel Salazar (ICBAS). University of Porto) ; Jerónimo, C. (Department of Pathology and Molecular Immunology. Institute of Biomedical Sciences Abel Salazar (ICBAS). University of Porto) ; Universitat Autònoma de Barcelona
Background: Prostate cancer (PCa), a major cause of cancer-related morbidity and mortality worldwide and mostly asymptomatic at earliest stages, is characterized by disruption of genetic and epigenetic balance. [...]
2019 - 10.1186/s12935-019-0835-9
Cancer Cell International, Vol. 19 Núm. 1 (29 2019) , p. 112  
5.
10 p, 1.3 MB Title : insoluble proteins catch heterologous soluble proteins into inclusion bodies by intermolecular interaction of aggregating peptides / Carratalá, Jose Vicente (Institut de Biotecnologia i de Biomedicina "Vicent Villar Palasí") ; Cisneros, Andrés (Institut de Biotecnologia i de Biomedicina "Vicent Villar Palasí") ; Hellman, Elijah (Institut de Biotecnologia i de Biomedicina "Vicent Villar Palasí") ; Villaverde Corrales, Antonio (Institut de Biotecnologia i de Biomedicina "Vicent Villar Palasí") ; Ferrer Miralles, Neus (Institut de Biotecnologia i de Biomedicina "Vicent Villar Palasí") ; Universitat Autònoma de Barcelona. Departament de Genètica i de Microbiologia
Protein aggregation is a biological event observed in expression systems in which the recombinant protein is produced under stressful conditions surpassing the homeostasis of the protein quality control system. [...]
2021 - 10.1186/s12934-021-01524-3
Microbial cell factories, Vol. 20 (February 2021)  
6.
17 p, 3.3 MB A functional genetic screen defines the AKT-induced senescence signaling network / Chan, K.T. (Sir Peter MacCallum Department of Oncology. University of Melbourne) ; Blake, S. (Division of Cancer Research. Peter MacCallum Cancer Centre) ; Zhu, H. (Sir Peter MacCallum Department of Oncology. University of Melbourne) ; Kang, J. (Division of Cancer Research. Peter MacCallum Cancer Centre) ; Trigos, A.S. (Sir Peter MacCallum Department of Oncology. University of Melbourne) ; Madhamshettiwar, P.B. (Victorian Centre for Functional Genomics. Peter MacCallum Cancer Centre) ; Diesch, Jeannine (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ; Paavolainen, L. (Institute for Molecular Medicine Finland (FIMM). HiLIFE. University of Helsinki) ; Horvath, P. (Synthetic and Systems Biology Unit. Hungarian Academy of Sciences) ; Hannan, R.D. (Department of Biochemistry and Molecular Biology. Monash University) ; George, A.J. (Department of Clinical Pathology. University of Melbourne) ; Sanij, E. (Department of Clinical Pathology. University of Melbourne) ; Hannan, K.M. (Department of Biochemistry and Molecular Biology. University of Melbourne) ; Simpson, K.J. (Victorian Centre for Functional Genomics. Peter MacCallum Cancer Centre) ; Pearson, R.B. (Department of Biochemistry and Molecular Biology. Monash University) ; Universitat Autònoma de Barcelona
Exquisite regulation of PI3K/AKT/mTORC1 signaling is essential for homeostatic control of cell growth, proliferation, and survival. Aberrant activation of this signaling network is an early driver of many sporadic human cancers. [...]
2020 - 10.1038/s41418-019-0384-8
Cell Death and Differentiation, Vol. 27 Núm. 2 (january 2020) , p. 725-741  
7.
13 p, 1.0 MB A pRb-responsive, RGD-modified, and hyaluronidase-armed canine oncolytic adenovirus for application in veterinary oncology / Laborda Jambrina, Eduardo (Universitat Autònoma de Barcelona. Departament de Bioquímica i de Biologia Molecular) ; Puig-Saus, Cristina (Institut Català d'Oncologia) ; Rodriguez-García, Alba (Institut Català d'Oncologia) ; Moreno, Rafael (Institut Català d'Oncologia) ; Cascalló, Manel (VCN Biosciences) ; Pastor Milán, Josep (Universitat Autònoma de Barcelona. Departament de Medicina i Cirurgia Animals) ; Alemany Bonastre, Ramon (Institut Català d'Oncologia)
Human and canine cancer share similarities such as genetic and molecular aspects, biological complexity, tumor epidemiology, and targeted therapeutic treatment. Lack of good animal models for human adenovirotherapy has spurred the use of canine adenovirus 2-based oncolytic viruses. [...]
2014 - 10.1038/mt.2014.7
The American Society of Gene & Cell Therapy, Vol. 22 Núm. 5 (Maig 2014) , p. 986-998  
8.
Overexpression of budding yeast protein phosphatase Ppz1 impairs translation / Calafí, Carlos (Institut de Biotecnologia i de Biomedicina "Vicent Villar Palasí") ; López-Malo, María (Institut de Biotecnologia i de Biomedicina "Vicent Villar Palasí") ; Velázquez, Diego (Institut de Biotecnologia i de Biomedicina "Vicent Villar Palasí") ; Zhang, Chunyi (Institut de Biotecnologia i de Biomedicina "Vicent Villar Palasí") ; Fernández-Fernández, José (Universidad de Sevilla. Departamento de Genética) ; Rodríguez-Galán, Olga (Universidad de Sevilla. Departamento de Genética) ; de la Cruz, Jesús (Universidad de Sevilla. Departamento de Genética) ; Ariño Carmona, Joaquín (Institut de Biotecnologia i de Biomedicina "Vicent Villar Palasí") ; Casamayor Gracia, Antonio (Institut de Biotecnologia i de Biomedicina "Vicent Villar Palasí") ; Universitat Autònoma de Barcelona. Departament de Bioquímica i de Biologia Molecular
The Ser/Thr protein phosphatase Ppz1 from Saccharomyces cerevisiae is the best characterized member of a family of enzymes only found in fungi. Ppz1 is regulated in vivo by two inhibitory subunits, Hal3 and Vhs3, which are moonlighting proteins also involved in the decarboxylation of the 4-phosphopantothenoylcysteine (PPC) intermediate required for coenzyme A biosynthesis. [...]
2020 - 10.1016/j.bbamcr.2020.118727
Biochimica et Biophysica Acta - Molecular Cell Research, Vol. 1867, Issue 8 (August 2020) , art. 118727  
9.
16 p, 2.9 MB Cyclophilins A and B oppositely regulate renal tubular epithelial cell phenotype / Sarró, Eduard (Hospital Universitari Vall d'Hebron. Institut de Recerca) ; Durán, Mónica (Hospital Universitari Vall d'Hebron. Institut de Recerca) ; Rico, Ana (Hospital Universitari Vall d'Hebron. Institut de Recerca) ; Bou-Teen, Diana (Cardiovascular Diseases Group) ; Fernández-Majada, Vanesa (Biomimetic Systems for Cell Engineering Laboratory) ; Croatt, Anthony J (Division of Nephrology and Hypertension and Department of Medicine) ; Nath, Karl A (Division of Nephrology and Hypertension and Department of Medicine) ; Salcedo, Maria Teresa (Hospital Universitari Vall d'Hebron. Institut de Recerca) ; Gundelach, Justin H (Department of Biochemistry and Molecular Biology) ; Batlle, Daniel (Division of Nephrology and Hypertension) ; Bram, Richard J (Department of Immunology) ; Meseguer, Anna (Universitat Autònoma de Barcelona. Departament de Bioquímica i de Biologia Molecular)
Restoration of kidney tubular epithelium following sublethal injury sequentially involves partial epithelial-mesenchymal transition (pEMT), proliferation, and further redifferentiation into specialized tubule epithelial cells (TECs). [...]
2020 - 10.1093/jmcb/mjaa005
Journal of Molecular Cell Biology, Vol. 12 (march 2020) , p. 499-514  
10.
14 p, 624.0 KB Classification and nomenclature of metacaspases and paracaspases : no more confusion with caspases / Minina, Elena A. (Swedish University of Agricultural Sciences and Linnean Center for Plant Biology. Department of Molecular Sciences (Sweden)) ; Staal, Jens (Ghent University. Department of Biomedical Molecular Biology (Belgium)) ; Alvarez, Vanina E. (Universidad Nacional de San Martin. Instituto de Investigaciones Biotecnológicas (Argentina)) ; Berges, John A. (University of Wisconsin-Milwaukee. Department of Biological Sciences and School of Freshwater Sciences (USA)) ; Berman-Frank, Ilana (University of Haifa. Department of Marine Biology (Israel)) ; Beyaert, Rudi (Heidelberg University. COS (Germany)) ; Bidle, Kay D. (Rutgers University. Department of Marine and Coastal Sciences (USA)) ; Bornancin, Frédéric (Novartis Institutes for BioMedical Research (Switzerland)) ; Casanova, Magali (Aix-Marseille Université. Centre National de la Recherche Scientifique. Institut de Microbiologie de la Méditerranée (France)) ; Cazzulo, Juan J. (Universidad Nacional de San Martin. Instituto de Investigaciones Biotecnológicas (Argentina)) ; Choi, Chang Jae (The University of Texas at Austin. Marine Science Institute (USA)) ; Sánchez Coll, Núria (Centre de Recerca en Agrigenòmica) ; Dixit, Vishva M. (Genentech. Department of Physiological Chemistry (USA)) ; Dolinar, Marko (University of Ljubljana. Faculty of Chemistry and Chemical Technology (Slovenia)) ; Fasel, Nicolas (University of Lausanne. Department of Biochemistry (Switzerland)) ; Funk, Christiane (Umeå University. Department of Chemistry (Sweden)) ; Gallois, Patrick (University of Manchester. Faculty of Biology, Medicine and Health (UK)) ; Gevaert, Kris (Ghent University. Department of Biomolecular Medicine (Belgium)) ; Gutierrez-Beltran, Emilio (Universidad de Sevilla. Instituto de Bioquímica Vegetal y Fotosíntesis) ; Hailfinger, Stephan (Eberhard Karls University. Interfaculty Institute for Biochemistry (Germany)) ; Klemenčič, Marina (University of Ljubljana. Faculty of Chemistry and Chemical Technology (Slovenia)) ; Koonin, Eugene V. (National Library of Medicine. National Center for Biotechnology Information (USA)) ; Krappmann, Daniel (Helmholtz Zentrum München - German Research Center for Environmental Health. Research Unit Cellular Signal Integration (Germany)) ; Linusson, Anna (Umeå University. Department of Chemistry (Sweden)) ; Machado, Maurício F. M. (University of Mogi das Cruzes. Interdisciplinary Center for Biochemical Research (Brazil)) ; Madeo, Frank (University of Graz. NAWI Graz. Institute of Molecular Biosciences (Austria)) ; Megeney, Lynn A. (University of Ottawa. Ottawa Hospital Research Institute. Sprott Centre for Stem Cell Research (Canada)) ; Moschou, Panagiotis N. (University of Crete. Department of Biology (Greece)) ; Mottram, Jeremy C. (University of York. York Biomedical Research Institute. Department of Biology (UK)) ; Nyström, Thomas (University of Gothenburg. Centre for Ageing and Health - AgeCap. Institute for Biomedicine (Sweden)) ; Osiewacz, Heinz D. (Goethe University. Institute for Molecular Biosciences (Germany)) ; Overall, Christopher M. (University of British Columbia. Life Sciences Institute. Departments of Oral Biological and Medical Sciences / and Biochemistry and Molecular Biology (Canada)) ; Pandey, Kailash C. (Indian Council of Medical Research. National Institute of Malaria Research (India)) ; Ruland, Jürgen (German Cancer Consortium (Germany)) ; Salvesen, Guy S. (Sanford Burnham Prebys Medical Discovery Institute (USA)) ; Shi, Yigong (Westlake University. School of Life Sciences (China)) ; Smertenko, Andrei (Washington State University. Institute of Biological Chemistry (USA)) ; Stael, Simon (Ghent University. Department of Plant Biotechnology and Bioinformatics (Belgium)) ; Ståhlberg, Jerry (Swedish University of Agricultural Sciences and Linnean Center for Plant Biology. Department of Molecular Sciences (Sweden)) ; Suárez, María Fernanda (Universidad de Málaga. Departamento de Biologia Molecular y Bioquimica) ; Thome, Margot (University of Lausanne. Department of Biochemistry (Switzerland)) ; Tuominen, Hannele (Umeå University. Umeå Plant Science Centre. Department of Plant Physiology (Sweden)) ; Van Breusegem, Frank (Ghent University. Department of Plant Biotechnology and Bioinformatics (Belgium)) ; Van der Hoorn, Renier A. L. (University of Oxford. Department of Plant Sciences (UK)) ; Vardi, Assaf (Weizmann Institute of Science. Department of Plant and Environmental Sciences (Israel)) ; Zhivotovsky, Boris (MV Lomonosov Moscow State University. Faculty of Fundamental Medicine (Russia)) ; Lam, Eric (Rutgers the State University of New Jersey. Department of Plant Biology (USA)) ; Bozhkov, Peter V. (Swedish University of Agricultural Sciences and Linnean Center for Plant Biology. Department of Molecular Sciences (Sweden))
Metacaspases and paracaspases are proteases that were first identified as containing a caspase-like structural fold (Uren et al. , 2000). Like caspases, meta- and paracaspases are multifunctional proteins regulating diverse biological phenomena, such as aging, immunity, proteostasis and programmed cell death. [...]
2020 - 10.1016/j.molcel.2019.12.020
Molecular Cell, Vol. 77, Issue 5 (March 2020) , p. 927-929  

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