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13 p, 2.3 MB |
Complement and coagulation cascades activation is the main pathophysiological pathway in early-onset severe preeclampsia revealed by maternal proteomics
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Youssef, Lina (Institut d'Investigacions Biomèdiques August Pi i Sunyer) ;
Miranda, Jezid (Institut d'Investigacions Biomèdiques August Pi i Sunyer) ;
Blasco Pelicano, Miquel (Hospital Clínic i Provincial de Barcelona) ;
Paules, Cristina (Institut d'Investigacions Biomèdiques August Pi i Sunyer) ;
Crovetto, Francesca (Institut d'Investigacions Biomèdiques August Pi i Sunyer) ;
Palomo, Marta (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ;
Torramade Moix, Sergi (Institut d'Investigacions Biomèdiques August Pi i Sunyer) ;
García Calderó, Héctor (Centro de Investigación Biomédica en Red de Enfermedades Hepáticas y Digestivas) ;
Tura Ceide, Olga (Institut d'Investigació Biomèdica de Girona) ;
Dantas, A. P (Institut d'Investigacions Biomèdiques August Pi i Sunyer) ;
Hernandez Gea, Virginia (Centro de Investigación Biomédica en Red de Enfermedades Hepáticas y Digestivas) ;
Herrero, Pol (Universitat Rovira i Virgili) ;
Canela, Núria (Universitat Rovira i Virgili) ;
Campistol Plana, Josep M (Centro de Investigación Biomédica en Red de Enfermedades Raras) ;
Garcia Pagan, Joan Carles (Centro de Investigación Biomédica en Red de Enfermedades Hepáticas y Digestivas) ;
Diaz-Ricart, Maribel (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ;
Gratacos, Eduard (Institut d'Investigacions Biomèdiques August Pi i Sunyer) ;
Crispi, Fatima (Centro de Investigación Biomédica en Red de Enfermedades Raras) ;
Universitat Autònoma de Barcelona
Preeclampsia is a pregnancy-specific multisystem disorder and a leading cause of maternal and perinatal morbidity and mortality. The exact pathogenesis of this multifactorial disease remains poorly defined. [...]
2021 -  10.1038/s41598-021-82733-z
Scientific reports, Vol. 11 Núm. 1 (december 2021) , p. 3048
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21 p, 1.4 MB |
The Interplay between Pathophysiological Pathways in Early-Onset Severe Preeclampsia Unveiled by Metabolomics
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Youssef, Lina (Institut d'Investigacions Biomèdiques August Pi i Sunyer) ;
Crovetto, Francesca (Institut d'Investigacions Biomèdiques August Pi i Sunyer) ;
Simoes, Rui Vasco (Champalimaud Research. Champalimaud Centre for the Unknown) ;
Miranda, Jezid (Institut d'Investigacions Biomèdiques August Pi i Sunyer) ;
Paules, Cristina (Institut d'Investigacions Biomèdiques August Pi i Sunyer) ;
Blasco Pelicano, Miquel (Hospital Clínic i Provincial de Barcelona) ;
Palomo, Marta (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ;
García Calderó, Héctor (Centro de Investigación Biomédica en Red de Enfermedades Hepáticas y Digestivas) ;
Tura Ceide, Olga (Institut d'Investigació Biomèdica de Girona) ;
Dantas, A. P (Institut d'Investigacions Biomèdiques August Pi i Sunyer) ;
Hernández-Gea, Virginia (Centro de Investigación Biomédica en Red de Enfermedades Hepáticas y Digestivas) ;
Herrero, Pol (Eurecat. Centre Tecnològic de Catalunya) ;
Canela, Núria (Eurecat. Centre Tecnològic de Catalunya) ;
Campistol Plana, Josep M. (Hospital Clínic i Provincial de Barcelona) ;
Garcia Pagan, Joan Carles (Centro de Investigación Biomédica en Red de Enfermedades Hepáticas y Digestivas) ;
Diaz-Ricart, Maribel (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ;
Gratacos, Eduard (Centro de Investigación Biomédica en Red de Enfermedades Raras) ;
Crispi, Fatima (Centro de Investigación Biomédica en Red de Enfermedades Raras)
Introduction: Preeclampsia is a multi-system disorder unique to pregnancy responsible for a great part of maternal and perinatal morbidity and mortality. The precise pathogenesis of this complex disorder is still unrevealed. [...]
2022 - 10.3390/life12010086
Life, Vol. 12 Núm. 1 (january 2022) , p. 86
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3.
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12 p, 1.8 MB |
Stenosis coexists with compromised α1-adrenergic contractions in the ascending aorta of a mouse model of Williams-Beuren syndrome
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Jiménez Altayó, Francesc (Universitat Autònoma de Barcelona. Departament de Farmacologia, de Terapèutica i de Toxicologia) ;
Ortiz-Romero, Paula (Universitat Pompeu Fabra. Departament de Ciències Experimentals i de la Salut) ;
Puertas Umbert, Lídia (Universitat Autònoma de Barcelona. Departament de Farmacologia, de Terapèutica i de Toxicologia) ;
Dantas, A. P (Institut d'Investigacions Biomèdiques August Pi i Sunyer) ;
Pérez, Belén (Universitat Autònoma de Barcelona. Departament de Farmacologia, de Terapèutica i de Toxicologia) ;
Vila Calsina, Elisabet (Universitat Autònoma de Barcelona. Departament de Farmacologia, de Terapèutica i de Toxicologia) ;
D'Ocon, Pilar (Universitat de València. Departament de Farmacologia) ;
Campuzano, Victoria (Universitat Pompeu Fabra. Departament de Ciències Experimentals i de la Salut)
Williams-Beuren syndrome (WBS) is a rare disorder caused by a heterozygous deletion of 26-28 contiguous genes that affects the brain and cardiovascular system. Here, we investigated whether WBS affects aortic structure and function in the complete deletion (CD) mouse model harbouring the most common deletion found in WBS patients. [...]
2020 - 10.1038/s41598-020-57803-3
Scientific reports, Vol. 10 (january 2020)
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4.
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17 p, 1.6 MB |
Late Onset of Estrogen Therapy Impairs Carotid Function of Senescent Females in Association with Altered Prostanoid Balance and Upregulation of the Variant ERα36
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Costa, Tiago J. (Universidade de São Paulo. Department of Pharmacology) ;
Jiménez Altayó, Francesc (Universitat Autònoma de Barcelona. Institut de Neurociències) ;
Echem, Cinthya (Universidade de São Paulo. Department of Pharmacology) ;
Akamine, Eliana Hiromi (Universidade de São Paulo. Department of Pharmacology) ;
Tostes, Rita (Universidade de São Paulo. Department of Pharmacology) ;
Vila Calsina, Elisabet (Universitat Autònoma de Barcelona. Institut de Neurociències) ;
Dantas, A. P. (Institut d'Investigacions Biomèdiques August Pi i Sunyer) ;
Catelli de Carvalho, Maria Helena (Universidade de São Paulo. Department of Pharmacology)
Recent analysis of clinical trials on estrogen therapy proposes the existence of a therapeutic window of opportunity for the cardiovascular benefits of estrogens, which depend on women's age and the onset of therapy initiation. [...]
2019 - 10.3390/cells8101217
Cells, Vol. 8 Núm. 10 (2019) , p. 1-17
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13 p, 1.8 MB |
Detrimental effects of testosterone addition to estrogen therapy involve cytochrome P-450-induced 20-HETE synthesis in aorta of ovariectomized spontaneously hypertensive rat (SHR), a model of postmenopausal hypertension
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Costa, Tiago J. (Universitat Autònoma de Barcelona. Institut de Neurociències) ;
Ceravolo, G. S. (Department of Physiological Sciences. State University of Londrina) ;
Echem, Cinthya (Department of Pharmacology. Institute of Biomedical Sciences. University of São Paulo) ;
Hashimoto, C. M. (Department of Pharmacology. Institute of Biomedical Sciences. University of São Paulo) ;
Costa, B. P. (Department of Pharmacology. Institute of Biomedical Sciences. University of São Paulo) ;
Santos-Eichler, R. A. (Department of Pharmacology. Institute of Biomedical Sciences. University of São Paulo) ;
Oliveira, M. A. (Department of Pharmacology. Institute of Biomedical Sciences. University of São Paulo) ;
Jiménez Altayó, Francesc (Universitat Autònoma de Barcelona. Institut de Neurociències) ;
Akamine, Eliana Hiromi (Department of Pharmacology. Institute of Biomedical Sciences. University of São Paulo) ;
Dantas, A. P. (Institut d'Investigacions Biomèdiques August Pi i Sunyer) ;
Carvalho, M. H. C. (Department of Pharmacology. Institute of Biomedical Sciences. University of São Paulo)
Postmenopausal period has been associated to different symptoms such as hot flashes, vulvovaginal atrophy, hypoactive sexual desire disorder (HSDD) and others. Clinical studies have described postmenopausal women presenting HSDD can benefit from the association of testosterone to conventional hormonal therapy. [...]
2018 - 10.3389/fphys.2018.00490
Frontiers in physiology, Vol. 9 Núm. MAY (august 2018) , p. 490
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12 p, 1.9 MB |
Differences in the Thoracic Aorta by Region and Sex in a Murine Model of Marfan Syndrome
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Jiménez Altayó, Francesc (Universitat Autònoma de Barcelona. Institut de Neurociències) ;
Siegert, Anna-Maria (Institut d'Investigacions Biomèdiques August Pi i Sunyer) ;
Bonorino, Fabio (Universitat de Barcelona. Departament de Biomedicina) ;
Meirelles, Thayna (Universitat de Barcelona. Departament de Biomedicina) ;
Barberà, Laura (Universitat de Barcelona. Departament de Biomedicina) ;
Dantas, A. P. (Institut d'Investigacions Biomèdiques August Pi i Sunyer) ;
Vila Calsina, Elisabet (Universitat Autònoma de Barcelona. Departament de Farmacologia, de Terapèutica i de Toxicologia) ;
Egea, Gustavo (Universitat de Barcelona. Departament de Biomedicina)
Marfan syndrome (MFS) is a hereditary disorder of the connective tissue that causes life-threatening aortic aneurysm, which initiates at the aortic root and can progress into the ascending portion. However, analysis of ascending aorta reactivity in animal models of MFS has remained elusive. [...]
2017 - 10.3389/fphys.2017.00933
Frontiers in physiology, Vol. 8 (november 2017)
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17 p, 2.3 MB |
Intracoronary Administration of Allogeneic Adipose Tissue-Derived Mesenchymal Stem Cells Improves Myocardial Perfusion But Not Left Ventricle Function, in a Translational Model of Acute Myocardial Infarction
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Bobi, Joaquim (Universitat de Barcelona) ;
Solanes, Núria (Universitat de Barcelona) ;
Fernández-Jiménez, Rodrigo (Centro de Investigación Biomédica en Red en Enfermedades Cardiovasculares) ;
Galán-Arriola, Carlos (Centro de Investigación Biomédica en Red en Enfermedades Cardiovasculares) ;
Dantas, A. P. (Universitat de Barcelona) ;
Fernández-Friera, Leticia (Centro de Investigación Biomédica en Red en Enfermedades Cardiovasculares) ;
Gálvez-Montón, Carolina (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Rigol-Monzó, Elisabet (Hospital Clínic i Provincial de Barcelona) ;
Agüero, Jaume (Hospital Universitari i Politècnic La Fe (València)) ;
Ramírez, José (Hospital Clínic i Provincial de Barcelona) ;
Roqué, Mercè (Universitat de Barcelona) ;
Bayés-Genís, Antoni (Universitat Autònoma de Barcelona. Departament de Medicina) ;
Sánchez-González, Javier (Philips Healthcare, Madrid) ;
García-Álvarez, Ana (Centro de Investigación Biomédica en Red en Enfermedades Cardiovasculares) ;
Sabaté, Manel (Universitat de Barcelona) ;
Rudilla, F. (Centro de Investigación Biomédica en Red en Enfermedades Cardiovasculares) ;
Ibanez, Borja (Centro de Investigación Biomédica en Red en Enfermedades Cardiovasculares) ;
Rigol, Montserrat (Universitat de Barcelona)
Autologous adipose tissue-derived mesenchymal stem cells (s) therapy is a promising strategy to improve post-myocardial infarction outcomes. In a porcine model of acute myocardial infarction, we studied the long-term effects and the mechanisms involved in allogeneic s administration on myocardial performance. [...]
2017 - 10.1161/JAHA.117.005771
Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, Vol. 6 (may 2017)
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11 p, 2.1 MB |
Transient Mesenteric Ischemia Leads to Remodeling of Rat Mesenteric Resistance Arteries
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Caracuel Cano, Laura (Universitat Autònoma de Barcelona. Institut de Neurociències) ;
Jiménez Altayó, Francesc (Universitat Autònoma de Barcelona. Institut de Neurociències) ;
Romo, Mónica (Universitat Autònoma de Barcelona. Departament de Farmacologia, de Terapèutica i de Toxicologia) ;
Márquez-Martín, Ana (Universitat Autònoma de Barcelona. Institut de Neurociències) ;
Dantas, A. P. (Institut d'Investigacions Biomèdiques August Pi i Sunyer) ;
Vila Calsina, Elisabet (Universitat Autònoma de Barcelona. Institut de Neurociències)
Mesenteric ischemia/reperfusion (I/R) is associated with high rates of morbidity and mortality. We studied the effect of mesenteric I/R on structural and mechanical properties of rat mesenteric resistance artery (MRA) that, once disrupted, might impact the outcome of this devastating clinical condition. [...]
2012 - 10.3389/fphys.2011.00118
Frontiers in physiology, Vol. 2 (january 2012)
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39 p, 2.5 MB |
Peroxynitrite formed during a transient episode of brain ischemia increases endothelium-derived hyperpolarization-type dilations in thromboxane/prostaglandin receptor-stimulated rat cerebral arteries
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Onetti Vilalta, Yara (Universitat Autònoma de Barcelona. Institut de Neurociències) ;
Dantas, A. P. (Institut d'Investigacions Biomèdiques August Pi i Sunyer) ;
Pérez, Belén (Universitat Autònoma de Barcelona. Institut de Neurociències) ;
McNeish, Alister J. (University of Reading. Reading School of Pharmacy) ;
Vila Calsina, Elisabet (Universitat Autònoma de Barcelona. Institut de Neurociències) ;
Jiménez Altayó, Francesc (Universitat Autònoma de Barcelona. Institut de Neurociències)
AIM: Increased thromboxane A2 and peroxynitrite are hallmarks of cerebral ischaemia/reperfusion (I/R). Stimulation of thromboxane/prostaglandin receptors (TP) attenuates endothelium-derived hyperpolarization (EDH). [...]
2016 - 10.1111/apha.12809
Acta Physiologica, Vol. 220, no. 1 (September 2016) , p. 150-166
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