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1.
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19 p, 4.3 MB |
MDA-LDL vaccination induces athero-protective germinal-center-derived antibody responses
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Martos-Folgado, Inmaculada (Medical Department. Pfizer S.L.U.) ;
del Monte-Monge, Alberto (Centro Nacional de Investigaciones Cardiovasculares. Lymphocyte Biology Lab) ;
Lorenzo, Cristina (Centro Nacional de Investigaciones Cardiovasculares. Lymphocyte Biology Lab) ;
Busse, Christian E. (Division of B Cell Immunology. German Cancer Research Center) ;
Delgado, Pilar (Centro Nacional de Investigaciones Cardiovasculares. Lymphocyte Biology Lab) ;
Mur, Sonia M. (Centro Nacional de Investigaciones Cardiovasculares. Lymphocyte Biology Lab) ;
Cobos-Figueroa, Laura (Grupo de Manufactura Avanzada con Láser del Centro Láser. Universidad Politécnica de Madrid) ;
Escolà-Gil, Joan Carles (Institut d'Investigació Biomèdica Sant Pau) ;
Martín-Ventura, Jose L. (Instituto de Investigación Sanitaria de la Fundación Jiménez Díaz) ;
Wardemann, Hedda (Division of B Cell Immunology. German Cancer Research Center) ;
Ramiro, Almudena R. (Lymphocyte Biology Lab. Centro Nacional de Investigaciones Cardiovasculares (CNIC))
Atherosclerosis is a chronic inflammatory disease of the arteries that can lead to thrombosis, infarction, and stroke and is the leading cause of mortality worldwide. Immunization of pro-atherogenic mice with malondialdehyde-modified low-density lipoprotein (MDA-LDL) neo-antigen is athero-protective. [...]
2022 -  10.1016/j.celrep.2022.111468
Cell reports, Vol. 41 Núm. 2 (november 2022) , p. 111468
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2.
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32 p, 9.6 MB |
Genomics of perivascular space burden unravels early mechanisms of cerebral small vessel disease
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Duperron, Marie-Gabrielle (Bordeaux University Hospital(França)) ;
Knol, Maria J. (Erasmus MC University Medical Center) ;
Le Grand, Quentin (Bordeaux Population Health Research Center) ;
Evans, Tavia E. (Erasmus MC University Medical Center) ;
Mishra, Aniket (University of Bordeaux) ;
Tsuchida, Ami (University of Bordeaux) ;
Roshchupkin, Gennady V (Erasmus MC University Medical Center) ;
Konuma, Takahiro (Osaka University Graduate School of Medicine) ;
Trégouët, David-Alexandre (University of Bordeaux) ;
Romero, Jose Rafael (The Framingham Heart Study) ;
Frenzel, Stefan (University Medicine Greifswald) ;
Luciano, Michelle (University of Edinburgh) ;
Hofer, Edith (Medical University of Graz) ;
Bourgey, Mathieu (McGill University) ;
Dueker, Nicole D. (University of Miami) ;
Delgado Martínez, María Pilar (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Hilal, Saima (National University of Singapore and National University Health System) ;
Tankard, Rick M. (Curtin University) ;
Dubost, Florian (Erasmus MC University Medical Center) ;
Shin, Jean (University of Toronto) ;
Saba, Yasaman (Medical University of Graz) ;
Armstrong, Nicola (Curtin University) ;
Bordes, Constance (Bordeaux Population Health Research Center) ;
Bastin, Mark E. (University of Edinburgh) ;
Beiser, Alexa (Boston University School of Public Health) ;
Brodaty, Henry (Dementia Collaborative Research Centre Assessment and Better Care) ;
Bülow, Robin (University Medicine Greifswald) ;
Carrera, Caty (Institut d'Investigació Biomèdica Sant Pau) ;
Chen, Christopher (National University of Singapore) ;
Cheng, Ching-Yu (Duke-NUS Medical School) ;
Deary, Ian J. (University of Edinburgh) ;
Gampawar, Piyush G. (Medical University of Graz) ;
Himali, Jayandra J. (UT Health San Antonio) ;
Jiang, Jiyang (University of New South Wales) ;
Kawaguchi, Takahisa (Kyoto University Graduate School of Medicine) ;
Li, Shuo (Boston University School of Public Health) ;
Macalli, Melissa (University of Bordeaux) ;
Marquis, Pascale (McGill University) ;
Morris, Zoe (Royal Infirmary of Edinburgh) ;
Muñoz Maniega, Susana (UK Dementia Research Institute Centre at the University of Edinburgh) ;
Miyamoto, Susumu (Kyoto University Hospital) ;
Okawa, Masakazu (Kyoto University Graduate School of Medicine) ;
Paradise, Matthew (University of New South Wales) ;
Parva, Pedram (Harvard Medical School) ;
Rundek, Tatjana (University of Miami) ;
Sargurupremraj, Muralidharan (University of Bordeaux) ;
Schilling, Sabrina (University of Bordeaux) ;
Setoh, Kazuya (Shizuoka Graduate University of Public Health) ;
Soukarieh, Omar (University of Bordeaux) ;
Tabara, Yasuharu (Shizuoka Graduate University of Public Health) ;
Teumer, Alexander (University Medicine Greifswald) ;
Thalamuthu, Anbupalam (University of New South Wales) ;
Trollor, Julian (UNSW) ;
Valdés Hernández, Maria C. (University of Edinburgh) ;
Vernooij, Meike W. (Erasmus MC University Medical Center) ;
Völker, Uwe (University Medicine Greifswald) ;
Wittfeld, Katharina (German Center for Neurodegenerative Diseases) ;
Wong, Tien Yin (Tsinghua University) ;
Wright, Margaret J. (University of Queensland) ;
Zhang, Junyi (Peking Union Medical College Hospital) ;
Zhao, Wanting (Duke-NUS Medical School) ;
Zhu, Yi-Cheng (Peking Union Medical College Hospital) ;
Schmidt, Helena (Medical University of Graz) ;
Sachdev, Perminder S. (the Prince of Wales Hospital) ;
Wen, Wei (University of New South Wales) ;
Yoshida, Kazumichi (Kyoto University Graduate School of Medicine) ;
Joutel, Anne (Université Paris Cité) ;
Satizabal, Claudia L. (UT Health San Antonio) ;
Sacco, Ralph L. (University of Miami) ;
Bourque, Guillaume (McGill University) ;
Lathrop, Mark (Victor Phillip Dahdaleh Institute of Genomic Medicine at McGill University) ;
Paus, Tomas (University of Toronto) ;
Fernandez-Cadenas, Israel (Institut d'Investigació Biomèdica Sant Pau) ;
Yang, Qiong (Boston University School of Public Health) ;
Mazoyer, Bernard (Bordeaux University Hospital (França)) ;
Boutinaud, Philippe (Fealinx) ;
Okada, Yukinori (University of Tokyo) ;
Grabe, Hans J. (German Center for Neurodegenerative Diseases) ;
Mather, Karen A (Neuroscience Research Australia) ;
Schmidt, Reinhold (Medical University of Graz) ;
Joliot, Marc (University of Bordeaux) ;
Ikram, M. Arfan (Erasmus MC University Medical Center) ;
Matsuda, Fumihiko (Kyoto University Graduate School of Medicine) ;
Tzourio, Christophe (Bordeaux University Hospital(França)) ;
Wardlaw, Joanna (University of Edinburgh) ;
Seshadri, Sudha (UT Health San Antonio) ;
Adams, Hieab (Universidad Adolfo Ibáñez) ;
Debette, Stéphanie (Bordeaux University Hospital(França)) ;
Universitat Autònoma de Barcelona
Perivascular space (PVS) burden is an emerging, poorly understood, magnetic resonance imaging marker of cerebral small vessel disease, a leading cause of stroke and dementia. Genome-wide association studies in up to 40,095 participants (18 population-based cohorts, 66. [...]
2023 - 10.1038/s41591-023-02268-w
Nature Medicine, Vol. 29 (april 2023) , p. 950-962
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3.
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17 p, 1.3 MB |
Altered methylation pattern in EXOC4 is associated with stroke outcome : an epigenome-wide association study
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Cullell, Natalia (Institut d'Investigació Biomèdica Sant Pau) ;
Soriano Tárraga, Carolina (NeuroGenomics and Informatics. Washington University School of Medicine) ;
Gallego-Fabrega, Cristina (Institut d'Investigació Biomèdica Sant Pau) ;
Cárcel-Márquez, Jara (Institut d'Investigació Biomèdica Sant Pau) ;
Muiño, Elena (Institut d'Investigació Biomèdica Sant Pau) ;
Llucià-Carol, Laia (Institut d'Investigació Biomèdica Sant Pau) ;
Lledós, Miquel (Institut d'Investigació Biomèdica Sant Pau) ;
Esteller, M (Institució Catalana de Recerca i Estudis Avançats) ;
Castro de Moura, Manuel (Programa de Epigenética y Biología del Cáncer (PEBC)) ;
Montaner, Joan (Instituto de Biomedicina de Sevilla) ;
Rosell Novel, Anna (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Delgado Martínez, María Pilar (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Martí-Fàbregas, Joan (Institut d'Investigació Biomèdica Sant Pau) ;
Krupinski, Jerzy (Centre for Bioscience. School of HealthCare Science. Manchester Metropolitan University) ;
Roquer, Jaume (Institut Hospital del Mar d'Investigacions Mèdiques) ;
Jiménez-Conde, Jordi (Institut Hospital del Mar d'Investigacions Mèdiques) ;
Fernandez-Cadenas, Israel (Institut d'Investigació Biomèdica Sant Pau) ;
Universitat Autònoma de Barcelona
Background and purpose: The neurological course after stroke is highly variable and is determined by demographic, clinical and genetic factors. However, other heritable factors such as epigenetic DNA methylation could play a role in neurological changes after stroke. [...]
2022 - 10.1186/s13148-022-01340-5
Clinical Epigenetics, Vol. 14 Núm. 1 (december 2022) , p. 124
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4.
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12 p, 1.1 MB |
A Polygenic Risk Score Based on a Cardioembolic Stroke Multitrait Analysis Improves a Clinical Prediction Model for This Stroke Subtype
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Cárcel-Márquez, Jara (Institut d'Investigació Biomèdica Sant Pau) ;
Muiño, Elena (Institut d'Investigació Biomèdica Sant Pau) ;
Gallego-Fabrega, Cristina (Institut d'Investigació Biomèdica Sant Pau) ;
Cullell, Natalia (Institut d'Investigació Biomèdica Sant Pau) ;
Lledós, Miquel (Institut d'Investigació Biomèdica Sant Pau) ;
Llucià-Carol, Laia (Universitat Autònoma de Barcelona. Departament de Genètica i de Microbiologia) ;
Sobrino, Tomás (Hospital Clínico Universitario (Santiago de Compostela, Galícia)) ;
Campos, Francisco (Hospital Clínico Universitario (Santiago de Compostela, Galícia)) ;
Castillo, José (Hospital Clínico Universitario (Santiago de Compostela, Galícia)) ;
Freijo, Marimar (Biocruces-Bizkaia Health Research Institute. Department of Neurology) ;
Arenillas, Juan F (Hospital Universitario de Valladolid) ;
Obach, Víctor (Hospital Clínic i Provincial de Barcelona) ;
Álvarez Sabín, José (Hospital Universitari Vall d'Hebron) ;
Molina, Carlos A. (Hospital Universitari Vall d'Hebron) ;
Ribó, Marc (Hospital Universitari Vall d'Hebron) ;
Jiménez-Conde, Jordi (Hospital del Mar (Barcelona, Catalunya)) ;
Roquer, Jaume (Hospital del Mar (Barcelona, Catalunya)) ;
Muñoz-Narbona, Lucia (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
López-Cancio, Elena (Hospital Central de Asturias (HUCA)) ;
Millán, Mònica (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Diaz-Navarro, Rosa (Institut d’Investigació Sanitària Illes Balears) ;
Vives-Bauza, Cristòfol (Institut d’Investigació Sanitària Illes Balears) ;
Serrano-Heras, Gemma (Complejo Hospitalario Universitario de Albacete) ;
Segura, Tomás (Complejo Hospitalario Universitario de Albacete) ;
Ibañez, Laura (Washington University School of Medicine. Department of Psychiatry) ;
Heitsch, Laura (Washington University School of Medicine. Department of Neurology) ;
Delgado, Pilar (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Dhar, Rajat (Washington University School of Medicine. Department of Neurology.) ;
Krupinski, Jerzy (Hospital Universitari MútuaTerrassa (Terrassa, Catalunya)) ;
Delgado Mederos, Raquel (Institut d'Investigació Biomèdica Sant Pau) ;
Prats-Sánchez, Luis Antonio (Institut d'Investigació Biomèdica Sant Pau) ;
Camps-Renom, Pol (Institut d'Investigació Biomèdica Sant Pau) ;
Blay, Natalia (Institut Germans Trias i Pujol) ;
Sumoy, Lauro (Institut Germans Trias i Pujol) ;
de Cid, Rafael (Institut Germans Trias i Pujol) ;
Montaner, Joan (Hospital Universitario Virgen Macarena (Sevilla, Andalusia)) ;
Cruchaga, Carlos (Washington University in St. Louis. Neurogenomics and Informatics Center.) ;
Lee, Jim-Moo (Washington University School of Medicine. Department of Neurology.) ;
Martí-Fàbregas, Joan (Institut d'Investigació Biomèdica Sant Pau) ;
Fernandez-Cadenas, Israel (Institut d'Investigació Biomèdica Sant Pau) ;
Universitat Autònoma de Barcelona
Background: Occult atrial fibrillation (AF) is one of the major causes of embolic stroke of undetermined source (ESUS). Knowing the underlying etiology of an ESUS will reduce stroke recurrence and/or unnecessary use of anticoagulants. [...]
2022 - 10.3389/fcvm.2022.940696
Frontiers in Cardiovascular Medicine, Vol. 9 (august 2022) , p. 940696
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13 p, 1.4 MB |
Compliance to Multidisciplinary Lifestyle Intervention Decreases Blood Pressure in Patients with Resistant Hypertension : A Cross-Sectional Pilot Study
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Espinel Garuz, Eugenia (Hospital Universitari Vall d'Hebron) ;
Azancot, María A (Hospital Universitari Vall d'Hebron) ;
Gomez-Garrido, Alba (Hospital Universitari Vall d'Hebron) ;
Beneria, Anna (Hospital Universitari Vall d'Hebron) ;
Caraben, Anna (Hospital Universitari Vall d'Hebron) ;
Andurell, Laura (Hospital Universitari Vall d'Hebron) ;
Delgado Martínez, María Pilar (Hospital Universitari Vall d'Hebron) ;
Castañé, Helena (Universitat Rovira i Virgili) ;
Joven, Jorge (Universitat Rovira i Virgili) ;
Seron, Daniel (Hospital Universitari Vall d'Hebron) ;
Universitat Autònoma de Barcelona
Hypertension is a common chronic medical condition. Treatment is not satisfactory in a significant proportion of patients with primary hypertension, despite the concurrent use of three or more medications with different mechanisms of action. [...]
2023 - 10.3390/jcm12020679
Journal of clinical medicine, Vol. 12 (january 2023)
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6.
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10 p, 2.3 MB |
New candidate blood biomarkers potentially associated with white matter hyperintensities progression
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Jiménez-Balado, Joan (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Pizarro Gonzálvez, Jesús (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Riba-Llena, Iolanda (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Penalba, Anna (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Faura, Júlia (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Palà, Elena (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Montaner, Joan (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Hernández-Guillamon, Mar (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Delgado Martínez, María Pilar (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Universitat Autònoma de Barcelona
We aimed to discover blood biomarkers associated with longitudinal changes in white matter hyperintensities (WMH). This study was divided into a discovery phase and a replication phase. Subjects in both studies were patients with hypertension, aged 50-70, who underwent two magnetic resonance imaging (MRI) sessions and blood extractions over a 4-year follow-up period. [...]
2021 - 10.1038/s41598-021-93498-w
Scientific reports, Vol. 11 (july 2021)
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7.
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7 p, 903.0 KB |
Relationship between Retinal Microvasculature, Cardiovascular Risk and Silent Brain Infarction in Hypertensive Patients
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Forés Raurell, Rosa (Institut Universitari d'Investigació en Atenció Primària Jordi Gol) ;
Manresa, J. M (Institut Universitari d'Investigació en Atenció Primària Jordi Gol) ;
López-Lifante, Victor M. (Institut Universitari d'Investigació en Atenció Primària Jordi Gol) ;
Heras, Antonio (Institut Universitari d'Investigació en Atenció Primària Jordi Gol) ;
Delgado Martínez, María Pilar (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Vázquez, Xose (Hospital Municipal de Badalona) ;
Ruiz, Susana (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Alzamora, M. Teresa (Institut Universitari d'Investigació en Atenció Primària Jordi Gol) ;
Torán Montserrat, Pere (Institut Universitari d'Investigació en Atenció Primària Jordi Gol) ;
Universitat Autònoma de Barcelona
Objective: The aims of this study are to analyze the role of artery-vein ratio AVR assessment using VesselMap 2 software (Imedos Systems) and cardiovascular risk evaluation by means of REGICOR in the prediction of silent brain infarction (SBI) in middle-age hypertensive patients from the ISSYS study. [...]
2021 - 10.3390/diagnostics11060937
Diagnostics, Vol. 11 (may 2021)
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8.
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14 p, 632.5 KB |
Diabetes, Albuminuria and the Kidney-Brain Axis
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Ariton, Diana María (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Jiménez-Balado, Joan (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Maisterra Santos, Olga (Hospital Universitari Vall d'Hebron) ;
Pujadas, Francesc (Hospital Universitari Vall d'Hebron) ;
Soler, María José (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Delgado Martínez, María Pilar (Hospital Universitari Vall d'Hebron) ;
Universitat Autònoma de Barcelona
Cognitive decline and kidney disease are significant public health problems that share similar characteristics and risk factors. The pathophysiology of the kidney-brain axis is not completely understood, and studies analysing the relationship between the biomarkers of kidney damage and cognitive impairment show different results. [...]
2021 - 10.3390/jcm10112364
Journal of clinical medicine, Vol. 10 (may 2021)
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9.
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15 p, 1.0 MB |
Circulating AQP4 Levels in Patients with Cerebral Amyloid Angiopathy-Associated Intracerebral Hemorrhage
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Marazuela, Paula (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Bonaterra-Pastra, Anna (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Faura, Júlia (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Penalba, Anna (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Pizarro Gonzálvez, Jesús (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Pancorbo, Olalla (Hospital Universitari Vall d'Hebron) ;
Rodríguez-Luna, David (Hospital Universitari Vall d'Hebron) ;
Vert, Carla (Hospital Universitari Vall d'Hebron) ;
Rovira, Alex (Hospital Universitari Vall d'Hebron) ;
Pujadas, Francesc (Hospital Universitari Vall d'Hebron) ;
Freijo, M. Mar (Instituto de Investigación Sanitaria Biocruces Bizkaia) ;
Tur, Silvia (Hospital Universitari Son Espases (Palma de Mallorca, Balears)) ;
Martínez-Zabaleta, Maite (Hospital Universitario de Donostia (Sant Sebastià, País Basc)) ;
Cardona, Pere-Joan (Hospital Universitari de Bellvitge) ;
Vera, Rocío (Hospital Universitario Ramón y Cajal (Madrid)) ;
Lebrato-Hernández, Lucia (Hospital Universitario Virgen del Rocío (Sevilla, Andalusia)) ;
Arenillas, Juan F.. (Universidad de Valladolid) ;
Pérez-Sánchez, Soledad (Hospital Universitario Virgen Macarena (Sevilla, Andalusia)) ;
Montaner, Joan (Universidad de Sevilla) ;
Delgado Martínez, María Pilar (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Hernandez Guillamon, Maria Mar (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Universitat Autònoma de Barcelona
Cerebral amyloid angiopathy (CAA) is a major cause of lobar intracerebral hemorrhage (ICH) in elderly patients. Growing evidence suggests a potential role of aquaporin 4 (AQP4) in amyloid-beta-associated diseases, including CAA pathology. [...]
2021 - 10.3390/jcm10050989
Journal of clinical medicine, Vol. 10 (march 2021)
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10.
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14 p, 672.9 KB |
Validation of the Spanish version of the questionnaire on Patient Empowerment in Long-Term Conditions
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Garcimartin, Paloma (Parc de Salut MAR de Barcelona) ;
Comín-Colet, Josep (Universitat de Barcelona. Departament de Ciències Clíniques) ;
Pardo Cladellas, Yolanda (Universitat Autònoma de Barcelona. Departament de Psiquiatria i de Medicina Legal) ;
Badosa, Neus (Parc de Salut MAR de Barcelona) ;
Linas, Anna (Parc de Salut MAR de Barcelona) ;
Rosenfeld, Laia (Hospital Universitari de Bellvitge) ;
Faraudo, Merçe (Hospital de Sant Joan Despí Moisès Broggi) ;
Valero, Oliver (Universitat Autònoma de Barcelona. Departament de Matemàtiques) ;
Hidalgo, Encarnación (Hospital Universitari de Bellvitge) ;
Cainzos-Achirica, Miguel (Hospital Universitari de Bellvitge) ;
Ruiz, Sonia (Institut Parc de Salut MAR de Barcelona) ;
Delgado-Hito, Pilar (Universitat de Barcelona)
Patient empowerment is a key factor in improving health outcomes. To evaluate the psychometric properties of the Spanish version of the questionnaire on Patient Empowerment in Long-Term Conditions (PELC) that evaluates the degree of empowerment of patients with chronic diseases. [...]
2020 - 10.1371/journal.pone.0233338
PloS one, Vol. 15 (june 2020)
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