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11 p, 1.9 MB |
A complex interplay between H2A.Z and HP1 isoforms regulates pericentric heterochromatin
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González Miranda, Jessica (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ;
Bosch-Presegué, Laia (Institut de Recerca I Innovació en Ciències de La Vida i de La Salut a La Catalunya Central) ;
Marazuela Duque, Anna (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ;
Guitart-Solanes, Anna (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ;
Espinosa-Alcantud, María Dolores (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ;
Fernandez, Agustín F. (Centro de Investigación Biomédica en Red de Enfermedades Raras) ;
Brown, Jeremy P. (Department of Immunology and Inflammation. The Hammersmith Hospital) ;
Ausió, Juan (University of Victoria. Department of Biochemistry and Microbiology) ;
Vazquez Prat, Berta Nieves (Universitat Autònoma de Barcelona. Departament de Biologia Cel·lular, de Fisiologia i d'Immunologia) ;
Singh, Prim B. (Nazarbayev University School of Medicine) ;
Fraga, Mario F. (Centro de Investigación Biomédica en Red de Enfermedades Raras) ;
Vaquero, Alejandro (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras)
Pericentric heterochromatin (PCH) plays an essential role in the maintenance of genome integrity and alterations in PCH have been linked to cancer and aging. HP1 α, β, and γ, are hallmarks of constitutive heterochromatin that are thought to promote PCH structure through binding to heterochromatin-specific histone modifications and interaction with a wide range of factors. [...]
2023 -  10.3389/fcell.2023.1293122
Frontiers in Cell and Developmental Biology, Vol. 11 (2023) , p. 1293122
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2.
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13 p, 1.9 MB |
Contribution of TEX15 genetic variants to the risk of developing severe non-obstructive oligozoospermia
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Guzmán-Jiménez, Andrea (Instituto de Investigación Sanitaria de Granada) ;
González-Muñoz, Sara (Instituto de Investigación Sanitaria de Granada) ;
Cerván-Martín, Miriam (Instituto de Investigación Sanitaria de Granada) ;
Rivera-Egea, Rocío (Instituto de Investigación Sanitaria La Fe (València)) ;
Garrido, Nicolás (Instituto de Investigación Sanitaria La Fe (València)) ;
Luján, Saturnino (Instituto de Investigación Sanitaria La Fe (València)) ;
Santos-Ribeiro, Samuel (University of Lisbon. Department of Obstetrics and Gynecology) ;
Castilla, José Antonio (CEIFER Biobanco-GAMETIA) ;
Gonzálvo, María Carmen (Hospital Universitario Virgen de las Nieves (Granada)) ;
Clavero, Ana (Hospital Universitario Virgen de las Nieves (Granada)) ;
Vicente, F.Javier (Hospital Universitario Virgen de las Nieves (Granada)) ;
Maldonado, Vicente (Complejo Hospitalario de Jaén) ;
Villegas-Salmerón, Javier (Centro de Investigación Biomédica (CIBM). Universidad de Granada. Departamento de Genética e Instituto de Biotecnología) ;
Burgos, Miguel (Centro de Investigación Biomédica (CIBM). Universidad de Granada. Departamento de Genética e Instituto de Biotecnología) ;
Jiménez, Rafael (Centro de Investigación Biomédica (CIBM). Universidad de Granada. Departamento de Genética e Instituto de Biotecnología) ;
Pinto, Maria Graça (Complejo Hospitalario de Jaén) ;
Pereira, Isabel (Hospital de Santa Maria. Centro Hospitalar Universitário de Lisboa Norte. Departamento de Obstetrícia. Ginecologia e Medicina da Reprodução) ;
Nunes, Joaquim (Hospital de Santa Maria. Centro Hospitalar Universitário de Lisboa Norte. Departamento de Obstetrícia. Ginecologia e Medicina da Reprodução) ;
Sánchez-Curbelo, Josvany (Institut d'Investigació Biomèdica Sant Pau) ;
López-Rodrigo, Olga (Fundació Puigvert) ;
Pereira-Caetano, Iris (Instituto Nacional de Saúde Dr. Ricardo Jorge. Departamento de Genética Humana) ;
Marques, Patricia Isabel (Institute of Molecular Pathology and Immunology of the University of Porto (IPATIMUP)) ;
Carvalho, Filipa (Faculdade de Medicina da Universidade do Porto. Serviço de Genética. Departamento de Patologia) ;
Barros, Alberto (Faculdade de Medicina da Universidade do Porto. Serviço de Genética. Departamento de Patologia) ;
Bassas, Lluís (Institut d'Investigació Biomèdica Sant Pau) ;
Seixas, Susana (Institute of Molecular Pathology and Immunology of the University of Porto (IPATIMUP)) ;
Gonçalves, João (ToxOmics-Centro de Toxicogenómica e Saúde Humana. Nova Medical School) ;
Lopes, Alexandra M. (CGPP-IBMC-Centro de Genética Preditiva e Preventiva. Instituto de Biologia Molecular e Celular. Universidade do Porto) ;
Larriba, Sara (Institut d'Investigació Biomèdica de Bellvitge) ;
Palomino-Morales, Rogelio J. (Universidad de Granada. Departamento de Bioquímica y Biología Molecular) ;
Carmona, F. David (Instituto de Investigación Sanitaria de Granada) ;
Bossini-Castillo, Lara (Instituto de Investigación Sanitaria de Granada)
Background: Severe spermatogenic failure (SPGF) represents one of the most relevant causes of male infertility. This pathological condition can lead to extreme abnormalities in the seminal sperm count, such as severe oligozoospermia (SO) or non-obstructive azoospermia (NOA). [...]
2022 - 10.3389/fcell.2022.1089782
Frontiers in Cell and Developmental Biology, Vol. 10 (December 2022) , p. 1089782
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3.
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19 p, 4.4 MB |
Divergent patterns of meiotic double strand breaks and synapsis initiation dynamics suggest an evolutionary shift in the meiosis program between American and Australian marsupials
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Valero-Regalón, F. Javier (Universidad Autónoma de Madrid) ;
Solé, Mireia (Universitat Autònoma de Barcelona. Departament de Biologia Cel·lular, de Fisiologia i d'Immunologia) ;
López-Jiménez, Pablo (Universidad Autónoma de Madrid) ;
Valerio-de Arana, María (Universidad Autónoma de Madrid) ;
Martín-Ruiz, Marta (Universidad Autónoma de Madrid) ;
de la Fuente, Roberto (The Polish Academy of Sciences) ;
Marin Gual, Laia (Universitat Autònoma de Barcelona. Departament de Biologia Cel·lular, de Fisiologia i d'Immunologia) ;
Renfree, Marilyn B. (The University of Melbourne) ;
Shaw, Geoff (The University of Melbourne) ;
Berríos, Soledad (Universidad de Chile) ;
Fernández-Donoso, Raúl (Universidad de Chile) ;
Waters, Paul D. (University of New South Wales) ;
Ruiz-Herrera Moreno, Aurora (Universitat Autònoma de Barcelona. Departament de Biologia Cel·lular, de Fisiologia i d'Immunologia) ;
Gómez, Rocío (Universidad Autónoma de Madrid) ;
Page, Jesús (Universidad Autónoma de Madrid)
In eutherian mammals, hundreds of programmed DNA double-strand breaks (DSBs) are generated at the onset of meiosis. The DNA damage response is then triggered. Although the dynamics of this response is well studied in eutherian mammals, recent findings have revealed different patterns of DNA damage signaling and repair in marsupial mammals. [...]
2023 - 10.3389/fcell.2023.1147610
Frontiers in Cell and Developmental Biology, Vol. 11 (April 2023) , art. 1147610
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4.
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30 p, 954.0 KB |
Circadian autonomy and rhythmic precision of the Arabidopsis female reproductive organ
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Okada, Masaaki (Centre de Recerca en Agrigenòmica) ;
Yang, Zhiyuan (Centre de Recerca en Agrigenòmica) ;
Mas, Paloma (Centre de Recerca en Agrigenòmica)
The plant circadian clock regulates essential biological processes including flowering time or petal movement. However, little is known about how the clock functions in flowers. Here, we identified the circadian components and transcriptional networks contributing to the generation of rhythms in pistils, the female reproductive organ. [...]
2022 - 10.1016/j.devcel.2022.08.013
Developmental cell, Vol. 57, Issue 18 (September 2022) , p. 2168-2180
2 documents
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20 p, 1.7 MB |
Seminal Microbiota of Idiopathic Infertile Patients and Its Relationship With Sperm DNA Integrity
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Garcia Segura, Sergio (Universitat Autònoma de Barcelona. Departament de Biologia Cel·lular, de Fisiologia i d'Immunologia) ;
Del Rey Azpiri, Javier (Universitat Autònoma de Barcelona. Departament de Biologia Cel·lular, de Fisiologia i d'Immunologia) ;
Closa, Laia (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
García-Martinez, Iris (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Hobeich, Carlos (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Castel, Ana Belén (Instituto de Fertilidad) ;
Vidal, Francisco (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Benet i Català, Jordi (Universitat Autònoma de Barcelona. Departament de Biologia Cel·lular, de Fisiologia i d'Immunologia) ;
Ribas-Maynou, Jordi (Universitat de Girona. Departament de Biologia Cel·lular) ;
Oliver Bonet, Maria (Universitat Autònoma de Barcelona. Departament de Biologia Cel·lular, de Fisiologia i d'Immunologia)
The development of new biomarkers for human male infertility is crucial to improve the diagnosis and the prognosis of this disease. Recently, seminal microbiota was shown to be related to sperm quality parameters, suggesting an effect in human fertility and postulating it as a biomarker candidate. [...]
2022 - 10.3389/fcell.2022.937157
Frontiers in Cell and Developmental Biology, Vol. 10 (June 2022) , art. 937157
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7.
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15 p, 2.1 MB |
MCL-1 Inhibition Overcomes Anti-apoptotic Adaptation to Targeted Therapies in B-Cell Precursor Acute Lymphoblastic Leukemia
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Manzano-Muñoz, A. (Institut de Bioenginyeria de Catalunya) ;
Alcon, Clara (Institut de Bioenginyeria de Catalunya) ;
Menéndez Bujan, Pablo (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ;
Ramírez, Manuel (Department of Pediatric Hematology and Oncology. Niño Jesús University Children's Hospital) ;
Seyfried, F. (Department of Pediatrics and Adolescent Medicine. Ulm University Medical Center) ;
Debatin, K.M. (Department of Pediatrics and Adolescent Medicine. Ulm University Medical Center) ;
Meyer, L.H. (Department of Pediatrics and Adolescent Medicine. Ulm University Medical Center) ;
Samitier, J. (Networking Biomedical Research Center in Bioengineering. Biomaterials and Nanomedicine (CIBER-BBN)) ;
Montero, J. (Institut de Bioenginyeria de Catalunya)
Multiple targeted therapies are currently explored for pediatric and young adult B-cell precursor acute lymphoblastic leukemia (BCP-ALL) treatment. However, this new armamentarium of therapies faces an old problem: choosing the right treatment for each patient. [...]
2021 - 10.3389/fcell.2021.695225
Frontiers in Cell and Developmental Biology, Vol. 9 (september 2021) , art. 695225
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18 p, 5.6 MB |
Lysine Methyltransferase Inhibitors Impair H4K20me2 and 53BP1 Foci in Response to DNA Damage in Sarcomas, a Synthetic Lethality Strategy
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Campillo-Marcos, Ignacio (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ;
Monte-Serrano, Eva (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ;
Navarro-Carrasco, Elena (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ;
García-González, Raúl (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ;
Lazo, Pedro A. (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras)
Background: Chromatin is dynamically remodeled to adapt to all DNA-related processes, including DNA damage responses (DDR). This adaptation requires DNA and histone epigenetic modifications, which are mediated by several types of enzymes; among them are lysine methyltransferases (KMTs). [...]
2021 - 10.3389/fcell.2021.715126
Frontiers in Cell and Developmental Biology, Vol. 9 (september 2021) , p. 715126
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17 p, 2.8 MB |
Recent advances in the pharmacological targeting of ubiquitin-regulating enzymes in cancer
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Montagut, Ana Maria (Universitat Ramon Llull) ;
Armengol, Marc Antoni (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ;
de Pablo, German Gorjón (Universitat Ramon Llull) ;
Estrada-Tejedor, Roger (Universitat Ramon Llull) ;
Borrell, José Ignacio (Universitat Ramon Llull) ;
Roué, Gaël (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ;
Universitat Autònoma de Barcelona
As a post-translational modification that has pivotal roles in protein degradation, ubiquitination ensures that intracellular proteins act in a precise spatial and temporal manner to regulate diversified cellular processes. [...]
2022 - 10.1016/j.semcdb.2022.02.007
Seminars in Cell and Developmental Biology, Vol. 132 (december 2022) , p. 213-229
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